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The cat-scratch procedure: A new technique for surgical management of primary spontaneous pneumothorax 猫抓法:一种治疗原发性自发性气胸的新技术
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-09-12 DOI: 10.1111/1744-1633.12719
Davor Stamenovic

Introduction

Surgery is an option as the primary treatment for patients with primary spontaneous pneumothorax. Talc pleurodesis and subtotal parietal pleurectomy have demonstrated virtually equal effectiveness in reducing recurrence but result in significant scarring, hindering further chest access if necessary. This paper introduces a new, less invasive technique for the surgical management of primary spontaneous pneumothorax.

Methods

The procedure can easily be conducted via a uniportal thoracoscopic approach. Following the standard identification of the air leak and subsequent bullectomy, short intermittent incisions are made in the parietal pleura, each following the course of the first, second, and third ribs, respectively. Subsequently, a paravertebral block catheter and a pleural drain are inserted, completing the procedure.

Results

Five patients underwent surgery using this approach. All five were discharged without any post-operative complications and showed no signs of recurrence within 2 weeks following surgery.

Conclusion

This paper presents a new, less invasive, and less extensive form of pleurectomy for primary spontaneous pneumothorax. The primary advantage of this technique is its ability to maintain chest accessibility, especially considering that some patients with pneumothorax may require further lung surgery in the future. In addition, the procedural time is shorter, and it is expected to have a smaller negative impact on respiratory mechanics.

手术是原发性自发性气胸患者的主要治疗方法之一。滑石粉胸膜切除术和胸膜次全切除术在减少复发方面的效果几乎相同,但会导致明显的疤痕,在必要时阻碍进一步的胸部手术。本文介绍一种新的微创手术治疗原发性自发性气胸的方法。方法经单门静脉胸腔镜入路即可完成手术。在标准的漏气诊断和随后的大疱切除术后,在胸膜壁层上切开短的间歇切口,每个切口分别沿着第一、第二和第三根肋骨的轨迹切开。随后,插入椎旁阻滞导管和胸腔引流管,完成手术。结果5例患者采用该入路行手术。5例患者均无术后并发症出院,术后2周内无复发迹象。结论本文提出了一种新的、创伤小、范围小的胸膜切除术治疗原发性自发性气胸。这项技术的主要优点是它能够保持胸部的可及性,特别是考虑到一些气胸患者可能需要进一步的肺部手术。此外,程序时间较短,预计对呼吸力学的负面影响较小。
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引用次数: 0
Macrophage M2 polarisation empowered reduction of abdominal adhesions via recombinant human type III collagen 巨噬细胞M2极化可通过重组人III型胶原减少腹部粘连
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-08-28 DOI: 10.1111/1744-1633.12714
Xin Lu, Yin-Jia Ding, Yang Wang, Xu-Dong Hong, Yang-Hong-Hong Fei, Ting-Ting Si, Jin-Fang Wu, Yue Zhou, Ai-Fen Chen, Xu-Dong Zhang, Jian Jin

Aim

This study aims to investigate the role of recombinant human type III collagen (RHC3) in preventing abdominal adhesion.

Patients and Methods

The amino acid sequence was analysed to determine the content of GPP fragments. RHC3 was co-cultured with macrophages, and the phenotypic classification of macrophages was based on immunofluorescence detection of inducible nitric oxide synthase for M1 macrophages and arginase 1 for M2 macrophages. This approach was used to assess the impact of RHC3 on promoting M2 polarisation. Levels of inflammatory factor levels, including interleukin 1-beta (IL-1β), tumour necrosis factor-alpha (TNF-α), and IL-10, were quantified using enzyme-linked immunosorbent assay to evaluate the improvement in inflammatory response. The capability of RHC3 to prevent abdominal adhesions was assessed by rinsing the abdominal cavity in an animal model.

Results

RHC3 contains GPP fragments that account for over 5% of its amino acid sequence. Cell studies indicated that RHC3 induced M2 polarisation in macrophages, significantly reduced levels of pro-inflammatory factors (IL-1β and TNF-α), and significantly increased levels of the anti-inflammatory factor IL-10. Similarly, animal studies demonstrated a significant reduction in abdominal adhesion scores.

Conclusion

These results suggest that RHC3 exhibits notable inflammation-ameliorating activity and effectively prevents abdominal adhesions when used as a lavage solution.

