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What Is the Economic Cost of FGR FGR的经济成本是什么?
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-12 DOI: 10.1111/1471-0528.18327
Andrew Sharp

Linked article: This is a mini commentary on Bray et al., pp. 61–70 in this issue. To view this article, visit https://doi.org/10.1111/1471-0528.18266.

链接文章:这是一篇关于Bray等人的迷你评论,第61-70页。要查看本文,请访问https://doi.org/10.1111/1471-0528.18266。
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引用次数: 0
The UK Maternity Crisis: Analysing the Underlying Causes to Find Solutions 英国产妇危机:分析潜在原因寻找解决方案。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-12 DOI: 10.1111/1471-0528.18326
Andrew D. Weeks, Sarah Espenhahn, Susie Crowe

Lord Darzi, in his recent report, concludes that ‘too many women, babies and families are being let down’ by UK maternity services [1]. Complex underlying factors have put UK maternity units under significant pressure with repeated reports of poor work cultures, over-stressed staff leaving the NHS, stories of birth trauma and calls for a national maternity inquiry. Whilst maternal and perinatal outcomes are significantly better than those in the United States [2], they lag behind those in many comparator countries in Scandinavia and the rest of Europe [3]. Whilst the proportion of obstetric related negligence claims sits at around 10% of the total, the costs of maternity negligence payments are soaring and at £1.1 billion per year are over a third of the total UK maternity budget [4]. The perception might be that standards have fallen and that outcomes are worsening. But despite decreasing births rates, whole time equivalent doctors and midwives have been increasing for many years [5], and term stillbirth and neonatal mortality and morbidity rates are steadily improving [6]. Judging by the most commonly used important outcome, perinatal mortality, you could argue that the standard of care has never been better. So, why does UK maternity care appear to be in crisis?

First, there is increasing medicalisation of birth caused by multiple interrelated factors (Figure 1). Pregnant women in the UK are becoming older, increasingly overweight, have more complex medical problems—all risk factors for adverse outcomes. The increased ability of fetal medicine to detect fetal abnormalities and identify women as ‘high risk’ mean that more parents are approaching birth with anxieties about the outcome. Meanwhile, recent studies have found that induction of labour can reduce many adverse medical outcomes, not least by preventing stillbirths [7-9]. Combining this with the national ambition around maternity safety [10] and the legal requirement to inform women of all options that can reduce stillbirth [11], means that many practitioners and women feel pressurised into labour induction. The increase in induction rates (to 33% nationally [12]) has led to delays [13] and poor experience, resulting in more women opting for a caesarean birth instead. The NHS maternity staffing and estate, designed to support high numbers of ‘low risk’ births, has yet to fully adapt to the increased numbers on ‘high risk’ care pathways, further exacerbating the problem.

Second, there is a shift in who controls birth. Traditionally, providers have adopted a very medical model in which the doctor was in charge, and this remains the case in societies with marked social hierarchies or in specialisms that deal with acute specialist pathologies such as oncology or general surgery. But society has moved on. The information revolution means

