Journal of Arthroplasty最新文献

Introduction: Obesity is associated with increased infection risk after primary total joint arthroplasty. In this retrospective cohort analysis, we sought to assess the association between body mass index (BMI) and infection recurrence after two-stage revision total joint arthroplasty (TJA) for periprosthetic joint infection (PJI).

Methods: Patients were grouped by BMI (< 30, 30 to 40, and ≥ 40) as non-obese, obese, and morbidly obese, and assessed for associations and timing of PJI reinfection as well as readmissions and complications.

Results: Following the two-stage revision, PJI reinfections increased from 11.5% in non-obese to 19.0% in obese and 25.9% in morbidly obese patients (P = 0.011). As BMI increased across the three groups, 90-day readmission rates following two-stage PJI revision significantly increased (8.6, 19.7, and 16.7%, respectively (P = 0.042)). The average time to reinfection decreased with obesity tercile (restricted-mean times of 4.5, 4.2, and 3.8 years with non-obese, obese, and morbidly obese, respectively (P = 0.023)).

Discussion: The success of PJI management with two-stage arthroplasty is significantly impacted by patient BMI, with morbidly obese subjects having the worst outcomes. Attempts to modify BMI before completion of two-stage PJI treatment should be considered in the morbidly obese given high rates of recurrence.

Background: Periprosthetic joint infection (PJI) is an uncommon, but serious complication in total joint arthroplasty. Personalized risk prediction and risk factor management may allow better preoperative assessment and improved outcomes. We evaluated different data-driven approaches to develop surgery-specific PJI prediction models using large-scale data from the electronic health records.

Methods: A large institutional arthroplasty registry was leveraged to collect data from 58,574 procedures of 41,844 patients who underwent at least one primary and/or revision hip and/or knee arthroplasty between 2000 and 2019. The registry dataset was augmented with additional clinical, procedural, and laboratory data from the electronic health records for more than 100 potential predictor variables. The main outcome was PJI within the first year after surgery. We implemented both traditional and machine learning methods for model development (lasso regression, relaxed lasso regression, ridge regression, random forest, stepwise regression, extreme gradient boosting, neural network) and used 10-fold cross-validation to calculate measures of model performance in terms of discrimination (c-statistic), cross-entropy loss, and calibration.

Results: All models performed similarly in predicting PJI risk, with negligible differences of less than 0.08 between the best and worst-performing models. The relaxed and fully relaxed lasso models using the Cox model structure outperformed the other models with concordances of 0.787 in primary hip arthroplasty and 0.722 in revision hip arthroplasty, with the number of predictors ranging from nine to 41. The concordances with the relaxed lasso models were 0.681 in primary and 0.699 in revision knee arthroplasty, with a higher number of predictors in the models. Predictors included in the models varied substantially across the four surgical groups.

Conclusions: The incorporation of additional data from the electronic health records offers limited improvement in PJI risk stratification. Furthermore, improvement in PJI risk prediction was modest with the machine learning approaches and may not justify the added complexity.

Introduction: Glucagon-like peptide-1 (GLP-1) agonists have emerged as a powerful diabetic treatment adjunct; however, their effects on outcomes following total hip arthroplasty (THA) are not well known. This study aimed to compare the risk of complications in patients who had type-2 diabetes mellitus (DM) who were on GLP-1 agonists with those who were not on these medications.

Methods: In total, 14,065 patients who had type-2 DM undergoing primary THA between 2016 and 2021 were retrospectively reviewed utilizing a national database. Propensity score matching was employed at a 1:4 ratio to match patients who used GLP-1 agonists (n = 812) to those who did not (n = 3,248). Patients were matched on age, sex, insulin status, presence of other diabetic medications, comorbidities, and smoking status. Multivariable logistic regressions were performed to examine 90-day and 1-year THA outcomes between groups.

Results: Patients who were not on GLP-1 agonists exhibited increased rates of extended hospital stays (≥ three days) (OR [odds ratio] 1.25, P = 0.01). Patients who were on GLP-1 agonists exhibited no significant differences in surgical or medical complication rates at 90 days compared to those not on GLP-1 agonists. There were also no significant differences in rates of all-cause revision THA, aseptic revision THA, or PJI during the 1-year postoperative period.

Conclusion: This study demonstrated that GLP-1 agonists were not associated with increased risks for medical or surgical complications in patients who had DM undergoing THA and were associated with lower rates of extended hospital stays after surgery. This study provides additional evidence regarding the association of GLP-1 agonist use before THA with postoperative outcomes. Given the potential for increased glycemic control and weight loss, more data is needed to delineate the role of GLP-1 agonists in the optimization of patients who have DM before THA to minimize postoperative complications.

Background: Managing acetabular defects and restoring the hip center of rotation in revision hip arthroplasty is considered a complex and challenging surgery. Among many existing options, porous tantalum components have shown favorable short-term (less than ten years) follow-up results. The present study aimed to describe clinical and radiographic outcomes in longer-term follow-up.

Methods: Between 2006 and 2013, 98 patients who underwent this surgical technique in our institute were clinically and radiographically reviewed. Re-revisions for aseptic loosening of the acetabular component were examined to consider the survivorship of the implant as the primary endpoint. The clinical outcome was measured using the Harris Hip Score (HHS). Radiological signs of osseointegration, radiolucency lines, acetabular stability, and position of the hip center of rotation (COR) were evaluated at the immediate postoperative and last follow-up radiographs.

