Introduction: Ralstonia pickettii is a rare environmental gram-negative bacterium that causes nosocomial infection due to its robust quorum-sensing system and constitution of biofilm in medical equipment and hospital instruments. Objectives: According to various case reports, Ralstonia is associated with catheter-related bacteremia, pneumonia, osteomyelitis, hemoperitoneum infection, meningitis, neonatal sepsis, endocarditis, and peritoneal fluid infection after internal surgery. Methods: In this study, rare cases of nosocomial R. pickettii bloodstream infection were reported in hospitalized patients with uterus and cervical cancer with metastatic squamous cell carcinoma to the colon under surgery and blood transfusion. Results: A 46-year-old woman was admitted to the general surgery department of the target teaching hospital for the chief complaint of abdominal pain, nausea, and vomiting. Before admission, she was under hysterectomy, colectomy, colostomy, and chemotherapy three weeks ago. She received packed red blood cells twice during hospitalization and surgery. In addition, two consecutive blood cultures were positive for R. pickettii using the BD BACTEC™ FX Instruments and confirmation by bioMérieux API 20NE. According to antibiogram test reports, Meropenem (1gr/Q8h/IV) was prescribed, and fortunately, blood culture results were negative after 14 days. In addition, the patient received pantoprazole (I.V. 40 mg) and octreotide (100 mcg/mL) during hospitalization. Conclusions: R. pickettii is responsible for bloodstream infection and sepsis in cancer departments, especially during common surgical operations, and blood transfusions, especially for cancer patients. Hence, recognizing the source of infection can be helpful in appropriate infection control and successful treatment.
导言：泡菜沙雷氏菌（Ralstonia pickettii）是一种罕见的环境革兰氏阴性菌，由于其强大的法定人数感应系统以及在医疗设备和医院器械中形成的生物膜，可导致医院内感染。研究目的根据各种病例报告，Ralstonia 与导管相关菌血症、肺炎、骨髓炎、血腹膜感染、脑膜炎、新生儿败血症、心内膜炎和内科手术后腹腔积液感染有关。方法：本研究报告了子宫癌、宫颈癌和结肠转移性鳞状细胞癌住院患者在手术和输血过程中发生的罕见病例。结果：目标教学医院普外科收治了一名 46 岁女性患者，主诉为腹痛、恶心和呕吐。入院前，她在三周前接受了子宫切除术、结肠切除术、结肠造口术和化疗。在住院和手术期间，她接受了两次红细胞包装。此外，使用 BD BACTEC™ FX 仪器进行了连续两次血液培养，结果均呈挑染葡萄球菌阳性，并由生物梅里埃 API 20NE 进行了确认。根据抗生素检测报告，医生给患者开了美罗培南（1gr/Q8h/IV），幸运的是，14 天后血培养结果呈阴性。此外，患者在住院期间还接受了泮托拉唑（静脉注射 40 毫克）和奥曲肽（100 微克/毫升）治疗。结论：在癌症科，尤其是在普通外科手术和输血过程中，特别是在癌症患者身上，皮卡氏菌是造成血流感染和败血症的罪魁祸首。因此，识别感染源有助于适当的感染控制和成功治疗。
{"title":"Rare Cases of Ralstonia pickettii Blood Stream Infection in Hospitalized Patients with Uterus and Cervical Cancer Under Surgery and Blood Transfusion: A Case Report","authors":"Mahrokh Rajaee, Farhad Moradi, Asiyeh Dezhkam","doi":"10.5812/jkums-142427","DOIUrl":"https://doi.org/10.5812/jkums-142427","url":null,"abstract":"Introduction: Ralstonia pickettii is a rare environmental gram-negative bacterium that causes nosocomial infection due to its robust quorum-sensing system and constitution of biofilm in medical equipment and hospital instruments. Objectives: According to various case reports, Ralstonia is associated with catheter-related bacteremia, pneumonia, osteomyelitis, hemoperitoneum infection, meningitis, neonatal sepsis, endocarditis, and peritoneal fluid infection after internal surgery. Methods: In this study, rare cases of nosocomial R. pickettii bloodstream infection were reported in hospitalized patients with uterus and cervical cancer with metastatic squamous cell carcinoma to the colon under surgery and blood transfusion. Results: A 46-year-old woman was admitted to the general surgery department of the target teaching hospital for the chief complaint of abdominal pain, nausea, and vomiting. Before admission, she was under hysterectomy, colectomy, colostomy, and chemotherapy three weeks ago. She received packed red blood cells twice during hospitalization and surgery. In addition, two consecutive blood cultures were positive for R. pickettii using the BD BACTEC™ FX Instruments and confirmation by bioMérieux API 20NE. According to antibiogram test reports, Meropenem (1gr/Q8h/IV) was prescribed, and fortunately, blood culture results were negative after 14 days. In addition, the patient received pantoprazole (I.V. 40 mg) and octreotide (100 mcg/mL) during hospitalization. Conclusions: R. pickettii is responsible for bloodstream infection and sepsis in cancer departments, especially during common surgical operations, and blood transfusions, especially for cancer patients. Hence, recognizing the source of infection can be helpful in appropriate infection control and successful treatment.","PeriodicalId":507382,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"75 7-8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139868650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Ralstonia