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Shifting the Paradigm: The Impact of AI at the Point of Care in Cancer Treatment 范式转变:人工智能在癌症治疗中的影响
Pub Date : 2024-06-01 DOI: 10.25270/jcp.2024.05.03
Stephen Speicher, Will Shapiro, Taylor Dias-Foundas
This report explores the transformative impact of artificial intelligence (AI) in health care, emphasizing its potential paradigm shift and current deployment in oncology.
本报告探讨了人工智能(AI)在医疗保健领域的变革性影响,强调了其潜在的模式转变和目前在肿瘤学领域的应用。
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引用次数: 0
PSA Outcomes and Clinical Surveillance Among Patients With Nonmetastatic Castration-Resistant Prostate Cancer Treated With a Next-Generation Androgen Receptor Inhibitor in Urology Practices With or Without In-Office Dispensing 泌尿外科诊所中使用新一代雄激素受体抑制剂治疗的非转移性阉割耐药前列腺癌患者的 PSA 结果和临床监测(无论是否进行诊室配药
Pub Date : 2024-06-01 DOI: 10.25270/jcp.2024.05.01
Sabree C Burbage, Dexter Waters, C. Rossi, F. Kinkead, Erik Muser, L. Ellis, Patrick Lefebvre, D. Pilon
This retrospective study used electronic medical record data from community-based urology practices in the US (February 1, 2017, to September 17, 2021) to describe prostate-specific antigen (PSA) outcomes and clinical sur­veillance patterns among patients with nonmetastatic castration-resistant pros­tate cancer (nmCRPC) receiving next-generation androgen receptor inhibitors (ARIs) with or without in-office dispensing (IOD) services. Patients who were prescribed apalutamide, darolutamide, or enzalutamide were classified in IOD+ (IOD access + fill), IOD– (IOD access + no fill), or non-IOD cohorts (no IOD ac­cess). Outcomes were described by cohort from 14 days following initial prescrip­tion to the earliest of initiation of a new ARI or advanced prostate cancer medi­cation, end of clinical activity, or end of data availability. In total, 3300 patients were included (IOD+: n = 615; IOD–: n = 2474; non-IOD: n = 211). PSA response defined as a decline ≥50% from the baseline PSA value (PSA50) achieved by 6 and 12 months was observed in 80.0% and 83.8% of patients in the IOD+ cohort, 63.8% and 72.3% in the IOD– cohort, and 62.5% and 69.1% in the non-IOD cohort. Patients in the IOD+ cohort underwent fewer bone scans, computerized tomog­raphy, and next-generation imaging than IOD– and non-IOD cohorts and also had longer time from treatment initiation to first follow-up imaging. IOD services may better support comprehensive disease management for patients with nmCRPC receiving next-generation ARIs and may be associated with better long-term clin­ical outcomes.
这项回顾性研究利用美国社区泌尿科诊所的电子病历数据(2017 年 2 月 1 日至 2021 年 9 月 17 日),描述了接受新一代雄激素受体抑制剂(ARIs)治疗的非转移性去势抵抗性前列腺癌(nmCRPC)患者的前列腺特异性抗原(PSA)结果和临床监测模式,无论患者是否接受诊室内配药(IOD)服务。处方阿帕鲁胺、达罗鲁胺或恩扎鲁胺的患者被分为IOD+(IOD访问+填充)、IOD-(IOD访问+无填充)或非IOD队列(无IOD访问)。研究结果按队列进行描述,时间从首次处方后 14 天开始,到最早开始使用新的 ARI 或晚期前列腺癌药物、临床活动结束或数据可用性结束为止。共纳入 3300 名患者(IOD+:n = 615;IOD-:n = 2474;非 IOD:n = 211)。IOD+队列中分别有80.0%和83.8%的患者观察到PSA反应,IOD-队列中分别有63.8%和72.3%的患者观察到PSA反应,非IOD队列中分别有62.5%和69.1%的患者观察到PSA反应,PSA反应的定义是在6个月和12个月内PSA值从基线下降≥50%(PSA50)。与IOD-和非IOD队列相比,IOD+队列中的患者接受骨扫描、计算机断层扫描和新一代成像的次数较少,而且从开始治疗到首次随访成像的时间较长。IOD服务可以更好地支持接受新一代ARI治疗的nmCRPC患者的综合疾病管理,并可能带来更好的长期临床疗效。
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引用次数: 0
Bringing Value to Health Care 为医疗保健带来价值
Pub Date : 2024-06-01 DOI: 10.25270/jcp.2024.05.02
Andrew L Pecora, Lili Brillstein, M. Albitar, Nasim Asfar, Joel Brill, Jeffrey R. Curtis, Andrew von Eschenbach, Deborah Goss, Andre Goy, Max Holfert, Andrew Ip, Allen Karp, Mark Lutes, Steven Madreperla, Patrick A. Roth, Miruna Sasu, Robert Shelley, Robin L. Smith, Nina Tandon, Dan Varga, Richard Winters
Health care in the US remains challenged by affordability, availabili­ty, and wasteful spending. To address these challenges, the various constituents in health care payment and delivery all seek to reduce total cost of care while maintaining or improving the relevant clinical outcome expected (value-based care). It is generally acknowledged that health care is not one system but is, in fact, fragmented in control and delivery between local and national commercial payers, government payers, employers, private and public providers, and drug and device manufacturers, all of whom are overseen by state and federal reg­ulations. To help guide further discussion on current and evolving value-based care strategies, this paper provides insights and perspective from each constit­uent involved in shaping health care payment and delivery throughout the US.
