Pub Date : 2024-06-15DOI: 10.18231/j.sajhp.2024.009
N. S. Sanjeeva Rao, K. Indu
History taking is an important tool available to the medical student to make a reasonable working diagnosis. The process of clinical reasoning helps give a comprehensive view of the patient’s needs and aids in patient centered care. Though 43.9% of the medicos strongly agreed that diagnosis is an important function of a doctor, only 18.3 % of the men and 10.6 % of the women were convinced that a good diagnosis was possible with case taking alone. Overall, only 7.3 % felt confident in taking a good history. The current study shows that history taking and physical examination is taking a lesser role in diagnosis. Communication with the patient is also seen as not necessary. This descriptive study involves 164 medicos (110 final years and 54 interns) who were administered a predetermined questionnaire. Findings were subjected to tests of significance like Chi square at 5% Level of significance.To identify the importance given to history taking in disease diagnosis among medicos. Undergraduate medical education must ensure training in communication, proper history taking and good examination skills. Small-group skills workshops using role-plays followed by effective feedback are ways to certifiable training in medical colleges.
{"title":"Importance of case history in disease diagnosis as perceived by medicos","authors":"N. S. Sanjeeva Rao, K. Indu","doi":"10.18231/j.sajhp.2024.009","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.009","url":null,"abstract":"History taking is an important tool available to the medical student to make a reasonable working diagnosis. The process of clinical reasoning helps give a comprehensive view of the patient’s needs and aids in patient centered care. Though 43.9% of the medicos strongly agreed that diagnosis is an important function of a doctor, only 18.3 % of the men and 10.6 % of the women were convinced that a good diagnosis was possible with case taking alone. Overall, only 7.3 % felt confident in taking a good history. The current study shows that history taking and physical examination is taking a lesser role in diagnosis. Communication with the patient is also seen as not necessary. This descriptive study involves 164 medicos (110 final years and 54 interns) who were administered a predetermined questionnaire. Findings were subjected to tests of significance like Chi square at 5% Level of significance.To identify the importance given to history taking in disease diagnosis among medicos. Undergraduate medical education must ensure training in communication, proper history taking and good examination skills. Small-group skills workshops using role-plays followed by effective feedback are ways to certifiable training in medical colleges.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.18231/j.sajhp.2024.011
Pankaj Lathiya, Girish Patel
As we all know that Hypothyroidism is going to be increased in 21st century. Homoeopathic sarcode like Thyroidinum can play an important role in treating cases of Hypothyroidism. An observational retrospective study was undertaken to study the impact of Thyroidinum as an intercurrent remedy. I have taken 40 cases for study & evaluated all cases with evidence of laboratory report at the interval of 3 months up to 1 year. In my clinical study I have seen that in various hypothyroid cases it worked very well as an intercurrent remedy with constitutional remedy from lower to higher potency. I got significant result in 31 cases, no result in 9 cases. So, I have found that we can increase our efficacy of result with use of ‘Thyroidinum’ as an intercurrent remedy.
{"title":"Role of Thyroidinum (sarcode) as an intercurrent remedy in treating various cases of Hypothyroidism","authors":"Pankaj Lathiya, Girish Patel","doi":"10.18231/j.sajhp.2024.011","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.011","url":null,"abstract":"As we all know that Hypothyroidism is going to be increased in 21st century. Homoeopathic sarcode like Thyroidinum can play an important role in treating cases of Hypothyroidism. An observational retrospective study was undertaken to study the impact of Thyroidinum as an intercurrent remedy. I have taken 40 cases for study & evaluated all cases with evidence of laboratory report at the interval of 3 months up to 1 year. In my clinical study I have seen that in various hypothyroid cases it worked very well as an intercurrent remedy with constitutional remedy from lower to higher potency. I got significant result in 31 cases, no result in 9 cases. So, I have found that we can increase our efficacy of result with use of ‘Thyroidinum’ as an intercurrent remedy.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.18231/j.sajhp.2024.012
Anju Paul, Amit Hiwarkar, Madhuri Patil, Kshitija Dipak Tonapi
Paediatric cases pose considerable anaesthetic challenges and are more challenging if they are posted for emergency surgeries with associated comorbidities like congenital hypothyroidism. Few reported cases of anaesthesia management of congenital hypothyroid cases are there in the literature. Challenges are due to the difficult airway, associated congenital anomalies and increased sensitivity to anaesthetic drugs. Knowledge of pathophysiology, preoperative optimization and proper selection and planning of anaesthesia techniques are essential for successful anaesthesia management of children with congenital hypothyroidism for emergency surgeries. Congenital hypothyroidism in a child poses significant challenges for anaesthesiologists because of altered physiology, airway anatomy and difficult airway and drug metabolism.