从历史上看,专业人员对何种程度的产妇干预是适当的达成了普遍共识,母亲的安全在很大程度上高于婴儿的安全。这个不言而喻的原则起源于高生育率时期,在这个时期,母亲再次生育的能力被优先考虑,即使这伴随着胎儿风险的增加。然而,当把选择权交给母亲时,大多数母亲现在会优先考虑婴儿的健康,而不是自己的安全,并选择干预主义的方法。其他人有不同的优先事项,并选择超出当前循证实践的管理。指南以人口标准为基础,试图提供独立的、合乎逻辑的风险-收益分析。但在为自己做决定时,这种逻辑通常是次要的,次要的是个人考虑,比如过去的负面护理经历、个人恐惧(官方报道的生育危机加剧了这种恐惧),以及在家长式的生育制度中对控制的渴望。不出所料,总体影响是分娩途径的多样化,医疗化(剖腹产和引产)和生理分娩都在增加,甚至在双胞胎和其他复杂妊娠等非传统群体中也是如此。最后,所有上述问题都需要增加工作人员的数量,理想情况下提供持续的护理。即使在传送带式“一刀切”的分娩系统中,也需要大量的专业人员来提供高质量的护理。但是,个性化护理和知情的产妇决策增加了咨询所需的时间。进行咨询的工作人员不仅需要知道最佳做法是什么,还要知道各种替代方案的证据和风险,而且还要有时间和技能与女性一起研究这些方法。而且,考虑到诉讼的高风险,医生告诉这位女士的详细记录需要输入新的(但有时很笨拙的)电脑病历。这一切都需要大量的培训和时间,并降低了与那些更脆弱的人交谈的能力。长时间的产前预约咨询,一个口才好、有能力的怀双胞胎的妇女想要在家分娩,很容易让一个不会说英语、患有糖尿病和高血压的40岁妇女没有时间接受必要的个性化护理。平衡需要遵守临床指南以优化安全性,同时提供妇女选择的护理,当它们不相容时可能会造成相当大的压力。如果你再加上产科医生角色的隐性压力,以及对复杂动态决策的内部和外部密集的回顾性审查,那么高水平的倦怠和疾病就不足为奇了。许多工作人员报告说,他们越来越失去心理安全感。上述分析可能看起来很复杂,让个别临床医生对如何解决这个问题感到绝望。的确,有许多因素要么不会改变,要么会随着时间的推移而加剧(例如,人口结构的变化),要么应该受到欢迎(例如,权力转向妇女的选择)。尽管有这些变化,即使在一个高度压力的系统中,仍然有可能提供富有同情心的个性化护理,确保妇女感到安全,倾听和支持,以做出对她们和她们的孩子正确的选择。然而,很明显,在持续提供这种服务方面存在着系统障碍,这些障碍需要在地方和制定国家战略和政策的人加以解决。首先,当上述分析在全国范围内公布时,许多临床医生似乎松了一口气,因为他们看到了一个解释他们为什么感到如此巨大压力的框架。许多人描述了当前形势下的道德伤害;由于当前系统对每次接触的时间限制,他们无法提供他们想要的标准护理,这反过来又导致了结果的不平等。其次,有一些由代际变化引起的系统压力,应该随着新一批临床医生的培训而消除。在上个世纪或英国以外的文化中接受培训的工作人员可能对护理有非常不同的社会结构,不承认妇女选择的中心地位,或者不知道如何安全地实施它。这可能是咨询中产生相当大摩擦的一个原因,并可能直接或间接导致妇女在没有医疗投入的情况下分娩,或选择根本不接受护理,而不是接受她们认为是控制性或强制性的护理。除了更多的工作人员培训之外,还应该对产前保健模式进行全面的全国审查,考虑到咨询的复杂性和对专家投入的需求。这将支持更个性化、更公平的医疗服务。第三,很明显,在某些情况下,产妇管理过程没有为报告复合伤害的家庭提供富有同情心的护理。 他们也没有创造一种文化,在这种文化中,员工可以安全地提出担忧,这限制了学习和预防不安全做法的机会。以了解创伤的护理为重点,对目前的情况进行审查,将有助于创造一种支持家庭和工作人员的学习文化。诉讼和辩护方面的困难不太容易解决,但世界其他地方使用的无过错赔偿制度可能提供一个解决方案。对详细的计算机化文件的需求将继续存在,但技术的进步将使这一工作变得不那么费力,因为自动语音转录减少了打字的需要,与女性分享咨询记录改善了沟通,从而改善了知情同意。遗憾的是,上述措施可能需要很多年才能产生广泛影响。此外,如果没有资金的大幅增加和重点的转移,这些目标也不会实现。妇女主导的个性化护理和高水平的干预是昂贵的,需要在人员配置模式上做出重大改变来支持它。有了最初的想法,然后在与S.E.和S.C.讨论后发展,然后写了手稿的初稿,由S.E.和S.C.编辑,所有作者在出版前都批准了最终版本。作者声明无利益冲突。
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引用次数: 0
Scientific Abstracts from the British Maternal & Fetal Medicine Society Annual Conference 8th-9th May 2025, ICC, Belfast, UK 补充:英国母胎医学学会年会科学摘要,2025年5月8 -9日,ICC,贝尔法斯特,英国。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-12 DOI: 10.1111/1471-0528.18234
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引用次数: 0
Preference for Face-to-Face Contraceptive Service Delivery Post-COVID-19 Pandemic: A Cross-Sectional Study covid -19大流行后面对面避孕服务提供的偏好:一项横断面研究
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-11 DOI: 10.1111/1471-0528.18323
Sophie Patterson, Nicola Rennie, Sue Mann, Ona McCarthy, Melissa Palmer, Rebecca S. French
<div> <section> <h3> Objective</h3> <p>To measure the prevalence of, and social positions associated with, preference for solely face-to-face contraceptive service delivery among women and people assigned female at birth in post-COVID-19 pandemic England.</p> </section> <section> <h3> Design</h3> <p>Cross-sectional online study.</p> </section> <section> <h3> Setting</h3> <p>England.</p> </section> <section> <h3> Sample</h3> <p>The Reproductive Health Survey for England (RHSE) recruited women and people assigned female at birth aged 16–55 living in England using an online non-probability convenience sampling strategy from September–October 2023. The study population was limited to contraception users who answered the question of interest.</p> </section> <section> <h3> Methods</h3> <p>Multivariable logistic regression identified variables independently associated with preference for face-to-face services.</p> </section> <section> <h3> Main Outcome Measures</h3> <p>Preference for face-to-face services, derived from response to the question ‘How would you prefer to access contraceptive services?’ (face-to-face vs. telephone/video/website/combination/no preference).