Pub Date : 2022-06-16DOI: 10.32552/2022.actamedica.737
Ceren Sucularlı, B. Tozkoparan, S. P. Aytaç
Objective: Polypharmacology, interaction of one drug with multiple targets, emerged as an effective approach in drug discovery and development. Bioinformatics and cheminformatics methods are essential tools for determination of polypharmacological profiles of newly synthesized or known compounds and drugs. Previously, three novel triazolothiadiazine derivatives; 1h, 3c and 3h, have been shown to induce apoptosis and cause cell cycle arrest on liver cancer cells. The aim of this study is to find possible action mechanisms and potential targets for these three triazolothiadiazine derivatives, and to investigate their potential as new therapeutic agents by using computational methods. Materials and Methods: PASS software was used to identify biological activities and Swiss Target Prediction and BindingDB databases to predict potential targets for 1h, 3c and 3h. PDE4A, ALR and DUSP1 proteins were selected for molecular docking analysis following the protein modeling of the three proteins. Results: Activity prediction results show that 1h, 3c and 3h might have phosphatase and signal transduction pathway inhibitor, hepatocyte growth factor antagonist, anti-inflammatory and antifungal activities. These derivatives are predicted as inhibitors of several phosphodiesterases by activity and target prediction tools. Conclusion: Based on prediction and molecular docking results, it is proposed that these compounds may have therapeutic properties through new predicted targets.
{"title":"In silico Activity and Target Prediction Analyses of Three Triazolothiadiazine Derivatives","authors":"Ceren Sucularlı, B. Tozkoparan, S. P. Aytaç","doi":"10.32552/2022.actamedica.737","DOIUrl":"https://doi.org/10.32552/2022.actamedica.737","url":null,"abstract":"Objective: Polypharmacology, interaction of one drug with multiple targets, emerged as an effective approach in drug discovery and development. Bioinformatics and cheminformatics methods are essential tools for determination of polypharmacological profiles of newly synthesized or known compounds and drugs. Previously, three novel triazolothiadiazine derivatives; 1h, 3c and 3h, have been shown to induce apoptosis and cause cell cycle arrest on liver cancer cells. The aim of this study is to find possible action mechanisms and potential targets for these three triazolothiadiazine derivatives, and to investigate their potential as new therapeutic agents by using computational methods.\u0000Materials and Methods: PASS software was used to identify biological activities and Swiss Target Prediction and BindingDB databases to predict potential targets for 1h, 3c and 3h. PDE4A, ALR and DUSP1 proteins were selected for molecular docking analysis following the protein modeling of the three proteins.\u0000Results: Activity prediction results show that 1h, 3c and 3h might have phosphatase and signal transduction pathway inhibitor, hepatocyte growth factor antagonist, anti-inflammatory and antifungal activities. These derivatives are predicted as inhibitors of several phosphodiesterases by activity and target prediction tools.\u0000Conclusion: Based on prediction and molecular docking results, it is proposed that these compounds may have therapeutic properties through new predicted targets.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"158 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79993651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-15DOI: 10.32552/2022.actamedica.745
Nesrin Damla Eyüpoğlu, Olgu Erkin Çınar, S. Aksu, Y. Büyükaşık, N. Sayınalp, H. Demiroğlu, H. Göker, O. Özcebe, I. Haznedaroglu
Objective: Chronic myeloid leukemia (CML) prognostication at the time of diagnosis is critical to determine the intensity of initial treatment. Event-free survival (EFS) has become a prominent concept of prognosis in the patients with chronic phase CML (CML-CP). The aim of this study is to assess the prognostic impact of bone marrow (BM) and peripheral blood (PB) cellular components, in correlation with the clinical parameters. Materials and Methods: One hundred forty-three patients with CML-CP on the front-line imatinib mesylate therapy were recruited into this study. Clinical and laboratory characteristics, therapeutic responses were recorded. Sokal, Euro/Hasford, The EUropean Treatment Outcome Study (EUTOS) and The EUTOS long-term survival (ELTS) scores were calculated for the studied patients. Results: Median follow-up time was 84 (IQR: 54-125) and median front-line therapeutic duration was 56 (IQR:23-89) months. Five-year EFS rate was 62.3% (95% CI: 53.9-70.7). The blast percentage in the BM, EUTOS scores, and basophil percentage in PB were related with the poor therapeutic outcomes in frontline therapy (p=0.002, p=0.002 and p=0.042, respectively). Although Sokal risk classification showed that the intermediate class had a higher event risk compared to the low-risk class (p=0.001), the predictive association disappeared in high-risk classes. Conclusion: EUTOS score system has better predictive capability for front-line imatinib therapy comparing with other indices. Higher blast percentage in BM and increased basophil percentage in PB are independent risk factors, adversely related with EFS in patients with CML.