Results: The cup survivorship was 96% at a mean follow-up of 14 years (range, 10 to 17). Global survivorship was 83.6% if any reason for re-revisions was considered as an endpoint. The most frequent complications were dislocation (13.7%) and infections (12%). Overall, 13 patients died, and 17 patients were lost to follow-up. There were 73 patients available for clinical and radiographic evaluation. The mean HHS was 81 (range, 39 to 100). More than 80% of hips showed radiological evidence of osseointegration, and no change was found in COR position at last follow-up radiographs.

Conclusion: The use of porous tantalum uncemented components to manage revision hip arthroplasty can be considered a favorable solution for managing acetabular defects and restoring the hip center of rotation with satisfactory clinical and radiological results in a long-term follow-up.

Background: This study aimed to describe the management and outcomes of aseptic revision total hip arthroplasty (arTHA) with unsuspected intra-operative positive cultures (UPCs) compared to those with sterile cultures.

Methods: A single tertiary center's institutional database was retrospectively reviewed for arTHA from January 2013 to October 2023. Pre-operative Musculoskeletal Infection Society (MSIS) scores were assigned to patients based on available infectious workup, and those who met the criteria for periprosthetic infection (PJI), received antibiotic spacers, or had less than 1-year follow-up were excluded. Patients were grouped and compared according to intra-operative culture results: sterile cultures, one UPC with a new organism, one UPC with the same organism as prior PJI, ≥ two UPCs with different organisms, and ≥ two UPCs with the same organism.

Results: There was a total of 604 arTHAs included in this study, of which 0.8% [five of 604] had ≥ two UPCs with different organisms, 1.5% [9 of 604] had ≥ 2 UPCs with the same organism, 9.8% [59 of 604] had one UPC with a new organism, 0.2% [one of 604] had 1 UPC with an organism from prior PJI, and 87.7% [530 of 604] of patients had sterile cultures. When comparing 5-year infection-free survival between patients who had one UPC with a new organism and sterile cultures, there was no difference (P = 0.40); however, patients who had ≥ two UPCs with different organisms (P < 0.001), patients who had ≥ two UPCs with the same organism (P = 0.001), and patients who had one UPC of an organism from prior PJI (P < 0.001) had statistically worse infection-free survival compared to patients with sterile cultures.

Conclusion: Infection-free survival at five years was similar between patients who had one UPC with a new organism and those who had sterile cultures; however, ≥ two UPCs and a history of PJI are both significant risk factors for re-revision for infection after arTHA.

Background: In total hip arthroplasty (THA), even if there is a dislocated hip, restoring the anatomical center of rotation increases long-term survival and hip function. Even with a shortening osteotomy, the procedure is still challenging due to soft-tissue tension. Therefore, soft tissue releases such as iliopsoas tenotomy may be necessary. In our study, we aimed to examine the effects of iliopsoas tenotomy on hip flexion and abduction strength in patients who underwent THA with shortening osteotomy for Crowe 3 and 4 hip dysplasia by using a hand dynamometer for measurement.

Methods: The present study examined 27 patients who underwent THA with shortening osteotomy in unilateral Crowe 3 and 4 hips. The patients' hip flexion and abduction strengths were measured with a hand dynamometer preoperatively and in the first year postoperatively.

Results: The average flexion strength of the operated side was less than the non-operated side before surgery. It also decreased further in the first six weeks. But the strength increased in the 12^th week and reached the same level as the non-operated side in the 6^th month. The average abduction strength was less than the non-operated side before the surgery, and it decreased further in the 6^th week after surgery. However, the strength increased during follow-ups and reached the non-operated side strengths in the 12^th week.

Conclusion: In conclusion, during THA procedures for highly dislocated hips, releasing the iliopsoas tendon at the level of the minor trochanter to facilitate distalization of the hip center of rotation does not adversely affect hip flexion and abduction strengths.

Background: Treatment of complex acetabular fractures in patients over 60 remains challenging. Functional treatments for these fractures have yielded disappointing outcomes. Internal fixation may fail facing this porotic bone, and postoperative non weight bearing may expose the patient to decubitus complications. Our hypothesis was that use of a dual mobility cup (DMC) reduces dislocation risk after concomitant internal fixation and total hip arthroplasty (THA) for acetabular fracture in patients who are over 60 years old.

Methods: A retrospective, observational non comparative and continuous study was conducted from January 2015 to September 2022. Patients aged over 60 years who had displaced acetabular fractures, treated surgically via concomitant internal fixation and THA, utilizing a DMC exclusively through the Kocher-Langenbeck approach and a minimum follow-up was of one year, were included. There were 45 patients (45 hips) who had an average age of 71 (range, 60 to 88) who were included (75.5% men). The main mechanisms of injury were the motor vehicle accidents (in 21 cases (46,7%)). Bi-column fractures were prevalent (46.6%). The analysis of complications included intraoperatively nerve palsy, postoperatively dislocations, deep infections, periprosthetic fractures and loosening. Clinical assessment included the Harris hip score (HHS) and the level of return to previous activities. Radiological evaluation assessed fracture union, periprosthetic osteolysis, graft integration, the presence of leg length discrepancy (LLD) and heterotopic ossification.

Results: There was one case of dislocation (2.2%) requiring reoperation for replacement of the prosthetic neck, and one patient (2.2%) experienced early THA infection, successfully treated with surgical lavage and antibiotics. Functional outcomes showed a mean HHS of 88 (range, 69 to 99) and 84% of patients resumed their previous activities. Radiological follow-up revealed no loosening.

Conclusion: This study has shown that the use of DMC in concomitant THA with Open Reduction and Internal Fixation (ORIF) for acetabular facture in patient over age 60 years achieved a low dislocation rate with favorable clinical and radiological outcomes and a low complication rate.