</p> </section> <section> <h3> Results</h3> <p>The study population included 28 328 participants: median age was 30 (IQR:24–38), 92.5% (<i>n</i> = 26 193) reported White ethnicity, and 96% (<i>n</i> = 27 296) identified as a woman/girl. Preference for solely face-to-face services services was reported by 24.7% (<i>n</i> = 6992/28 328). In adjusted analysis, preference for face-to-face was associated with younger and older age; not having degree-level qualifications, self-reporting financial hardship, living with a disability, identifying as a woman/girl, and not being in a (cohabiting) relationship. Whilst there was a significant independent association between paid employment and preference for face-to-face services, effect direction was dependent on ethnicity.</p> </section> <section> <h3> Conclusions</h3> <p>Although a minority of participants reported a preference for solely face-to-face services, they may represent those with the highest unmet need for contraceptive services. Maintaining
目的了解covid -19大流行后英格兰妇女和出生时被指定为女性的人对单独面对面避孕服务的偏好程度及其与社会地位的关系。设计横断面在线研究:英国生殖健康调查(RHSE)于2023年9月至10月采用在线非概率方便抽样策略,招募了16-55岁居住在英格兰的女性和被指定为女性的人。研究人群仅限于回答感兴趣问题的避孕使用者。方法多变量logistic回归识别与面对面服务偏好独立相关的变量。主要结局指标面对面服务的参考,来自对“你希望如何获得避孕服务?”(面对面vs.电话/视频/网站/组合/没有偏好)。结果研究人群包括28328名参与者:中位年龄为30岁(IQR:24-38), 92.5% (n = 26193)为白人,96% (n = 27296)为女性/女孩。24.7%的人更喜欢单独的面对面服务(n = 6992/ 28328)。在调整分析中,面对面的偏好与年龄有关;没有学位资格,自我报告经济困难,有残疾,认为自己是女人/女孩,没有(同居)关系。虽然有偿就业和面对面服务偏好之间存在显著的独立关联,但影响方向取决于种族。结论:虽然少数参与者报告了单独面对面服务的偏好,但他们可能代表了那些未满足避孕服务需求的最高群体。在日益数字化的医疗环境中,在避孕服务提供中保持选择对于促进公平、以人为本的生殖保健至关重要。
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引用次数: 0
Metformin Treatment in PCOS Pregnancies Reduces Maternal Infections and Increases the Risk of Allergies and Eczema in the Offspring: Post Hoc Analyses of Two Randomised Controlled Trials and One Follow-Up Study 二甲双胍治疗妊娠多囊卵巢综合征可降低母体感染并增加后代过敏和湿疹的风险:两项随机对照试验和一项随访研究的事后分析
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-11 DOI: 10.1111/1471-0528.18320
Mariell Ryssdal, Johanne E. Skage, Anders H. Jarmund, Liv Guro E. Hanem, Tone S. Løvvik, Guro F. Giskeødegård, Ann-Charlotte Iversen, Eszter Vanky
<div> <section> <h3> Objective</h3> <p>To evaluate the effect of metformin on immunological outcomes in pregnant women with polycystic ovary syndrome (PCOS) and their offspring.</p> </section> <section> <h3> Design</h3> <p>Post hoc analyses of two randomised controlled trials (PregMet and PregMet2) and one follow-up study (PedMet).</p> </section> <section> <h3> Setting</h3> <p>Women followed at multiple hospitals in Norway, Sweden and Iceland, and offspring followed at multiple hospitals in Norway.</p> </section> <section> <h3> Population or Sample</h3> <p>Pregnant women with PCOS, randomised to metformin or placebo from the first trimester to delivery, and offspring exposed to metformin or placebo in utero.</p> </section> <section> <h3> Methods</h3> <p>Maternal infections and allergic diseases in offspring were compared using logistic regression. Maternal body mass index (BMI), offspring BMI <i>z</i>-score and maternal infections were evaluated as effect modifiers or mediators.</p> </section> <section> <h3> Main Outcome Measures</h3> <p>Incidence of maternal infections during pregnancy, delivery, and postpartum, and allergic diseases in offspring at 8-year follow-up.</p> </section> <section> <h3> Results</h3> <p>Altogether 634 women and 145 offspring were included. Women treated with metformin experienced fewer overall infections during pregnancy (OR = 0.68, 95% CI: 0.50–0.93), particularly viral infections (OR = 0.71, 95% CI: 0.51–0.99). Offspring exposed to metformin in utero had a higher incidence of allergies (OR = 4.83, 95% CI: 1.47–21.8) and eczema (OR = 2.42, 95% CI: 1.14–5.33). Maternal BMI did not modify the effect of metformin, and offspring BMI <i>z</i>-score or maternal infections did not mediate the relationship between metformin treatment and increased allergies and eczema in offspring.</p> </section> <section> <h3> Conclusions</h3> <p>Metformin treatment in pregnant women with PCOS reduced maternal infections during pregnancy and increased the incidence of allergies and eczema in offspring at 8-year follow-up.</p> </section> <section> <h3> Trial Registration</h3>