{"title":"A child with congenital hypothyroidism posted for emergency surgery- anaesthesia challenges","authors":"Anju Paul, Amit Hiwarkar, Madhuri Patil, Kshitija Dipak Tonapi","doi":"10.18231/j.sajhp.2024.012","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.012","url":null,"abstract":"Paediatric cases pose considerable anaesthetic challenges and are more challenging if they are posted for emergency surgeries with associated comorbidities like congenital hypothyroidism. Few reported cases of anaesthesia management of congenital hypothyroid cases are there in the literature. Challenges are due to the difficult airway, associated congenital anomalies and increased sensitivity to anaesthetic drugs. Knowledge of pathophysiology, preoperative optimization and proper selection and planning of anaesthesia techniques are essential for successful anaesthesia management of children with congenital hypothyroidism for emergency surgeries. Congenital hypothyroidism in a child poses significant challenges for anaesthesiologists because of altered physiology, airway anatomy and difficult airway and drug metabolism.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.18231/j.sajhp.2024.010
S.M. Anandh, MS Raju, Raju Karthikeyan, M.S Senthil, L. Lakshmi
The abdomen is called Pandora’s Box by surgeons, because one is not sure what will come out of it when one opens it. Even well experienced surgeons are constantly amazed at the variety of pathology they have encountered on opening up patients’ abdomen. In spite of so many new investigations at our disposal like ultrasound, CT scan and MRI, the human belly defies them all and reveals its secret only when confronted by a surgeon’s scalpel. We have to deal with the mystery inside the tummy on the operating table! Pandora’s box is an artefact in Greek mythology, Pandoras box was a gift from the Gods to Pandora the first woman on earth. It contained all evils of the world unknowingly Pandora opened, though she hastened to close the container, only thing that was left behind the box was Hope – spreading the pessimistic meaning of “ deceptive expectation “. Based on this story this idiom has grown “to open a Pandora’s box“ means we may expect something and go and may get something entirely different.
{"title":"Human abdomen still a pandora’s box","authors":"S.M. Anandh, MS Raju, Raju Karthikeyan, M.S Senthil, L. Lakshmi","doi":"10.18231/j.sajhp.2024.010","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.010","url":null,"abstract":"The abdomen is called Pandora’s Box by surgeons, because one is not sure what will come out of it when one opens it. Even well experienced surgeons are constantly amazed at the variety of pathology they have encountered on opening up patients’ abdomen. In spite of so many new investigations at our disposal like ultrasound, CT scan and MRI, the human belly defies them all and reveals its secret only when confronted by a surgeon’s scalpel. We have to deal with the mystery inside the tummy on the operating table! Pandora’s box is an artefact in Greek mythology, Pandoras box was a gift from the Gods to Pandora the first woman on earth. It contained all evils of the world unknowingly Pandora opened, though she hastened to close the container, only thing that was left behind the box was Hope – spreading the pessimistic meaning of “ deceptive expectation “. Based on this story this idiom has grown “to open a Pandora’s box“ means we may expect something and go and may get something entirely different.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.18231/j.sajhp.2024.014
Abinav Sarvesh, Samidha Waradkar Thakur
Cardiac Implantable Electronic Devices (CIEDs) are special devices which are implanted in to human body to treat various cardiac rhythm disorders and heart failure. Anaesthesiologists are now starting to encounter more patients with CIEDs undergoing various surgeries. Hence, it is of paramount importance to know about these devices and its management peri-operatively. Good communication between the anaesthetist, CIED team and surgeon is essential. Understanding the basic functioning of CIEDs and making a detailed preoperative plan can help anticipate and avoid most of the complications. Knowledge about managing intraoperative complications such as dysrhythmias is essential. All these combined with a vigilant monitoring even in the postoperative period is the key for a successful outcome.