{"title":"Event-free Survival in Patients with Chronic Myeloid Leukemia Receiving Front-line Imatinib Mesylate","authors":"Nesrin Damla Eyüpoğlu, Olgu Erkin Çınar, S. Aksu, Y. Büyükaşık, N. Sayınalp, H. Demiroğlu, H. Göker, O. Özcebe, I. Haznedaroglu","doi":"10.32552/2022.actamedica.745","DOIUrl":"https://doi.org/10.32552/2022.actamedica.745","url":null,"abstract":"Objective: Chronic myeloid leukemia (CML) prognostication at the time of diagnosis is critical to determine the intensity of initial treatment. Event-free survival (EFS) has become a prominent concept of prognosis in the patients with chronic phase CML (CML-CP). The aim of this study is to assess the prognostic impact of bone marrow (BM) and peripheral blood (PB) cellular components, in correlation with the clinical parameters.\u0000Materials and Methods: One hundred forty-three patients with CML-CP on the front-line imatinib mesylate therapy were recruited into this study. Clinical and laboratory characteristics, therapeutic responses were recorded. Sokal, Euro/Hasford, The EUropean Treatment Outcome Study (EUTOS) and The EUTOS long-term survival (ELTS) scores were calculated for the studied patients.\u0000Results: Median follow-up time was 84 (IQR: 54-125) and median front-line therapeutic duration was 56 (IQR:23-89) months. Five-year EFS rate was 62.3% (95% CI: 53.9-70.7). The blast percentage in the BM, EUTOS scores, and basophil percentage in PB were related with the poor therapeutic outcomes in frontline therapy (p=0.002, p=0.002 and p=0.042, respectively). Although Sokal risk classification showed that the intermediate class had a higher event risk compared to the low-risk class (p=0.001), the predictive association disappeared in high-risk classes.\u0000Conclusion: EUTOS score system has better predictive capability for front-line imatinib therapy comparing with other indices. Higher blast percentage in BM and increased basophil percentage in PB are independent risk factors, adversely related with EFS in patients with CML.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"41 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77746705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.730
Ç. M. Ayaz, A. Baştuğ
Objectives: Coronavirus disease 2019 (COVID-19) may have a severe course in high-risk patients and people living with Human immunodeficiency virus (HIV, PLWH)) are also in this risk group. The aim of the study was to compare the history of COVID-19, vaccination status, vaccine doses, and vaccine preferences of PLWH with the normal population.Materials and Methods: This study was a retrospective cross-sectional survey study. The PLWH were study group and patients without chronic disease were selected as a control group.Results: A total of 326 patients, 163 HIV positive and 163 without chronic disease, were included in the study. Of the patients, 142 (88.1%) were male, and the mean age was 46.69 ± 13.72 years. The number of patients who were not vaccinated was 36 (11.1%). When unvaccinated PLWH were evaluated, it was observed that women were less vaccinated than male patients (p=0.01). In PLWH, 145 (89.0%) of patients were vaccinated with single dose, 129 (79.1%) of patients with double dose, and 123 (75.5%) of patients with full dose; in the control group, 145 (89.0%) of patients with single dose, 131 (80.9%) of patients with double dose and 126 (77.3%) of patients with full dose were vaccinated. There was no difference between the groups in the preference of inactivated and mRNA vaccines (p=1.0). Before vaccination, 42 (12.9%) patients were infected. Twenty (12.3%) of these patients were in PLWH group, while 22 (13.5%) patients were in the control group. There were 28 (9.8%) patients who had COVID-19 during or after vaccination, and 10 (6.9%) of them were in PLWH group; 18 (12.4%) of them were in the control group.Conclusion: In our study, no difference was found in the vaccination status, vaccine preference, vaccination doses and COVID-19 history between two groups.
