Eric Jauniaux, Christoph Lees, Amar Bhide, Elizabeth Daly-Jones, Deepa Srinivasan, Yinka Oyelese
{"title":"The placenta and umbilical cord in prenatal care: Unseen, overlooked and misunderstood.","authors":"Eric Jauniaux, Christoph Lees, Amar Bhide, Elizabeth Daly-Jones, Deepa Srinivasan, Yinka Oyelese","doi":"10.1111/1471-0528.17936","DOIUrl":"https://doi.org/10.1111/1471-0528.17936","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Saleem, Haleema Yasmin, Janet L Moore, Anum Rahim, Iram Shakeel, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Musaku Mwenechanya, Elwyn Chomba, Shivaprasad S Goudar, Avinash Kavi, Richard J Derman, Nancy F Krebs, Lester Figueroa, Manolo Mazariegos, Paul Nyongesa, Sherri Bucher, Fabian Esamai, Archana Patel, Manjushree Waikar, Poonam Shivkumar, Patricia L Hibberd, William A Petri, Sk Masum Billah, Rashidul Haque, Waldemar A Carlo, Alan Tita, Marion Koso-Thomas, Jennifer Hemingway-Foday, Elizabeth M McClure, Robert L Goldenberg
Objective: To describe the intrapartum and postpartum use of non-study antibiotics in low- and middle-income countries (LMICs) during the double-blinded NICHD Global Network Azithromycin in Labor (A-PLUS) trial.
Design: The antibiotic use sub-study was a planned prospective, observational sub-study of the A-PLUS trial.
Settings: The study was carried out in hospitals or health centres affiliated with eight sites of the Global Network for Women's and Children's Health Research (Global Network) in seven countries: Bangladesh, Pakistan, India (two sites), Kenya, Zambia, The Democratic Republic of the Congo (DRC) and Guatemala.
Population: Totally, 29 278 pregnant women enrolled in the A-PLUS trial.
Methods: We collected data on 29 278 pregnant women admitted to a facility for delivery related to non-study antibiotic use overall and during three time periods: (1) in the facility prior to delivery, (2) after delivery until facility discharge and (3) after discharge to 42 days post-partum.
Main outcome measures: Non-study antibiotic use overall and for treatment or prophylaxis by the site during the three time periods.
Results: Of the 29 278 women in the study, 5020 (17.1%; 95% CI 16.7%-17.6%) received non-study antibiotics in the facility prior to delivery, 11 956 (40.8%; 95% CI 40.3%-41.4%) received non-study antibiotics in the facility after delivery, and 13 390 (47.6%; 95% CI 47.0%-48.2%) women received non-study antibiotics after delivery and after facility discharge. Antibiotics were prescribed more often among women in the Asian and Guatemalan sites than in the African sites. In the three time-periods, among those receiving antibiotics, prophylaxis was the indication in 82.3%, 97.7% and 90.7% of the cases, respectively. The type of antibiotics used varied substantially by time-period and site, but generally, penicillin-type drugs, cephalosporin-type drugs and metronidazole were used more frequently than other types.
Conclusions: Across the eight sites of the Global Network, in the facility before delivery, and in the post-partum periods before and after facility discharge, antibiotics were used frequently, but use was highly variable by site and time-period.
