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Hepatitis C and interferon-associated retinopathy: A case report 丙型肝炎和干扰素相关视网膜病变1例报告
Pub Date : 2011-12-01 DOI: 10.1016/j.optm.2010.11.016
Ann M. Van Wie O.D.

Background

Hepatitis C is a common virus affecting approximately 170 million people worldwide. The main ocular manifestations of hepatitis C virus include a Sjögren-type of dry eye syndrome and an ischemic retinopathy secondary to treatment with interferon or a result of a systemic vasculitis induced by the infection itself. Current treatment for hepatitis C is a combination therapy using pegylated (long-lasting) interferon and ribavirin. This treatment, however, is not without ocular sequelae. Interferon-associated retinopathy is present in > 50% of patients taking the drug and is mainly characterized by cotton wool spots and retinal hemorrhages. The pathogenesis of this disorder is not specifically known. Fortunately, many patients remain asymptomatic, and the retinal changes are usually reversible.

Case Report

A 48-year-old black man presented to the clinic complaining of decreased vision in both eyes for the previous few weeks. His medical history was positive for hypertension and hepatitis C for which he was being treated. At his examination, he had interferon retinopathy diagnosed. Soon thereafter, his treatment for hepatitis C was discontinued, and when he returned for follow-up 4 months later, his retinal findings had resolved.

Conclusions

An overview of hepatitis C and its recommended therapy and possible ocular side effects are reviewed, as well as the differential diagnosis of interferon-associated retinopathy, 1 of the main side effects of treatment.

丙型肝炎是一种常见的病毒,影响着全世界约1.7亿人。丙型肝炎病毒的主要眼部表现包括Sjögren-type干眼综合征和继发于干扰素治疗或由感染本身引起的全身血管炎的缺血性视网膜病变。目前丙型肝炎的治疗是使用聚乙二醇化(长效)干扰素和利巴韦林的联合治疗。然而,这种治疗并非没有眼部后遗症。干扰素相关性视网膜病变存在于>50%的患者服用该药,主要表现为棉絮斑和视网膜出血。这种疾病的发病机制尚不清楚。幸运的是,许多患者仍然无症状,视网膜的改变通常是可逆的。病例报告一名48岁黑人男子前来就诊,主诉前几周双眼视力下降。他的病史呈高血压和丙型肝炎阳性,他正在接受治疗。在检查中,他被诊断为干扰素视网膜病变。此后不久,他的丙型肝炎治疗停止,4个月后,当他返回随访时,他的视网膜病变已经消失。结论综述了丙型肝炎的概况及其推荐治疗方法和可能的眼部副作用,以及干扰素相关性视网膜病变的鉴别诊断,干扰素相关性视网膜病变是治疗的主要副作用之一。
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引用次数: 6
Guidelines for Authors 作者指南
Pub Date : 2011-12-01 DOI: 10.1016/S1529-1839(11)00555-0
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引用次数: 0
Toric soft contact lens fit in a postoperative LASIK keratoectasia patient with high and irregular astigmatism 环形软性接触镜适合于高度不规则散光的LASIK角膜扩张术后患者
Pub Date : 2011-12-01 DOI: 10.1016/j.optm.2011.06.011
David P. Roncone O.D.

Background

Keratoectasia is a rare but well-known complication after laser-assisted in situ keratomileusis (LASIK). Patients with this condition can have high and irregular astigmatism. When the treatment of the high astigmatic correction cannot be accomplished surgically or when the keratoectasia patient rejects surgical enhancement, optical correction with devices such as soft or rigid gas-permeable contact lenses may be pursued. In fact, toric soft contact lenses are a good first option for fitting postoperative keratoectasia patients.