{"title":"Are COVID-19 Vaccine Preference and COVID-19 Risk Differ In Individuals Living with HIV from The Normal Population?","authors":"Ç. M. Ayaz, A. Baştuğ","doi":"10.32552/2022.actamedica.730","DOIUrl":"https://doi.org/10.32552/2022.actamedica.730","url":null,"abstract":"Objectives: Coronavirus disease 2019 (COVID-19) may have a severe course in high-risk patients and people living with Human immunodeficiency virus (HIV, PLWH)) are also in this risk group. The aim of the study was to compare the history of COVID-19, vaccination status, vaccine doses, and vaccine preferences of PLWH with the normal population.Materials and Methods: This study was a retrospective cross-sectional survey study. The PLWH were study group and patients without chronic disease were selected as a control group.Results: A total of 326 patients, 163 HIV positive and 163 without chronic disease, were included in the study. Of the patients, 142 (88.1%) were male, and the mean age was 46.69 ± 13.72 years. The number of patients who were not vaccinated was 36 (11.1%). When unvaccinated PLWH were evaluated, it was observed that women were less vaccinated than male patients (p=0.01). In PLWH, 145 (89.0%) of patients were vaccinated with single dose, 129 (79.1%) of patients with double dose, and 123 (75.5%) of patients with full dose; in the control group, 145 (89.0%) of patients with single dose, 131 (80.9%) of patients with double dose and 126 (77.3%) of patients with full dose were vaccinated. There was no difference between the groups in the preference of inactivated and mRNA vaccines (p=1.0). Before vaccination, 42 (12.9%) patients were infected. Twenty (12.3%) of these patients were in PLWH group, while 22 (13.5%) patients were in the control group. There were 28 (9.8%) patients who had COVID-19 during or after vaccination, and 10 (6.9%) of them were in PLWH group; 18 (12.4%) of them were in the control group.Conclusion: In our study, no difference was found in the vaccination status, vaccine preference, vaccination doses and COVID-19 history between two groups.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"156 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79855170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.727
A. Firat, Özlem Önerci Çelebi, H. M. Hayran
The human vomeronasal organ (VNO) is a structure situated under the anteroinferior side of the nasal septum. It is mainly described in the rodents and found as a part of the accessory olfactory system. It has been shown to consist of specialized olfactory sensory cells, which function in perception of pheromones. With a large number of literature on the human VNO, there is little concensus of its persistence and functionality in human. During a routine dissection of nasal cavity, we recognized a one-sided vomeronasal pit in one of the six fresh-frozen cadavers (17 %) and described the position and structure of this rare structure morphologically. The present study summarizes the literature about the VNO and describes its structural and functional findings.
{"title":"Is Human Vomeronasal Organ A Myth or A Neglected Structure?","authors":"A. Firat, Özlem Önerci Çelebi, H. M. Hayran","doi":"10.32552/2022.actamedica.727","DOIUrl":"https://doi.org/10.32552/2022.actamedica.727","url":null,"abstract":"The human vomeronasal organ (VNO) is a structure situated under the anteroinferior side of the nasal septum. It is mainly described in the rodents and found as a part of the accessory olfactory system. It has been shown to consist of specialized olfactory sensory cells, which function in perception of pheromones. With a large number of literature on the human VNO, there is little concensus of its persistence and functionality in human. During a routine dissection of nasal cavity, we recognized a one-sided vomeronasal pit in one of the six fresh-frozen cadavers (17 %) and described the position and structure of this rare structure morphologically. The present study summarizes the literature about the VNO and describes its structural and functional findings.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"2 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80786830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.741
Elçin Özçelik Eroğlu, M. Yıldız, A. A. Anıl Yağcıoğlu, Ö. Türkoğlu, Oguz Kaan Yalcinkaya, A. Ertugrul, S. Karahan, M. Yazıcı
Objective: To evaluate the mental health of patients with schizophrenia spectrum disorders with the prolongation of the pandemic. Materials and Methods: This descriptive cross-sectional study was conducted between August-October 2020. Fifty-two patients with schizophrenia spectrum disorders who were hospitalized prior to the onset of the pandemic between March 2019-March 2020 at the inpatient clinic were reassessed during the pandemic. The Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression-Severity (CGI-S) Scale, Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) and Fear of COVID-19 Scale were used to evaluate psychopathology during the pandemic. The PANSS and the CGI severity scores at discharge from the inpatient clinic for each patient were obtained from the medical records review for comparison along with sociodemographic variables.Results: A total of 34 patients, 33 with schizophrenia (97.1%) and 1 with schizoaffective disorder (2.9%) were included. There was no significant difference between the pre- and during the pandemic assessments in the PANSS total and the CGI severity scores. The PANSS total, the CGI, HAM-D, HAM-A and the Fear of COVID-19 scale scores, medical comorbidity and utilization of psychiatric health care services were significantly higher in patients who reported subjectively increased psychiatric symptoms during the pandemic. There was no significant difference in the change of PANSS total and CGI scores between the two groups. Fear of COVID-19 Scale and HAM-A scores were correlated positively. Conclusion: During pandemic increase in psychiatric symptoms may be related not only to psychosis but also depression, anxiety. According to the results of patients who reported subjectively increased psychiatric symptoms during the pandemic, while the psychotic symptoms did not worsen during the pandemic, patients with higher anxiety or depression scores reported an increase in their symptoms and were more likely to seek help.