目的探讨重组人ⅲ型胶原(RHC3)对腹腔粘连的预防作用。方法采用氨基酸序列分析方法测定GPP片段的含量。RHC3与巨噬细胞共培养,通过免疫荧光检测M1巨噬细胞诱导型一氧化氮合酶和M2巨噬细胞精氨酸酶1,对巨噬细胞进行表型分类。这种方法被用来评估rh3对促进M2极化的影响。炎症因子水平,包括白细胞介素1- β (IL-1β)、肿瘤坏死因子α (TNF-α)和IL-10,采用酶联免疫吸附法定量,以评估炎症反应的改善。在动物模型中,通过冲洗腹腔来评估RHC3预防腹腔粘连的能力。结果RHC3含有GPP片段,占其氨基酸序列的5%以上。细胞研究表明,RHC3诱导巨噬细胞M2极化,显著降低促炎因子(IL-1β和TNF-α)水平,显著升高抗炎因子IL-10水平。同样,动物研究表明腹腔粘连评分显著降低。结论RHC3作为灌洗液具有明显的消炎作用,可有效预防腹腔粘连。
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引用次数: 0
Optimal timing of surgery for inguinal hernia in premature neonates 早产儿腹股沟疝的最佳手术时机
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-08-20 DOI: 10.1111/1744-1633.12713
Guoqiang Chen, Hai Zhou, Jian Yang, Bingshan Xia, Jia Gao, Qianming Xiang, Chunbao Guo MD, PhD, Gongli Chen

Aim

The surgical repair of inguinal hernias represents a significant risk for premature infants. Despite ongoing discourse, the optimal approach to hernia management remains contentious. Our investigation aims to establish the most favourable timing for inguinal repair in premature neonates.

Patients and Methods

Our investigation involved the analysis of medical records for 536 neonates, born prematurely, who underwent inguinal hernia repair from January 2018 to December 2023. We dichotomised the cohort into two groups: those who received early repair and those who underwent late repair. The timing of the surgery was primarily determined by the surgeon's decision, in conjunction with familial consent to the surgical intervention. The primary endpoints were the incidence of recurrence or incarceration within 1 year after surgery. The secondary endpoints encompassed length of neonatal intensive care unit stay, post-operative ventilator dependency, and frequency of return visits, whether to the inpatient and emergency department or an outpatient clinical setting, for hernia-related issues.

Results

The analysis encompassed a total of 454 neonates born prematurely, of which 163 underwent early repair, while 291 received late repair for inguinal hernia. The demographic data between the two groups demonstrated no significant differences. The occurrences of hernia recurrence and post-operative apnoea presented similar trends across both cohorts. Notably, the late repair group exhibited an increased incidence of preoperative incarceration and return visits due to hernia complications. In this group, testicular atrophy or ovarian necrosis was observed in five cases, despite the overall absence of significant differences.

Conclusions

Our findings suggest that the surgical repair of inguinal hernia in preterm neonates, performed at the time of presentation to our clinics, is both safe and feasible. However, a delay in hernia repair appears to be associated with a heightened risk of severe complications, such as testicular atrophy or ovarian necrosis.

目的腹股沟疝的手术修复是早产儿的重要风险。尽管有持续的讨论,疝气治疗的最佳方法仍然存在争议。我们的研究旨在确定早产儿腹股沟修复的最佳时机。患者与方法本研究分析了2018年1月至2023年12月536例早产儿腹股沟疝修补术的医疗记录。我们将队列分为两组:接受早期修复的组和接受晚期修复的组。手术的时机主要取决于外科医生的决定,以及家属对手术干预的同意。主要终点是术后1年内复发或嵌顿的发生率。次要终点包括新生儿重症监护病房的住院时间、术后呼吸机依赖性和因疝气相关问题而复诊的频率,无论是住院和急诊部门还是门诊临床环境。结果分析454例早产儿腹股沟疝,其中早期修补163例,晚期修补291例。两组的人口统计数据无显著差异。疝复发和术后呼吸暂停的发生率在两个队列中呈现相似的趋势。值得注意的是,由于疝并发症,晚期修复组表现出术前嵌顿和复诊的发生率增加。在本组中,有5例出现睾丸萎缩或卵巢坏死,尽管总体上没有显著差异。结论:早产儿腹股沟疝的手术修复,在到我们诊所就诊时进行,是安全可行的。然而,疝气修复的延迟似乎与严重并发症的风险增加有关,如睾丸萎缩或卵巢坏死。
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引用次数: 0
Drain amylase values for clinically relevant post-operative pancreatic fistulae 胰瘘术后引流淀粉酶值的临床意义
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-08-15 DOI: 10.1111/1744-1633.12715
Pipit Burasakarn MD, PhD, Sermsak Hongjinda MD, Anuparp Thienhiran MD, Pusit Fuengfoo MD

Aim

This study aims to identify the cut-off drain amylase (DA) values on the first, third, and fifth post-operative days (POD1-DA, POD3-DA, and POD5-DA) that are correlated with clinically relevant post-operative pancreatic fistula (CR-POPF).

