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Confounding by Indication, Confounding Variables, Covariates, and Independent Variables: Knowing What These Terms Mean and When to Use Which Term 指示性混杂、混杂变量、共变因素和独立变量:了解这些术语的含义以及何时使用这些术语
Pub Date : 2024-02-11 DOI: 10.1177/02537176241227586
Chittaranjan Andrade
The terms independent variables, covariates, confounding variables, and confounding by indication are often imprecisely used in the context of regression. Independent variables are the full set of variables whose influence on the outcome is studied. Covariates are the independent variables that are included not because they are of interest but because their influence on the outcome can be adjusted for, leaving a more precise understanding of how the single remaining independent variable influences the outcome. Confounding variables are variables that are associated with both independent variables and outcomes; so, the relationship identified between independent variables and outcomes may be due to the confounding variable rather than to the independent variable. Potential confounders should be identified, measured, and adjusted for in regression, just as other covariates are. Confounding by indication occurs when the presence of the independent variable is driven by the confounding variable. Confounding by indication is a special kind of confounding; a confounding variable is a special kind of covariate; and a covariate is a special kind of independent variable in regression analysis. These terms and concepts are explained with the help of examples.
自变量、协变量、混杂变量和指示混杂等术语在回归中的使用往往不够精确。自变量是指对研究结果产生影响的全部变量。共变量是指那些被纳入的自变量,纳入这些变量并不是因为它们有意义,而是因为可以调整它们对结果的影响,从而更精确地了解剩余的单一自变量是如何影响结果的。混杂变量是与自变量和结果都相关的变量;因此,自变量和结果之间的关系可能是由混杂变量而非自变量造成的。与其他协变量一样,在回归中也应识别、测量和调整潜在的混杂变量。当自变量的存在受到混杂变量的影响时,就会出现指示性混杂。指示混杂是一种特殊的混杂;混杂变量是一种特殊的协变量;协变量是回归分析中一种特殊的自变量。我们将通过实例来解释这些术语和概念。
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引用次数: 0
Cognitive Functioning Among Community-dwelling Older Adults in Rural Population of Lucknow and Its Association with Comorbidities 勒克瑙农村人口中居住在社区的老年人的认知功能及其与合并症的关系
Pub Date : 2024-02-06 DOI: 10.1177/02537176231225838
Pratyaksha Pandit, Reema Kumari, A. Tripathi, Prabhakar Mishra
The transitional state between normal aging and dementia is known as Cognitive impairment (CI) where a person has memory complaints and objective evidence of CI but no evidence of dementia. With the globe undergoing a “demographic transition,” the magnitude of neurodegenerative disorders is rising. In India, 27.3% of older persons with comorbidities had CI. Early identification of CI will likely help initiate proper remedial intervention, leading to better overall outcomes. In order to determine the prevalence of CI in older persons and whether it is associated with co-morbid conditions, this study was designed. A descriptive cross-sectional study was conducted among 350 older adults aged ≥60 residing in rural areas of Lucknow, selected using multistage cluster sampling. The Hindi Mental State Examination (HMSE) scale was used to assess cognitive function. A pretested semi-structured questionnaire was used to collect information on sociodemographic characteristics and comorbidity status. Among 350 participants, with mean ± SD age 70.66 ± 9.53 years, the prevalence of CI as per HMSE (<23) was 24.9%. Overall, the mean HMSE score was less in individuals with (25.2) than without (27.19) comorbidities. Those with comorbidities had significantly lower mean scores in all individual domains of HMSE. CI affects one-fourth of the older adult population. Risk increases with the presence of comorbidities. Hence, screening, and early treatment are recommended.
