Maturitas最新文献

{"title":"Comment on the paper “Effect of duration of hormonal contraceptive use on breast cancer risk: a systematic review and meta-analysis of cohort studies”","authors":"Wanzhi Jiang , Qinghong Yu","doi":"10.1016/j.maturitas.2025.108800","DOIUrl":"10.1016/j.maturitas.2025.108800","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108800"},"PeriodicalIF":3.6,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter titled “Comment on the paper Effect of duration of hormonal contraceptive use on breast cancer risk: a systematic review and meta-analysis of cohort studies”","authors":"Carmen Sayon-Orea , Miguel A. Martínez-González","doi":"10.1016/j.maturitas.2025.108801","DOIUrl":"10.1016/j.maturitas.2025.108801","url":null,"abstract":"","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108801"},"PeriodicalIF":3.6,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145663099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative hyperglycemia and postoperative adverse events in geriatric hip fracture surgery: Glycemic thresholds and exposure persistence","authors":"Yazhou Liu ,&nbsp;Ying Yang ,&nbsp;Yuhao Li ,&nbsp;Zhe Yang ,&nbsp;Xiaodong Yang","doi":"10.1016/j.maturitas.2025.108791","DOIUrl":"10.1016/j.maturitas.2025.108791","url":null,"abstract":"<div><h3>Background</h3><div>Preoperative blood glucose levels are closely related to the occurrence of postoperative adverse events for geriatric patients undergoing surgery for hip fracture. However, the specific association between preoperative blood glucose levels and postoperative pressure ulcers (PU), postoperative delirium (POD), and prolonged length of stay (LOS) requires further investigation.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included hip fracture patients from 2017 to 2024. Preoperative blood glucose levels were analyzed both as a continuous variable and as a categorical variable to examine their association with postoperative PU, POD, and LOS. Statistical analyses were conducted using multivariable logistic regression, propensity score matching analysis and generalized linear models.</div></div><div><h3>Results</h3><div>The results showed that for each 1 mmol/L increase in preoperative blood glucose, the risk of developing postoperative pressure ulcers and delirium increased by 21 % and 28 %, respectively, while hospital stay was prolonged by 0.54 days. Notably, in subgroups of male patients, those aged 70–79 years, those with no prior history of hypertension or delirium, those with surgical time ≥ 1.6 h, and those with time from admission to surgery &gt;5 days, the positive correlation between preoperative blood glucose levels and PU and POD was even stronger. When preoperative blood glucose levels exceeded 6.09 mmol/L (for PU and LOS) and 6.17 mmol/L (for POD), timely intervention became crucial.</div></div><div><h3>Conclusions</h3><div>Preoperative hyperglycemia is significantly associated with postoperative PU, POD, and LOS in geriatric patients undergoing surgery for hip fracture. Early intervention, particularly glucose management for specific high-risk groups, may help reduce the incidence of adverse events.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108791"},"PeriodicalIF":3.6,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength in patients with subclinical hypothyroidism or subclinical hyperthyroidism compared with that in euthyroid individuals: A systematic review and meta-analysis","authors":"Ana M. Fernández-Alonso ,&nbsp;Pascual García-Alfaro ,&nbsp;Faustino R. Pérez-López","doi":"10.1016/j.maturitas.2025.108780","DOIUrl":"10.1016/j.maturitas.2025.108780","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis assessed handgrip strength in patients with either subclinical hypothyroidism or subclinical hyperthyroidism as compared with euthyroid individuals.</div></div><div><h3>Methods</h3><div>We searched in Web of Science, Scopus, and PubMed databases for information about cross-sectional studies comparing subclinical hypothyroid or subclinical hyperthyroid patients and euthyroid control individuals. The quality of included studies was evaluated with the Newcastle-Ottawa Scale. Random-effect meta-analyses were conducted to minimize the effects of uncertainty associated with inter-study variability. Results are reported as mean differences, standardized mean differences, or odds ratios with 95 % confidence intervals. Heterogeneity between studies was assessed using I² and τ² statistics.