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The placenta and umbilical cord in prenatal care: Unseen, overlooked and misunderstood. 产前护理中的胎盘和脐带:看不见、忽视和误解。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-14 DOI: 10.1111/1471-0528.17936
Eric Jauniaux, Christoph Lees, Amar Bhide, Elizabeth Daly-Jones, Deepa Srinivasan, Yinka Oyelese
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引用次数: 0
Intrapartum and postpartum antibiotic use in seven low- and middle-income countries: Findings from the A-PLUS trial. 七个中低收入国家的产前和产后抗生素使用情况:A-PLUS试验结果。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-14 DOI: 10.1111/1471-0528.17930
Sarah Saleem, Haleema Yasmin, Janet L Moore, Anum Rahim, Iram Shakeel, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Musaku Mwenechanya, Elwyn Chomba, Shivaprasad S Goudar, Avinash Kavi, Richard J Derman, Nancy F Krebs, Lester Figueroa, Manolo Mazariegos, Paul Nyongesa, Sherri Bucher, Fabian Esamai, Archana Patel, Manjushree Waikar, Poonam Shivkumar, Patricia L Hibberd, William A Petri, Sk Masum Billah, Rashidul Haque, Waldemar A Carlo, Alan Tita, Marion Koso-Thomas, Jennifer Hemingway-Foday, Elizabeth M McClure, Robert L Goldenberg

Objective: To describe the intrapartum and postpartum use of non-study antibiotics in low- and middle-income countries (LMICs) during the double-blinded NICHD Global Network Azithromycin in Labor (A-PLUS) trial.

Design: The antibiotic use sub-study was a planned prospective, observational sub-study of the A-PLUS trial.

Settings: The study was carried out in hospitals or health centres affiliated with eight sites of the Global Network for Women's and Children's Health Research (Global Network) in seven countries: Bangladesh, Pakistan, India (two sites), Kenya, Zambia, The Democratic Republic of the Congo (DRC) and Guatemala.

Population: Totally, 29 278 pregnant women enrolled in the A-PLUS trial.

Methods: We collected data on 29 278 pregnant women admitted to a facility for delivery related to non-study antibiotic use overall and during three time periods: (1) in the facility prior to delivery, (2) after delivery until facility discharge and (3) after discharge to 42 days post-partum.

Main outcome measures: Non-study antibiotic use overall and for treatment or prophylaxis by the site during the three time periods.

Results: Of the 29 278 women in the study, 5020 (17.1%; 95% CI 16.7%-17.6%) received non-study antibiotics in the facility prior to delivery, 11 956 (40.8%; 95% CI 40.3%-41.4%) received non-study antibiotics in the facility after delivery, and 13 390 (47.6%; 95% CI 47.0%-48.2%) women received non-study antibiotics after delivery and after facility discharge. Antibiotics were prescribed more often among women in the Asian and Guatemalan sites than in the African sites. In the three time-periods, among those receiving antibiotics, prophylaxis was the indication in 82.3%, 97.7% and 90.7% of the cases, respectively. The type of antibiotics used varied substantially by time-period and site, but generally, penicillin-type drugs, cephalosporin-type drugs and metronidazole were used more frequently than other types.

Conclusions: Across the eight sites of the Global Network, in the facility before delivery, and in the post-partum periods before and after facility discharge, antibiotics were used frequently, but use was highly variable by site and time-period.