美国的医疗保健仍然面临着可负担性、可用性和浪费性开支的挑战。为了应对这些挑战,医疗支付和医疗服务的各个组成部分都在寻求降低医疗服务的总成本,同时保持或改善相关的预期临床效果(基于价值的医疗服务)。人们普遍认为,医疗保健并不是一个系统,事实上,在控制和提供方面,地方和国家商业支付方、政府支付方、雇主、私营和公共医疗服务提供者以及药品和器械制造商之间是分散的,所有这些都受到州和联邦法规的监督。为了帮助指导有关当前和不断发展的价值医疗战略的进一步讨论,本文提供了参与塑造全美医疗支付和服务的各相关方的见解和观点。
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引用次数: 0
Patient-Reported Outcomes in Hematopoietic Stem Cell Transplant Recipients: Design, Implementation, and Pilot Results 造血干细胞移植受者的患者报告结果:设计、实施和试点结果
Pub Date : 2024-04-01 DOI: 10.25270/jcp.2024.03.02
C. Hayes, A. V. Van Citters, Wenyan Zhao, Kate L. Caldon, Charlotte M. Coughenour, T. Tosteson, Anna N. A. Tosteson, Kenneth R. Meehan
Background: Patient-reported outcome measures (PROMs) offer a collaborative opportunity between the patient and the care team to improve the quality of care. Objectives: To define PROMs in patients receiving hematopoietic stem cell transplant (HSCT), a pre-visit questionnaire (PVQ) was developed, which included a single agenda-setting question, the PROMIS-29 survey, and the National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT). Study Design: Patients completed the PVQ 1 month prior to transplant (baseline) and at 1, 3, 6, and 12 months following transplant. Results: Sixty-five patients (n = 27 allogenic; n = 38 autologous) participated. Survey completion rates were 95% at 1 month post-transplant, 74% at 6 months, and 65% at one year. One month following transplant, patients’ fatigue (P < .001) increased, while physical (P < .001) and social (P < .001) functions decreased. Each returned to baseline at 3 months (P < .001). Fatigue was more pronounced in allogeneic recipients (P = .017) and autologous recipients recovered physical function much sooner (P = .021). Conclusions: This study confirms the feasibility of capturing PROMs longitudinally in patients receiving HSCT and demonstrates significant changes in fatigue and physical and social functioning following transplant.
