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First person – Emily D. McParland and T. Amber Butcher 第一人--艾米莉-D-麦克帕兰和 T. 安伯-布彻
Pub Date : 2024-03-15 DOI: 10.1242/jcs.262094
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Emily D. McParland and T. Amber Butcher are co-first authors on ‘ The Dilute domain in Canoe is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness’, published in JCS. Emily and Amber conducted the research described in this article while they were postbaccalaureate research assistants in the labs of Dr Mark Peifer (E.D.M. and T.A.B.) and Dr Kevin Slep (T.A.B.) at Chapel Hill Department of Biology, University of North Carolina, USA. Emily is now a PhD student in the lab of Dr Thomas Roberts at Brown University, Providence, USA, where she is broadly interested in functional morphology and muscle biomechanics, and focuses on the function of the collagenous extracellular matrix in muscle force production. Amber is a PhD student in the lab of Dr Eric Greene at Columbia University Department of Biochemistry and Molecular Biophysics, New York, USA, where she uses biochemical and biophysical techniques to investigate protein function, most recently within the context of homologous recombination.
First Person 是对《细胞科学杂志》上发表的部分论文的第一作者进行的系列采访,帮助研究人员在发表论文的同时宣传自己。Emily D. McParland和T. Amber Butcher是发表在《细胞科学杂志》上的《Canoe中的Dilute结构域并非连接细胞接头和细胞骨架的关键,但支持形态发生的稳健性》一文的共同第一作者。艾米丽和安博在美国北卡罗来纳大学教堂山分校生物学系马克-佩弗博士(E.D.M.和T.A.B.)和凯文-斯莱普博士(T.A.B.)的实验室担任学士后研究助理期间进行了本文所述的研究。艾米丽现在是美国普罗维登斯布朗大学托马斯-罗伯茨博士实验室的一名博士生,她对功能形态学和肌肉生物力学有着广泛的兴趣,重点研究胶原细胞外基质在肌肉力量产生中的功能。Amber 是美国纽约哥伦比亚大学生物化学和分子生物物理学系 Eric Greene 博士实验室的博士生,她利用生物化学和生物物理技术研究蛋白质功能,最近的研究是同源重组。
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引用次数: 0
First person – Liheng Yang (杨利恒) 第一人 - 杨利恒(Liheng Yang)
Pub Date : 2024-03-01 DOI: 10.1242/jcs.262031
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Liheng Yang (杨利恒) is first author on ‘ Trophoblast organoids with physiological polarity model placental structure and function’, published in JCS. Liheng is a Senior Research Associate in the lab of Carolyn Coyne at Department of Integrative Immunobiology, Duke University School of Medicine, Durham, USA, investigating using human placenta organoids to explore the underlying mechanisms of the innate immune defense against pathogen infection at the maternal–fetal interface.
First Person 是对《细胞科学杂志》(Journal of Cell Science)上发表的部分论文的第一作者的系列采访,帮助研究人员在发表论文的同时宣传自己。杨利恒(Liheng Yang)是发表在《细胞科学》(JCS)上的 "Trophoblast organoids with physiological polarity model placental structure and function "一文的第一作者。杨利恒是美国杜克大学医学院综合免疫生物学系 Carolyn Coyne 实验室的高级助理研究员,研究利用人体胎盘器官组织探索母胎界面先天性免疫防御病原体感染的内在机制。
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引用次数: 0
First person – Michelle Ly 第一人称 - Michelle Ly
Pub Date : 2024-03-01 DOI: 10.1242/jcs.262025
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Michelle Ly is first author on ‘ Integrin-based adhesions promote cell–cell junction and cytoskeletal remodelling to drive embryonic wound healing’, published in JCS. Michelle conducted the research described in this article while a MASc student in Rodrigo Fernandez-Gonzalez's lab at University of Toronto, Canada where she investigated the molecular mechanisms underlying cell migration and cell–extracellular matrix adhesion, and their roles in embryology and developmental processes. She is now a Research Assistant in the lab of Stewart Russel at the CReATe Fertility Centre, Toronto, Canada, working to pinpoint biomarkers associated with successful early embryo development.
First Person 是对《细胞科学杂志》上发表的部分论文的第一作者进行的系列采访,帮助研究人员在发表论文的同时宣传自己。Michelle Ly是《细胞科学杂志》上发表的 "基于整合素的粘附促进细胞-细胞连接和细胞骨架重塑,从而推动胚胎伤口愈合 "一文的第一作者。米歇尔在加拿大多伦多大学罗德里戈-费尔南德斯-冈萨雷斯(Rodrigo Fernandez-Gonzalez)实验室攻读硕士学位期间,研究了细胞迁移和细胞-细胞外基质粘附的分子机制,以及它们在胚胎学和发育过程中的作用。她现在是加拿大多伦多 CReATe 生育中心 Stewart Russel 实验室的研究助理,致力于找出与早期胚胎成功发育相关的生物标志物。
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引用次数: 0
First person – Celia Segui-Perez 第一人称 - Celia Segui-Perez
Pub Date : 2024-03-01 DOI: 10.1242/jcs.262029
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Celia Segui-Perez is first author on ‘ MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C’, published in JCS. Celia is a PhD student in the lab of Karin Strijbis at the Department of Biomolecular Health Sciences, Utrecht University, The Netherlands, investigating the role of mucins in health and disease.