Patients and Methods

All data were retrospectively collected from patients who underwent pancreatectomy at the Department of Surgery, Phramongkutklao Hospital, from January 2015 to December 2023. A total of 195 patients were included in the study.

Results

A total of 195 patients were analysed, including 35 patients with CR-POPF, with a mean age of 60.84 years. There were no statistically significant differences in demographic data between patients with CR-POPF and those without. In addition, no statistical differences were observed in pancreatic duct diameter (3 mm vs 2 mm), operative time (468.9 min vs 500.29 min), or blood loss (600 mL vs 600 mL) between the CR-POPF and no CR-POPF groups. Length of hospital stays was longer in the CR-POPF group compared with the no CR-POPF group (33 days vs 11 days, P = .001). In addition, the CR-POPF group had significantly higher rates of post-operative pancreatic haemorrhage (20% vs 2.5%), bile leakage (5.71% vs 0%), delayed gastric emptying (45.71% vs 3.13%), wound complications (34.29% vs 5%), and mortality (17.14% vs 1.88%) compared with the no CR-POPF group. The optimal cut-off values for CR-POPF were 1313 U/L on day 1 (D1; area under the curve [AUC] 0.72, 95% confidence interval [CI] 0.65–0.84, sensitivity 91%, specificity 52%), 492 U/L on D3 (AUC 0.77, 95% CI 0.70–0.83, sensitivity 91%, specificity 64%), and 360 U/L on D5 (AUC 0.65, 95% CI 0.52–0.75, sensitivity 69%, specificity 61%). There were no significant perioperative factors associated with CR-POPF in our study.

Conclusion

DA levels of 1313, 492, and 360 U/L on post-operative D1, D3, and D5, respectively, were associated with CR-POPF. Drain removal can be safely performed without the risk of CR-POPF when these levels are met.

目的 本研究旨在确定术后第一天、第三天和第五天(POD1-DA、POD3-DA 和 POD5-DA)的排水淀粉酶(DA)临界值与临床相关的术后胰瘘(CR-POPF)的相关性。 患者和方法 所有数据均为回顾性收集,来自 2015 年 1 月至 2023 年 12 月期间在 Phramongkutklao 医院外科接受胰腺切除术的患者。研究共纳入 195 名患者。 结果 共分析了 195 名患者,其中包括 35 名 CR-POPF 患者,平均年龄为 60.84 岁。CR-POPF 患者与非 CR-POPF 患者的人口统计学数据差异无统计学意义。此外,在胰管直径(3 毫米对 2 毫米)、手术时间(468.9 分钟对 500.29 分钟)或失血量(600 毫升对 600 毫升)方面,CR-POPF 组和非 CR-POPF 组之间也没有统计学差异。与无 CR-POPF 组相比,CR-POPF 组的住院时间更长(33 天 vs 11 天,P = .001)。此外,与无 CR-POPF 组相比,CR-POPF 组的术后胰腺出血率(20% vs 2.5%)、胆汁渗漏率(5.71% vs 0%)、胃排空延迟率(45.71% vs 3.13%)、伤口并发症率(34.29% vs 5%)和死亡率(17.14% vs 1.88%)都明显更高。CR-POPF 的最佳临界值为:第 1 天 1313 U/L(D1;曲线下面积 [AUC] 0.72,95% 置信区间 [CI] 0.65-0.84,灵敏度 91%,特异度 52%),D3 492 U/L(AUC 0.77,95% CI 0.70-0.83,灵敏度 91%,特异度 64%),D5 360 U/L(AUC 0.65,95% CI 0.52-0.75,灵敏度 69%,特异度 61%)。在我们的研究中,没有与 CR-POPF 相关的重要围手术期因素。 结论 术后 D1、D3 和 D5 的 DA 水平分别为 1313、492 和 360 U/L 与 CR-POPF 相关。当达到这些水平时,可以安全地拔除引流管,而不会有 CR-POPF 的风险。
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引用次数: 0
Posterior components separation with transversus abdominis release and sublay mesh reinforcement in large ventral hernia repair 大型腹股沟疝修补术中的腹横肌松解和下层网片加固后部组件分离术
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-07-23 DOI: 10.1111/1744-1633.12709
Ahmed Hassan El-Halby MBBCh, Tamer M. Elmahdy MD, Ahmed Fakhr El-Deen El-Samongy MD, Osama Helmy Elkhadrawy MD