{"title":"Intrapartum and postpartum antibiotic use in seven low- and middle-income countries: Findings from the A-PLUS trial.","authors":"Sarah Saleem, Haleema Yasmin, Janet L Moore, Anum Rahim, Iram Shakeel, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Musaku Mwenechanya, Elwyn Chomba, Shivaprasad S Goudar, Avinash Kavi, Richard J Derman, Nancy F Krebs, Lester Figueroa, Manolo Mazariegos, Paul Nyongesa, Sherri Bucher, Fabian Esamai, Archana Patel, Manjushree Waikar, Poonam Shivkumar, Patricia L Hibberd, William A Petri, Sk Masum Billah, Rashidul Haque, Waldemar A Carlo, Alan Tita, Marion Koso-Thomas, Jennifer Hemingway-Foday, Elizabeth M McClure, Robert L Goldenberg","doi":"10.1111/1471-0528.17930","DOIUrl":"https://doi.org/10.1111/1471-0528.17930","url":null,"abstract":"<p><strong>Objective: </strong>To describe the intrapartum and postpartum use of non-study antibiotics in low- and middle-income countries (LMICs) during the double-blinded NICHD Global Network Azithromycin in Labor (A-PLUS) trial.</p><p><strong>Design: </strong>The antibiotic use sub-study was a planned prospective, observational sub-study of the A-PLUS trial.</p><p><strong>Settings: </strong>The study was carried out in hospitals or health centres affiliated with eight sites of the Global Network for Women's and Children's Health Research (Global Network) in seven countries: Bangladesh, Pakistan, India (two sites), Kenya, Zambia, The Democratic Republic of the Congo (DRC) and Guatemala.</p><p><strong>Population: </strong>Totally, 29 278 pregnant women enrolled in the A-PLUS trial.</p><p><strong>Methods: </strong>We collected data on 29 278 pregnant women admitted to a facility for delivery related to non-study antibiotic use overall and during three time periods: (1) in the facility prior to delivery, (2) after delivery until facility discharge and (3) after discharge to 42 days post-partum.</p><p><strong>Main outcome measures: </strong>Non-study antibiotic use overall and for treatment or prophylaxis by the site during the three time periods.</p><p><strong>Results: </strong>Of the 29 278 women in the study, 5020 (17.1%; 95% CI 16.7%-17.6%) received non-study antibiotics in the facility prior to delivery, 11 956 (40.8%; 95% CI 40.3%-41.4%) received non-study antibiotics in the facility after delivery, and 13 390 (47.6%; 95% CI 47.0%-48.2%) women received non-study antibiotics after delivery and after facility discharge. Antibiotics were prescribed more often among women in the Asian and Guatemalan sites than in the African sites. In the three time-periods, among those receiving antibiotics, prophylaxis was the indication in 82.3%, 97.7% and 90.7% of the cases, respectively. The type of antibiotics used varied substantially by time-period and site, but generally, penicillin-type drugs, cephalosporin-type drugs and metronidazole were used more frequently than other types.</p><p><strong>Conclusions: </strong>Across the eight sites of the Global Network, in the facility before delivery, and in the post-partum periods before and after facility discharge, antibiotics were used frequently, but use was highly variable by site and time-period.</p>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Levin, Walter Gotlieb, Pedro Ramirez, Raanan Meyer, Yoav Brezinov
{"title":"ChatGPT in a gynaecologic oncology multidisciplinary team tumour board: A feasibility study.","authors":"Gabriel Levin, Walter Gotlieb, Pedro Ramirez, Raanan Meyer, Yoav Brezinov","doi":"10.1111/1471-0528.17929","DOIUrl":"https://doi.org/10.1111/1471-0528.17929","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing HPV vaccination and education to reduce vaginal cancer incidence.","authors":"Tomoyuki Kawada","doi":"10.1111/1471-0528.17935","DOIUrl":"https://doi.org/10.1111/1471-0528.17935","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating waterbirth risks: A deep dive into the POOL cohort study's research gaps.","authors":"Wei-Zhen Tang, Tai-Hang Liu, Xia Lan","doi":"10.1111/1471-0528.17934","DOIUrl":"https://doi.org/10.1111/1471-0528.17934","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obstetric anal sphincter injuries during instrumental vaginal delivery.","authors":"Prathamesh Lanjewar, Avir Sarkar","doi":"10.1111/1471-0528.17931","DOIUrl":"https://doi.org/10.1111/1471-0528.17931","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Cooper, Maya Al-Memar, Kristofer Linton-Reid, Keith Edmonds, Gillian Rose, Nuala Dixon, Cillian McNamara, Christina Fotopoulou, Katherine Van Ree, Nishat Bharwani
Objective: To correlate the clinical history with imaging findings of women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.