{"title":"Anaesthetic management in patients with cardiac implantable electronic devices","authors":"Abinav Sarvesh, Samidha Waradkar Thakur","doi":"10.18231/j.sajhp.2024.014","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.014","url":null,"abstract":"Cardiac Implantable Electronic Devices (CIEDs) are special devices which are implanted in to human body to treat various cardiac rhythm disorders and heart failure. Anaesthesiologists are now starting to encounter more patients with CIEDs undergoing various surgeries. Hence, it is of paramount importance to know about these devices and its management peri-operatively. Good communication between the anaesthetist, CIED team and surgeon is essential. Understanding the basic functioning of CIEDs and making a detailed preoperative plan can help anticipate and avoid most of the complications. Knowledge about managing intraoperative complications such as dysrhythmias is essential. All these combined with a vigilant monitoring even in the postoperative period is the key for a successful outcome.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-15DOI: 10.18231/j.sajhp.2024.008
Tejaswi Chillara, Tanniru Samatha, Katnam Shylaja, Arelli Sukanya, Khairul Islam
Now-a-days alcoholism is major complication for development of different diseases. According to our literature review chronic alcoholic consumption will cause the lot of health complications. People without any comorbidities are also diagnosed with the lot of health complications at early age because of alcohol consumption. Our aim of the study is to identify the lipid changes in chronic alcoholic patients and how it effects on their health.To monitor the lipid changes in alcoholic persons.A prospective observational study was conducted for duration of six months, the data has been collected in 456 patients over six months of period and the data was collected with informed consent from the persons. All the data was collected by interacting with persons by using data collection form and laboratory reports were studied.In our study, 456 male populations were included. Out of 456 members, 272 people were alcoholics, and 184 members were non-alcoholic. Out of 272 population 180 are chronic alcoholics and 92 are occasional alcoholics. Out of 456 members young adults (18-25) 182 (39.9%) persons and old adults (26-40) were 274 (60%) persons296 members are taking alcohol with food and 160 members are taking without food. Out of 456 population 438 (96%) persons are non-vegetarians and 18(4%) members are vegetarians. Out of 272, 104 members were drinking beer, 58 were cheap liquor, 25 were Officers' choice, 18 were royal stag, 22 were blenders pride, 15 were signature, 23 were mixed brands, and 7 were others. In our study 156 persons were drinking sweetened beverages, 52(33.3%) members are daily beverage intakes and 104(33.3%) Members are occasionally beverage intakes. According to our study most commonly used sugary beverage brands are thumps up 93(59%), 48(31%) Sting,15(10%) other sugary beverages. Out of 156, Triglycerides were elevated in 47 and LDL was elevated in 36 persons, VLDL elevated in 4 persons and T. Cholesterol elevated in 5 members, Normal lipid profile in 64 persons. Out of 456 persons, 314(69%) are undiagnosed and 142(31%) are diagnosed with lipid changes. According to our common complications associated with alcohol consumption 39 were cardiac, 56 were hepatic, 9 were renal, and 38 were others (pancreatitis, stroke, cholelithiasis).In our study, we concluded that alcohol consumption will mainly affect triglyceride levels. Elevation of triglyceride levels is associated with the quantity and duration of alcohol intake. Normal Intake of alcohol does not cause lipid changes. Excessive intake of beer and cheap liquor increases TG. Excessive alcohol intake and fat intake will increase the LDL, Triglycerides, VLDL and decrease HDL. Excessive intake of sweetened beverages may also cause dyslipidaemia. Because it contains a high number of calories. The most common complication associated with elevation of triglycerides are hypertension, cardiovascular disease. Alcohol intake with food or without food shows the same complications but the absorptio
