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Neoadjuvant chemotherapy versus upfront surgery for resectable colorectal liver metastases: A systemic review and meta-analysis 新辅助化疗与先期手术治疗可切除的结直肠肝转移瘤:系统回顾和荟萃分析
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-10-12 DOI: 10.1111/1744-1633.12662
Pipit Burasakarn MD, PhD, Sermsak Hongjinda MD, Pusit Fuengfoo MD, Anuparp Thienhiran MD

Aim

To compare the differences between neoadjuvant chemotherapy with resection and upfront surgery for patients with resectable colorectal cancer with liver metastases.

Patients and Methods

The following electronic databases were searched for systematic literature: PubMed, Cochrane Library and Google Scholar. Studies fulfilling the following criteria were included in the analysis: compared neoadjuvant chemotherapy and upfront surgery; included patients with resectable metastases at the time of presentation; reported the long-term results, including overall survival (OS) and disease-free survival (DFS); and identified early adverse postoperative events, including 30-day mortality and overall postoperative complications.

Results

Over 24 studies with 8700 patients were analysed. Patients were divided into the neoadjuvant chemotherapy group (n = 3490, 40.1%) and the upfront surgery group (n = 5172, 59.4%). The meta-analysis showed no statistically significant difference in terms of overall morbidities [odds ratio (OR) 1.19, 95% confidence interval (CI) 0.84-1.67] and mortality (OR 1.48, 95% CI 0.75-2.92) between the neoadjuvant chemotherapy and upfront surgery groups. However, the meta-analysis showed a favourable OS in the upfront surgery group (OR 1.21, 95% CI 1.06-1.38) and favourable DFS in the upfront surgery group (OR 1.71, 95% CI 1.38-2.12), including the subgroups of 1-, 3-, 5-year DFS (OR 1.38, 95% CI 1.06-1.8; OR 2.06, 95% CI 1.35-3.14 and OR 1.65, 95% CI 1.18-2.29, respectively).

Conclusion

Neoadjuvant chemotherapy has no benefit for resectable colorectal cancer with liver metastases; therefore, upfront surgery should be considered as the treatment of choice.

目的 比较对可切除并伴有肝转移的结直肠癌患者进行新辅助化疗和切除术与先期手术的差异。 患者和方法 在以下电子数据库中搜索系统性文献:PubMed、Cochrane Library 和 Google Scholar。符合以下标准的研究均纳入分析:比较了新辅助化疗和前期手术;纳入了发病时有可切除转移灶的患者;报告了长期结果,包括总生存期(OS)和无病生存期(DFS);确定了术后早期不良事件,包括 30 天死亡率和术后总并发症。 结果 对超过 24 项研究的 8700 名患者进行了分析。患者分为新辅助化疗组(3490 人,40.1%)和前期手术组(5172 人,59.4%)。荟萃分析表明,新辅助化疗组和前期手术组在总发病率[几率比(OR)1.19,95% 置信区间(CI)0.84-1.67]和死亡率(OR 1.48,95% CI 0.75-2.92)方面没有明显的统计学差异。然而,荟萃分析显示,前期手术组的OS(OR 1.21,95% CI 1.06-1.38)和DFS(OR 1.71,95% CI 1.38-2.12)均优于新辅助化疗组,包括1年、3年和5年DFS亚组(分别为OR 1.38,95% CI 1.06-1.8;OR 2.06,95% CI 1.35-3.14和OR 1.65,95% CI 1.18-2.29)。 结论 新辅助化疗对肝转移的可切除结直肠癌没有益处,因此应将前期手术作为首选治疗方法。
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引用次数: 0
Infrahyoid flap—a good substitute for free flaps in oral reconstruction during the COVID-19 pandemic 舌骨下皮瓣-在COVID - 19大流行期间用于口腔重建的游离皮瓣的良好替代品
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-09-19 DOI: 10.1111/1744-1633.12660
Tam-Lin Chow FRCS (Edin), FHKAM (Surgery), Siu-Chung Fung FCDSHK (OMS), FHKAM (Dental Surgery), Calvin K. P. Tsui FRCS (Edin), FHKAM (Surgery), Jeren Jin Mun Lim FRCS (Edin), FHKAM (Surgery)

Aim

During the coronavirus disease 2019 (COVID-19) pandemic, experts have recommended simplifying the process of reconstruction following the extirpation of head and neck cancer by favouring the use of pedicled flaps over free flaps. This approach reduces the duration of the operation and mitigates the risk of free flap failure, which can be exacerbated by the hypercoagulopathy state seen in infected patients. We aim to contribute our experience with the pedicled infrahyoid flap, a procedure not previously reported in Hong Kong.