背景:患者报告结果指标(PROMs)为患者和护理团队提供了一个合作机会,以提高护理质量。目的:确定接受造血干细胞移植(HSV)患者的 PROMs:为确定接受造血干细胞移植(HSCT)患者的PROMs,开发了就诊前调查问卷(PVQ),其中包括一个单一的议程设置问题、PROMIS-29调查和美国国家综合癌症网络(NCCN)压力温度计(DT)。研究设计:患者在移植前 1 个月(基线)以及移植后 1、3、6 和 12 个月完成 PVQ。研究结果65 名患者(n = 27 名异体患者;n = 38 名自体患者)参与了研究。移植后 1 个月的调查完成率为 95%,6 个月为 74%,一年为 65%。移植后一个月,患者的疲劳感(P < .001)增加,而身体(P < .001)和社交(P < .001)功能下降。三个月后,这两项功能均恢复到基线水平(P < .001)。疲劳在异体受者中更为明显(P = .017),而自体受者的身体功能恢复得更快(P = .021)。结论:这项研究证实了在接受造血干细胞移植的患者中纵向采集 PROMs 的可行性,并证明了移植后疲劳、身体和社会功能的显著变化。
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引用次数: 0
Comprehensive Genomic Testing: Tissue Stewardship and Best Practices 综合基因组测试:组织管理与最佳实践
Pub Date : 2024-04-01 DOI: 10.25270/jcp.2024.03.01
R. Previs, Maureen E. Cooper, Kyle C. Strickland, Heidi Ko, Michelle F. Green, F. Koohestani, S. Hastings, Zachary D. Wallen, S. Pabla, Jeffrey M. Conroy, M. Nesline, Shengle Zhang, Durga Prasad Dash, Brian J. Caveney, Marcia Eisenberg, Eric A Severson, Shakti H. Ramkissoon
Biomarker-driven targeted therapies have shaped the oncology treatment landscape for patients with advanced solid tumors over the past decade. Comprehensive genomic profiling (CGP) has played a key role in precision medicine as it enables simultaneous identification of multiple biomarkers to guide cancer diagnosis, therapy selection, and prognostication. As a result, tissue stewardship for successful CGP testing is paramount. In addition, widespread adoption of less invasive sampling techniques leaves less diagnostic tissue for additional or future testing as smaller biopsies are acquired. To help oncology care practitioners overcome these challenges, this paper provides an overview of current genomic testing methodologies and offers guidelines on best practices for tissue stewardship and preanalytic practices for successful CGP testing and efficient turnaround times for laboratory tests.
过去十年来,生物标志物驱动的靶向疗法塑造了晚期实体瘤患者的肿瘤治疗格局。全面基因组分析(CGP)在精准医疗中发挥了关键作用,因为它能同时鉴定多种生物标记物,为癌症诊断、治疗选择和预后提供指导。因此,成功进行 CGP 检测的组织管理至关重要。此外,随着微创取样技术的广泛应用,由于活检样本较少,可供额外或未来检测的诊断组织也越来越少。为了帮助肿瘤护理从业人员克服这些挑战,本文概述了当前的基因组检测方法,并提供了组织管理和分析前实践的最佳实践指南,以便成功进行 CGP 检测并缩短实验室检测的周转时间。
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引用次数: 0
The Key Factors Driving Low Participation in the Enhancing Oncology Model 导致 "加强肿瘤治疗模式 "参与率低的关键因素
Pub Date : 2024-02-01 DOI: 10.25270/jcp.2024.01.01
Theresa Dreyer
This study investigates the challenges leading to a substantial de­cline in participation among academic oncology practices within the Enhancing Oncology Model (EOM), introduced as a successor to the Oncology Care Mod­el (OCM) by the CMS Innovation Center. Analyzing the withdrawal of 14 practic­es from the EOM, previously part of the OCM Collaborative, three primary factors are identified: immediate downside risk in a context of narrow provider margins, inadequate risk adjustment failing to appropriately account for drug costs, and onerous reporting burdens for extensive clinical data. Under the EOM, immedi­ate downside risk for seven specified cancers diverged significantly from the OCM’s upside-only risk structure, posing financial challenges for practices. Inad­equate risk adjustment, particularly the omission of crucial clinical data, raised concerns about the model’s focus on drug costs without considering essen­tial patient-specific variables. The study also highlights the burden of reporting requirements, exacerbated by reduced enhanced services payments, impacting practices financially. To address these challenges and encourage EOM participa­tion, policy options are proposed. These include reconsidering financial risk lev­els, refining target price methodology to incorporate clinical data, and reducing reporting burdens by aligning data requirements with EOM financial and quality methodologies. These adjustments aim to strengthen the EOM, fostering more accurate performance measurement and incentivizing high-quality patient care delivery in oncology practices.