{"title":"Effect of alcohol consumption on lipid profile","authors":"Tejaswi Chillara, Tanniru Samatha, Katnam Shylaja, Arelli Sukanya, Khairul Islam","doi":"10.18231/j.sajhp.2024.008","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.008","url":null,"abstract":"Now-a-days alcoholism is major complication for development of different diseases. According to our literature review chronic alcoholic consumption will cause the lot of health complications. People without any comorbidities are also diagnosed with the lot of health complications at early age because of alcohol consumption. Our aim of the study is to identify the lipid changes in chronic alcoholic patients and how it effects on their health.To monitor the lipid changes in alcoholic persons.A prospective observational study was conducted for duration of six months, the data has been collected in 456 patients over six months of period and the data was collected with informed consent from the persons. All the data was collected by interacting with persons by using data collection form and laboratory reports were studied.In our study, 456 male populations were included. Out of 456 members, 272 people were alcoholics, and 184 members were non-alcoholic. Out of 272 population 180 are chronic alcoholics and 92 are occasional alcoholics. Out of 456 members young adults (18-25) 182 (39.9%) persons and old adults (26-40) were 274 (60%) persons296 members are taking alcohol with food and 160 members are taking without food. Out of 456 population 438 (96%) persons are non-vegetarians and 18(4%) members are vegetarians. Out of 272, 104 members were drinking beer, 58 were cheap liquor, 25 were Officers' choice, 18 were royal stag, 22 were blenders pride, 15 were signature, 23 were mixed brands, and 7 were others. In our study 156 persons were drinking sweetened beverages, 52(33.3%) members are daily beverage intakes and 104(33.3%) Members are occasionally beverage intakes. According to our study most commonly used sugary beverage brands are thumps up 93(59%), 48(31%) Sting,15(10%) other sugary beverages. Out of 156, Triglycerides were elevated in 47 and LDL was elevated in 36 persons, VLDL elevated in 4 persons and T. Cholesterol elevated in 5 members, Normal lipid profile in 64 persons. Out of 456 persons, 314(69%) are undiagnosed and 142(31%) are diagnosed with lipid changes. According to our common complications associated with alcohol consumption 39 were cardiac, 56 were hepatic, 9 were renal, and 38 were others (pancreatitis, stroke, cholelithiasis).In our study, we concluded that alcohol consumption will mainly affect triglyceride levels. Elevation of triglyceride levels is associated with the quantity and duration of alcohol intake. Normal Intake of alcohol does not cause lipid changes. Excessive intake of beer and cheap liquor increases TG. Excessive alcohol intake and fat intake will increase the LDL, Triglycerides, VLDL and decrease HDL. Excessive intake of sweetened beverages may also cause dyslipidaemia. Because it contains a high number of calories. The most common complication associated with elevation of triglycerides are hypertension, cardiovascular disease. Alcohol intake with food or without food shows the same complications but the absorptio","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In a 51-year-old male scheduled for elective surgery, a video laryngoscopy showed a foreign body near the right pyriform sinus. It was removed with Magill forceps and found to be remnants of the tablet. He had taken a tablet of Pantoprazole 2 hours prior to surgery with sips of water. In the postoperative period, he confirmed he had no difficulty in swallowing and his lower cranial nerve examination was normal. He did mention he needed more water to swallow the tablet given prior to surgery. Our departmental protocol has been allowing sips of water for tablets on the morning of surgery. The factors like size of the tablet, amount of water, and position of the head do affect the swallowing of a tablet. Following this incident now we provide clear instructions to our patients about morning oral medications.