Patients and Methods

We conducted a retrospective study including patients who underwent infrahyoid flap reconstruction following resection of oral cavity cancer. Data for a total of nine patients were retrospectively retrieved from the hospital's computerised systems, and these patients were evaluated for demographic information, clinicopathologic parameters as well as oral function and reconstruction outcomes.

Results

Among the nine infrahyoid flaps used, eight were myocutaneous flaps and one was a muscle flap. The dimensions of the flap skin ranged from 24.0 to 46.72 cm2. All of the flaps, with the exception of one case that experienced epidermolysis of the flap skin, exhibited complete survival. Fortunately, the epidermolysis healed without complications, such as the development of an orocutaneous fistula. The average time required for flap harvesting was approximately 1 hour. All nine patients were able to resume oral feeding and achieved satisfactory speech outcomes. Seven of these patients survived without any tumour recurrence, but unfortunately, two patients died due to lung metastases.

Conclusions

The infrahyoid flap proves to be a viable alternative to free flaps for the repair of medium-sized oral defects, especially in compromised patients and during the COVID-19 pandemic.

目的在2019冠状病毒病(COVID - 19)大流行期间,专家们建议通过使用带蒂皮瓣而不是自由皮瓣来简化头颈癌切除后的重建过程。这种方法缩短了手术时间,降低了游离皮瓣失败的风险,而感染患者的高凝血状态可能会加剧游离皮瓣失败的风险。我们的目标是贡献我们的经验带蒂舌骨下皮瓣,一个程序以前没有报道在香港。我们对口腔癌切除术后行舌骨下瓣重建术的患者进行了回顾性研究。从医院的计算机系统中回顾性检索了总共9例患者的数据,并对这些患者的人口统计信息、临床病理参数、口腔功能和重建结果进行了评估。结果9个舌骨下瓣中8个为肌皮瓣,1个为肌瓣。皮瓣皮肤尺寸为24.0 ~ 46.72 cm 2。除一例皮瓣皮肤表皮松解外,所有皮瓣均完全存活。幸运的是,表皮松解愈合无并发症,如口皮瘘的发展。皮瓣收获的平均时间约为1小时。9例患者均能恢复口腔喂养并取得满意的言语效果。其中7名患者存活下来,没有任何肿瘤复发,但不幸的是,2名患者因肺转移而死亡。结论舌骨下瓣是修复中等大小口腔缺损的可行选择,特别是在受损患者和COVID - 19大流行期间。
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引用次数: 0
The enhanced recovery after surgery program in elderly patients over 75 years of age undergoing elective colorectal cancer surgery 75岁以上择期结直肠癌手术的老年患者术后增强恢复(ERAS)项目
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-09-19 DOI: 10.1111/1744-1633.12661
Dorothy Sze Wing Hung, Colin Wai Ho Chu, Kam Hung Kwok

Aim

The enhanced recovery after surgery (ERAS) program has been well established for patients undergoing colorectal surgery. However, there has been a lack of studies on its use for elderly patients. Our unit implemented the ERAS program in September 2018. The aim of this study is to evaluate the outcome of the ERAS program in patients over 75 years who are undergoing colorectal surgery.

Patients and Methods

In this retrospective study, we compared all patients aged 75 and above who were admitted to Queen Elizabeth Hospital for elective colorectal cancer surgery before the implementation of the ERAS program (1 January 2016 to 31 August 2018) with those treated after its implementation (1 April 2019 to March 2022). The primary end point was the post-operative length of stay. The secondary end points were wound infection, retention of urine, pneumonia, deep vein thrombosis, pulmonary embolism, use of total parenteral nutrition, acute coronary syndrome, blood transfusion, reoperation, in-hospital mortality, unplanned readmission within 28 days and Clinical Fragility Score.

