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Ameliorative effect of Curcuma longa against arsenic induced reproductive toxicity in Charles Foster rats 莪术对砷引起的查尔斯-福斯特大鼠生殖毒性的改善作用
Pub Date : 2024-03-11 DOI: 10.53555/jaz.v45i3.3782
Shazia Naheed Akhter, Rekha Kumari, Arun Kumar
The present study aims to develop the antidote against arsenic induced male reproductive toxicity in animal models. The study was carried out on Charles Foster Rats after the approval from Institutional Animal Ethics Committee. A total of n=18, rats (12 weeks old) of an average weight of 160 ± 20 g were used for the study. The study group included n=6 control and n= 12 treated with sodium arsenite orally at the dose of 8mg/Kg b.w daily for 40 days. The n= 6 animals were dissected and rest n=6 was administered orally with Curcuma longa rhizome ethanolic extract at the dose of 600mg/Kg b.w per day for 40 days. At the end of the entire experiment, all the animals were dissected out and their reproductive organs were taken out, especially epididymis for sperm counts, sperm motility, sperm mortality, sperm morphology. The blood samples were collected for the hormonal assay (testosterone and luteinizing hormone), as well as for hematological and biochemical analysis. The study showed, high magnitude of degeneration in the reproductive organs of the rats in the arsenic treated group. There were degenerative fluctuations in the sperm counts, sperm motility, sperm mortality, sperm morphology and in the hormonal parameters, as well as in the hematological and biochemical parameters in the arsenic treated rats. But, after the administration of Curcuma longa, there was significant amelioration in all these parameters. Therefore, the present study shows that Curcuma longa plays vital role to combat arsenic induced male reproductive toxicity.
本研究旨在开发针对砷诱导的雄性生殖毒性动物模型的解毒剂。经动物伦理委员会批准,本研究以查尔斯-福斯特大鼠为研究对象。研究共使用了 18 只大鼠(12 周大),平均体重为 160 ± 20 克。研究组包括 n=6 对照组和 n=12 亚砷酸钠治疗组,亚砷酸钠剂量为每天 8 毫克/千克体重,连续 40 天。对 n=6 只动物进行解剖,其余 n=6 只动物按每天 600 毫克/千克体重的剂量口服莪术根茎乙醇提取物,连续 40 天。整个实验结束后,解剖所有动物,取出其生殖器官,尤其是附睾,检测精子数量、精子活力、精子死亡率和精子形态。采集的血液样本用于激素检测(睾酮和黄体生成素)以及血液和生化分析。研究结果表明,砷处理组大鼠的生殖器官退化程度较高。砷处理组大鼠的精子数量、精子活力、精子死亡率、精子形态、激素参数以及血液和生化参数都出现了退化性波动。但在服用姜黄后,所有这些参数都有明显改善。因此,本研究表明,莪术在对抗砷引起的雄性生殖毒性方面发挥着重要作用。
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引用次数: 0
Protective and antidote effect of Foeniculum vulgare against Sodium Arsenite induced hepatotoxicity and testicular toxicity in Charles Foster rats 茴香对亚砷酸钠诱导的查尔斯-福斯特大鼠肝毒性和睾丸毒性的保护和解毒作用
Pub Date : 2024-03-11 DOI: 10.53555/jaz.v45i3.4270
P. Niraj, Rana Vikram Singh, Prabhat Shankar, A. Ghosh, Arun Kumar
Arsenic poisoning in groundwater is the most common environmental pollutant, which is leading to serious pollution worldwide. Chronic arsenic exposure from drinking water to humans causes major public health-related issues. The present study was conducted to investigate the antidote effects of Foeniculum vulgare (Fennel) against arsenic-induced hepatotoxicity and testicular toxicity in Charles Foster rats. In the present study, twenty-four male Charles Foster rats (120±5gm) were divided into four Groups (n=6), where control Group-I received a normal diet and water; Group - II and Group - III received sodium arsenite (8 mg per kg body weight per day) for 90 days. Group III was left with a normal diet and water for the next 60 days for auto-recovery. The group IV rats were administered Foeniculum vulgare (Funnel) hydroxyl ethanolic seed extract at a dose of 150 mg per kg body weight for 60 days in a 