Design: Retrospective cohort study.
Setting: A UK IOTA and ESGO-certified tertiary referral centre for disorders of reproductive development.
Population: All patients with a diagnosis of MRKH and who had undergone an MRI pelvis between 1 January 2011 and 31 April 2021 were included.
Methods: MRI images were analysed by specialist gynaecological radiologists. Clinical data was extracted from an electronic patient record system. Statistical analysis was computed in R (version 4.1.2), R base stats package and ggstatsplot (v0.5.0).
Main outcome measures: Clinical history and predefined imaging features.
Results: One hundred and thirty-four patients were included. Median age at MRI was 18 years (10-64 years). Half (48.2%) of women presenting had a history of pain, most often abdominal (84.6%) or vaginal (9.2%). Remnants were identified in 91.8% of women (n = 123). 4.5% of women had imaging features of endometriosis (n = 6). Women with a functional remnants were significantly more likely to experience pain (p < 0.001). Pain history was not strongly associated with ectopic ovarian position. Common gynaecological pathology such as endometriosis, ovarian cysts and fibroids were also identified.
Conclusions: We identify that majority of women with MRKH will have uterine remnants with a connecting fibrous band, and an ectopic ovarian position 44.0% of cases. Abdominal pain was significantly associated with functional remnants on MRI. Further work is required to identify how other gynaecological pathology impacts women with MRKH.
{"title":"Magnetic resonance imaging and clinical features of Mayer-Rokitansky-Küster-Hauser syndrome: A 10-year review from a dedicated specialist centre.","authors":"Nina Cooper, Maya Al-Memar, Kristofer Linton-Reid, Keith Edmonds, Gillian Rose, Nuala Dixon, Cillian McNamara, Christina Fotopoulou, Katherine Van Ree, Nishat Bharwani","doi":"10.1111/1471-0528.17928","DOIUrl":"https://doi.org/10.1111/1471-0528.17928","url":null,"abstract":"<p><strong>Objective: </strong>To correlate the clinical history with imaging findings of women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>A UK IOTA and ESGO-certified tertiary referral centre for disorders of reproductive development.</p><p><strong>Population: </strong>All patients with a diagnosis of MRKH and who had undergone an MRI pelvis between 1 January 2011 and 31 April 2021 were included.</p><p><strong>Methods: </strong>MRI images were analysed by specialist gynaecological radiologists. Clinical data was extracted from an electronic patient record system. Statistical analysis was computed in R (version 4.1.2), R base stats package and ggstatsplot (v0.5.0).</p><p><strong>Main outcome measures: </strong>Clinical history and predefined imaging features.</p><p><strong>Results: </strong>One hundred and thirty-four patients were included. Median age at MRI was 18 years (10-64 years). Half (48.2%) of women presenting had a history of pain, most often abdominal (84.6%) or vaginal (9.2%). Remnants were identified in 91.8% of women (n = 123). 4.5% of women had imaging features of endometriosis (n = 6). Women with a functional remnants were significantly more likely to experience pain (p < 0.001). Pain history was not strongly associated with ectopic ovarian position. Common gynaecological pathology such as endometriosis, ovarian cysts and fibroids were also identified.</p><p><strong>Conclusions: </strong>We identify that majority of women with MRKH will have uterine remnants with a connecting fibrous band, and an ectopic ovarian position 44.0% of cases. Abdominal pain was significantly associated with functional remnants on MRI. Further work is required to identify how other gynaecological pathology impacts women with MRKH.</p>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of hormone therapy on cardiovascular risk in postmenopausal women: Insights and recommendations.","authors":"Luyang Su, Zeqing Du, Cuiqiao Meng","doi":"10.1111/1471-0528.17932","DOIUrl":"https://doi.org/10.1111/1471-0528.17932","url":null,"abstract":"","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alice Self, Michael Schlussel, Gary S. Collins, Ferdinand Dhombres, Nicolas Fries, Georges Haddad, Laurent J. Salomon, Mona Massoud, Aris T. Papageorghiou