Results

A total of 258 patients were included. The median length of stay was 8.4 days in the pre-ERAS group vs 6.8 days in the ERAS group. In-patient death (1.4% in the pre-ERAS group vs 0.9% in the ERAS group) and readmission rate (7.7% in the pre-ERAS group vs 12.2% in the ERAS group) were similar between the two groups. About 31.5% of patients in the pre-ERAS group had higher Clinical Fragility Scale post-operatively as compared with 7.8% in the ERAS group.

Conclusion

The ERAS program shortened the length of hospital stay by 1.6 days, and patients had lower Clinical Fragility Scale post-operatively. Adverse events were not increased. The ERAS program can be safely applied to elderly patients with colorectal cancer.

【摘要】目的结肠直肠手术后增强恢复(ERAS)方案已经建立。然而,关于其在老年患者中的应用的研究一直缺乏。我们单位于2018年9月实施了ERAS计划。本研究的目的是评估ERAS项目在75岁以上接受结直肠手术的患者中的效果。患者和方法在这项回顾性研究中,我们比较了在ERAS计划实施前(2016年1月1日至2018年8月31日)和实施后(2019年4月1日至2022年3月)在伊丽莎白女王医院接受选择性结直肠癌手术的所有75岁及以上患者。主要终点为术后住院时间。次要终点为伤口感染、尿潴留、肺炎、深静脉血栓形成、肺栓塞、全肠外营养的使用、急性冠状动脉综合征、输血、再手术、院内死亡率、28天内意外再入院和临床脆弱性评分。结果共纳入258例患者。ERAS前组的中位住院时间为8.4天,ERAS组为6.8天。两组患者的死亡率(ERAS前组为1.4%,ERAS组为0.9%)和再入院率(ERAS前组为7.7%,ERAS组为12.2%)相似。ERAS前组约31.5%的患者术后临床脆性评分较高,而ERAS组为7.8%。结论ERAS方案使患者住院时间缩短1.6 d,患者术后临床脆弱性评分较低。不良事件没有增加。ERAS项目可以安全地应用于老年结直肠癌患者。
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引用次数: 0
Acute appendicitis during the fifth wave of the COVID-19 pandemic in a local cluster: A retrospective cohort study COVID - 19第五波大流行期间的急性阑尾炎:一项回顾性队列研究
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-27 DOI: 10.1111/1744-1633.12651
M. P. Luk, T. W. Hung, L. M. Yu, M. Y. Kan, C. H. Lau

Introduction

Acute appendicitis is a common surgical emergency. This study aims to determine whether there are any delays in patients attending the emergency department, potentially leading to an increase in the rates of complicated appendicitis and post-operative complications during the fifth wave of the coronavirus disease 2019 (COVID-19) pandemic in a local cluster in Hong Kong.

Methods

In this retrospective cohort study, we analysed 138 patients diagnosed with acute appendicitis during the fifth wave of the COVID-19 pandemic and pre-COVID-19 period. The main study parameters were the duration between the onset of symptoms and attendance to the accident and emergency department, severity of appendicitis, post-operative complication(s), operation time and total hospital length of stay.

Results

There was no delay in presentation between the two groups of patients. The rates of complicated appendicitis and post-operative complications were comparable between the two groups. There was a significantly shorter length of stay for patients with acute appendicitis patients during the fifth wave of the pandemic.

Conclusion

The perspective of the general public towards the COVID-19 pandemic is changing. Increased understanding of the COVID-19 infection and availability of antiviral medications against COVID-19 could be useful to eliminate patient's anxiety when attending medical care in public hospitals.