{"title":"Pill in the pyriform sinus, What anaesthesiologists should know about it","authors":"Deepak Ganjigere Palaksha, Binesh Badyal, Kavita Sandhu","doi":"10.18231/j.sajhp.2024.013","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.013","url":null,"abstract":"In a 51-year-old male scheduled for elective surgery, a video laryngoscopy showed a foreign body near the right pyriform sinus. It was removed with Magill forceps and found to be remnants of the tablet. He had taken a tablet of Pantoprazole 2 hours prior to surgery with sips of water. In the postoperative period, he confirmed he had no difficulty in swallowing and his lower cranial nerve examination was normal. He did mention he needed more water to swallow the tablet given prior to surgery. Our departmental protocol has been allowing sips of water for tablets on the morning of surgery. The factors like size of the tablet, amount of water, and position of the head do affect the swallowing of a tablet. Following this incident now we provide clear instructions to our patients about morning oral medications.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.sajhp.2024.001
S. Chaudhry, A. Trailokya, Manoj Naik
Hodgkins LymphomaHL) was first described by Thomas Hodgkin in 1832., is a malignant disorder, a rare B cell lymphoma (mutant lymphocytes) with reasonable outcome due to the fair cure rates achieved by modern chemotherapy and/or radiotherapy. The incidence of HL is 2.6 cases per 100,000 people, accounts for 10% lymphoma cases. The Epstein–Barr virus (EBV) is detected in nearly 45% of HL patients Most of the affected patients are between ages 20 to 40 years. HL is uncommon in children < 5 years of age. The Reed-Sternberg (RS), large cells 50 micrometers in diameter which secrete cytokines to recruit reactive cells that include IL-5 and transforming growth factor-beta (TGF-beta). The RS cells are positive for CD 30 and CD15 & sometimes for CD 20. They are negative for CD 45. The 5-year overall survival (OS) in stage 1 or stage IIa is approximately 90%;, the stage 4 disease has a 5-year OS of approximately 60%. More than 80 percent of all patients diagnosed with Hodgkin lymphoma can be cured by current treatment approaches. The cure rate is higher, approaching 90 percent, in younger patients and those with early-stage Hodgkins lymphoma (ESHL). Pragmatic therapeutic approach includes brief chemotherapy (ABVD- Adriamycin), bleomycin, vinblastine sulfate, and dacarbazine. For 3–4 cycles), For advanced-stage classic (CD30-positive) Hodgkin lymphoma, the combination of doxorubicin, vinblastine, dacarbazine, and brentuximab has emerged as a more effective, Patients with recurrent Hodgkin lymphoma would require high-dose chemotherapy followed by ASCT. Hodgkin lymphoma that recurs after ASCT would be managed by the checkpoint inhibitors nivolumab and pembrolizumab. Radiotherapy plays a role as a single modality in early stage lymphocyte-predominant HL. The role of autologous transplant was established decades ago by two randomized controlled trials demonstrating an improvement in PFS but not OS in patients with relapsed/refractory HL.
{"title":"Novel therapeutics for Hodgkin's lymphoma","authors":"S. Chaudhry, A. Trailokya, Manoj Naik","doi":"10.18231/j.sajhp.2024.001","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.001","url":null,"abstract":"Hodgkins LymphomaHL) was first described by Thomas Hodgkin in 1832., is a malignant disorder, a rare B cell lymphoma (mutant lymphocytes) with reasonable outcome due to the fair cure rates achieved by modern chemotherapy and/or radiotherapy. The incidence of HL is 2.6 cases per 100,000 people, accounts for 10% lymphoma cases. The Epstein–Barr virus (EBV) is detected in nearly 45% of HL patients Most of the affected patients are between ages 20 to 40 years. HL is uncommon in children < 5 years of age. The Reed-Sternberg (RS), large cells 50 micrometers in diameter which secrete cytokines to recruit reactive cells that include IL-5 and transforming growth factor-beta (TGF-beta). The RS cells are positive for CD 30 and CD15 & sometimes for CD 20. They are negative for CD 45. The 5-year overall survival (OS) in stage 1 or stage IIa is approximately 90%;, the stage 4 disease has a 5-year OS of approximately 60%. More than 80 percent of all patients diagnosed with Hodgkin lymphoma can be cured by current treatment approaches. The cure rate is higher, approaching 90 percent, in younger patients and those with early-stage Hodgkins lymphoma (ESHL). Pragmatic therapeutic approach includes brief chemotherapy (ABVD- Adriamycin), bleomycin, vinblastine sulfate, and dacarbazine. For 3–4 cycles), For advanced-stage classic (CD30-positive) Hodgkin lymphoma, the combination of doxorubicin, vinblastine, dacarbazine, and brentuximab has emerged as a more effective, Patients with recurrent Hodgkin lymphoma would require high-dose chemotherapy followed by ASCT. Hodgkin lymphoma that recurs after ASCT would be managed by the checkpoint inhibitors nivolumab and pembrolizumab. Radiotherapy plays a role as a single modality in early stage lymphocyte-predominant HL. The role of autologous transplant was established decades ago by two randomized controlled trials demonstrating an improvement in PFS but not OS in patients with relapsed/refractory HL.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Statins are the most commonly used lipid-lowering drugs in cardiovascular patients. Rosuvastatin is a majorly used statin. Rosuvastatin will induce myopathy; it is a rare side effect. In my case report, the patient experiencing muscle cramps for 3 years on and off. He consulted a cardiologist. The doctor advised Atorvastatin. He has been on rosuvastatin for 6 months. From the last 6 months, he has not experienced and myopathy symptoms.
