Jun Cheng, Jinjin Pan, Dongmei Zhao, Xuejiao Ma, Qiulin Sun, Jiabin Li
Abstract The global prevalence of hepatitis C virus (HCV) infection is approximately 3%, with a post-infection chronicity rate of up to 50%–85%. HCV reactivation can occur when anti-HCV positive individuals receive antineoplastic therapy. In this study, we report a case of an anti-HCV positive patient with negative HCV RNA after 12 weeks of direct antiviral therapy. Two months later, sorafenib was used to treat hepatocellular carcinoma, and HCV reactivation occurred after 8 months of the treatment. HCV RNA was negative after 12 weeks of antiviral treatment with Sofosbuvir-velpatasvir. We also discussed the mechanism of HCV reactivation caused by sorafenib and the antiviral treatment regimen after HCV reactivation with the relevant literature.
{"title":"HCV Reactivation in a Patient with Hepatocellular Carcinoma Due to Sorafenib: A Case Report","authors":"Jun Cheng, Jinjin Pan, Dongmei Zhao, Xuejiao Ma, Qiulin Sun, Jiabin Li","doi":"10.2147/IMCRJ.S444521","DOIUrl":"https://doi.org/10.2147/IMCRJ.S444521","url":null,"abstract":"Abstract The global prevalence of hepatitis C virus (HCV) infection is approximately 3%, with a post-infection chronicity rate of up to 50%–85%. HCV reactivation can occur when anti-HCV positive individuals receive antineoplastic therapy. In this study, we report a case of an anti-HCV positive patient with negative HCV RNA after 12 weeks of direct antiviral therapy. Two months later, sorafenib was used to treat hepatocellular carcinoma, and HCV reactivation occurred after 8 months of the treatment. HCV RNA was negative after 12 weeks of antiviral treatment with Sofosbuvir-velpatasvir. We also discussed the mechanism of HCV reactivation caused by sorafenib and the antiviral treatment regimen after HCV reactivation with the relevant literature.","PeriodicalId":508214,"journal":{"name":"International Medical Case Reports Journal","volume":"13 4","pages":"121 - 124"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139871642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Report of Two Contrasting Cases of Epstein–Barr Virus–Associated Hemophagocytic Lymphohistiocytosis: Comparison to Infectious Mononucleosis and Flow Cytometric Analysis of Bone Marrow","authors":"Shiro Ono, Kiyomi Yoshimoto, Masaki Matsubara, Nobushiro Nishimura, Hiromasa Kawashima, Ryo Yoneima, Noritaka Yada, Kenji Nishio","doi":"10.2147/imcrj.s443996","DOIUrl":"https://doi.org/10.2147/imcrj.s443996","url":null,"abstract":"","PeriodicalId":508214,"journal":{"name":"International Medical Case Reports Journal","volume":"35 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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