急性阑尾炎是一种常见的外科急症。我们的目的是确定在香港本地聚集的第5波COVID - 19期间,患者是否有延误到急诊科就诊,从而增加复杂阑尾炎和术后并发症的发生率。在这项回顾性队列研究中,我们分析了138例在COVID - 19第五波和前COVID期间诊断为急性阑尾炎的患者。主要研究参数包括从症状出现到到急诊科(AED)的时间、阑尾炎的严重程度、任何术后并发症、手术时间和总住院时间。两组患者的表现没有延迟。两组的阑尾炎并发症及术后并发症发生率相当。急性阑尾炎患者的住院时间明显缩短。公众对COVID - 19大流行的看法正在发生变化。更多地了解COVID - 19感染和针对COVID - 19的抗病毒药物的可用性,可能有助于消除患者在公立医院接受医疗服务时的焦虑。这篇文章受版权保护。版权所有。
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引用次数: 0
Generative artificial intelligence and surgeons 生成型人工智能与外科医生
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-26 DOI: 10.1111/1744-1633.12648
Paul B. S. Lai
ChatGPT (Chat Generative Pre-trained Transformer) is regarded as the prime mover of the digital revolution. The first version called GPT-1 was released in 2018 and in just a couple of years, the more recent versions have shown the platform to be exponentially powerful. Outside the medical world, the use of generative artificial intelligence (AI) tools is increasingly common in marketing and sales, product and service development, and service operations. AI is also increasingly used in medicine and the application of AI in actual clinical services such as the interpretation of plain chest X-rays or certain pathology settings has opened up new possibilities as well as controversies within the medical profession. Some individuals who have tried ChatGPT consider it to be a slightly more advanced version of a ‘chatbot’, and they have noticed instances where it provides incorrect information or answers. However, a recent cross-sectional study has shown that a chatbot can generate better quality and more empathetic responses to patient questions than real physicians answering questions in an online forum. This editorial is not going to discuss the technical aspects of using ChatGPT or how to write ‘prompts’ that would enhance the ability of ChatGPT to generate something more desirable. Rather, I would like to raise a few possibilities where generative AI could help with surgical training.
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引用次数: 1
Surgical Practice May 2023 CME for Fellows 外科实践2023年5月研究员CME
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-26 DOI: 10.1111/1744-1633.12644
Questions True False 1. Clinical presentation for pulmonary embolism includes: A. Desaturation ☑ ☐ B. Hypertension ☐ ☑ C. Bradycardia ☐ ☑ D. Chest pain ☑ ☐ E. Haemoptysis ☑ ☐ 2. Risk factors for post-operative pulmonary embolism includes: A. Young age ☐ ☑ B. Malignancy ☑ ☐ C. Post-operative infection ☑ ☐ D. Diabetics ☐ ☑ E. Smoking ☐ ☑ 3. Concerning post-operative pulmonary embolism: A. It has a low mortality rate. ☐ ☑ B. It is a relatively uncommon post-operative complication. ☑ ☐ C. The diagnosis of post-operative pulmonary embolism might be underestimated. ☑ ☐ D. Patients with post-operative pulmonary embolism might be asymptomatic. ☑ ☐ E. Over-treating pulmonary embolism in asymptomatic patients might lead to adverse health consequences including increasing bleeding risk after anticoagulation ☑ ☐
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引用次数: 0
The Best Original Paper Award 最佳原创论文奖
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-26 DOI: 10.1111/1744-1633.12645
Dr Lysander Hin CHAU (Co-authors: Dr Tsui-lin NG, Dr Chi-fai KAN, Dr Chi-hang YEE, Dr Lok-hei LEUNG, Dr Kwok-leung HO, Dr Hing-shing SO, Dr Sau-kwan CHU) from Department of surgery, Urology Division, Tuen Mun Hospital, Tuen Mun, Hong Kong, for their work titled “Radical prostatectomy for prostate cancer: Hong Kong status in the era of Surgical Outcomes Monitoring and Improvement Programme”. The manuscript was published in Volume 26, Issue 2, May 2022, Pages 108–114.
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引用次数: 0
Surgical Practice August 2023 CME for Fellows 外科实践2023年8月研究员CME
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-26 DOI: 10.1111/1744-1633.12647
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引用次数: 0
Robotic distal splenopancreatectomy 机器人远端脾胰腺切除术
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-14 DOI: 10.1111/1744-1633.12650
Andrea González De Godos, Pablo Marcos Santos, Pilar Pinto Fuentes, David Pacheco Sánchez

Aim

The use of minimally invasive approaches for pancreaticobiliary surgery has recently gained wider acceptance. Surgical arms with unparalleled flexibility, manual dexterity, 3D imaging and tremor elimination have increased anatomical access and decreased the difficulty of surgery. We describe a case of mucinous cystadenoma treated with robotic distal splenopancreatectomy.