{"title":"Acase report on rosuvastatin-induced myopathy","authors":"Tejaswi Chillara, MD Sony, Namilikonda Rachana, Oragala Sridhar","doi":"10.18231/j.sajhp.2024.007","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.007","url":null,"abstract":"Statins are the most commonly used lipid-lowering drugs in cardiovascular patients. Rosuvastatin is a majorly used statin. Rosuvastatin will induce myopathy; it is a rare side effect. In my case report, the patient experiencing muscle cramps for 3 years on and off. He consulted a cardiologist. The doctor advised Atorvastatin. He has been on rosuvastatin for 6 months. From the last 6 months, he has not experienced and myopathy symptoms.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.sajhp.2024.003
Tshetiz Dahal, Bonish Raj Subedi
Treatment options for patients with non-small-cell lung cancer (NSCLC) with EGFR mutations are limited due to resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Osimertinib or afatinib alone, in a preclinical model, created drug-resistant clones with EGFR secondary mutations, but their combination inhibited the emergence of these mutations. In a Phase II trial, we looked into the alternating-dose therapy of osimertinib and afatinib in patients with EGFR-mutant NSCLC. Patients with stage IV NSCLC with an activating EGFR mutation who had never received treatment were included. Every eight weeks, osimertinib (80 mg/day) and afatinib (20 mg/day) were given in alternate cycles. Utilising circulating tumour DNA collected both before and after therapy, genomic analysis was carried out. The median progression-free survival among the 50 enrolled patients was 21.3 months. A total of 70.3% of respondents responded. Overall median survival was not attained. 35 plasma samples were acquired after the development of resistance; 5 of these samples displayed an elevated MET gene copy number and 3 displayed a BRAF mutation. However, no secondary EGFR mutation was found. The effectiveness of our approach was comparable to that of osimertinib alone, as had been observed in untreated advanced NSCLC patients with EGFR mutations in the past. The treatment may stop the emergence of EGFR secondary mutations that lead to medication resistance, despite the small sample size. To determine the importance of this treatment, more research is required.
{"title":"Clinical phase II trial shows that combining osimertinib and afatinib resistance EGFR recurrent mutation in EGFR-mutant lung cancer","authors":"Tshetiz Dahal, Bonish Raj Subedi","doi":"10.18231/j.sajhp.2024.003","DOIUrl":"https://doi.org/10.18231/j.sajhp.2024.003","url":null,"abstract":"Treatment options for patients with non-small-cell lung cancer (NSCLC) with EGFR mutations are limited due to resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Osimertinib or afatinib alone, in a preclinical model, created drug-resistant clones with EGFR secondary mutations, but their combination inhibited the emergence of these mutations. In a Phase II trial, we looked into the alternating-dose therapy of osimertinib and afatinib in patients with EGFR-mutant NSCLC. Patients with stage IV NSCLC with an activating EGFR mutation who had never received treatment were included. Every eight weeks, osimertinib (80 mg/day) and afatinib (20 mg/day) were given in alternate cycles. Utilising circulating tumour DNA collected both before and after therapy, genomic analysis was carried out. The median progression-free survival among the 50 enrolled patients was 21.3 months. A total of 70.3% of respondents responded. Overall median survival was not attained. 35 plasma samples were acquired after the development of resistance; 5 of these samples displayed an elevated MET gene copy number and 3 displayed a BRAF mutation. However, no secondary EGFR mutation was found. The effectiveness of our approach was comparable to that of osimertinib alone, as had been observed in untreated advanced NSCLC patients with EGFR mutations in the past. The treatment may stop the emergence of EGFR secondary mutations that lead to medication resistance, despite the small sample size. To determine the importance of this treatment, more research is required.","PeriodicalId":507469,"journal":{"name":"Southeast Asian Journal of Health Professional","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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