介于正常衰老和痴呆之间的过渡状态被称为认知障碍(CI),即一个人有记忆障碍和认知障碍的客观证据,但没有痴呆的证据。随着全球经历 "人口结构转型",神经退行性疾病的发病率正在上升。在印度,27.3%患有合并症的老年人患有 CI。及早发现 CI 可能有助于启动适当的补救干预措施,从而获得更好的总体疗效。为了确定 CI 在老年人中的发病率,以及它是否与并发症有关,我们设计了这项研究。本研究采用多阶段群组抽样法,对居住在勒克瑙农村地区的 350 名年龄≥60 岁的老年人进行了描述性横断面研究。采用印地语精神状态检查(HMSE)量表评估认知功能。预先测试的半结构化问卷用于收集有关社会人口学特征和合并症状况的信息。350 名参与者的平均(±SD)年龄为 70.66 ± 9.53 岁,根据 HMSE(<23),CI 患病率为 24.9%。总体而言,合并症患者的 HMSE 平均得分(25.2 分)低于非合并症患者(27.19 分)。有合并症的人在 HMSE 的所有单个领域的平均得分都明显较低。CI 影响着四分之一的老年人口。随着合并症的出现,风险也随之增加。因此,建议进行筛查并及早治疗。
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引用次数: 0
Cognitive Functioning Among Community-dwelling Older Adults in Rural Population of Lucknow and Its Association with Comorbidities 勒克瑙农村人口中居住在社区的老年人的认知功能及其与合并症的关系
Pub Date : 2024-02-06 DOI: 10.1177/02537176231225838
Pratyaksha Pandit, Reema Kumari, A. Tripathi, Prabhakar Mishra
The transitional state between normal aging and dementia is known as Cognitive impairment (CI) where a person has memory complaints and objective evidence of CI but no evidence of dementia. With the globe undergoing a “demographic transition,” the magnitude of neurodegenerative disorders is rising. In India, 27.3% of older persons with comorbidities had CI. Early identification of CI will likely help initiate proper remedial intervention, leading to better overall outcomes. In order to determine the prevalence of CI in older persons and whether it is associated with co-morbid conditions, this study was designed. A descriptive cross-sectional study was conducted among 350 older adults aged ≥60 residing in rural areas of Lucknow, selected using multistage cluster sampling. The Hindi Mental State Examination (HMSE) scale was used to assess cognitive function. A pretested semi-structured questionnaire was used to collect information on sociodemographic characteristics and comorbidity status. Among 350 participants, with mean ± SD age 70.66 ± 9.53 years, the prevalence of CI as per HMSE (<23) was 24.9%. Overall, the mean HMSE score was less in individuals with (25.2) than without (27.19) comorbidities. Those with comorbidities had significantly lower mean scores in all individual domains of HMSE. CI affects one-fourth of the older adult population. Risk increases with the presence of comorbidities. Hence, screening, and early treatment are recommended.
介于正常衰老和痴呆之间的过渡状态被称为认知障碍(CI),即一个人有记忆障碍和认知障碍的客观证据,但没有痴呆的证据。随着全球经历 "人口结构转型",神经退行性疾病的发病率正在上升。在印度,27.3%患有合并症的老年人患有 CI。及早发现 CI 可能有助于启动适当的补救干预措施,从而获得更好的总体疗效。为了确定 CI 在老年人中的发病率,以及它是否与并发症有关,我们设计了这项研究。本研究采用多阶段群组抽样法,对居住在勒克瑙农村地区的 350 名年龄≥60 岁的老年人进行了描述性横断面研究。采用印地语精神状态检查(HMSE)量表评估认知功能。预先测试的半结构化问卷用于收集有关社会人口学特征和合并症状况的信息。350 名参与者的平均(±SD)年龄为 70.66 ± 9.53 岁,根据 HMSE(<23),CI 患病率为 24.9%。总体而言,合并症患者的 HMSE 平均得分(25.2 分)低于非合并症患者(27.19 分)。有合并症的人在 HMSE 的所有单个领域的平均得分都明显较低。CI 影响着四分之一的老年人口。随着合并症的出现,风险也随之增加。因此,建议进行筛查并及早治疗。
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引用次数: 0
Substance Use Among People Seeking Health Care Services in Primary Health Care Settings in Coastal Karnataka 卡纳塔克邦沿海地区初级医疗机构就医者中的药物使用情况
Pub Date : 2024-02-05 DOI: 10.1177/02537176231225640
Anusha Viswanathan, Akhila Doddamani, S. Praharaj, Akhil Pandey, Priyanka Bantwal, Muralidhar M. Kulkarni
Patients with substance use disorders are common in general medical practice and are a major risk factor for several non-communicable diseases. Appropriate screening is a vital step for providing brief interventions which can provide a good opportunity to tackle this crisis and in achieving target 3.5 of the sustainable development goal which includes strengthening the prevention and treatment of substance abuse. To study the magnitude of substance use and factors associated with it among people seeking health care services at primary care settings. The cross-sectional study recruited people seeking services at primary care settings to screen for substance users (SU) and determine the associated factors. The data was collected using a pretested semi-structured questionnaire including socio-demographic characteristics, health status and the Alcohol, Smoking and Substance Involvement Screening Test tool. The study showed that 43.4% of the participants were SU. The current use of smokeless tobacco was higher compared to tobacco smoking (21.3% and 4.7%). The multivariate logistic regression showed that advancing age (AOR: 2.61 and 95% CI of 1.01–6.79), male gender (AOR: 705 and 95% CI of 4.25–11.70), primary and middle school (AOR: 3.24 and 95% CI of 1.52–6.92) literacy status, unemployed (AOR: 0.49 and 95% CI of 0.25–0.95), religion and other backward caste (AOR: 2.42 and 95% CI of 1.37–4.30) were significant correlates of SU. Substance use was reported by two-fifths of the participants seeking services at primary care centres in our study and stresses the need for incorporating brief interventions to prevent higher degrees of dependence and its complications.