{"title":"Effects of the COVID-19 Pandemic on Patients with Schizophrenia Spectrum Disorders","authors":"Elçin Özçelik Eroğlu, M. Yıldız, A. A. Anıl Yağcıoğlu, Ö. Türkoğlu, Oguz Kaan Yalcinkaya, A. Ertugrul, S. Karahan, M. Yazıcı","doi":"10.32552/2022.actamedica.741","DOIUrl":"https://doi.org/10.32552/2022.actamedica.741","url":null,"abstract":"Objective: To evaluate the mental health of patients with schizophrenia spectrum disorders with the prolongation of the pandemic. Materials and Methods: This descriptive cross-sectional study was conducted between August-October 2020. Fifty-two patients with schizophrenia spectrum disorders who were hospitalized prior to the onset of the pandemic between March 2019-March 2020 at the inpatient clinic were reassessed during the pandemic. The Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression-Severity (CGI-S) Scale, Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) and Fear of COVID-19 Scale were used to evaluate psychopathology during the pandemic. The PANSS and the CGI severity scores at discharge from the inpatient clinic for each patient were obtained from the medical records review for comparison along with sociodemographic variables.Results: A total of 34 patients, 33 with schizophrenia (97.1%) and 1 with schizoaffective disorder (2.9%) were included. There was no significant difference between the pre- and during the pandemic assessments in the PANSS total and the CGI severity scores. The PANSS total, the CGI, HAM-D, HAM-A and the Fear of COVID-19 scale scores, medical comorbidity and utilization of psychiatric health care services were significantly higher in patients who reported subjectively increased psychiatric symptoms during the pandemic. There was no significant difference in the change of PANSS total and CGI scores between the two groups. Fear of COVID-19 Scale and HAM-A scores were correlated positively. Conclusion: During pandemic increase in psychiatric symptoms may be related not only to psychosis but also depression, anxiety. According to the results of patients who reported subjectively increased psychiatric symptoms during the pandemic, while the psychotic symptoms did not worsen during the pandemic, patients with higher anxiety or depression scores reported an increase in their symptoms and were more likely to seek help.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"46 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89941406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.714
Ç. M. Ayaz, B. Başpınar, E. Kayaçetin
Objectives: Diarrhea is a common health problem and may occur for many infectious and non-infectious causes. In this study, it was aimed to investigate the causes, methods used in diagnosis and the results obtained in patients who applied to the gastroenterology clinic with the complaint of diarrhea.Materials and methods: 187 patients who presented with diarrhea between 01.11.2019-01.11.2020 were included in this study. Results: Acute diarrhea was detected in 32 (17.1%) out of 187 patients, persistent in 34 (18.2%), and chronic diarrhea in 121 (64.7%). The cause of diarrhea was detected in 148 (79.1%) patients. Infectious cause in 66 (%44.6) patients; inflammatory bowel disease (IBD) in 41 (27.7%) patients; irritable bowel syndrome (IBS) in 22 (14.9%) patients and less frequently as other diagnose were listed. The cause of diarrhea was detected in 73.6% of patients with chronic complaints, and this rate was 87.5% in acute diarrhea; and 91.2% of those presenting with persistent diarrhea (p = 0.04). Lower C reactive protein levels were found in irritable bowel syndrome compared to other diarrheal causes (p<0.001). It was observed that anti-infective treatment was used more frequently in acute and persistent diarrhea compared to chronic diarrhea (p <0.001).Conclusion: Although application to outpatient clinics were more frequent due to chronic diarrhea, acute and persistent diarrhea were also not rare (35.3%). The reason to explain diarrhea has been found in the majority of patients. Infectious induced diarrhea was seen as the most common cause, it was followed by IBD and IBS, respectively. When prescribing anti-infective agents, clinical, laboratory and microbiological results should be considered and inappropriate drug use should be avoided.