目的探讨二甲双胍对多囊卵巢综合征(PCOS)孕妇及其子代免疫结局的影响。设计对两项随机对照试验(PregMet和PregMet2)和一项随访研究(PedMet)进行事后分析。在挪威、瑞典和冰岛的多家医院对妇女进行了随访,对她们的后代进行了随访。人群或样本:患有多囊卵巢综合征的孕妇,从妊娠早期到分娩随机分配到二甲双胍或安慰剂组,其后代在子宫内暴露于二甲双胍或安慰剂组。方法采用logistic回归方法对产妇感染和子代变态反应性疾病进行比较。评估母亲体重指数(BMI)、子代BMI z-score和母亲感染作为影响调节因子或中介因子。主要结局指标:8年随访期间孕妇妊娠、分娩和产后感染的发生率以及子代过敏性疾病的发生率。结果共纳入妇女634例,子代145例。接受二甲双胍治疗的妇女在怀孕期间总体感染较少(OR = 0.68, 95% CI: 0.50-0.93),特别是病毒感染(OR = 0.71, 95% CI: 0.51-0.99)。在子宫内暴露于二甲双胍的后代过敏(OR = 4.83, 95% CI: 1.47-21.8)和湿疹(OR = 2.42, 95% CI: 1.14-5.33)的发生率较高。母体BMI没有改变二甲双胍的效果,子代BMI z-score或母体感染没有介导二甲双胍治疗与子代过敏和湿疹增加之间的关系。结论经8年随访,二甲双胍治疗可降低妊娠期母体感染,增加子代过敏和湿疹的发生率。临床试验注册号:NCT03259919, NCT00159536和NCT01587378。
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引用次数: 0
Medical Interventions and Women's Perceptions of Respectful Intrapartum Care: A National Survey-Based Cohort Study 医疗干预和妇女对分娩时尊重护理的看法:一项基于全国调查的队列研究。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-11 DOI: 10.1111/1471-0528.18329
Karin Johnson, Charlotte Elvander, Kari Johansson, Sissel Saltvedt, Malin Edqvist
<div> <section> <h3> Objective</h3> <p>To investigate whether women's perceptions of respectful intrapartum care are influenced by the use of epidural, oxytocin, or episiotomy.</p> </section> <section> <h3> Design</h3> <p>National survey-based cohort study using data from the Swedish Pregnancy Survey 8 weeks postpartum (NPS-8) merged with Swedish Pregnancy Register (SPR) data.</p> </section> <section> <h3> Setting</h3> <p>Sweden, 2022–2023.</p> </section> <section> <h3> Population</h3> <p>Primiparous women with a singleton pregnancy, cephalic presentation, spontaneous onset of labour, a live fetus at ≥ 37 weeks gestation, and a vaginal birth.</p> </section> <section> <h3> Methods</h3> <p>Associations between respectful care and epidural analgesia, oxytocin, or episiotomy and their combinations were analysed using logistic regression to estimate adjusted odds ratios (aOR) with 95% confidence intervals (CI).</p> </section> <section> <h3> Main Outcome Measures</h3> <p>Four NPS-8 items assessing women's perceptions of being treated respectfully, receiving support, being informed, and being involved in decision-making during childbirth.</p> </section> <section> <h3> Results</h3> <p>Of 34 111 women, 20 363 (59.7%) responded, with the majority feeling respected during childbirth. Compared with women who had spontaneous vaginal births, those with instrumental births more frequently reported inadequate support (17.7% vs. 11.0%), insufficient information (25.1% vs. 16.2%), and lack of involvement in decision-making (29.2% vs. 17.1%). Among women with spontaneous vaginal births, those subjected to an episiotomy were less likely to report being involved in decision-making (77.8% vs. 83.8%; aOR 0.60, 95% CI 0.50–0.73). The combination of episiotomy and oxytocin was associated with the lowest adjusted odds of involvement in decision-making (77.0% vs. 84.6%; aOR 0.54, 95% CI 0.43–0.69).</p> </section> <section> <h3> Conclusion</h3> <p>Women with spontaneous vaginal births were less likely to report being involved in decision-making when they underwent an episiotomy, or if oxytocin augmentation was followed by an episiotomy.</p> </section>
目的探讨硬膜外、催产素或会阴切开术是否会影响妇女对分娩时尊重性护理的看法。设计:采用瑞典妊娠调查产后8周(NPS-8)数据与瑞典妊娠登记(SPR)数据合并的全国基于调查的队列研究。SETTINGSweden, 2022 - 2023。人群:单胎妊娠、头位分娩、自然分娩、妊娠≥37周活胎和阴道分娩的初产妇。方法采用logistic回归分析尊重护理与硬膜外镇痛、催产素或会阴切开术及其组合的相关性,以95%可信区间(CI)估计调整优势比(aOR)。主要结果测量:四个NPS-8项目评估妇女在分娩过程中被尊重对待、得到支持、知情和参与决策的感受。结果34111名妇女中,有20363名(59.7%)回应,大多数妇女在分娩时感到受到尊重。与自然阴道分娩的妇女相比,器械分娩的妇女更经常报告支持不足(17.7%对11.0%),信息不足(25.1%对16.2%),缺乏决策参与(29.2%对17.1%)。在自然阴道分娩的妇女中,接受外阴切开术的妇女报告参与决策的可能性较小(77.8%对83.8%;(or 0.60, 95% CI 0.50-0.73)。会阴切开术联合催产素与参与决策的最低调整几率相关(77.0% vs. 84.6%;(or 0.54, 95% CI 0.43-0.69)。结论:阴道自然分娩的妇女在接受外阴切开术或在外阴切开术后增加催产素后参与决策的可能性较小。
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引用次数: 0
Anxiety and Arterial Stiffness in High-Risk Pregnancies: A Secondary Analysis of a Prospective Cohort Study 高危妊娠的焦虑和动脉僵硬:一项前瞻性队列研究的二次分析。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-08 DOI: 10.1111/1471-0528.18325
Mekayla Forrest, Maria Matossian, Helena Papacostas Quintanilla, Isabelle Malhamé, Tina Montreuil, Stella S. Daskalopoulou