药物滥用障碍患者在全科医疗实践中很常见,是多种非传染性疾病的主要风险因素。适当的筛查是提供简短干预的重要步骤,可为应对这一危机和实现可持续发展目标 3.5(包括加强药物滥用的预防和治疗)提供良机。研究在基层医疗机构寻求医疗服务的人群中药物滥用的程度及其相关因素。这项横断面研究招募了在基层医疗机构寻求服务的人群,以筛查药物使用者(SU)并确定相关因素。数据收集采用了一份经过预先测试的半结构化问卷,包括社会人口学特征、健康状况以及酒精、吸烟和药物滥用筛查测试工具。研究显示,43.4%的参与者为 SU。与吸烟相比,目前使用无烟烟草的比例更高(21.3% 和 4.7%)。多变量逻辑回归显示,年龄增长(AOR:2.61,95% CI:1.01-6.79)、男性(AOR:705,95% CI:4.25-11.70)、小学和初中(AOR:3.24,95% CI 为 1.52-6.92)、失业(AOR:0.49,95% CI 为 0.25-0.95)、宗教信仰和其他落后种姓(AOR:2.42,95% CI 为 1.37-4.30)是 SU 的显著相关因素。在我们的研究中,五分之二到初级保健中心寻求服务的参与者报告了使用药物的情况,这强调了有必要采取简短干预措施,以防止出现更严重的药物依赖及其并发症。
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引用次数: 0
Substance Use Among People Seeking Health Care Services in Primary Health Care Settings in Coastal Karnataka 卡纳塔克邦沿海地区初级医疗机构就医者中的药物使用情况
Pub Date : 2024-02-05 DOI: 10.1177/02537176231225640
Anusha Viswanathan, Akhila Doddamani, S. Praharaj, Akhil Pandey, Priyanka Bantwal, Muralidhar M. Kulkarni
Patients with substance use disorders are common in general medical practice and are a major risk factor for several non-communicable diseases. Appropriate screening is a vital step for providing brief interventions which can provide a good opportunity to tackle this crisis and in achieving target 3.5 of the sustainable development goal which includes strengthening the prevention and treatment of substance abuse. To study the magnitude of substance use and factors associated with it among people seeking health care services at primary care settings. The cross-sectional study recruited people seeking services at primary care settings to screen for substance users (SU) and determine the associated factors. The data was collected using a pretested semi-structured questionnaire including socio-demographic characteristics, health status and the Alcohol, Smoking and Substance Involvement Screening Test tool. The study showed that 43.4% of the participants were SU. The current use of smokeless tobacco was higher compared to tobacco smoking (21.3% and 4.7%). The multivariate logistic regression showed that advancing age (AOR: 2.61 and 95% CI of 1.01–6.79), male gender (AOR: 705 and 95% CI of 4.25–11.70), primary and middle school (AOR: 3.24 and 95% CI of 1.52–6.92) literacy status, unemployed (AOR: 0.49 and 95% CI of 0.25–0.95), religion and other backward caste (AOR: 2.42 and 95% CI of 1.37–4.30) were significant correlates of SU. Substance use was reported by two-fifths of the participants seeking services at primary care centres in our study and stresses the need for incorporating brief interventions to prevent higher degrees of dependence and its complications.