目的描述中低收入国家(LMICs)在国家儿童疾病防治中心(NICHD)全球网络产程中阿奇霉素双盲试验(A-PLUS)期间产前和产后使用非试验抗生素的情况:抗生素使用子研究是 A-PLUS 试验的一项计划性前瞻性观察子研究:研究在七个国家的八个全球妇幼健康研究网络(全球网络)下属医院或保健中心进行:孟加拉国、巴基斯坦、印度(两个地点)、肯尼亚、赞比亚、刚果民主共和国和危地马拉:方法:我们收集了 29 278 名参加 A-PLUS 试验的孕妇的数据:我们收集了 29 278 名在医疗机构分娩的孕妇的数据,这些数据涉及非研究抗生素使用的总体情况和三个时间段:(1) 分娩前在医疗机构,(2) 分娩后至出院,(3) 出院后至产后 42 天:主要结果测量指标:非研究抗生素的总体使用情况,以及三个时间段内各医疗机构治疗或预防抗生素的使用情况:在参与研究的 29 278 名产妇中,有 5020 人(17.1%;95% CI 16.7%-17.6%)在分娩前在医疗机构接受了非研究抗生素治疗,有 11 956 人(40.8%;95% CI 40.3%-41.4%)在分娩后在医疗机构接受了非研究抗生素治疗,有 13 390 人(47.6%;95% CI 47.0%-48.2%)在分娩后和出院后接受了非研究抗生素治疗。亚洲和危地马拉地区的产妇比非洲地区的产妇更常使用抗生素。在这三个时间段内,接受抗生素治疗的病例中,分别有 82.3%、97.7% 和 90.7% 的病例以预防为主。不同时期和不同地点使用的抗生素种类差别很大,但一般来说,青霉素类药物、头孢菌素类药物和甲硝唑的使用频率高于其他类型的抗生素:在全球网络的八个地点中,在分娩前、分娩后出院前和出院后,抗生素的使用频率很高,但不同地点和不同时间段的使用情况差异很大。
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引用次数: 0
ChatGPT in a gynaecologic oncology multidisciplinary team tumour board: A feasibility study. 妇科肿瘤多学科小组肿瘤委员会的 ChatGPT:可行性研究。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-14 DOI: 10.1111/1471-0528.17929
Gabriel Levin, Walter Gotlieb, Pedro Ramirez, Raanan Meyer, Yoav Brezinov
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引用次数: 0
Enhancing HPV vaccination and education to reduce vaginal cancer incidence. 加强 HPV 疫苗接种和教育,降低阴道癌发病率。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-12 DOI: 10.1111/1471-0528.17935
Tomoyuki Kawada
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引用次数: 0
Evaluating waterbirth risks: A deep dive into the POOL cohort study's research gaps. 评估水中分娩风险:深入探讨 POOL 队列研究的研究空白。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-12 DOI: 10.1111/1471-0528.17934
Wei-Zhen Tang, Tai-Hang Liu, Xia Lan
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引用次数: 0
Obstetric anal sphincter injuries during instrumental vaginal delivery. 器械阴道分娩时产科肛门括约肌损伤。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-12 DOI: 10.1111/1471-0528.17931
Prathamesh Lanjewar, Avir Sarkar
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引用次数: 0
Magnetic resonance imaging and clinical features of Mayer-Rokitansky-Küster-Hauser syndrome: A 10-year review from a dedicated specialist centre. Mayer-Rokitansky-Küster-Hauser综合征的磁共振成像和临床特征:来自一家专科中心的 10 年回顾。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-12 DOI: 10.1111/1471-0528.17928
Nina Cooper, Maya Al-Memar, Kristofer Linton-Reid, Keith Edmonds, Gillian Rose, Nuala Dixon, Cillian McNamara, Christina Fotopoulou, Katherine Van Ree, Nishat Bharwani

Objective: To correlate the clinical history with imaging findings of women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.

Design: Retrospective cohort study.

Setting: A UK IOTA and ESGO-certified tertiary referral centre for disorders of reproductive development.

Population: All patients with a diagnosis of MRKH and who had undergone an MRI pelvis between 1 January 2011 and 31 April 2021 were included.

Methods: MRI images were analysed by specialist gynaecological radiologists. Clinical data was extracted from an electronic patient record system. Statistical analysis was computed in R (version 4.1.2), R base stats package and ggstatsplot (v0.5.0).

Main outcome measures: Clinical history and predefined imaging features.

Results: One hundred and thirty-four patients were included. Median age at MRI was 18 years (10-64 years). Half (48.2%) of women presenting had a history of pain, most often abdominal (84.6%) or vaginal (9.2%). Remnants were identified in 91.8% of women (n = 123). 4.5% of women had imaging features of endometriosis (n = 6). Women with a functional remnants were significantly more likely to experience pain (p < 0.001). Pain history was not strongly associated with ectopic ovarian position. Common gynaecological pathology such as endometriosis, ovarian cysts and fibroids were also identified.

Conclusions: We identify that majority of women with MRKH will have uterine remnants with a connecting fibrous band, and an ectopic ovarian position 44.0% of cases. Abdominal pain was significantly associated with functional remnants on MRI. Further work is required to identify how other gynaecological pathology impacts women with MRKH.

