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Acta Gastro-Enterologica Belgica最新文献

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Hepatic chemoembolization: clinical and experimental correlation. 肝化疗栓塞:临床与实验的相关性。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
S Wallace, Z Kan, C Li

Chemoembolization has become the preferred treatment for patients with inoperable, hypervascular hepatic malignancies in the Far East, but controversial elsewhere. In vivo microscopy in addition to other experimental procedures are used in this presentation to better understand the mechanisms involved in chemoembolization. In chemoembolization Lipiodol acts as a contrast material, a vehicle for chemotherapy and an embolic agent. Although not optimal, Lipiodol injected into the hepatic artery, traverses the peribiliary plexus to the portal veins resulting in a dual embolization. Chemoembolization creates ischemia, slows arterial flow and increases the contact time between the infusate and the neoplasms, increasing the tumor cell kill. However, the vascular occlusion also produces infarction and fibrosis compounding the already existing cirrhosis frequently associated with hepatocellular carcinoma. Lipiodol/ethanol (3:1) injected into the segmental or lobar hepatic artery supplying the neoplasm also gains access to the associated portal venous branches causing focal ablation. This preoperative approach is easier to perform than direct portal vein occlusion, with less parenchymal damage and comparable hypertrophy of the remnant liver frequently necessary for adequate hepatic function following resection. Polymer-drug conjugates, e.g. PG-TXL, have considerable potential for intra-arterial delivery especially with the dramatic increase in concentration of the drug in the tumor and its efficacy. Using in vivo microscopy especially with green fluorescent protein (GFP) gene as an efficient and non-toxic tumor cell marker, the events leading to hepatic metastases can be documented which will serve to better evaluate these varied techniques of chemoembolization.

化疗栓塞已成为远东地区无法手术的高血管性肝脏恶性肿瘤患者的首选治疗方法,但在其他地区存在争议。在本报告中,除了其他实验程序外,还使用了体内显微镜来更好地了解化学栓塞的机制。在化疗栓塞中,脂醇作为造影剂、化疗载体和栓塞剂。虽然不是最理想的,但脂醇注入肝动脉,穿过胆管周围丛到达门静脉,导致双重栓塞。化疗栓塞造成缺血,减缓动脉血流,增加输液和肿瘤之间的接触时间,增加肿瘤细胞的杀伤。然而,血管闭塞也会导致梗死和纤维化,使已经存在的肝硬化复合,通常与肝细胞癌相关。向供应肿瘤的肝节段动脉或肝叶动脉注射醇/乙醇(3:1)也可进入相关的门静脉分支,引起局灶性消融。这种术前方法比直接门静脉阻断更容易实施,肝实质损伤更小,残肝的肥厚往往是切除后肝功能恢复所必需的。聚合物药物缀合物,如PG-TXL,具有相当大的动脉内给药潜力,特别是随着肿瘤中药物浓度的急剧增加及其疗效。使用体内显微镜,特别是使用绿色荧光蛋白(GFP)基因作为高效无毒的肿瘤细胞标记物,可以记录导致肝转移的事件,这将有助于更好地评估这些不同的化疗栓塞技术。
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引用次数: 0
Treatment of chronic hepatitis B: lamivudine. 慢性乙型肝炎的治疗:拉米夫定。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
N Leung
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引用次数: 0
Prognostic factors determining the outcome of treatment in chronic hepatitis C. 决定慢性丙型肝炎治疗结果的预后因素。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
S J Hadziyannis

After a brief introduction in terminology and a distinction between predictors and determinants or response to therapy in chronic hepatitis C, a review of the wide literature on this topic is presented. None of the pretreatment variables or combination of them can be used as an absolute predictor of response in individual patients. Prognostic factors can help in clinical practice for informing and counseling patients of the likelihood of response. Information on pretreatment HCV RNA levels and HCV genotype can improve the cost benefit of therapy. Predictors of response should be properly evaluated in terms of positive predictive value, negative predictive value and accuracy. The strongest hitherto predictor of sustained response to any therapeutic regimen in chronic hepatitis is the clearance of HCV RNA during treatment. Recent data suggest that sequencing of several regions of the HCV genome may provide important prognostic information on the outcome of therapy. In complex and difficult to treat subsets of patients with chronic HCV infection, available data on predictors and determinants of the outcome of treatment are limited.