药物滥用障碍患者在全科医疗实践中很常见,是多种非传染性疾病的主要风险因素。适当的筛查是提供简短干预的重要步骤,可为应对这一危机和实现可持续发展目标 3.5(包括加强药物滥用的预防和治疗)提供良机。研究在基层医疗机构寻求医疗服务的人群中药物滥用的程度及其相关因素。这项横断面研究招募了在基层医疗机构寻求服务的人群,以筛查药物使用者(SU)并确定相关因素。数据收集采用了一份经过预先测试的半结构化问卷,包括社会人口学特征、健康状况以及酒精、吸烟和药物滥用筛查测试工具。研究显示,43.4%的参与者为 SU。与吸烟相比,目前使用无烟烟草的比例更高(21.3% 和 4.7%)。多变量逻辑回归显示,年龄增长(AOR:2.61,95% CI:1.01-6.79)、男性(AOR:705,95% CI:4.25-11.70)、小学和初中(AOR:3.24,95% CI 为 1.52-6.92)、失业(AOR:0.49,95% CI 为 0.25-0.95)、宗教信仰和其他落后种姓(AOR:2.42,95% CI 为 1.37-4.30)是 SU 的显著相关因素。在我们的研究中,五分之二到初级保健中心寻求服务的参与者报告了使用药物的情况,这强调了有必要采取简短干预措施,以防止出现更严重的药物依赖及其并发症。
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引用次数: 0
Zolpidem-induced Brief Psychotic Reactions Zolpidem-induced Psychotic Reactions: A Case Series 唑吡坦诱发的短暂精神反应 唑吡坦诱发的精神反应:病例系列
Pub Date : 2024-02-04 DOI: 10.1177/02537176231222573
S. Chahal, Aarti Karahda, N. Govil, Arun Kumar Pandey
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引用次数: 0
Course and Outcome of Anorexia Nervosa in Adolescents from a Tertiary-level Mental Health Setting in India: A Retrospective Chart Review 印度三级心理健康机构青少年厌食症的病程和结果:回顾性病历
Pub Date : 2024-02-04 DOI: 10.1177/02537176231222574
L. Sravanti, A. Velusamy, U. Karki, J. Kommu, S. Girimaji
Anorexia nervosa is one of the least studied mental health conditions in the Indian setting. The objective of this study was to assess the course and outcome of anorexia nervosa in adolescents who had presented to a tertiary care child and adolescent psychiatry center over a period of 10 years. The present study is a retrospective chart review of adolescents (up to the age of 18 years) with a diagnosis of anorexia nervosa, coded as F50.0 or F50.1 according to ICD 10, from 1st April 2009 to 31st March 2019. Data were extracted from the case records using standardized abstraction forms and evaluated using descriptive and nonparametric statistics. The average age at presentation and the average age at onset were 14.1 years and 13.1 years, respectively. The male-to-female ratio of the sample who got admitted was 1:9. The average duration of hospital stay was about 30 days. The duration of in-patient care and weight gain were positively correlated, with severe to extremely ill adolescents improving even in less than one month of in-patient care. Seventy per cent of the admitted adolescents followed up. The functional outcome as measured by a ‘return to school’ improved in 57.1% of the sample. The present study highlights the collaborative multidisciplinary and individualized treatment approach employed for adolescents diagnosed with anorexia nervosa within an inpatient mental health facility in India. Adolescents who presented with more severe illness at the initial assessment, such as an early onset of symptoms and a low BMI, experienced substantial weight gain that exhibited a positive correlation with the length of their stay in the inpatient facility.