{"title":"Evaluation of Patients with Diarrhea Applying to the Outpatient Gastroenterology Clinic of Research Hospital","authors":"Ç. M. Ayaz, B. Başpınar, E. Kayaçetin","doi":"10.32552/2022.actamedica.714","DOIUrl":"https://doi.org/10.32552/2022.actamedica.714","url":null,"abstract":"Objectives: Diarrhea is a common health problem and may occur for many infectious and non-infectious causes. In this study, it was aimed to investigate the causes, methods used in diagnosis and the results obtained in patients who applied to the gastroenterology clinic with the complaint of diarrhea.Materials and methods: 187 patients who presented with diarrhea between 01.11.2019-01.11.2020 were included in this study. Results: Acute diarrhea was detected in 32 (17.1%) out of 187 patients, persistent in 34 (18.2%), and chronic diarrhea in 121 (64.7%). The cause of diarrhea was detected in 148 (79.1%) patients. Infectious cause in 66 (%44.6) patients; inflammatory bowel disease (IBD) in 41 (27.7%) patients; irritable bowel syndrome (IBS) in 22 (14.9%) patients and less frequently as other diagnose were listed. The cause of diarrhea was detected in 73.6% of patients with chronic complaints, and this rate was 87.5% in acute diarrhea; and 91.2% of those presenting with persistent diarrhea (p = 0.04). Lower C reactive protein levels were found in irritable bowel syndrome compared to other diarrheal causes (p<0.001). It was observed that anti-infective treatment was used more frequently in acute and persistent diarrhea compared to chronic diarrhea (p <0.001).Conclusion: Although application to outpatient clinics were more frequent due to chronic diarrhea, acute and persistent diarrhea were also not rare (35.3%). The reason to explain diarrhea has been found in the majority of patients. Infectious induced diarrhea was seen as the most common cause, it was followed by IBD and IBS, respectively. When prescribing anti-infective agents, clinical, laboratory and microbiological results should be considered and inappropriate drug use should be avoided.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"15 4","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72460602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.732
Nazan Akel, Ceyda Şahan, A. Demir
Work-aggravated asthma is an important and common subtype of work-related asthma. Air pollutants in the workplace are important risk factors for triggering asthma symptoms. Air pollutants can be caused by the operating conditions of the work process, as well as by indoor and outdoor air pollution. In this study, a case of work-aggravated asthma is discussed. An office worker, who had been following up with a diagnosis of asthma for 6 years, was diagnosed with work-aggravated asthma. The reason underlying this diagnosis was the smoke and dust from nearby factories as well as the antiseptic substances used in the workplace. Following the diagnosis, the patient’s workplace was changed by the management. After such change, the patient’s symptoms have relieved and she needed less inhaler therapy than before. In summary, work-aggravated asthma can be exacerbated by factors in the workplace environment. Hence, the workplace environment should also be carefully questioned while assessing the risk factors at work.