Aim

Ventral abdominal hernia is a prevalent condition among surgical patients. Large ventral hernias with defects >10 cm that cannot be closed primarily, often with loss of domain requiring abdominal wall reconstruction, pose a surgical challenge. Our study aimed to evaluate the outcomes of posterior components separation (PCS) with transversus abdominis release (TAR) and sublay mesh reinforcement in large ventral hernia repair, particularly in terms of surgical site occurrences (SSOs) and hernia recurrence.

Patients and Methods

Our study included 40 adult patients presented to Tanta University Hospitals with a large ventral hernia (defect width ≥10 cm) from December 2021 to January 2023. All patients were submitted to PCS with TAR and sublay mesh reinforcement.

Results

The mean age of the study population was 47.32 (standard deviation [SD] 9.31) years (range 36–65 years) with a mean body mass index of 33.55 (SD 3.42) kg/m2 (range 28.35–38.72 kg/m2). The major risk factors were obesity (95.00%), smoking (45.00%), and multiparity (45.00%). Midline incisional hernia was the most common type in 28 patients (70.00%). Thirty-four patients (85%) achieved successful midline closure, while six patients required additional anterior components separation technique to achieve tensionless midline closure and an onlay mesh for functional reconstruction. Post-operative SSOs occurred in 12 patients (30.00%), with subcutaneous seroma in 8 patients (20.00%) and wound dehiscence and necrosis in 4 patients (10.00%). Two patients (5.00%) experienced recurrence after a mean follow-up period of 19.25 (SD 3.52) months.

Conclusions

PCS with TAR and sublay mesh reinforcement is a reliable and durable technique for complex ventral hernia repair with low morbidity and recurrence rates. However, long-term clinical outcomes with more cases are required to properly evaluate this technique.

腹股沟疝是外科病人的常见病。腹壁缺损大于 10 厘米的大块腹股沟疝无法主要闭合,通常会导致腹壁缺损,需要进行腹壁重建,这给手术带来了挑战。我们的研究旨在评估后部组件分离术(PCS)与腹横肌松解术(TAR)和亚层网片加固术在大型腹股沟疝修补术中的效果,特别是在手术部位发生率(SSO)和疝气复发方面。研究对象的平均年龄为 47.32(标准差 [SD] 9.31)岁(范围为 36-65 岁),平均体重指数为 33.55(标准差 3.42)kg/m2(范围为 28.35-38.72 kg/m2)。主要风险因素为肥胖(95.00%)、吸烟(45.00%)和多胎(45.00%)。中线切口疝是最常见的类型,有 28 名患者(70.00%)。34名患者(85%)成功实现了中线闭合,6名患者需要额外的前部组件分离技术来实现无张力中线闭合,并使用嵌体网片进行功能重建。12 名患者(30.00%)发生了术后 SSO,其中 8 名患者(20.00%)出现皮下血清肿,4 名患者(10.00%)出现伤口裂开和坏死。2 名患者(5.00%)在平均 19.25 个月(SD 3.52)的随访期后复发。然而,要正确评估这项技术,还需要更多病例的长期临床结果。
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引用次数: 0
Joint replacement and peroneal nerve flap transfer repair surgery for deficiency in the fifth metatarsal bone of the right foot 右脚第五跖骨缺损的关节置换和腓肠神经瓣转移修复手术
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-07-11 DOI: 10.1111/1744-1633.12707
Dawei Wang, Chen Xie, Baoguo Cheng, Hongyue Men, Nanfei Zheng, Zongyu Li

The use of 3D printing technology for prosthetic treatment of forefoot bone defects is relatively uncommon. In December 2021, our research team successfully treated a patient presenting with a bone defect in the fifth metatarsal of the right foot, along with accompanying soft tissue and tendon defects. Following an initial debridement treatment, in April 2022, the patient underwent a right foot flap transfer repair. This procedure, performed under general anaesthesia, also included the implantation of a 3D-printed titanium metatarsophalangeal joint replacement for the fifth toe. After a 12-month post-operative assessment, the donor site displayed normal characteristics and the affected foot exhibited a complete and intact appearance. The patient reported no pain or discomfort during weight-bearing activities and exhibited a normal gait pattern without signs of limping. Both aesthetic and functional recovery outcomes were deemed satisfactory.