神经性厌食症是印度研究最少的精神疾病之一。本研究旨在评估 10 年间在一家三级儿童和青少年精神病学中心就诊的青少年厌食症的病程和结果。本研究对2009年4月1日至2019年3月31日期间被诊断为神经性厌食症的青少年(18岁以下)进行了回顾性病历审查,根据ICD 10编码为F50.0或F50.1。研究人员使用标准化摘要表从病例记录中提取数据,并使用描述性和非参数统计方法对数据进行评估。患者的平均就诊年龄和平均发病年龄分别为 14.1 岁和 13.1 岁。入院样本的男女比例为 1:9。平均住院时间约为 30 天。住院治疗时间的长短与体重的增加呈正相关,病情严重到极度严重的青少年甚至在住院治疗不到一个月的时间里体重就有所改善。70%的入院青少年接受了后续治疗。以 "重返校园 "为衡量标准,57.1%的样本青少年的功能状况有所改善。本研究强调了印度一家精神卫生住院机构针对被诊断为神经性厌食症的青少年所采用的多学科协作和个性化治疗方法。在初次评估时病情较为严重的青少年,如症状出现较早和体重指数较低的青少年,其体重大幅增加,这与他们在住院机构的住院时间呈正相关。
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引用次数: 0
Common Mental Disorders and Their Correlates: A Community-based Survey Among Women in Southern Karnataka, India 常见精神障碍及其相关因素:印度南部卡纳塔克邦妇女社区调查
Pub Date : 2024-02-04 DOI: 10.1177/02537176231220543
Rakshitha R Shenoy, Divya Arvind Prabhu, A. Pandey, S. Praharaj, RS Shetty
About 10% of Indians have common mental disorders (CMDs) which include depression and anxiety. These disorders are common in women, which not only impacts on their quality of life but also their family members. The objective of the study was to estimate the prevalence of CMDs, and factors associated with them among women residing in coastal Karnataka. A cross-sectional study was carried out among 980 women aged between 18 and 60 years from 2019 to 2021. Women were administered a baseline questionnaire along with Patient Health Questionnaire-9 (PHQ-9), Generalised Anxiety Disorder questionnaire-7 (GAD-7) and Cohen’s Perceived Stress Scale-4 (PSS-4). Data were collected using Epi-info and were analysed using SPSS version 15.0. Association between CMDs and socio-demographic, reproductive health and behavioural factors were expressed as crude and adjusted odds ratio (OR) with 95% confidence intervals (CI). The prevalence of CMDs among women was 5.7%, with 4.6% having depression and 3.37% with anxiety disorders. Multivariate logistic regression analysis showed that residing in urban areas (OR = 2.15; 95% CI:1.10–4.17), having a chronic illness (OR = 2.38; 95% CI:1.14–4.97), history of recent bereavement in the family (OR = 2.20; 95% CI:1.02–4.75), early marriage (OR = 2.63; 95% CI:1.09–6.33), history of abortion (OR = 2.89; 95% CI:1.42–5.92), and exposure to domestic violence (OR = 3.08; 95% CI:1.14–8.33) were significantly correlated with CMDs in this sample. The study revealed that CMDs were prevalent among the surveyed women, which calls for routine screening of women for CMDs in primary care settings for early identification and appropriate interventions.
约 10% 的印度人患有常见精神障碍(CMD),其中包括抑郁症和焦虑症。这些疾病常见于女性,不仅影响她们的生活质量,也影响她们的家庭成员。这项研究的目的是估计居住在卡纳塔克邦沿海地区的妇女中常见精神障碍的发病率及其相关因素。从 2019 年至 2021 年,对 980 名年龄在 18 岁至 60 岁之间的妇女进行了横断面研究。研究人员对妇女进行了基线问卷调查,同时还进行了患者健康问卷-9(PHQ-9)、广泛性焦虑症问卷-7(GAD-7)和科恩感知压力量表-4(PSS-4)的问卷调查。数据使用 Epi-info 收集,并使用 SPSS 15.0 版进行分析。CMD与社会人口学、生殖健康和行为因素之间的关系以粗略和调整后的几率比(OR)及95%置信区间(CI)表示。妇女的 CMD 患病率为 5.7%,其中 4.6% 患有抑郁症,3.37% 患有焦虑症。多变量逻辑回归分析显示,居住在城市地区(OR = 2.15; 95% CI:1.10-4.17)、患有慢性疾病(OR = 2.38; 95% CI:1.14-4.97)、家庭近期有丧偶史(OR = 2.20; 95% CI:1。在该样本中,早婚(OR = 2.63;95% CI:1.09-6.33)、流产史(OR = 2.89;95% CI:1.42-5.92)和遭受家庭暴力(OR = 3.08;95% CI:1.14-8.33)与 CMDs 显著相关。研究显示,CMD 在受访妇女中很普遍,这就要求在初级保健机构中对妇女进行常规的 CMD 筛查,以便及早发现并采取适当的干预措施。