pickettii is a rare environmental gram-negative bacterium that causes nosocomial infection due to its robust quorum-sensing system and constitution of biofilm in medical equipment and hospital instruments. Objectives: According to various case reports, Ralstonia is associated with catheter-related bacteremia, pneumonia, osteomyelitis, hemoperitoneum infection, meningitis, neonatal sepsis, endocarditis, and peritoneal fluid infection after internal surgery. Methods: In this study, rare cases of nosocomial R. pickettii bloodstream infection were reported in hospitalized patients with uterus and cervical cancer with metastatic squamous cell carcinoma to the colon under surgery and blood transfusion. Results: A 46-year-old woman was admitted to the general surgery department of the target teaching hospital for the chief complaint of abdominal pain, nausea, and vomiting. Before admission, she was under hysterectomy, colectomy, colostomy, and chemotherapy three weeks ago. She received packed red blood cells twice during hospitalization and surgery. In addition, two consecutive blood cultures were positive for R. pickettii using the BD BACTEC™ FX Instruments and confirmation by bioMérieux API 20NE. According to antibiogram test reports, Meropenem (1gr/Q8h/IV) was prescribed, and fortunately, blood culture results were negative after 14 days. In addition, the patient received pantoprazole (I.V. 40 mg) and octreotide (100 mcg/mL) during hospitalization. Conclusions: R. pickettii is responsible for bloodstream infection and sepsis in cancer departments, especially during common surgical operations, and blood transfusions, especially for cancer patients. Hence, recognizing the source of infection can be helpful in appropriate infection control and successful treatment.
导言：泡菜沙雷氏菌（Ralstonia pickettii）是一种罕见的环境革兰氏阴性菌，由于其强大的法定人数感应系统以及在医疗设备和医院器械中形成的生物膜，可导致医院内感染。研究目的根据各种病例报告，Ralstonia 与导管相关菌血症、肺炎、骨髓炎、血腹膜感染、脑膜炎、新生儿败血症、心内膜炎和内科手术后腹腔积液感染有关。方法：本研究报告了子宫癌、宫颈癌和结肠转移性鳞状细胞癌住院患者在手术和输血过程中发生的罕见病例。结果：目标教学医院普外科收治了一名 46 岁女性患者，主诉为腹痛、恶心和呕吐。入院前，她在三周前接受了子宫切除术、结肠切除术、结肠造口术和化疗。在住院和手术期间，她接受了两次红细胞包装。此外，使用 BD BACTEC™ FX 仪器进行了连续两次血液培养，结果均呈挑染葡萄球菌阳性，并由生物梅里埃 API 20NE 进行了确认。根据抗生素检测报告，医生给患者开了美罗培南（1gr/Q8h/IV），幸运的是，14 天后血培养结果呈阴性。此外，患者在住院期间还接受了泮托拉唑（静脉注射 40 毫克）和奥曲肽（100 微克/毫升）治疗。结论：在癌症科，尤其是在普通外科手术和输血过程中，特别是在癌症患者身上，皮卡氏菌是造成血流感染和败血症的罪魁祸首。因此，识别感染源有助于适当的感染控制和成功治疗。
{"title":"Rare Cases of Ralstonia pickettii Blood Stream Infection in Hospitalized Patients with Uterus and Cervical Cancer Under Surgery and Blood Transfusion: A Case Report","authors":"Mahrokh Rajaee, Farhad Moradi, Asiyeh Dezhkam","doi":"10.5812/jkums-142427","DOIUrl":"https://doi.org/10.5812/jkums-142427","url":null,"abstract":"Introduction: Ralstonia pickettii is a rare environmental gram-negative bacterium that causes nosocomial infection due to its robust quorum-sensing system and constitution of biofilm in medical equipment and hospital instruments. Objectives: According to various case reports, Ralstonia is associated with catheter-related bacteremia, pneumonia, osteomyelitis, hemoperitoneum infection, meningitis, neonatal sepsis, endocarditis, and peritoneal fluid infection after internal surgery. Methods: In this study, rare cases of nosocomial R. pickettii bloodstream infection were reported in hospitalized patients with uterus and cervical cancer with metastatic squamous cell carcinoma to the colon under surgery and blood transfusion. Results: A 46-year-old woman was admitted to the general surgery department of the target teaching hospital for the chief complaint of abdominal pain, nausea, and vomiting. Before admission, she was under hysterectomy, colectomy, colostomy, and chemotherapy three weeks ago. She received packed red blood cells twice during hospitalization and surgery. In addition, two consecutive blood cultures were positive for R. pickettii using the BD BACTEC™ FX Instruments and confirmation by bioMérieux API 20NE. According to antibiogram test reports, Meropenem (1gr/Q8h/IV) was prescribed, and fortunately, blood culture results were negative after 14 days. In addition, the patient received pantoprazole (I.V. 40 mg) and octreotide (100 mcg/mL) during hospitalization. Conclusions: R. pickettii is responsible for bloodstream infection and sepsis in cancer departments, especially during common surgical operations, and blood transfusions, especially for cancer patients. Hence, recognizing the source of infection can be helpful in appropriate infection control and successful treatment.","PeriodicalId":507382,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139808735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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