First Person 是对《细胞科学杂志》上发表的部分论文的第一作者进行的系列采访,帮助研究人员在发表论文的同时宣传自己。Celia Segui-Perez 是《细胞科学杂志》上发表的 "MUC13 通过蛋白激酶 C 负向调节紧密连接蛋白和肠上皮屏障完整性 "一文的第一作者。Celia 是荷兰乌得勒支大学生物分子健康科学系 Karin Strijbis 实验室的博士生,研究粘蛋白在健康和疾病中的作用。
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引用次数: 0
First person – Ruturaj 第一人称 - 鲁图拉杰
Pub Date : 2024-03-01 DOI: 10.1242/jcs.262027
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Ruturaj is first author on ‘ Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B’, published in JCS. Ruturaj is a PhD student in the lab of Arnab Gupta at Indian Institute of Science Education and Research Kolkata, investigating the trafficking mechanisms of ATPases in polarized epithelia.
First Person 是对《细胞科学杂志》上发表的部分论文的第一作者的系列采访,帮助研究人员在发表论文的同时宣传自己。Ruturaj是《细胞科学杂志》上发表的 "Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B "一文的第一作者。Ruturaj 是印度加尔各答科学教育与研究所 Arnab Gupta 实验室的博士生,研究极化上皮细胞中 ATP 酶的贩运机制。
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引用次数: 0
Cell scientist to watch – Ginny G. Farías 值得关注的细胞科学家 - Ginny G. Farías
Pub Date : 2024-03-01 DOI: 10.1242/jcs.261992
Ginny G. Farías is an Assistant Professor of Cell Biology at Utrecht University in The Netherlands. She trained in molecular neurobiology with Prof. Nibaldo Inestrosa during PhD at the Pontifical Catholic University of Chile in Santiago, Chile, where she studied mechanisms of neurodegeneration in Alzheimer's disease. She then completed a postdoctoral fellowship with Prof. Juan Bonifacino at the National Institutes of Health in Bethesda, Maryland, USA. As a postdoc, she focused on understanding the fundamental cellular processes that drive polarized trafficking of proteins in neurons. In 2018, she started her lab at Utrecht University, where her group develops sophisticated tools to investigate how the local organisation and dynamics of organelles contribute to neuronal polarity. For our Special Issue on Cell and Tissue Polarity, we spoke with Ginny over Zoom about her perseverance to become an independent researcher, fascination with neuronal organisation and support for open access science.
Ginny G. Farías 是荷兰乌得勒支大学细胞生物学助理教授。她在智利圣地亚哥的智利天主教大学攻读博士学位期间,师从 Nibaldo Inestrosa 教授学习分子神经生物学,研究阿尔茨海默病的神经变性机制。之后,她在美国马里兰州贝塞斯达的国家卫生研究院完成了胡安-博尼法奇诺教授的博士后研究。作为一名博士后,她专注于了解驱动神经元中蛋白质极化贩运的基本细胞过程。2018年,她在乌得勒支大学开始了自己的实验室,她的研究小组开发了复杂的工具来研究细胞器的局部组织和动力学如何促进神经元的极性。对于我们的《细胞与组织极性特刊》,我们通过 Zoom 与 Ginny 谈论了她成为独立研究人员的毅力、对神经元组织的痴迷以及对开放获取科学的支持。
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引用次数: 0
First person – Alex van Vliet 第一人 - 亚历克斯-范弗利特
Pub Date : 2024-02-15 DOI: 10.1242/jcs.262015
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Alex van Vliet is first author on ‘ Exploring the ATG9A interactome uncovers interaction with VPS13A’, published in JCS. Alex conducted the research described in this article while a Postdoctoral Training Fellow in Sharon Tooze's lab at The Francis Crick Institute, London, UK. He is now an MRC Postdoc in the lab of Sean Munro at MRC Laboratory of Molecular Biology, Cambridge, UK, investigating the mechanisms of membrane trafficking.