Patients and Methods

A 72-year-old woman presented with anorexia, nausea, constipation and weight loss of 9 kg in 3 months. Imaging and histological studies indicated it likely to be a mucinous cystadenoma of the body–tail of the pancreas. Robotic distal splenopancreatectomy was performed with intraoperative identification and splenic artery ligation.

Results

The patient made an uneventful recovery and was discharged on postoperative day 7. A pathology study confirmed mucinous cystadenoma with focal low-grade epithelial dysplasia and clear margins.

Conclusion

Robotic distal pancreatectomy is a safe and feasible approach in appropriately selected patients. Although the procedural cost is higher with the robotic approach, some argue that this is balanced by the shorter overall length of stay, thus making robotic distal pancreatectomy a cost-effective option.

使用微创入路胰胆道手术最近得到了广泛的接受。手术臂具有无与伦比的灵活性、手工灵巧性、3D成像和震颤消除,增加了解剖通路,降低了手术难度。我们描述了一位72岁的女性,在三个月内出现厌食、恶心、便秘和体重减轻9公斤。影像学和组织学研究表明它可能是胰腺体尾的粘液囊腺瘤。机器人远端脾胰腺切除术在术中识别和脾动脉结扎。患者顺利康复,术后第7天出院。病理证实黏液性囊腺瘤伴局灶性低级别上皮异常增生,边缘清晰。机器人远端胰腺切除术(RDP)在适当选择的患者中是安全可行的。虽然机器人方法的程序成本较高,但一些人认为,这与较短的总停留时间相平衡,使RDP成为一种经济有效的选择。这篇文章受版权保护。版权所有。
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引用次数: 0
A short report regarding an economic and anatomy-based simulated skin model 关于基于经济和解剖学的模拟皮肤模型的简短报告
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2023-08-09 DOI: 10.1111/1744-1633.12649
Billy Ho Hung Cheung, Valerie Wai Yee Ho, Kent-Man Chu

Background

Conventionally, the Objective Structured Clinical Examination (OSCE) requires the recruitment of patients with appropriate physical signs, which became impossible during the fifth wave of the local COVID-19 pandemic. To host the final OSCE without any actual patients, our department developed a skin model from readily available materials.

Setting

One of the final-year surgical OSCE stations focused on the identification and management of benign subcutaneous lesions, including sebaceous cysts (also called epidermal inclusion cysts) and lipomas.

The design

The model starts with a low-cost skin model from Limbs & Things (cost: US $6.9–10/piece). The sebaceous cyst model involved dissection of the superficial ‘skin’ flap. The lesion was re-created using gel held by a plastic wall created by a glove fingertip sealed off by silk sutures. Additional modifications were made to the lipoma model to differentiate these two types of lesions. The pass rate in this station was similar to that of actual patients. Assessment of the models by experienced surgeons showed that they were easy to differentiate and suitable for teaching and assessment.

Conclusion

This anatomy-based, low-cost skin model is easily reproducible and might serve as a good adjunct for clinical year teaching and assessment.

传统上,客观结构化临床检查(OSCE)要求招募有适当体征的患者,这在当地第五波COVID-19大流行期间成为不可能。为了在没有任何实际病人的情况下主持最后的欧安组织,我们部门用现成的材料开发了一个皮肤模型。欧安组织最后一年的一个外科工作站专注于识别和管理良性皮下病变,包括皮脂腺囊肿(也称为表皮包皮囊肿)和脂肪瘤。该模型从四肢&物品(成本:US $ 6.9-10 /件)。皮脂腺囊肿模型涉及浅层“皮肤”皮瓣的剥离。病变部位是用用丝线缝合的手套指尖形成的塑料墙固定凝胶重建的。为了区分这两种类型的病变,我们对脂肪瘤模型进行了额外的修改。该站的通过率与实际患者的通过率相近。经验丰富的外科医生对模型的评估表明,模型易于区分,适合教学和评估。结论该皮肤模型具有可重复性好、成本低的特点,可作为临床年度教学和评估的辅助手段。
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引用次数: 0
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Surgical Practice
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