Objectives

In a high-risk pregnant population with singleton pregnancies, the primary objective was to evaluate the association between anxiety and arterial stiffness (AS) and the secondary objective was to investigate whether anxiety is associated with the incidence of preeclampsia.

Design

Secondary analysis of a prospective cohort study (2012–2016).

Setting

Two tertiary care antenatal clinics in Montreal, Canada.

Participants

High-risk pregnant individuals with pre-existing hypertension, diabetes, renal dysfunction, previous preeclampsia, or age ≥ 35 years were included. Exclusion criteria were excessive alcohol or drug use and cardiovascular disease. People with pregnancy loss, incomplete questionnaires and loss to follow-up were excluded from analysis.

Methods

Participants were enrolled before 14-weeks' gestation, with follow-up assessments of AS every 4 weeks until delivery. Anxiety symptoms were assessed every trimester by the Beck Anxiety Inventory and by self-reported history of emotional disorders (anxiety/depression).

Main Outcome Measures

AS and wave reflection parameters, primarily carotid-femoral pulse wave velocity and preeclampsia diagnosis.

Results

Of 235 individuals recruited, 161 were included in this secondary analysis. Baseline anxiety symptoms were present in 35.4% of participants. Anxiety was associated with a significant increase in carotid-femoral pulse wave velocity across gestation, which persisted after adjustments for relevant confounders, in a combined mixed-effects model (B = 0.27, 95% confidence interval [CI] = 0.008–0.530, p = 0.04). A severity-response relationship was observed, where greater anxiety severity correlated with higher AS. Twelve participants (7.5%) developed preeclampsia. The association between anxiety and preeclampsia risk showed a non-significant trend (odds ratio [OR] = 2.77, 95% CI = 0.84–9.18). However, a history of emotional disorders significantly elevated preeclampsia risk (OR = 3.91, 95% CI = 1.14–13.40), independent of other

