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Psychological aspects of infertility. 不孕症的心理问题。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2029
Tewes Wischmann

The unfulfilled desire for children is a significant problem worldwide. The psychological effects of this development are usually underestimated, while the myth of "psychogenic infertility" stubbornly persists. This article first provides an overview of the basic facts on the subject before highlighting the psychological effects of both the diagnosis of infertility and the therapeutic options. Psychological aspects of "third-party" reproduction and further developments after childbirth or without a child are discussed, followed by a brief outline of the general and specific subject matter addressed in infertility counselling. The article concludes with reflections on the possible psychological consequences of further medical developments in this area.

求子心切却得不到满足是全世界的一个重大问题。这种发展所造成的心理影响通常被低估，而 "心理性不孕 "的神话却顽固地存在着。本文首先概述了这一问题的基本事实，然后重点介绍了不孕症诊断和治疗方案的心理影响。文章还讨论了 "第三者 "生育的心理问题，以及生育后或无子女情况下的进一步发展，随后简要概述了不孕症咨询中涉及的一般和特殊主题。文章最后对这一领域的进一步医学发展可能带来的心理后果进行了思考。
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引用次数: 0
GfH-Promotionspreise 2024. GfH 2024 年博士奖。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2031
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引用次数: 0
"Wir gründeten die Zeitschrift medizinischegenetik, weil die Humangenetiker ein Forum für ihr Fach brauchten": Der Initiator Prof. Dr. med. Jan Murken über die Herausforderungen und Notwendigkeiten, in den ausgehenden 80er Jahren eine deutschsprachige Zeitschrift zu gründen - ein Interview anlässlich seines 90. Geburtstags. "我们创办《医学遗传学》杂志是因为人类遗传学家需要一个学科论坛"：发起人 Jan Murken 教授谈 20 世纪 80 年代末创办德语期刊的挑战和必要性--在他 90 岁生日之际接受采访。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2033
Christine Scholz
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引用次数: 0
37. Tumorgenetische Arbeitstagung: 8.–10. Mai 2025, Leipzig. 第 37 届肿瘤遗传学研讨会：2025 年 5 月 8-10 日，莱比锡。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2030
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引用次数: 0
Reproductive genetics and health. 生殖遗传学与健康
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2036
Margot J Wyrwoll, Johanna Steingröver

For those affected, infertility is linked to impaired overall health and reduced life expectancy. In particular, infertile individuals bear an increased risk for cardiovascular disease (CVD) and different types of cancer, partially due to lifestyle differences and to genetic alterations that cause both infertility and an increased cancer risk. Genetic variants causing an increased CVD risk are more commonly found in infertile individuals, but their link to infertility remains unclear. Offspring of infertile couples, conceived via medically assisted reproduction, are as likely as their parents to exhibit or develop adiposity, hormonal alterations such as insulin resistance, and infertility. The effects on health of subsequent generations are completely unclear.

对于受影响的人来说，不孕症与整体健康受损和预期寿命缩短有关。特别是，不孕不育者罹患心血管疾病（CVD）和不同类型癌症的风险会增加，部分原因是生活方式的差异以及导致不孕不育和癌症风险增加的基因变异。导致心血管疾病风险增加的基因变异在不育症患者中更为常见，但它们与不育症的关系仍不清楚。通过医学辅助生殖技术受孕的不育夫妇的后代和他们的父母一样，都有可能出现或发展为肥胖、荷尔蒙改变（如胰岛素抵抗）和不育症。对后代健康的影响还完全不清楚。
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引用次数: 0
Genetics of female and male infertility. 女性和男性不孕症的遗传学。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2040
Corinna Friedrich, Frank Tüttelmann

Infertility is defined as the inability to conceive within one year of unprotected intercourse, and the causes are equally distributed between both sexes. Genetics play a crucial role in couple infertility and respective diagnostic testing should follow available guidelines. Appropriate tiered genetic analyses require comprehensive physical examination of both partners in an infertile couple. A wide range of chromosomal and monogenic variants can be the underlying genetic cause of infertility in both women and men. Accurate clinical phenotyping, together with identification of the genetic origin, helps to recommend the proper treatment and to counsel couples on the success rates and potential risks for offspring.

不孕症的定义是在无保护措施的性交后一年内无法受孕，男女双方的不孕原因各占一半。遗传在夫妇不孕症中起着至关重要的作用，相应的诊断测试应遵循现有指南。要进行适当的分层遗传分析，需要对不孕夫妇双方进行全面的身体检查。各种染色体变异和单基因变异都可能是导致男女不孕不育的潜在遗传原因。准确的临床表型分析以及基因来源的鉴定有助于推荐适当的治疗方法，并就成功率和对后代的潜在风险为夫妇提供咨询。
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引用次数: 0
Verleihung der GfH-Ehrenmitgliedschaft 2024 an Prof. Dr. med. Klaus Zerres. 授予 Klaus Zerres 博士教授 2024 年 GfH 荣誉会员资格。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2034
Sabine Rudnik-Schöneborn
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引用次数: 0
Institut für Humangenetik der Medizinischen Universität Innsbruck feiert seine 60-jährige Geschichte und gibt Ausblicke in die Zukunft der Genomischen Medizin. 因斯布鲁克医科大学人类遗传学研究所庆祝其成立 60 周年，并展望基因组医学的未来。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2038
Beatrix Mühlegger, Johannes Zschocke
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引用次数: 0
Verleihung der GfH-Ehrenmedaille 2024 an Dr. rer. nat. Holger Prokisch. 向 Holger Prokisch 博士颁发 2024 年 GfH 荣誉奖章。
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2035
André Reis
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引用次数: 0
Heidelberg: PD Dr. rer. nat. Sandra Hoffmann - Leiterin der Forschungsgruppe Kardiogenetik. Heidelberg: PD Dr rer. nat. Sandra Hoffmann - Head of the Cardiogenetics Research Group.
IF 1.1 4区 生物学
Medizinische Genetik
Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI: 10.1515/medgen-2024-2041
Sandra Hoffmann
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引用次数: 0
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