The Mediterranean basin and Northern Africa are projected to be among the most vulnerable areas to climate change. This research documents, analyzes, and synthesizes the projected changes in precipitation P, evapotranspiration E, net water supply from the atmosphere to the surface P–E, and surface soil moisture over these regions as simulated by 17 global climate models from the sixth exercise of the Coupled Model Intercomparison Project (CMIP6) under two Shared Socioeconomic Pathways, SSP2-4.5, and SSP5-8.5. It also explores the sensitivity of the results to the chosen climate scenario and model resolution and assesses how the projections have evolved from the fifth exercise (CMIP5). Models project a statistically robust drying over the entire Mediterranean and coastal North Africa. Over the Northern Mediterranean sector, a significant precipitation decrease reaching −0.4 ∓ 0.1 mm