目的:在高危单胎妊娠人群中,主要目的是评估焦虑与动脉硬化(AS)之间的关系,次要目的是调查焦虑是否与先兆子痫的发生率相关。设计前瞻性队列研究(2012-2016)的二次分析。加拿大蒙特利尔的两个三级保健产前诊所。参与者:包括既往存在高血压、糖尿病、肾功能不全、既往有子痫前期或年龄≥35岁的高危孕妇。排除标准为过度酒精或药物使用和心血管疾病。妊娠失败、问卷不完整、随访失败者排除在分析之外。方法参与者在妊娠14周前入组,每4周随访一次,直至分娩。每三个月通过贝克焦虑量表和自我报告的情绪障碍史(焦虑/抑郁)评估焦虑症状。主要观察指标和波反射参数,主要是颈动脉-股动脉脉波速度和子痫前期诊断。结果在招募的235个人中,有161人被纳入了这次二次分析。35.4%的参与者存在基线焦虑症状。在综合混合效应模型中,焦虑与妊娠期间颈动脉-股动脉脉波速度的显著增加相关,在校正相关混杂因素后仍持续存在(B = 0.27, 95%可信区间[CI] = 0.008-0.530, p = 0.04)。严重程度-反应关系被观察到,更严重的焦虑程度与更高的AS相关。12名参与者(7.5%)出现先兆子痫。焦虑与子痫前期风险的相关性无显著趋势(优势比[OR] = 2.77, 95% CI = 0.84-9.18)。然而,情绪障碍史显著增加子痫前期风险(OR = 3.91, 95% CI = 1.14-13.40),独立于其他危险因素。结论高危妊娠焦虑与AS的增加呈严重反应性相关,并可能与子痫前期风险相关。将心理健康评估与传统的产科评估结合起来,可以加强对产妇并发症的预测和管理。
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引用次数: 0
Effects of Prophylactic Oxytocin or Carbetocin on Troponin Release and Postpartum Haemorrhage at Planned Caesarean Delivery: A Double-Blind Randomised Controlled Trial 预防性催产素或催产素对计划剖宫产肌钙蛋白释放和产后出血的影响:一项双盲随机对照试验。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-07 DOI: 10.1111/1471-0528.18312
Maria E. Bekkenes, Marte M. Jørgensen, Anne F. Jacobsen, Morten W. Fagerland, Helene Rakstad-Larsen, Lars Aaberge, Olav Klingenberg, Trude Steinsvik, Lars Asphaug, Leiv Arne Rosseland
<div> <section> <h3> Objective</h3> <p>Oxytocin may cause dose-dependent myocardial side effects. We investigated if carbetocin, a long-acting oxytocin analogue, causes similar changes.</p> </section> <section> <h3> Design</h3> <p>Double-blind randomised trial.</p> </section> <section> <h3> Setting</h3> <p>University Hospitals, Oslo, Norway.</p> </section> <section> <h3> Population</h3> <p>240 singleton pregnant women, 18–50 years, undergoing planned caesarean delivery.</p> </section> <section> <h3> Methods</h3> <p>Participants, randomised 1:1, received oxytocin 2.5 IU or carbetocin 100 μg intravenously immediately after delivery.</p> </section> <section> <h3> Main Outcome Measures</h3> <p>The primary endpoint was change from baseline in cardiac troponin I (cTnI) serum concentration at 6–10 h postpartum. Secondary endpoints included blood loss, uterine tone (numerical rating scale 0–10), rescue treatment, and healthcare costs 48 h postpartum.</p> </section> <section> <h3> Results</h3> <p>215 patients underwent a planned caesarean delivery and received their allocated study drug (oxytocin group, <i>n</i> = 112; carbetocin group, <i>n</i> = 103). We detected no difference in median change from baseline cTnI concentration at 6–10 h postpartum (0.0 [95% CI –1.09 to 1.09] ng/L; <i>p</i> = 1.00). Median (interquartile range [IQR]) estimated blood loss was similar: oxytocin, 395 (96 to 627) mL; carbetocin, 335 (127 to 570) mL (group difference: −41 mL [95% CI –158 to 76]; <i>p</i> = 0.49). Rescue treatment utilisation was higher with oxytocin (46.4%) versus carbetocin (27.2%); risk difference. (−19.2% [95% CI –31.2 to −6.3]; <i>p</i> = 0.004). Median (IQR) uterine tone at 5 min after delivery was lower with oxytocin (7 [6 to 8]) versus carbetocin (8 [7 to 9]; group difference 1.0 NRS [95% CI 1.0 to 1.0]; <i>p</i> < 0.001). Despite carbetocin costing 10 times more than oxytocin, mean total healthcare costs were similar, adjusted group difference 31 NOK ($3 USD; €3; [95% CI –361 to 298 NOK]; <i>p</i> = 0.85).</p> </section> <section> <h3> Conclusions</h3> <p>Ischaemic myocardial risk and healthcare costs were comparable for both drugs. Patients receiving carbetocin maintained better uterine tone and required fewer rescue treatments.</p> </section> <section> <h3> T
目的催产素可能引起剂量依赖性心肌副作用。我们调查了长效催产素类似物卡比催产素是否会引起类似的变化。设计:双盲随机试验。大学医院,奥斯陆,挪威。人口:计划剖腹产的单胎孕妇240例,年龄18-50岁。方法1∶1随机分组,分娩后立即静脉注射催产素2.5 IU或卡贝霉素100 μg。主要结局指标:主要终点是产后6-10小时心肌肌钙蛋白I (cTnI)血清浓度较基线的变化。次要终点包括出血量、子宫张力(数值评分0-10)、抢救治疗和产后48小时的医疗费用。结果215例患者接受了计划剖宫产,并接受了分配的研究药物(催产素组,n = 112;卡贝菌素组,n = 103)。我们检测到产后6-10小时cTnI浓度与基线相比的中位数变化无差异(0.0 [95% CI -1.09至1.09]ng/L;p = 1.00)。中位数(四分位数间距[IQR])估计失血量相似:催产素,395(96至627)mL;卡贝菌素,335 (127 ~ 570)mL(组差:-41 mL [95% CI: -158 ~ 76];p = 0.49)。催产素(46.4%)比催产素(27.2%)在抢救治疗中的使用率更高;风险不同。(-19.2% [95% CI -31.2至-6.3];p = 0.004)。分娩后5分钟,催产素组子宫张力中位数(IQR)较催产素组低(7[6 ~ 8]),催产素组较催产素组低(8 [7 ~ 9]);组间差异1.0 NRS [95% CI 1.0 ~ 1.0];p < 0.001)。尽管催产素的成本是催产素的10倍,但平均总医疗成本相似,调整后的组差异为31挪威克朗(3美元;€3;[95% CI -361 ~ 298 NOK];p = 0.85)。结论两种药物的心肌缺血风险和医疗费用具有可比性。接受卡贝菌素治疗的患者维持子宫张力较好,需要的抢救治疗较少。试验注册号:2014-000507-27;ClinicalTrials.gov标识符:NCT03899961(02/04/2019)。
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引用次数: 0
The Effect of Animated Educational Video to Reduce Anxiety Levels Before Outpatient Medical Abortion: A Randomised Controlled Trial 门诊药物流产前,动画教育视频对降低焦虑水平的影响:一项随机对照试验。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-04 DOI: 10.1111/1471-0528.18321
Nuttamon Dejchaiyasak, Waranyu Lertrat, Komkrit Aimjirakul, Orawee Chinthakanan, Orawin Vallibhakara

Objective

To determine the efficacy of an animated educational video combined with traditional counselling to reduce anxiety levels among pregnant women seeking outpatient medical abortion.

Design

Randomised controlled trial with two parallel groups.

Setting

Single centre in Bangkok, Thailand.

Population or Sample

60 pregnant women seeking outpatient medical abortion.

Methods

Participants received either an animated educational video combined with traditional counselling (n = 30) or traditional counselling alone (n = 30).