在简要介绍了术语以及慢性丙型肝炎治疗反应的预测因素和决定因素的区别之后,我们将对有关这一主题的大量文献进行回顾。没有任何一种治疗前变量或变量组合可以作为个体患者治疗反应的绝对预测因素。预后因素有助于在临床实践中告知和指导患者出现应答的可能性。关于治疗前 HCV RNA 水平和 HCV 基因型的信息可以提高治疗的成本效益。应从阳性预测值、阴性预测值和准确性方面对应答预测因子进行适当评估。迄今为止,慢性肝炎治疗方案持续应答的最强预测指标是治疗期间 HCV RNA 的清除率。最近的数据表明,对 HCV 基因组的几个区域进行测序可为治疗结果提供重要的预后信息。对于复杂且难以治疗的慢性 HCV 感染患者,有关治疗结果的预测因素和决定因素的现有数据非常有限。
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引用次数: 0
An overview on a novel adjuvanted prophylactic hepatitis B vaccine. 新型佐剂预防性乙型肝炎疫苗概述。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
S Thoelen
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引用次数: 0
Improvement of chronic active hepatitis C in chronically infected chimpanzees after therapeutic vaccination with the HCV E1 protein. 治疗性接种HCV E1蛋白后慢性感染黑猩猩慢性活动性丙型肝炎的改善
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
G Maertens, S Priem, A Ducatteeuw, E Verschoorl, B Verstrepen, T Roskams, V Desmet, S Fuller, K Van Hoek, P Vandeponseele, F Bosman, M A Buyse, L J van Doorn, J Heeney, A Kos, E Depla
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引用次数: 0
Lymphangioma of the colon: a case report and review of the Japanese literature. 结肠淋巴管瘤:1例报告及日本文献复习。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
T Hatada, H Ikeda, A Tanigawa, Y Fujiwara, Y Hanada, T Yamamura

Intraabdominal lymphangiomas are rare, although these lesions can occur in the mesentery, omentum, retroperitoneum, or gastrointestinal tract wall. Here we report a case of lymphangioma of the transverse colon and review the other cases reported in the Japanese literature. Our patient presented with lower abdominal pain and barium enema revealed a filling defect in the transverse colon. Colonoscopy disclosed a submucosal tumor, which changed shape with alteration the patient's position and showed the cushion sign. This lesion was covered with normal-looking mucosa. A correct diagnosis was made from these findings. Knowledge of these endoscopic features may help physicians to provide appropriate diagnosis and treatment of colonic lymphangioma.

腹内淋巴管瘤是罕见的,尽管这些病变可以发生在肠系膜、网膜、腹膜后或胃肠道壁。在此,我们报告一例横结肠淋巴管瘤,并回顾其他在日本文献报道的病例。我们的病人表现为下腹部疼痛和钡灌肠显示横结肠充盈缺损。结肠镜检查发现黏膜下肿瘤,其形状随患者体位改变而改变,呈垫状征。病灶被外观正常的粘膜覆盖。根据这些发现作出了正确的诊断。了解这些内窥镜特征可以帮助医生对结肠淋巴管瘤进行适当的诊断和治疗。
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引用次数: 0
S gene variation of HBV. HBV 的 S 基因变异。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
W F Carman
{"title":"S gene variation of HBV.","authors":"W F Carman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"182-4"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment for chronic hepatitis B: interferon what we have learned after so many years? 慢性乙型肝炎的治疗:干扰素这么多年后我们学到了什么?
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
F Nevens
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引用次数: 0
Hepatitis C: virology, clinical aspects and the relation to cryoglobulinemia. 丙型肝炎:病毒学、临床方面以及与冷球蛋白血症的关系。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
J M Pawlotsky
{"title":"Hepatitis C: virology, clinical aspects and the relation to cryoglobulinemia.","authors":"J M Pawlotsky","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"200-1"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21764651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of hepatocellular carcinoma and its viral risk factors. 肝细胞癌的流行病学及其病毒风险因素。
IF 1.5 4区 医学 Q2 Medicine Pub Date : 2000-04-01
M C Kew
{"title":"Epidemiology of hepatocellular carcinoma and its viral risk factors.","authors":"M C Kew","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50942,"journal":{"name":"Acta Gastro-Enterologica Belgica","volume":"63 2","pages":"227-9"},"PeriodicalIF":1.5,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21765296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Acta Gastro-Enterologica Belgica
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