90-day pre-treated sodium arsenite group (8 mg per kg body weight). After complete dose duration, all the treated animals were sacrificed the same day for haematological, biochemical, hormonal, and histopathological studies. In the arsenic treated rats, there were significant (p<0.001) changes in serum levels of SGPT, SGOT, urea, uric acid and creatinine as well as in haematological parameters. And there was also decease in the sperm count and sperm motility, accompanied by an increased incidence of sperm abnormalities and hormonal imbalances leading to infertility. In contrast, after the administration of F. vulgare seeds hydroxy-ethanolic extract to arsenic-treated rats, significant (p<0.001) improvements were observed in hepatic and renal parameters as well as haematological parameters. In the arsenic-intoxicant rat, after administration of F. vulgare seeds hydroxyl ethanolic extract, there was a significant (p<001) reduction in the arsenic concentration in blood, liver, and kidney tissues as well as serum LPO. The histopathological study also showed the F. vulgare seeds hydroxy-ethanolic extract significantly restored the cellular integrity of testicular cells, leading to their normal functioning against arsenic-induced toxicity.
地下水中的砷中毒是最常见的环境污染物,正在导致全球范围内的严重污染。人类从饮用水中长期接触砷会导致严重的公共健康问题。本研究旨在调查茴香对砷诱导的查尔斯-福斯特大鼠肝毒性和睾丸毒性的解毒作用。在本研究中,24 只雄性查尔斯-福斯特大鼠(120±5gm)被分为四组(n=6),其中对照组 - I 接受正常饮食和水;组 - II 和组 - III 接受亚砷酸钠(每天每公斤体重 8 毫克),为期 90 天。第三组在接下来的 60 天内保持正常饮食和饮水,以进行自我恢复。在预处理亚砷酸钠(每公斤体重 8 毫克)90 天的组别中,第 IV 组大鼠以每公斤体重 150 毫克的剂量服用茴香(漏斗)羟基乙醇种子提取物 60 天。在整个剂量持续时间结束后,所有处理过的动物都在同一天被处死,以进行血液学、生物化学、激素和组织病理学研究。砷处理过的大鼠血清中的 SGPT、SGOT、尿素、尿酸和肌酐水平以及血液学参数都发生了显著变化(p<0.001)。此外,精子数量和精子活力也出现下降,精子畸形和内分泌失调的发生率增加,导致不育。与此相反,在给砷处理的大鼠服用 F. vulgare 种子羟乙醇提取物后,肝脏和肾脏参数以及血液学参数都有显著改善(p<0.001)。在砷中毒大鼠中,服用 F. vulgare 种子羟基乙醇提取物后,血液、肝脏和肾脏组织中的砷浓度以及血清 LPO 都有显著降低(p<001)。组织病理学研究还表明,鹅掌楸种子羟乙醇提取物能显著恢复睾丸细胞的完整性,使其在砷中毒中恢复正常功能。
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引用次数: 0
K+ Ions Crosslinked Kappa-Carrageenan/Methylene Blue Composite Film. Part-1: Synthesis, Characterization and Application as Controlled Release Device for Photodynamic Therapy Application K+ 离子交联卡帕卡拉胶/亚甲基蓝复合膜。第 1 部分:光动力疗法应用中作为控释装置的合成、表征和应用
Pub Date : 2024-03-10 DOI: 10.53555/jaz.v45i3.4387
Aniteshma Chanpuria, M. Bajpai, S. Bajpai, Seema Tiwari, Sonali Bhosle
K+ ions crosslinked (KC/MB) Methylene blue photosensitizer loaded composite film is prepared for photodynamic therapy (PDT) application as Photosensitizer released by composite film can conveniently be controlled by using different quantities of K+ ions and this application is based on dynamic interaction between light with suitable wavelength, photosensitizer and molecular oxygen, promoting the death of the target tissue or bacterial cells. In this work, the Methylene Blue (MB) loaded Carrageenan polymeric film was prepared by the method of direct addition of MB into pre-polymerization solution of Carrageenan (KC). This composite film and plain KC film were characterized by FTIR, XRD and SEM analysis. The characteristic peaks of MB photosensitizer were obtained in FTIR spectrum of composite film. The composite film KC/MB shows prominence of amorphous nature may be due to MB is present in very small quantity. The SEM analysis reveals that the composite film (KC/MB) having much more smooth surface texture throughout the film. Finally, the result of effect of variation in degree of crosslinking on amount of MB release is, as the amount of K+ ions used to crosslink the film increases, MB release decreases.
