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Advances in Organometallic Chemistry最新文献

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40 Years of GEQO-RSEQ GEQO-RSEQ 40年
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2022-01-01 DOI: 10.1016/s0065-3055(22)x0002-6
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引用次数: 0
Copyright 版权
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2021-01-01 DOI: 10.1016/s0065-3055(21)00025-3
{"title":"Copyright","authors":"","doi":"10.1016/s0065-3055(21)00025-3","DOIUrl":"https://doi.org/10.1016/s0065-3055(21)00025-3","url":null,"abstract":"","PeriodicalId":50855,"journal":{"name":"Advances in Organometallic Chemistry","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-3055(21)00025-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55896926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3rd Symposium in Carbene and Nitrene Chemistry 第三届碳和硝基化学研讨会
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2021-01-01 DOI: 10.1016/s0065-3055(21)x0003-2
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引用次数: 0
Copyright 版权
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2020-01-01 DOI: 10.1016/s0065-3055(20)30006-x
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引用次数: 0
Copyright 版权
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2020-01-01 DOI: 10.1016/s0065-3055(20)30022-8
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引用次数: 0
Contributors 贡献者
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2020-01-01 DOI: 10.1016/s0065-3055(20)30024-1
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引用次数: 0
Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression. 环状 RNA Cdr1as 通过抑制 miR-1270 上调 SCAI 以抑制卵巢癌的顺铂抗性
IF 8.8 2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2019-12-06 Epub Date: 2019-07-29 DOI: 10.1016/j.omtn.2019.07.012
Zhao Zhao, Mei Ji, Qianqing Wang, Nannan He, Yue Li

The aim of this study is to explore the roles of circular RNA (circRNA) Cdr1as on cisplatin resistance in ovarian cancer and explore the underlying mechanisms. We investigated the expression of circRNAs in five paired cisplatin-sensitive and cisplatin-resistant tissues of ovarian cancer by microarray analysis. The quantitative real-time PCR analysis was to investigate the expression pattern of Cdr1as in cisplatin-resistant ovarian cancer patient tissues and cell lines. Then, the effects of Cdr1as on cisplatin resistance, cell proliferation, and apoptosis were assessed in ovarian cancer cells. In this study, Cdr1as was observed to be downregulated in cisplatin-resistant patient tissues and cell lines. Overexpression of Cdr1as inhibited cell proliferation and promoted the cisplatin-induced cell apoptosis in ovarian cancer cells. Then we demonstrated that repressed Cdr1as promoted the miR-1270 expression, and miR-1270 could bind to the predicted binding site of Cdr1as. Furthermore, we found that miR-1270 displayed its role via modulating the Suppressor of Cancer Cell Invasion (SCAI) expression. Importantly, we demonstrated that Cdr1as was downregulated in serum exosomes from cisplatin-resistant patients. In summary, our study demonstrated that Cdr1as sensitizes ovarian cancer to cisplatin by regulating the miR-1270/SCAI signaling pathway.

本研究旨在探讨环状 RNA（circRNA）Cdr1as 在卵巢癌顺铂耐药中的作用及其内在机制。我们通过芯片分析研究了5个成对的顺铂敏感和顺铂耐药卵巢癌组织中循环RNA的表达。实时定量 PCR 分析是为了研究 Cdr1as 在顺铂耐药卵巢癌患者组织和细胞系中的表达模式。然后，评估了Cdr1as对顺铂耐药、细胞增殖和凋亡的影响。在这项研究中，观察到Cdr1as在顺铂耐药的患者组织和细胞系中下调。Cdr1as的过表达抑制了卵巢癌细胞的增殖，并促进了顺铂诱导的细胞凋亡。然后，我们证明了被抑制的Cdr1as能促进miR-1270的表达，而miR-1270能与Cdr1as的预测结合位点结合。此外，我们还发现 miR-1270 通过调节癌细胞侵袭抑制因子（SCAI）的表达而发挥作用。重要的是，我们发现 Cdr1as 在顺铂耐药患者的血清外泌体中被下调。总之，我们的研究表明，Cdr1as通过调节miR-1270/SCAI信号通路使卵巢癌对顺铂敏感。
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引用次数: 0
Recent advances in transition metal-mediated transformations of white phosphorus 过渡金属介导的白磷转化研究进展
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2019-07-11 DOI: 10.1016/BS.ADOMC.2019.06.001
Franco Scalambra, M. Peruzzini, A. Romerosa
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引用次数: 8
Boranes in Organic Chemistry 有机化学中的硼烷
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2019-06-30 DOI: 10.7591/9781501741432
H. Brown
Publisher Summary This chapter discusses boranes in organic chemistry, diborane as a reducing agent, volatile compounds of uranium, the alkali metal hydride approach to diborane, and alkali metal borohydrides. The search for solvents led to the discovery of sodium borohydride's being an excellent reducing agent for aldehydes and ketones. The search for catalysts to enhance the reducing power of sodium borohydride led to an anomalous result in the reduction of ethyl oleate. Investigation of this anomalous result led to the discovery of hydroboration. Hydroboration made the organoboranes readily available for the first time. This led to a systematic exploration of the chemistry of the organoboranes and established the fact that they constitute the most versatile organometallic available currently. The chapter describes molecular addition compounds and steric strains, steric assistance in solvolysis, the nonclassical ion problem, selective reductions, hydroboration, and versatile organoboranes. On the theoretical side, study of the dissociation of addition compounds of amines with trimethylborane, boron trifluoride, and borane provides a new quantitative approach to steric strains. These studies quickly removed doubts as to the importance of steric effects in chemical behavior and led to the study of related carbon compounds and the establishment of steric effects as an important factor in their behavior. One phase of these studies involved steric assistance to ionization in highly branched tertiary halides and related derivatives.
出版商摘要本章讨论了有机化学中的硼烷、作为还原剂的乙硼烷、铀的挥发性化合物、乙硼烷的碱金属氢化物方法以及碱金属硼氢化物。对溶剂的探索导致发现硼氢化钠是一种极好的醛酮还原剂。寻找提高硼氢化钠还原能力的催化剂导致油酸乙酯还原的异常结果。对这一异常结果的调查导致了硼氢化的发现。硼氢化使有机硼烷首次易于获得。这导致了对有机硼烷化学的系统探索，并确立了它们构成目前最通用的有机金属的事实。本章描述了分子加成化合物和空间菌株、溶剂解中的空间辅助、非经典离子问题、选择性还原、硼氢化和多功能有机硼烷。在理论方面，研究胺与三甲基硼烷、三氟化硼和硼烷的加成化合物的离解为空间菌株的研究提供了一种新的定量方法。这些研究很快消除了人们对空间效应在化学行为中重要性的怀疑，并导致了对相关碳化合物的研究，并确定空间效应是其行为中的一个重要因素。这些研究的一个阶段涉及高度支化的叔卤化物和相关衍生物的空间辅助电离。
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引用次数: 25
Copyright 版权
2区 化学 Q1 Chemistry
Advances in Organometallic Chemistry
Pub Date : 2019-01-01 DOI: 10.1016/s0065-3055(19)30029-2
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引用次数: 0
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