目的将Mayer-Rokitansky-Küster-Hauser(MRKH)综合征女性患者的临床病史与影像学检查结果联系起来:设计:回顾性队列研究:英国一家经 IOTA 和 ESGO 认证的生殖发育障碍三级转诊中心:方法:所有确诊为 MRKH 并在 2011 年 1 月 1 日至 2021 年 4 月 31 日期间接受过磁共振骨盆成像检查的患者均纳入研究范围:磁共振成像图像由专业妇科放射医师进行分析。临床数据从电子病历系统中提取。统计分析使用 R(4.1.2 版)、R base stats 软件包和 ggstatsplot(v0.5.0)进行计算:临床病史和预定义的影像学特征:结果:共纳入 134 名患者。核磁共振成像时的中位年龄为 18 岁(10-64 岁)。半数(48.2%)女性患者有疼痛病史,多为腹痛(84.6%)或阴道疼痛(9.2%)。91.8%的妇女(n = 123)发现了残留物。4.5%的妇女有子宫内膜异位症的影像学特征(n = 6)。有功能性残留物的妇女更容易感到疼痛(p 结论:有功能性残留物的妇女更容易感到疼痛:我们发现,大多数 MRKH 妇女都会有子宫残留和连接纤维带,44.0% 的病例有异位卵巢。腹痛与核磁共振成像中的功能性残留物有明显关联。还需要进一步研究其他妇科病变对 MRKH 妇女的影响。
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引用次数: 0
The impact of hormone therapy on cardiovascular risk in postmenopausal women: Insights and recommendations. 激素疗法对绝经后妇女心血管风险的影响:见解和建议。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-09 DOI: 10.1111/1471-0528.17932
Luyang Su, Zeqing Du, Cuiqiao Meng
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引用次数: 0
External validation of models to estimate gestational age in the second and third trimester using ultrasound: A prospective multicentre observational study 利用超声波估算第二和第三孕期胎龄模型的外部验证:前瞻性多中心观察研究。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-08 DOI: 10.1111/1471-0528.17922
Alice Self, Michael Schlussel, Gary S. Collins, Ferdinand Dhombres, Nicolas Fries, Georges Haddad, Laurent J. Salomon, Mona Massoud, Aris T. Papageorghiou
<div> <section> <h3> Objectives</h3> <p>Accurate assessment of gestational age (GA) is important at both individual and population levels. The most accurate way to estimate GA in women who book late in pregnancy is unknown. The aim of this study was to externally validate the accuracy of equations for GA estimation in late pregnancy and to identify the best equation for estimating GA in women who do not receive an ultrasound scan until the second or third trimester.</p> </section> <section> <h3> Design</h3> <p>This was a prospective, observational cross-sectional study.</p> </section> <section> <h3> Setting</h3> <p>57 prenatal care centres, France.</p> </section> <section> <h3> Participants</h3> <p>Women with a singleton pregnancy and a previous 11–14-week dating scan that gave the observed GA were recruited over an 8-week period. They underwent a standardised ultrasound examination at one time point during the pregnancy (15–43 weeks), measuring 12 foetal biometric parameters that have previously been identified as useful for GA estimation.</p> </section> <section> <h3> Main Outcome Measures</h3> <p>A total of 189 equations that estimate GA based on foetal biometry were examined and compared with GA estimation based on foetal CRL. Comparisons between the observed GA and the estimated GA were made using <i>R</i><sup>2</sup>, calibration slope and intercept. RMSE, mean difference and 95% range of error were also calculated.</p> </section> <section> <h3> Results</h3> <p>A total of 2741 pregnant women were examined. After exclusions, 2339 participants were included. In the 20 best performing equations, the intercept ranged from −0.22 to 0.30, the calibration slope from 0.96 to 1.03 and the RSME from 0.67 to 0.87. Overall, multiparameter models outperformed single-parameter models. Both the 95% range of error and mean difference increased with gestation. Commonly used models based on measurement of the head circumference alone were not amongst the best performing models and were associated with higher 95% error and mean difference.</p> </section> <section> <h3> Conclusions</h3> <p>We provide strong evidence that GA-specific equations based on multiparameter models should be used to estimate GA in late pregnancy. However, as all methods of GA assessment
目的:准确评估孕龄(GA)对个人和人群都很重要。估算孕晚期妇女孕龄的最准确方法尚不清楚。本研究旨在从外部验证孕晚期孕龄估算公式的准确性,并确定最佳公式,以估算在妊娠第二或第三个月才接受超声波扫描的妇女的孕龄:设计:这是一项前瞻性、观察性横断面研究:地点:法国 57 家产前护理中心:在为期 8 周的时间里,招募了单胎妊娠且之前在 11-14 周的孕期扫描中观察到胎儿性别的妇女。她们在孕期的一个时间点(15-43周)接受了标准化超声波检查,测量了12个胎儿生物测量参数,这些参数之前已被确认为有助于估计胎儿性别:主要结果测量:共研究了 189 个基于胎儿生物测量的 GA 估算方程,并与基于胎儿 CRL 的 GA 估算进行了比较。使用 R2、校准斜率和截距对观察到的 GA 与估计的 GA 进行比较。还计算了 RMSE、平均差和 95% 的误差范围:共有 2741 名孕妇接受了检查。排除后,共纳入 2339 名参与者。在 20 个表现最好的方程中,截距范围从-0.22 到 0.30,校准斜率从 0.96 到 1.03,RSME 从 0.67 到 0.87。总体而言,多参数模型优于单参数模型。95% 误差范围和平均差都随着妊娠期的增加而增加。仅以测量头围为基础的常用模型并不是表现最好的模型,其 95% 误差和平均差也较高:我们提供了强有力的证据,证明基于多参数模型的GA特异性方程应用于估计孕晚期的GA。然而,由于妊娠晚期的所有 GA 评估方法都与较大的预测间期有关,因此,改善早期产前超声检查的可及性仍是当务之急:本研究的提案及相应的方法学综述已在 PROSPERO 国际系统综述注册中心注册(注册号:CRD4201913776)。
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引用次数: 0
Delivering in or out of water, the OASI rates in the POOL cohort study are disturbingly high. 无论是否在水中分娩,POOL 队列研究中的 OASI 率都高得令人不安。
IF 4.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-08-08 DOI: 10.1111/1471-0528.17933
Jan Willem de Leeuw, Katariina Laine, Margareta Manresa, Sari Raisanen, Vladimir Kalis, Zdenĕk Rušavý, Renaud de Tayrac
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引用次数: 0
期刊
Bjog-An International Journal of Obstetrics and Gynaecology
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