K+ 离子交联(KC/MB)亚甲基蓝光敏剂负载复合膜是为光动力疗法(PDT)应用而制备的,因为复合膜释放的光敏剂可以通过使用不同数量的 K+ 离子方便地进行控制,这种应用是基于合适波长的光、光敏剂和分子氧之间的动态相互作用,促进靶组织或细菌细胞的死亡。在这项工作中,通过在卡拉胶(KC)的预聚合溶液中直接添加甲基蓝(MB)的方法,制备了负载甲基蓝(MB)的卡拉胶聚合物薄膜。通过傅立叶变换红外光谱(FTIR)、X 射线衍射(XRD)和扫描电镜分析,对这种复合薄膜和普通 KC 薄膜进行了表征。在复合薄膜的傅立叶变换红外光谱中获得了甲基溴光敏剂的特征峰。KC/MB 复合薄膜显示出明显的无定形性质,这可能是由于甲基溴的含量极少。扫描电镜分析表明,复合薄膜(KC/MB)的整个表面纹理更加光滑。最后,交联程度的变化对甲基溴释放量的影响结果是,随着用于交联薄膜的 K+ 离子量的增加,甲基溴释放量减少。
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引用次数: 0
A Systematic Review On Treatment Of Hypertension 高血压治疗的系统回顾
Pub Date : 2024-03-09 DOI: 10.53555/jaz.v45is3.4431
Dr. Kiran C. Mahajan, Mr. Sushant S. Gaikwad, Mr. Datta M. Chaudhari, Mohini S. Deore, Dr. Ganesh Y. Dama
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引用次数: 0
AI-Enhanced Comprehensive Analysis Of The Research Perspective On The Microbiome And Methane Production In Cow Rumen 人工智能增强了对牛瘤胃微生物组和甲烷生产研究前景的全面分析
Pub Date : 2024-03-09 DOI: 10.53555/jaz.v45i3.3831
Tyler Li
Methane emissions from ruminant livestock, particularly cows, have been a topic of interest because of their negative environmental impact, including contributing to greenhouse gas accumulation and accelerating climate change. Understanding the cow's rumen microbiome can provide valuable insights for devising effective emission reduction strategies. Despite the recognized environmental impact of methane emissions from cows, however, a systematic review on the cow rumen microbiome has not yet been done. This study aims to fill this gap by performing an unbiased bibliometric analysis to review the effect of the rumen microbiome on methane emissions through cross-check of multiple data sources. While the bibliometric analysis offers a quantitative approach to assess research trends and identify areas of potential exploration within the field of the cow rumen microbiome, this study also evaluated the concurrently growing interest in the potential of artificial intelligence (AI) tools, specifically ChatGPT by OpenAI in terms of its efficacy and accuracy in enhancing scientific research project. Through the fusion of conventional research methodologies and AI-driven insights, this study aspires to provide a holistic perspective on the cow rumen microbiome's profound influence on methane emissions, while also exploring the untapped potential of AI in advancing scientific inquiry.