使用三维打印技术对前足骨质缺损进行修复治疗的情况相对少见。2021 年 12 月,我们的研究团队成功治疗了一名右脚第五跖骨骨缺损并伴有软组织和肌腱缺损的患者。经过初步清创治疗后,患者于 2022 年 4 月接受了右足皮瓣转移修复术。该手术在全身麻醉下进行,还包括为第五趾植入 3D 打印的钛金属跖趾关节替代物。经过 12 个月的术后评估,供体部位显示出正常特征,患足外观完整无缺。患者在负重活动时无疼痛或不适感,步态正常,无跛行迹象。美学和功能恢复结果均令人满意。
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引用次数: 0
Does the COVID-19 pandemic change clinic features and treatment of intussusception in children? COVID-19 大流行是否会改变儿童肠套叠的临床特征和治疗方法?
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-07-03 DOI: 10.1111/1744-1633.12706
Begüm Pişiren, Özlem Boybeyi, Tutku Soyer MD

Aim

Social restrictions during the coronavirus disease 2019 (COVID-19) pandemic decreased the incidence of viral diseases. Intussusception may exhibit seasonal variation, and viral aetiology is a common cause of idiopathic cases. This retrospective study was conducted to evaluate the impact of the COVID-19 pandemic on the clinical course and treatment of intussusception in children.

Patients and Methods

Patients admitted between March 2017 and December 2021 were retrospectively evaluated for age, gender, clinical findings, symptoms, length and localisation of intussusception, and treatment. They were categorised into two groups: before the pandemic (BP) and during the pandemic (DP).

Results

A total of 55 patients were included in the study, with 54 (78%) in the BP group and 11 (22%) in the DP group. The median age of the patients was significantly younger in the DP group (P < .05). Contrast enema reduction was a common treatment choice in the BP group, whereas ultrasound-guided hydrostatic reduction was more popular in the DP group (P < .05). The median time to start oral feeding and length of hospitalisation were significantly shorter in the DP group (P < .05). While there was no difference in seasonal occurrences of intussusception, idiopathic causes were more common in the BP group (P < .05). The incidence of intussusception with a leading point as an underlying aetiology was significantly higher in the DP group (P < .05).

Conclusion

During the pandemic, the rate of idiopathic intussusception significantly decreased, with leading points accounting for half of the cases.

2019 年冠状病毒病(COVID-19)大流行期间的社会限制降低了病毒性疾病的发病率。肠套叠可能呈现季节性变化,病毒病因是特发性病例的常见病因。这项回顾性研究旨在评估COVID-19大流行对儿童肠套叠临床病程和治疗的影响。对2017年3月至2021年12月期间收治的患者的年龄、性别、临床表现、症状、肠套叠长度和定位以及治疗情况进行了回顾性评估。他们被分为两组:大流行前(BP)和大流行期间(DP)。研究共纳入55名患者,其中BP组54人(78%),DP组11人(22%)。DP组患者的中位年龄明显更小(P < .05)。造影剂灌肠减容术是 BP 组常用的治疗方法,而超声引导静水压减容术在 DP 组更受欢迎(P < .05)。DP组开始口服喂养的中位时间和住院时间明显更短(P < .05)。虽然肠套叠的季节性发生率没有差异,但特发性肠套叠在 BP 组更为常见(P < .05)。在大流行期间,特发性肠套叠的发病率明显下降,其中前驱点占了一半。
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引用次数: 0
Surgical Practice May 2024 issue CME for Fellows 外科实践》2024 年 5 月刊 为研究员举办的继续医学教育
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-06-23 DOI: 10.1111/1744-1633.12703
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引用次数: 0
Risk management in surgical practice 外科实践中的风险管理
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-06-23 DOI: 10.1111/1744-1633.12701
Paul B. S. Lai
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引用次数: 0
Surgical Practice February 2024 CME for Fellows 外科实践 2024 年 2 月研究员继续医学教育
IF 0.3 4区 医学 Q4 SURGERY Pub Date : 2024-06-23 DOI: 10.1111/1744-1633.12696
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引用次数: 0
期刊
Surgical Practice
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