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引用次数: 0
Zolpidem-induced Brief Psychotic Reactions Zolpidem-induced Psychotic Reactions: A Case Series 唑吡坦诱发的短暂精神反应 唑吡坦诱发的精神反应:病例系列
Pub Date : 2024-02-04 DOI: 10.1177/02537176231222573
S. Chahal, Aarti Karahda, N. Govil, Arun Kumar Pandey
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引用次数: 0
Common Mental Disorders and Their Correlates: A Community-based Survey Among Women in Southern Karnataka, India 常见精神障碍及其相关因素:印度南部卡纳塔克邦妇女社区调查
Pub Date : 2024-02-04 DOI: 10.1177/02537176231220543
Rakshitha R Shenoy, Divya Arvind Prabhu, A. Pandey, S. Praharaj, RS Shetty
About 10% of Indians have common mental disorders (CMDs) which include depression and anxiety. These disorders are common in women, which not only impacts on their quality of life but also their family members. The objective of the study was to estimate the prevalence of CMDs, and factors associated with them among women residing in coastal Karnataka. A cross-sectional study was carried out among 980 women aged between 18 and 60 years from 2019 to 2021. Women were administered a baseline questionnaire along with Patient Health Questionnaire-9 (PHQ-9), Generalised Anxiety Disorder questionnaire-7 (GAD-7) and Cohen’s Perceived Stress Scale-4 (PSS-4). Data were collected using Epi-info and were analysed using SPSS version 15.0. Association between CMDs and socio-demographic, reproductive health and behavioural factors were expressed as crude and adjusted odds ratio (OR) with 95% confidence intervals (CI). The prevalence of CMDs among women was 5.7%, with 4.6% having depression and 3.37% with anxiety disorders. Multivariate logistic regression analysis showed that residing in urban areas (OR = 2.15; 95% CI:1.10–4.17), having a chronic illness (OR = 2.38; 95% CI:1.14–4.97), history of recent bereavement in the family (OR = 2.20; 95% CI:1.02–4.75), early marriage (OR = 2.63; 95% CI:1.09–6.33), history of abortion (OR = 2.89; 95% CI:1.42–5.92), and exposure to domestic violence (OR = 3.08; 95% CI:1.14–8.33) were significantly correlated with CMDs in this sample. The study revealed that CMDs were prevalent among the surveyed women, which calls for routine screening of women for CMDs in primary care settings for early identification and appropriate interventions.
约 10% 的印度人患有常见精神障碍(CMD),其中包括抑郁症和焦虑症。这些疾病常见于女性,不仅影响她们的生活质量,也影响她们的家庭成员。这项研究的目的是估计居住在卡纳塔克邦沿海地区的妇女中常见精神障碍的发病率及其相关因素。从 2019 年至 2021 年,对 980 名年龄在 18 岁至 60 岁之间的妇女进行了横断面研究。研究人员对妇女进行了基线问卷调查,同时还进行了患者健康问卷-9(PHQ-9)、广泛性焦虑症问卷-7(GAD-7)和科恩感知压力量表-4(PSS-4)的问卷调查。数据使用 Epi-info 收集,并使用 SPSS 15.0 版进行分析。CMD与社会人口学、生殖健康和行为因素之间的关系以粗略和调整后的几率比(OR)及95%置信区间(CI)表示。妇女的 CMD 患病率为 5.7%,其中 4.6% 患有抑郁症,3.37% 患有焦虑症。多变量逻辑回归分析显示,居住在城市地区(OR = 2.15; 95% CI:1.10-4.17)、患有慢性疾病(OR = 2.38; 95% CI:1.14-4.97)、家庭近期有丧偶史(OR = 2.20; 95% CI:1。在该样本中,早婚(OR = 2.63;95% CI:1.09-6.33)、流产史(OR = 2.89;95% CI:1.42-5.92)和遭受家庭暴力(OR = 3.08;95% CI:1.14-8.33)与 CMDs 显著相关。研究显示,CMD 在受访妇女中很普遍,这就要求在初级保健机构中对妇女进行常规的 CMD 筛查,以便及早发现并采取适当的干预措施。
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引用次数: 0
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Indian Journal of Psychological Medicine
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