</div></div><div><h3>Results</h3><div>Seven studies with low or moderate risk of bias were eligible for inclusion in the meta-analysis of patients with either subclinical hypothyroidism or hyperthyroidism compared with euthyroid individuals. The meta-analysis of five studies of patients with subclinical hypothyroidism showed they had lower handgrip strength (standardized mean difference: −0.61, 95 % confidence interval −1.15, −0.07; <em>p</em> = 0.03) and lower thyroxine levels (standardized mean difference: −0.52, 95 % confidence interval −0.87, −0.16; <em>p</em> = 0.004) than euthyroid individuals. They also had a higher body mass index (mean difference: 1.05, 95 % confidence interval: 0.17, 1.93, <em>p</em> = 0.02), higher total cholesterol (standardized mean difference 0.28, 95 % confidence interval 0.09, 0.46, <em>p</em> = 0.003) and lower thyroxine levels (standardized mean difference: −0.52, 95 % confidence interval −0.87, −0.16; <em>p</em> = 0.004), and a higher risk of sarcopenia (odds ratio: 2.12, 95 % confidence interval 1.40, 3.22, <em>p</em> = 0.0004) than euthyroid individuals. The meta-analyses of four studies of patients with subclinical hyperthyroidism did not show differences in measured outcomes compared with euthyroid individuals.</div></div><div><h3>Conclusions</h3><div>Patients with subclinical hypothyroidism have lower handgrip strength than euthyroid individuals. There was no significant difference in handgrip strength between patients with subclinical hyperthyroidism and euthyroid individuals.</div><div>PROSPERO registration: CRD420251004586.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108780"},"PeriodicalIF":3.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual assault referral centers for survivors of rape in Finland – A review of their development and support for survivors","authors":"Jenni Krogell ,&nbsp;Katja Kero ,&nbsp;Rauni Klami ,&nbsp;Sari Pelkonen ,&nbsp;Riina Korjamo","doi":"10.1016/j.maturitas.2025.108787","DOIUrl":"10.1016/j.maturitas.2025.108787","url":null,"abstract":"<div><div>In Finland, multidisciplinary sexual assault referral centers (SARCs) primarily serve victims of rape within one month of the incident. The services are offered at no cost and are available to individuals aged 16 and over, irrespective of sex or gender, and regardless of whether they decide to report the assault to the authorities. Services consist of medical and forensic examinations, trauma support and counselling. Follow-up and treatment of sexually transmitted diseases and potential pregnancy are included.</div><div>Specialized services and standardized examination and follow-up protocols have increased the quality of forensic medical examination and samples. Trauma-informed psychosocial support services are available from the outset. Sensitive but active follow-up from the same place have improved the rape survivor's recovery.</div><div>This paper reviews the history of SARCs in Finland and the care they provide to survivors of sexual violence.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108787"},"PeriodicalIF":3.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-national evidence on frailty–depression multi-trajectories and osteoporosis risk: Findings from the ELSA and HRS cohorts","authors":"Shufang Deng ,&nbsp;Rui Xie ,&nbsp;Wei Zhao ,&nbsp;Zhaoheng Chen ,&nbsp;Zeping Chen","doi":"10.1016/j.maturitas.2025.108790","DOIUrl":"10.1016/j.maturitas.2025.108790","url":null,"abstract":"<div><h3>Background</h3><div>Frailty and depression commonly co-occur in older adults and may jointly elevate the risk of osteoporosis. However, evidence on their long-term multi-trajectories and impact on osteoporosis is limited, particularly across different populations.</div></div><div><h3>Methods</h3><div>We analyzed data from 2971 participants aged ≥50 years without osteoporosis at baseline in the English Longitudinal Study of Ageing (ELSA) and 5199 participants from the U.S. Health and Retirement Study (HRS). Group-based multi-trajectories modeling identified frailty–depression trajectories, and incident osteoporosis was ascertained through self-reported physician diagnosis during follow-up. Cox proportional hazards models estimated associations of trajectory groups with osteoporosis risk, adjusting for demographics and lifestyle factors.</div></div><div><h3>Results</h3><div>Over a median follow-up of 10 years in ELSA and 7.9 years in HRS, three consistent frailty–depression trajectories were identified in both cohorts—stable low, increasing moderate, and persistent high—accompanied by 220 (7.4 %) and 867 (16.7 %) incident osteoporosis cases, respectively. Compared with the stable low frailty–low depression group, the risk of osteoporosis was significantly higher for the persistent high frailty–high depression group (ELSA: HR = 2.52, 95 % CI 1.50–4.24; HRS: HR = 2.66, 95 % CI 2.12–3.35) and for the increasing moderate frailty–moderate depression group (ELSA: HR = 1.47, 95 % CI 1.03–2.09; HRS: HR = 1.45, 95 % CI 1.24–1.70).</div></div><div><h3>Conclusion</h3><div>Across both the UK and US cohorts, long-term multi-trajectories of frailty and depression were strongly associated with the incidence of osteoporosis. Individuals with persistent high frailty–high depression had the greatest risk, whereas those with increasing moderate frailty–moderate depression also experienced cumulative risk. Prevention should extend beyond skeletal targets to include early, integrated strategies addressing functional decline and mental health in older adults.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108790"},"PeriodicalIF":3.