反刍家畜(尤其是奶牛)排放的甲烷对环境造成了负面影响,包括造成温室气体积累和加速气候变化,因此一直是人们关注的话题。了解奶牛瘤胃微生物组可以为制定有效的减排策略提供宝贵的见解。尽管奶牛排放的甲烷对环境的影响已得到公认,但有关奶牛瘤胃微生物组的系统综述尚未完成。本研究旨在填补这一空白,通过对多个数据源进行交叉检验,对瘤胃微生物组对甲烷排放的影响进行无偏见的计量分析。文献计量分析提供了一种定量方法来评估研究趋势并确定奶牛瘤胃微生物组领域的潜在探索领域,同时本研究还评估了与此同时人们对人工智能(AI)工具潜力日益增长的兴趣,特别是 OpenAI 的 ChatGPT 在提高科研项目效率和准确性方面的潜力。通过融合传统研究方法和人工智能驱动的洞察力,本研究希望提供一个全面的视角,探讨奶牛瘤胃微生物组对甲烷排放的深远影响,同时探索人工智能在推进科学研究方面尚未开发的潜力。
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引用次数: 0
Comparative Analysis of Diabetic Prediction Using Machine Learning Algorithms 使用机器学习算法预测糖尿病的比较分析
Pub Date : 2024-03-08 DOI: 10.53555/jaz.v45is4.4308
Ms. Madhuvanthi B, Dr. Baskaran T S
Diabetes mellitus (DM) is a severe worldwide health problem, and its prevalence is quickly growing. It is a spectrum of metabolic illnesses definite by continually increased blood glucose levels. Undiagnosed diabetes can lead to a variety of difficulties, including retinopathy, nephropathy, neuropathy, and other vascular abnormalities. In this context, machine learning (ML) technologies may be mainly useful for early disease identification, diagnosis, and therapy monitoring. The core idea of this study is to detect the strong ML algorithm to forecast it. For this numerous ML algorithms were chosen i.e., support vector machine (SVM), Naïve Bayes (NB), K nearest neighbor (KNN), random forest (RF), logistic regression (LR), and decision tree (DT), according to this work. Two, Pima Indian diabetic (PID) and Germany diabetes datasets were used and the research was implemented using Waikato environment for knowledge analysis (WEKA) 3.8.6 tool. This research discussed performance matrices and error rates of classifiers for both datasets. The outcomes showed that for the PID database (PIDD), SVM works improved with an accuracy of 74% whereas for Germany RF and KNN work improved with 98.7% accuracy. This study can helps healthcare facilities and researchers in understanding the value and application of ML algorithms in predicting diabetes at an initial stage
糖尿病(DM)是一个严重的世界性健康问题,其发病率正在迅速增长。它是由血糖水平持续升高引起的一系列代谢性疾病。未确诊的糖尿病会导致各种问题,包括视网膜病变、肾病、神经病变和其他血管异常。在这种情况下,机器学习(ML)技术可能主要用于疾病的早期识别、诊断和治疗监测。本研究的核心思想是检测出预测疾病的强 ML 算法。为此,本研究选择了多种 ML 算法,即支持向量机 (SVM)、奈夫贝叶斯 (NB)、K 近邻 (KNN)、随机森林 (RF)、逻辑回归 (LR) 和决策树 (DT)。研究使用了皮马印度糖尿病(PID)和德国糖尿病两个数据集,并使用怀卡托知识分析环境(WEKA)3.8.6 工具实施了研究。该研究讨论了两个数据集的性能矩阵和分类器的错误率。结果显示,对于 PID 数据库 (PIDD),SVM 的准确率提高了 74%,而对于德国 RF 和 KNN,准确率提高了 98.7%。这项研究有助于医疗机构和研究人员了解 ML 算法在糖尿病初期预测中的价值和应用。
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引用次数: 0
Enhancing Face Recognition Accuracy On Low-Resolution Databases Using Interpolation Techniques And Feature Extraction Techniques 利用插值技术和特征提取技术提高低分辨率数据库中的人脸识别精度
Pub Date : 2024-03-08 DOI: 10.53555/jaz.v45i3.4347
Bhavna Bhadkare, Dr. Varsha Jotwani
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引用次数: 0
SERVICES QUALITY IN RELIGIOUS TOURISM WITH REFERENCE TO NAVAGRAHA TEMPLES IN THANJAVUR DISTRICT 以比贾维尔地区的纳瓦格拉哈寺庙为参照,探讨宗教旅游的服务质量问题
Pub Date : 2024-03-07 DOI: 10.53555/jaz.v45i3.4247
Arockkia joseph jerald Commerce, Dr. N. Periyasami
This research delves into the realm of Religious Tourism Service Quality, specifically focusing on the Navagraha Temples in the culturally rich Thanjavur District. As the oldest form of tourism, religious pilgrimage has witnessed substantial growth in recent years. The study employs the World Tourism Organization's standards to assess safety, hygiene, accessibility, transparency, authenticity, and harmony in the context of these temples. Using a structured questionnaire and statistical analysis, the research unveils pilgrims' perceptions of service quality across various dimensions and establishes correlations with overall satisfaction. The findings provide valuable insights for practitioners, temple management, and policymakers in enhancing the religious tourism experience in this region.