Main Outcome Measures

Postintervention anxiety levels were assessed by the Spielberger State–Trait Anxiety Inventory (STAI), and satisfaction levels were measured by a 5-point Likert-type scale.

Results

There were no significant differences in demographic characteristics between groups. The postintervention STAI scores were significantly lower in the video group compared to the non-video group (32.70 ± 4.96 vs. 41.47 ± 8.57, p < 0.01). The odds of moderate to severe anxiety were significantly lower in the video group (OR 10.29, 95% CI 2.56–41.37). Patient satisfaction levels were similarly high in both groups (4.92 ± 0.27 vs. 4.85 ± 0.36, p = 0.42).

Conclusions

Incorporating an animated educational video into traditional counselling effectively reduced anxiety in pregnant women seeking outpatient medical abortion while maintaining high levels of satisfaction with the medical service provided.

目的探讨动画教育视频结合传统咨询对降低门诊药物流产孕妇焦虑水平的效果。设计两组平行随机对照试验。中心位于泰国曼谷。人口或样本:寻求门诊药物流产的孕妇60例。方法参与者分别接受动画教育视频和传统咨询(n = 30)或单独接受传统咨询(n = 30)。主要结果测量采用Spielberger状态-特质焦虑量表(STAI)评估被测者干预焦虑水平,采用李克特5分量表测量满意度水平。结果两组患者人口学特征无显著差异。视频组干预后STAI评分明显低于非视频组(32.70±4.96∶41.47±8.57,p < 0.01)。视频组出现中度至重度焦虑的几率明显较低(OR 10.29, 95% CI 2.56-41.37)。两组患者满意度相似(4.92±0.27比4.85±0.36,p = 0.42)。结论将动画教育视频融入传统咨询中,可有效降低门诊药物流产孕妇的焦虑情绪,同时保持较高的医疗服务满意度。
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引用次数: 0
When Is Postpartum Haemorrhage Treatment Initiated? A Nested Observational Study Within the E-MOTIVE Trial 产后出血治疗何时开始?E-MOTIVE试验中的嵌套观察性研究。
IF 4.3 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2025-08-04 DOI: 10.1111/1471-0528.18293
Kristie-Marie Mammoliti, Fernando Althabe, Christina Easter, Adam Devall, James Martin, Adeosun Love Funmi, Rahmatu Yusuf, Fatima Abubakar, Lolade Christiana Arigbede, JimKelly Mugambi, Polycarp Oyoo, Masumbuko Sambusa, Akwinata Banda, Fawzia Samuels, Sara Willemse, Sibongile Doris Khambule, Hilal Mukhtar Shu'aib, Aminu Ado Wakili, Jenipher Okore, Ard Mwampashi, Mandisa Singata-Madliki, Edna Arends, Elani Muller, Hadiza Galadanci, Zahida Qureshi, Fadhlun Alwy Al-Beity, G. Justus Hofmeyr, Sue Fawcus, Neil Moran, George Gwako, Alfred Osoti, Ioannis Gallos, Arri Coomarasamy

Objective

To compare the frequency and timing of postpartum haemorrhage (PPH) treatment initiation between hospitals implementing the MOTIVE treatment bundle (which consisted of uterine Massage, Oxytocic drugs, Tranexamic acid, IntraVenous fluids and Examination) and those following usual care.

Design

Nested prospective observational study.

Setting

Hospitals in Nigeria, Kenya, Tanzania and South Africa participating in the E-MOTIVE trial.

Population or Sample

Healthcare workers treating PPH.

Methods

Between June and December 2022, we observed healthcare workers for 1–2 weeks in 39 E-MOTIVE and 39 usual care hospitals across Nigeria, Kenya, Tanzania, and South Africa managing vaginal birth and treating PPH. We descriptively compared the frequency and timing from PPH detection to treatment initiation of individual treatments and the MOTIVE bundle, between E-MOTIVE care and usual care.

Results

Among 2578 observations in E-MOTIVE care hospitals, 295 (11%) PPHs were treated, and among 2834 observations in usual care hospitals, 219 (8%) PPHs were treated. In E-MOTIVE care hospitals, 97% (286/295) of women with PPH received the MOTIVE bundle, compared to 36% (79/219) in usual care. Median initiation times for the first component were similar (0 vs. 1 min), but E-MOTIVE care hospitals achieved faster initiation of all components (13 min, IQR 6–18) compared to usual care (18 min, IQR 10–25). In total, 79% (233/295) of women in E-MOTIVE care had all components initiated within 20 min, compared to 22% (48/219) in usual care.

Conclusions

Timely and comprehensive management of PPH using the MOTIVE bundle, particularly initiating all components within 15–20 min, was commonly observed in the E-MOTIVE care hospitals. Scaling up E-MOTIVE care should emphasise timely bundle initiation to strengthen PPH treatment and improve maternal health outcomes in low-and-middle-income countries.