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of socioeconomic position and depression with frailty among older adults: Cross-sectional evidence from 17 countries","authors":"Yizhong Ye ,&nbsp;Lushaobo Shi ,&nbsp;Zengping Shi ,&nbsp;Qinqin Jiang ,&nbsp;Hongli Yan ,&nbsp;Chunquan Ou ,&nbsp;Chen Mao ,&nbsp;Dong Wang","doi":"10.1016/j.maturitas.2025.108788","DOIUrl":"10.1016/j.maturitas.2025.108788","url":null,"abstract":"<div><h3>Objectives</h3><div>This study describes the cross-national variation in socioeconomic disparities in frailty among older adults, assesses whether depression mediates the relationship between socioeconomic position and frailty, and examines the extent of the interactive or joint effects of depression and socioeconomic position on frailty.</div></div><div><h3>Study design</h3><div>A cross-sectional analysis was conducted using population-based data from five aging cohorts across 17 countries. Frailty was assessed using the modified Fried Frailty Phenotype scale, which comprises five domains. Educational level and total household income were used to measure socioeconomic position. Multivariable logistic regression was used to calculate the odds ratios and 95 % confidence intervals for the associations, and pooled odds ratios were estimated using a random-effect meta-analysis. Mediation and interaction analyses explored the association between socioeconomic position, depression, and frailty.</div></div><div><h3>Results</h3><div>Among the 104,136 adults (mean age 64.29 years), 27,115 were frail. The prevalence of frailty varied widely across countries (Switzerland, 6.00 %; India, 46.51 %). Participants occupying a low socioeconomic position had a significantly higher risk of frailty than those in higher socioeconomic positions, with the association more pronounced in high-income countries. Depression mediated 30.9 % of the association between socioeconomic position and frailty. A significant additive interaction of low socioeconomic position and depression on frailty (1.98) was observed. Individuals occupying a low socioeconomic position who had depression had a markedly higher risk of frailty than those in a high socioeconomic position and no depression.</div></div><div><h3>Conclusions</h3><div>Socioeconomic disparities in frailty vary across countries. The combined effects of socioeconomic position and depression highlight the need for integrated interventions to reduce frailty and promote healthy, equitable aging globally.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108788"},"PeriodicalIF":3.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fezolinetant compared with elinzanetant for the treatment of vasomotor symptoms associated with menopause: A matching-adjusted indirect comparison","authors":"Petra Stute ,&nbsp;Marla Shapiro C.M. ,&nbsp;Antonia Morga ,&nbsp;Ting-an Tai ,&nbsp;Mayank Ajmera ,&nbsp;Bogdan Muresan ,&nbsp;Karla Martins ,&nbsp;Yechu Hua ,&nbsp;Angela Zhao ,&nbsp;Jingyi Liu ,&nbsp;Rossella E. Nappi","doi":"10.1016/j.maturitas.2025.108782","DOIUrl":"10.1016/j.maturitas.2025.108782","url":null,"abstract":"<div><h3>Objectives</h3><div>Vasomotor symptoms (VMS) are a burden for women in menopause. Despite the availability of hormone therapy (HT), many cannot or do not wish to utilise it. The efficacy of the neurokinin receptor antagonists fezolinetant and elinzanetant has been established in clinical trials. Matching-adjusted indirect comparison (MAIC), which controls for the differences in treatment effect modifiers between trials and provides robust estimates of relative treatment effects, was used here to compare the efficacy of fezolinetant and elinzanetant in individuals with VMS associated with menopause.</div></div><div><h3>Study design</h3><div>Patient-level data from the fezolinetant SKYLIGHT-1/2 trials were used to match the population and study design of elinzanetant OASIS-1/2 trials. Treatment effect modifiers were identified and MAIC analyses were performed.</div></div><div><h3>Main outcome measures</h3><div>VMS frequency and severity, Patient-Reported Outcomes Measurement Information System Sleep Disturbance – Short Form 8b (PROMIS SD SF 8b), Menopause Specific Quality of Life Questionnaire (MENQOL).</div></div><div><h3>Results</h3><div>The OASIS-1/2 trial populations had higher mean VMS frequency/severity and greater sleep disturbance at baseline. Fezolinetant and elinzanetant had comparable efficacy in reducing VMS frequency and severity. Sleep disturbance improved with both drugs but more with elinzanetant. Improvement in sleep disturbance did not translate into a significant difference in overall QoL, as measured by MENQOL.</div></div><div><h3>Conclusions</h3><div>MAIC analysis found that fezolinetant and elinzanetant had a similar efficacy profile for reduction of VMS frequency and severity. Differences in reduction of sleep disturbances did not result in differences in QoL. Neurokinin receptor antagonists provide an alternative to HT and other non-HT options for the treatment of VMS associated with menopause.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"205 ","pages":"Article 108782"},"PeriodicalIF":3.