First Person 是对《细胞科学杂志》上发表的部分论文的第一作者进行的系列采访,帮助研究人员在发表论文的同时宣传自己。Alex van Vliet 是发表在《细胞科学杂志》上的 "Exploring the ATG9A interactome uncovers interaction with VPS13A "一文的第一作者。亚历克斯是在英国伦敦弗朗西斯-克里克研究所莎伦-托兹实验室担任博士后培训研究员期间开展本文所述研究的。他现在是英国剑桥大学 MRC 分子生物学实验室肖恩-芒罗实验室的一名 MRC 博士后,研究膜贩运的机制。
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引用次数: 0
Cell scientist to watch – Dan Dickinson 值得关注的细胞科学家 - 丹-迪金森
Pub Date : 2024-02-15 DOI: 10.1242/jcs.261964
Dan Dickinson is an Assistant Professor in Molecular Biosciences at the University of Texas at Austin (UT Austin), USA. He completed his doctoral studies at Stanford University in California, co-mentored by Prof. Bill Weis and Prof. James Nelson, where he became fascinated with cell polarity in the amoeba Dictyostelium discoideum. He next moved to Prof. Bob Goldstein's lab at the University of North Carolina at Chapel Hill for his postdoctoral research, where he developed a single-cell method to probe protein interactions in Caenorhabditis elegans zygotes. In 2017, he started his own lab at UT Austin. Intrigued by capacity of proteins to generate complex patterns across scales, his group aims to close the gap between biochemistry and cell biology using single-cell methods to investigate cell polarity in diverse contexts. For our Special Issue on Cell and Tissue Polarity, we spoke with Dan over Zoom about his goals as a researcher and educator and his dedication to teaching students the joy of scientific inquiry.
丹-迪金森是美国得克萨斯大学奥斯汀分校分子生物科学助理教授。他在加州斯坦福大学完成了博士学业,由 Bill Weis 教授和 James Nelson 教授共同指导,在那里他对盘状变形虫的细胞极性产生了浓厚的兴趣。随后,他来到北卡罗来纳大学教堂山分校鲍勃-戈尔茨坦教授的实验室从事博士后研究,在那里他开发了一种单细胞方法,用于探测秀丽隐杆线虫子囊中的蛋白质相互作用。2017 年,他在UT Austin 成立了自己的实验室。他的研究小组对蛋白质产生跨尺度复杂模式的能力很感兴趣,旨在缩小生物化学与细胞生物学之间的差距,利用单细胞方法研究各种情况下的细胞极性。在《细胞与组织极性特刊》中,我们与 Dan 通过 Zoom 谈论了他作为研究人员和教育工作者的目标,以及他教导学生科学探究乐趣的奉献精神。
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引用次数: 0
Cell scientist to watch – Jörg Renkawitz 值得关注的细胞科学家 - 约尔格-伦卡维茨(Jörg Renkawitz
Pub Date : 2024-02-15 DOI: 10.1242/jcs.261954
Jörg Renkawitz is an endowed Peter Hans Hofschneider Professor in Molecular Medicine at Ludwig Maximilians-University Munich, Germany. Following his bachelor and Master's degrees in biochemistry, during which he was first introduced to the field of cell motility, he completed his doctoral work with Prof. Dr Stefan Jentsch at the Max Planck Institute of Biochemistry in Martinsried, Germany, studying the mechanisms of DNA repair. Still intrigued by the mechanics of migrating cells, he moved to the Institute of Science and Technology in Vienna, Austria for his postdoc with Prof. Dr Michael Sixt, which cemented his passion for understanding how motile cells navigate their environments. In 2018, he started his own lab at Ludwig Maximilians-University Munich, and now applies his molecular expertise to unravel the mechanobiology of the immune system by combining omics approaches with engineered microenvironments and high-throughput imaging. We spoke with Jörg over Zoom to learn about his career path, rigorous approaches to experimental design and mentorship philosophy.
约尔格-伦卡维茨是德国慕尼黑路德维希-马克西米利安大学分子医学彼得-汉斯-霍夫施奈德教授。在获得生物化学学士和硕士学位期间,他首次接触到细胞运动领域,之后在德国马丁斯里德马克斯-普朗克生物化学研究所师从斯特凡-詹茨教授完成了博士学业,研究 DNA 修复机制。他仍然对迁移细胞的力学原理很感兴趣,于是来到奥地利维也纳科技研究所,跟随迈克尔-西斯特(Michael Sixt)博士教授做博士后研究,这坚定了他对了解运动细胞如何在环境中导航的热情。2018年,他在慕尼黑路德维希-马克西米利安大学(Ludwig Maximilians-University Munich)成立了自己的实验室,现在他将自己的分子专业知识应用于通过将全局学方法与工程微环境和高通量成像相结合来揭示免疫系统的机械生物学。我们通过中联重科采访了约尔格,了解他的职业道路、严谨的实验设计方法和导师理念。
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引用次数: 0
First person – Shweta Santra 第一人 - Shweta Santra
Pub Date : 2024-02-15 DOI: 10.1242/jcs.261999
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Shweta Santra is first author on ‘ Estimates of differential toxin expression governing heterogeneous intracellular lifespans of Streptococcus pneumoniae’, published in JCS. Shweta is a PhD student in the lab of Anirban Banerjee at Indian Institute of Technology, Bombay, India, working on decoding host–pathogen interactions and understanding cellular processes.
First Person 是对《细胞科学杂志》上发表的部分论文的第一作者的系列采访,帮助研究人员在发表论文的同时宣传自己。Shweta Santra 是《细胞科学杂志》上发表的 "肺炎链球菌异质性细胞内寿命的毒素表达差异估计 "一文的第一作者。Shweta 是印度孟买印度理工学院 Anirban Banerjee 实验室的博士生,致力于解码宿主与病原体之间的相互作用和了解细胞过程。
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引用次数: 0
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Journal of Cell Science
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