{"title":"Work-Aggravated Asthma in the Workplace Due to Environmental Exposure: A Case Report","authors":"Nazan Akel, Ceyda Şahan, A. Demir","doi":"10.32552/2022.actamedica.732","DOIUrl":"https://doi.org/10.32552/2022.actamedica.732","url":null,"abstract":"Work-aggravated asthma is an important and common subtype of work-related asthma. Air pollutants in the workplace are important risk factors for triggering asthma symptoms. Air pollutants can be caused by the operating conditions of the work process, as well as by indoor and outdoor air pollution. In this study, a case of work-aggravated asthma is discussed. An office worker, who had been following up with a diagnosis of asthma for 6 years, was diagnosed with work-aggravated asthma. The reason underlying this diagnosis was the smoke and dust from nearby factories as well as the antiseptic substances used in the workplace. Following the diagnosis, the patient’s workplace was changed by the management. After such change, the patient’s symptoms have relieved and she needed less inhaler therapy than before. In summary, work-aggravated asthma can be exacerbated by factors in the workplace environment. Hence, the workplace environment should also be carefully questioned while assessing the risk factors at work.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"72 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89208172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.661
Zahit Taş, M. Ç. Sönmezer, G. Telli Dizman, A. Inkaya, Ö. Uzun, M. Akova
A 74-year-old female from a rural district in Central Anatolia, Turkey, was admitted with persisting fever, malaise, cough, and vomiting. There is no abnormal finding on physical examination. There was no petechiae, purpura, ecchymosis, or bleeding in organ systems at any time. Laboratory findings showed increased D-dimer level and acute inflammation biomarkers such as C-reactive protein, ferritin, and thrombocytopenia with prolonged prothrombin time. Since the patient applied with clinic features indicating a viral infection and on a pandemic period, firstly, we focused on coronavirus disease 2019 (COVID-19 )disease. However, the probability was reduced with negative chest imaging and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction (RT-PCR) results. Any patient admitting with symptoms indicative of COVID-19 disease during the pandemic era should also be evaluated for other infections, especially endemic zoonotic infections such as brucellosis, Crimean-Congo hemorrhagic fever (CCHF), Q fever. In this case, serologic tests were all negative (Leptospira Toxoplasma, Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Rubella, Brucella, Coxiella, Hepatitis B, Hepatitis C). The patient was found to be IgM and RNA positive for the CCHF virus by ELISA and polymerase chain reaction (PCR) methods, respectively. In endemic areas, CCHF is one of the diseases which should be considered in the differential diagnosis. In addition, it is essential to accurately identify CCHF infection using proper medical tests to prevent misdiagnosis amid this COVID-19 pandemic. Hence, we need to keep an eye on the cases that come from endemic rural areas in the Central Anatolia region of Turkey. Herein, we present a case of CCHF patients initilally evaluated to have COVID-19.
{"title":"A Case of Crimean-Congo Haemorrhagic Fever (CCHF) Mimicking the COVID-19 Disease","authors":"Zahit Taş, M. Ç. Sönmezer, G. Telli Dizman, A. Inkaya, Ö. Uzun, M. Akova","doi":"10.32552/2022.actamedica.661","DOIUrl":"https://doi.org/10.32552/2022.actamedica.661","url":null,"abstract":"A 74-year-old female from a rural district in Central Anatolia, Turkey, was admitted with persisting fever, malaise, cough, and vomiting. There is no abnormal finding on physical examination. There was no petechiae, purpura, ecchymosis, or bleeding in organ systems at any time. Laboratory findings showed increased D-dimer level and acute inflammation biomarkers such as C-reactive protein, ferritin, and thrombocytopenia with prolonged prothrombin time. Since the patient applied with clinic features indicating a viral infection and on a pandemic period, firstly, we focused on coronavirus disease 2019 (COVID-19 )disease. However, the probability was reduced with negative chest imaging and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction (RT-PCR) results. Any patient admitting with symptoms indicative of COVID-19 disease during the pandemic era should also be evaluated for other infections, especially endemic zoonotic infections such as brucellosis, Crimean-Congo hemorrhagic fever (CCHF), Q fever. In this case, serologic tests were all negative (Leptospira Toxoplasma, Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Rubella, Brucella, Coxiella, Hepatitis B, Hepatitis C). The patient was found to be IgM and RNA positive for the CCHF virus by ELISA and polymerase chain reaction (PCR) methods, respectively. In endemic areas, CCHF is one of the diseases which should be considered in the differential diagnosis. In addition, it is essential to accurately identify CCHF infection using proper medical tests to prevent misdiagnosis amid this COVID-19 pandemic. Hence, we need to keep an eye on the cases that come from endemic rural areas in the Central Anatolia region of Turkey. Herein, we present a case of CCHF patients initilally evaluated to have COVID-19.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"43 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87291560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.740
E. Aladağ, E. Bulut, Pınar Demirayak, Bilge Volkan Salancı, K. Karlı Oğuz, B. Erbaş, E. Ergün, B. B. Doğu, M. Cankurtaran, M. Halil
Objecives: Recently, imaging biomarkers like flouro-deoxi-glucose positron emission tomography (FDG-PET) become even more important for evaluation probable AD. The aim of this study was to evaluate the possible correlation between Montreal Cognitive Assessment Test (MoCA) and metabolic function of brain regions determined by FDG-PET in patients with probable AD. Materials and methods: Thirty seven (37) patients who had diagnosis of probable AD were included. MoCA test and metabolic measurements of brain regions by FDG-PET were performed in all patients. A visual scoring was performed to obtain the rates of hypometabolism in brain regions.Results: Median age of the patients was 77 (minimum 65-maximum 83) years. On the right hemisphere, MOCA test score decreased according to visual FDG-PET score of parietal lobe (15±5.1, 11.8±8.4 and 8.5±5.9; p=0.032). MOCA test score was 16±5.8, 13.1±7.6 and 9.1±6.1 in patients with left temporal lobe and 15.2±5.2, 11.8±7.8 and 8.5±5.9 in patients with left parietal lobe according to visual FDG-PET scores respectively (p=0.035; p=0.02). The comparison of the other right and left hemisphere regions and MOCA test scores were not significant.Conclusion: The present study is emphasized that the MoCA test which is easily applied in outpatient clinics can be demonstrated the hypometabolism of bilateral parietal and left temporal brain regions related with pathophysiology of AD.