目的比较采用MOTIVE治疗方案(包括子宫按摩、催产药物、氨甲环酸、静脉输液和检查)的医院与常规护理的医院产后出血(PPH)开始治疗的频率和时间。设计嵌套前瞻性观察研究。尼日利亚、肯尼亚、坦桑尼亚和南非的医院参与了E-MOTIVE试验。人群或样本:治疗PPH的医护人员。方法在2022年6月至12月期间,我们在尼日利亚、肯尼亚、坦桑尼亚和南非的39家E-MOTIVE医院和39家普通护理医院观察了1-2周的医护人员,这些医院负责阴道分娩和治疗PPH。我们描述性地比较了从PPH检测到个体治疗开始的频率和时间,以及E-MOTIVE护理和常规护理之间的MOTIVE bundle。结果在E-MOTIVE护理医院2578例患者中,治疗了295例(11%),在普通护理医院2834例患者中,治疗了219例(8%)。在E-MOTIVE护理医院,97% (286/295)PPH妇女接受了MOTIVE捆绑治疗,而在常规护理中,这一比例为36%(79/219)。第一个成分的起始时间中位数相似(0 vs. 1分钟),但E-MOTIVE护理医院与常规护理(18分钟,IQR 10-25)相比,所有成分的起始时间更快(13分钟,IQR 6-18)。总的来说,79%(233/295)接受E-MOTIVE治疗的妇女在20分钟内启动了所有组件,而常规治疗的这一比例为22%(48/219)。结论在E-MOTIVE护理医院中,及时、全面地使用MOTIVE治疗方案,特别是在15-20分钟内启动所有组件,是PPH管理的普遍现象。扩大E-MOTIVE护理应强调及时启动捆绑治疗,以加强PPH治疗并改善低收入和中等收入国家的孕产妇健康结果。
{"title":"When Is Postpartum Haemorrhage Treatment Initiated? A Nested Observational Study Within the E-MOTIVE Trial","authors":"Kristie-Marie Mammoliti,&nbsp;Fernando Althabe,&nbsp;Christina Easter,&nbsp;Adam Devall,&nbsp;James Martin,&nbsp;Adeosun Love Funmi,&nbsp;Rahmatu Yusuf,&nbsp;Fatima Abubakar,&nbsp;Lolade Christiana Arigbede,&nbsp;JimKelly Mugambi,&nbsp;Polycarp Oyoo,&nbsp;Masumbuko Sambusa,&nbsp;Akwinata Banda,&nbsp;Fawzia Samuels,&nbsp;Sara Willemse,&nbsp;Sibongile Doris Khambule,&nbsp;Hilal Mukhtar Shu'aib,&nbsp;Aminu Ado Wakili,&nbsp;Jenipher Okore,&nbsp;Ard Mwampashi,&nbsp;Mandisa Singata-Madliki,&nbsp;Edna Arends,&nbsp;Elani Muller,&nbsp;Hadiza Galadanci,&nbsp;Zahida Qureshi,&nbsp;Fadhlun Alwy Al-Beity,&nbsp;G. Justus Hofmeyr,&nbsp;Sue Fawcus,&nbsp;Neil Moran,&nbsp;George Gwako,&nbsp;Alfred Osoti,&nbsp;Ioannis Gallos,&nbsp;Arri Coomarasamy","doi":"10.1111/1471-0528.18293","DOIUrl":"10.1111/1471-0528.18293","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the frequency and timing of postpartum haemorrhage (PPH) treatment initiation between hospitals implementing the MOTIVE treatment bundle (which consisted of uterine Massage, Oxytocic drugs, Tranexamic acid, IntraVenous fluids and Examination) and those following usual care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Nested prospective observational study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Hospitals in Nigeria, Kenya, Tanzania and South Africa participating in the E-MOTIVE trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Population or Sample</h3>\u0000 \u0000 <p>Healthcare workers treating PPH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Between June and December 2022, we observed healthcare workers for 1–2 weeks in 39 E-MOTIVE and 39 usual care hospitals across Nigeria, Kenya, Tanzania, and South Africa managing vaginal birth and treating PPH. We descriptively compared the frequency and timing from PPH detection to treatment initiation of individual treatments and the MOTIVE bundle, between E-MOTIVE care and usual care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 2578 observations in E-MOTIVE care hospitals, 295 (11%) PPHs were treated, and among 2834 observations in usual care hospitals, 219 (8%) PPHs were treated. In E-MOTIVE care hospitals, 97% (286/295) of women with PPH received the MOTIVE bundle, compared to 36% (79/219) in usual care. Median initiation times for the first component were similar (0 vs. 1 min), but E-MOTIVE care hospitals achieved faster initiation of all components (13 min, IQR 6–18) compared to usual care (18 min, IQR 10–25). In total, 79% (233/295) of women in E-MOTIVE care had all components initiated within 20 min, compared to 22% (48/219) in usual care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Timely and comprehensive management of PPH using the MOTIVE bundle, particularly initiating all components within 15–20 min, was commonly observed in the E-MOTIVE care hospitals. Scaling up E-MOTIVE care should emphasise timely bundle initiation to strengthen PPH treatment and improve maternal health outcomes in low-and-middle-income countries.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50729,"journal":{"name":"Bjog-An International Journal of Obstetrics and Gynaecology","volume":"132 11","pages":"1664-1672"},"PeriodicalIF":4.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/1471-0528.18293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Bjog-An International Journal of Obstetrics and Gynaecology
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