本研究深入探讨了宗教旅游服务质量问题,特别关注文化丰富的丹贾武尔区的纳瓦格拉哈寺庙。作为最古老的旅游形式,宗教朝圣近年来出现了大幅增长。本研究采用世界旅游组织的标准来评估这些寺庙的安全、卫生、可及性、透明度、真实性与和谐性。通过结构化问卷和统计分析,研究揭示了朝圣者对各方面服务质量的看法,并确定了与总体满意度之间的相关性。研究结果为从业人员、寺庙管理者和政策制定者提供了宝贵的见解,有助于提升该地区的宗教旅游体验。
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引用次数: 0
An overview on major diseases, damage pattern, and management of Mango (Mangifera indica L.) fruit and tree 芒果(Mangifera indica L.)果树的主要病害、危害模式和管理概述
Pub Date : 2024-03-07 DOI: 10.53555/jaz.v45i2.4008
Tirthankar Dalui, Subhankar Kumar Sarkar
Mango is one of the most important tropical fruits grown throughout the world particularly in Asia with high economic and nutritional value. However, several diseases and pests cause significant damages to different parts of mango trees and mango fruits, resulting in severe economic losses to farmers and the agricultural sector. Some of the major mango diseases are anthracnose, powdery mildew, die back, and mango malformation. These diseases affect various parts of mango tree, including leaves, flowers, fruits, stems, and roots. The causative organisms of mango diseases include fungi, bacteria, and viruses. Of these, the majority is caused by fungi. Some of the common fungal diseases of mango include anthracnose, powdery mildew, stem-end rot, and sooty mould. Therefore, it is a pressing need to accurately identify the causative organisms for determination of the best management strategy for an effective control. To manage mango diseases, farmers and researchers use several approaches, including cultural practices, chemical control, biological control, and genetic resistance. In this article, the major mango diseases, damage patterns, and management strategies for sustainable mango production has been critically reviewed and presented.
芒果是世界上最重要的热带水果之一,尤其是在亚洲,具有很高的经济和营养价值。然而,一些病虫害对芒果树的不同部位和芒果果实造成严重破坏,给农民和农业部门造成严重的经济损失。芒果的一些主要病害有炭疽病、白粉病、枯萎病和芒果畸形。这些病害影响芒果树的各个部分,包括叶、花、果实、茎和根。芒果病害的致病菌包括真菌、细菌和病毒。其中,大部分是由真菌引起的。芒果常见的真菌病害包括炭疽病、白粉病、茎端腐烂病和煤烟霉病。因此,迫切需要准确识别致病菌,以确定有效控制的最佳管理策略。为了防治芒果病害,果农和研究人员采用了多种方法,包括栽培方法、化学防治、生物防治和遗传抗性。本文对芒果的主要病害、危害模式以及可持续芒果生产的管理策略进行了严格的审查和介绍。
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引用次数: 0
A Study Of The Educational Aspiration Of Higher Secondary School Students In East Khasi Hills District, Meghalaya 关于梅加拉亚邦东 Khasi Hills 县高中生教育愿望的研究
Pub Date : 2024-03-07 DOI: 10.53555/jaz.v45i3.4386
Dr. Alfa Mary Kurbah
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引用次数: 0
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Journal of Advanced Zoology
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