{"title":"Comparison of Visual Rating Scale Based on Brain 18F-FDG-PET and Montreal Cognitive Assessment Test in Probable Alzheimer’s Disease","authors":"E. Aladağ, E. Bulut, Pınar Demirayak, Bilge Volkan Salancı, K. Karlı Oğuz, B. Erbaş, E. Ergün, B. B. Doğu, M. Cankurtaran, M. Halil","doi":"10.32552/2022.actamedica.740","DOIUrl":"https://doi.org/10.32552/2022.actamedica.740","url":null,"abstract":"Objecives: Recently, imaging biomarkers like flouro-deoxi-glucose positron emission tomography (FDG-PET) become even more important for evaluation probable AD. The aim of this study was to evaluate the possible correlation between Montreal Cognitive Assessment Test (MoCA) and metabolic function of brain regions determined by FDG-PET in patients with probable AD. Materials and methods: Thirty seven (37) patients who had diagnosis of probable AD were included. MoCA test and metabolic measurements of brain regions by FDG-PET were performed in all patients. A visual scoring was performed to obtain the rates of hypometabolism in brain regions.Results: Median age of the patients was 77 (minimum 65-maximum 83) years. On the right hemisphere, MOCA test score decreased according to visual FDG-PET score of parietal lobe (15±5.1, 11.8±8.4 and 8.5±5.9; p=0.032). MOCA test score was 16±5.8, 13.1±7.6 and 9.1±6.1 in patients with left temporal lobe and 15.2±5.2, 11.8±7.8 and 8.5±5.9 in patients with left parietal lobe according to visual FDG-PET scores respectively (p=0.035; p=0.02). The comparison of the other right and left hemisphere regions and MOCA test scores were not significant.Conclusion: The present study is emphasized that the MoCA test which is easily applied in outpatient clinics can be demonstrated the hypometabolism of bilateral parietal and left temporal brain regions related with pathophysiology of AD.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"163 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88027770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.32552/2022.actamedica.639
M. Tümer, Hazar Kökten, Aysun Ankay Yılbaş, F. Sarıcaoğlu
Desbuquois syndrome (DS) is a rare disease that can be accompanied by a difficult airway. In the literature, there are usually case reports about the mortal forms in childhood. We wanted to share our anesthesia experience in an adult patient with DS who underwent orthopedic surgery. We used videolaryngoscopy for intubation with coronavirus precautions. Adult patients with DS can be managed safely with adequate difficult airway preparation.
{"title":"Anesthesia Management in An Adult Patient with Desbuquois Syndrome","authors":"M. Tümer, Hazar Kökten, Aysun Ankay Yılbaş, F. Sarıcaoğlu","doi":"10.32552/2022.actamedica.639","DOIUrl":"https://doi.org/10.32552/2022.actamedica.639","url":null,"abstract":"Desbuquois syndrome (DS) is a rare disease that can be accompanied by a difficult airway. In the literature, there are usually case reports about the mortal forms in childhood. We wanted to share our anesthesia experience in an adult patient with DS who underwent orthopedic surgery. We used videolaryngoscopy for intubation with coronavirus precautions. Adult patients with DS can be managed safely with adequate difficult airway preparation.","PeriodicalId":50891,"journal":{"name":"Acta Medica Mediterranea","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78196313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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