本研究调查了导致肿瘤学术实践大幅减少参与增强肿瘤学模式(EOM)的挑战,该模式是 CMS 创新中心作为肿瘤学护理模式(OCM)的后续模式推出的。在分析了 14 家临床实践机构退出 EOM(之前是 OCM 合作项目的一部分)的原因后,我们发现了三个主要因素:在医疗服务提供者利润空间狭小的情况下,存在直接的下行风险;风险调整不足,未能适当考虑药物成本;以及大量临床数据的繁重报告负担。在 EOM 下,七种特定癌症的直接下行风险与 OCM 的上行风险结构有很大差异,给医疗机构带来了财务挑战。风险调整的不足,尤其是关键临床数据的遗漏,引起了人们对该模型只关注药物成本而不考虑患者特定变量的担忧。研究还强调了报告要求带来的负担,强化服务支付的减少加剧了这一负担,对医疗实践造成了财务影响。为了应对这些挑战并鼓励 EOM 的参与,研究提出了一些政策方案。其中包括重新考虑财务风险水平,改进目标价格方法以纳入临床数据,以及通过使数据要求与 EOM 财务和质量方法相一致来减轻报告负担。这些调整旨在加强 EOM,促进更准确的绩效衡量,并激励肿瘤诊疗机构为患者提供高质量的医疗服务。
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引用次数: 0
Enhancing Multidisciplinary Team Processes in Lung Cancer Care: A Self-Assessment Toolkit and Best Practices 加强肺癌护理中的多学科团队流程:自我评估工具包和最佳做法
Pub Date : 2024-02-01 DOI: 10.25270/jcp.2024.01.02
Poka Cui, Peter Blanshard, María Teresa Campos-Partera, A. Moucquot, S. H. R. Naqvi, D. Dellamonica, Heather Moses
Multidisciplinary teams (MDTs) play a pivotal role in the comprehen­sive management of cancer. MDT meetings (MDTMs) bring together specialized experts across the entire patient care spectrum, convening regularly to discuss patient cases, select optimal diagnostic strategies, and determine the most ap­propriate treatment modalities. By fostering cross-disciplinary interaction, MDTs aim to enhance patient outcomes and elevate the collective proficiency within a health care institution, promoting knowledge dissemination and ensuring health care practitioners remain abreast of the latest clinical insights. This study’s methods comprised an extensive review of existing literature coupled with in­terviews involving lung cancer MDTs from 24 medical centers across Europe and Canada. The research focused on elucidating dynamics and variations observed among lung cancer MDTs, outlining an optimal MDT process, identifying varianc­es in the study sample, and introducing a comprehensive self-assessment tool­kit for continuous evaluation and improvement. The report discusses how these results should be used to self-optimize hospital MDTs, promote standardization, and encourage increased cross-hospital best practices sharing. With this, MDTs will be better positioned to deliver on the key goal of improved patient outcomes while promoting equality of access to health care.
多学科团队(MDT)在癌症的综合治疗中发挥着举足轻重的作用。多学科团队会议(MDTMs)汇集了整个患者护理领域的专业专家,定期召开会议讨论患者病例、选择最佳诊断策略并确定最合适的治疗方式。通过促进跨学科互动,多学科会诊旨在提高患者的治疗效果,提升医疗机构的集体能力,促进知识传播,确保医疗从业人员掌握最新的临床见解。本研究的方法包括广泛查阅现有文献,以及对欧洲和加拿大 24 家医疗中心的肺癌 MDT 进行访谈。研究重点在于阐明肺癌 MDT 的动态变化,勾勒出最佳 MDT 流程,确定研究样本中的差异,并为持续评估和改进引入一套全面的自我评估工具包。报告讨论了应如何利用这些结果对医院 MDT 进行自我优化,促进标准化,并鼓励加强跨医院的最佳实践分享。这样,MDT 就能更好地实现改善患者治疗效果的关键目标,同时促进医疗服务的平等性。
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引用次数: 0
The Impact of Social Determinants of Health Beyond Race on Survival in Metastatic Prostate Cancer: A Systematic Literature Review 种族之外的健康社会决定因素对转移性前列腺癌患者生存期的影响:系统性文献综述
Pub Date : 2023-12-01 DOI: 10.25270/jcp.2023.11.01
S. Freedland, Imtiaz Samjoo, Emily Rosta, A. Lansing, Alexandra Hall, Manvir Rai, A. Niyazov, J. Nazari, B. Arondekar
A systematic literature review by Stephen J. Freedland, MD, and colleagues summarizes the current evidence relating to social determinants of health beyond race and survival in patients with metastatic prostate cancer.
Stephen J. Freedland 医学博士及其同事撰写了一篇系统性文献综述,总结了目前与种族以外的健康社会决定因素和转移性前列腺癌患者存活率有关的证据。
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引用次数: 0
Clinical and Economic Impact of Implementing HealthPathways at a Musculoskeletal Radiology Department 在肌肉骨骼放射科实施健康之路的临床和经济影响
Pub Date : 2023-12-01 DOI: 10.25270/jcp.2023.11.02
Simon Davies, Kathleen Lyons, Kausik Mukherjee, Ramakrishna Kishore, Khurram Hashmi, Maria Dyban, Anna Kuczynska
Simon R. Davies, MBBCh, and colleagues investigate the impact of HealthPathways on management and primary care clinicians in a musculoskeletal radiology department.
MBBCh Simon R. Davies 及其同事调查了 HealthPathways 对肌肉骨骼放射科管理和初级保健临床医生的影响。
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引用次数: 0
期刊
Journal of Clinical Pathways
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