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in the relationship between dynapenic abdominal obesity and the risk of motoric cognitive risk syndrome in older Chinese adults: A national prospective cohort study","authors":"Qing Li ,&nbsp;Chengxiang Song ,&nbsp;Hao Zhou ,&nbsp;Junli Li ,&nbsp;Mao Chen","doi":"10.1016/j.maturitas.2025.108786","DOIUrl":"10.1016/j.maturitas.2025.108786","url":null,"abstract":"<div><h3>Objectives</h3><div>Dynapenic abdominal obesity is associated with adverse health outcomes in older adults. However, the longitudinal relationship between dynapenic abdominal obesity and motoric cognitive risk syndrome, a pre-dementia condition, remains unclear. We aimed to elucidate this association in older males and females.</div></div><div><h3>Methods</h3><div>A total of 3309 individuals from the 2011 and 2015 waves of the China Health and Retirement Longitudinal Study were enrolled. Individuals were categorized into 4 groups based on sex-specific thresholds for handgrip strength (&lt; 28 kg for males and &lt; 18 kg for females) and waist circumference (≥ 90 cm for males and ≥ 85 cm for females): non-dynapenic/non-abdominal obesity, non-dynapenic/abdominal obesity, dynapenic/non-abdominal obesity and dynapenic/abdominal obesity. Multivariable logistic regression analysis was performed to investigate the relationship between dynapenic abdominal obesity and motoric cognitive risk syndrome risk.</div></div><div><h3>Results</h3><div>Over a 4-year follow-up, 410 (12.4 %) individuals experienced motoric cognitive risk syndrome. Individuals in the dynapenic/abdominal obesity group exhibited a markedly elevated risk of motoric cognitive risk syndrome as compared with those in the non-dynapenic/non-abdominal obesity group (odds ratio = 2.56, 95 % confidence interval 1.74–3.78, <em>P</em> &lt; 0.001). This association was pronounced among males but not females. Further analyses revealed that the association was primarily driven by dynapenia, whereas abdominal obesity made only a modest contribution in males and showed no effect in females.</div></div><div><h3>Conclusions</h3><div>Dynapenic abdominal obesity was significantly associated with an increased risk of developing motoric cognitive risk syndrome, especially among older males.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108786"},"PeriodicalIF":3.6,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between anti-Müllerian hormone, hypertension and vascular age: the Generation R Study, a population-based prospective cohort study","authors":"R.H.M. Dykgraaf ,&nbsp;S. Schalekamp-Timmermans ,&nbsp;S.A.A. van den Berg ,&nbsp;E.J. Vinke ,&nbsp;E.A.P. Steegers ,&nbsp;J.S.E. Laven ,&nbsp;Y.V. Louwers","doi":"10.1016/j.maturitas.2025.108785","DOIUrl":"10.1016/j.maturitas.2025.108785","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to explore the relationship between levels of anti-Müllerian hormone (AMH) and the risk of hypertension and vascular ageing in a population-based cohort.</div></div><div><h3>Study design</h3><div>This study was embedded in the Generation R Study, a prospective population-based cohort study of children and their parents in the City of Rotterdam, the Netherlands. The present study included all women at the first recall visit with available data on AMH and blood pressure (<em>n</em> = 4883) and analysed the association between AMH and hypertension. AMH levels (first recall visit) and carotid artery intima-medial thickness (CIMT) measurements (second recall visit) were used to analyse the association between AMH serum levels and CIMT as a proxy for vascular age (<em>n</em> = 3508).</div></div><div><h3>Results</h3><div>A higher age and lower AMH percentiles (adjusted for age) were associated with an increased risk of hypertension. Women with AMH percentiles &lt;p10 had a 2.1 times higher risk of hypertension than women with AMH levels &gt;p90 (<em>P</em> &lt; .001). Vascular age, conducted from CIMT measurements (second recall visit), was on average 9.8 years older than chronological age in those with an AMH below p10 (first recall visit). This difference was 6.1 years in those with an AMH exceeding p90. Similarly, differences in medians between the groups were significant (<em>p</em> &lt; 0,008).</div></div><div><h3>Conclusions</h3><div>This large prospective cohort study shows that low AMH levels later in life, independent of age, are associated with hypertension. The results indicate that diminished ovarian reserve at a younger age is associated with indicators of vascular alterations. Women with low AMH levels should not only be counseled about potential fertility issues, but should also be informed about their increased risk of vascular damage in order to take appropriate preventive measures. In the future, AMH may serve as a prospective marker for the early detection of cardiovascular diseases.</div></div>","PeriodicalId":51120,"journal":{"name":"Maturitas","volume":"204 ","pages":"Article 108785"},"PeriodicalIF":3.6,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}