Case report

A 58-year-old white male presented for an examination with a complaint of decreased distance vision in the right eye (OD) after having traditional LASIK for myopia with astigmatism in both eyes (OU) in 1999 and limbal relaxing incision enhancement OD in 2003. Refraction showed high mixed astigmatism OD (+1.75 -5.75×075). Slit lamp examination found irregularity of the cornea, evidenced by an inferior cone with pigmented Fleischer ring OD. Video keratometry had keratometry readings of 43.50 at 160, 39.87 at 070, elevated shape measure (0.40), elevated corneal irregularity measure (3.96), an inferior cone on the elevation map, and asymmetric bowtie with elongation inferonasally on the axial map, which confirmed the diagnosis of postoperative keratoectasia. Because new surgical treatments at that time for corneal ectasia were in their infancy and not approved by the U.S. Food and Drug Administration, the patient opted for a trial toric soft contact lens fitting, which improved his corrected distance visual acuity to 20/25.

Conclusion

This case report confirms that toric soft contact lenses are a good first choice in fitting patients with high and irregular astigmatism from postoperative LASIK corneal ectasia. It also confirms that excellent vision and comfort with toric soft contact lenses is possible in these patients.

背景:角膜扩张是激光辅助原位角膜磨除术(LASIK)后罕见但众所周知的并发症。患有这种疾病的患者可能会有高度和不规则的散光。当高散光矫正的治疗不能通过手术完成,或当角膜扩张患者拒绝手术增强,光学矫正装置,如软性或刚性透气性隐形眼镜可以追求。事实上,环面软性隐形眼镜是适合术后角膜扩张患者的首选。病例报告一名58岁白人男性,1999年行传统LASIK治疗双眼散光近视(OU), 2003年行角膜缘松弛切口增强手术(OD)后,主诉右眼远视力下降。折射显示高混合散光OD (+1.75 -5.75×075)。裂隙灯检查发现角膜不规则,可见下锥体,有色素性弗莱舍环外径。视频测角结果为:160时43.50,070时39.87,形状升高(0.40),角膜不规则度升高(3.96),仰角图下锥体,轴向图不对称领结鼻间延伸,术后诊断为角膜扩张。由于当时角膜扩张的新手术治疗还处于起步阶段,而且没有得到美国食品和药物管理局的批准,患者选择了一种试用的环形软性隐形眼镜,这将他的矫正距离视力提高到了20/25。结论本病例证实环面软性隐形眼镜是LASIK术后高度散光和不规则散光患者的首选。这也证实了在这些患者中使用环面软性隐形眼镜可以获得良好的视力和舒适度。
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引用次数: 6
Vision Rehabilitation: Multidisciplinary Care of the Patient Following Brain Injury 视力康复:脑损伤后患者的多学科护理
Pub Date : 2011-12-01 DOI: 10.1016/j.optm.2011.10.009
Leonard J. Press O.D.
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引用次数: 46
Optometry Referees 2010-2011 2010-2011验光裁判
Pub Date : 2011-12-01 DOI: 10.1016/S1529-1839(11)00561-6
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引用次数: 0
Lipemia retinalis: a combination of genetics and the American diet and lifestyle. 视网膜脂血症:基因与美国饮食和生活方式的结合。
Pub Date : 2011-11-03 DOI: 10.1016/J.OPTM.2011.05.008
Samantha L C Nogales, A. Grimes, Huey-Fen Song
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引用次数: 4
Interactions of visual and cognitive stress 视觉和认知压力的相互作用
Pub Date : 2011-11-01 DOI: 10.1016/j.optm.2011.07.003
Niru K. Nahar Ph.D. , Sowjanya Gowrisankaran Ph.D. , John R. Hayes Ph.D. , James E. Sheedy O.D., Ph.D.

Background

The objective of this research is to assess the ocular and muscular response to long-duration reading under different visual and cognitive difficulty levels.

Methods

Thirty-five subjects, with 20/20 vision and without history of ocular pathology or cognitive deficits, participated in the study. Subjects read under different visual and cognitive difficulty levels for 6 (30-minute) conditions. Upper and lower orbicularis oculi, frontalis, and trapezius muscle activities were recorded using surface electromyography (EMG). Aperture size, pupil diameter, and pulse rate of the subjects were recorded with a video camera, pulse meter, and ISCAN eye tracker (ISCAN Inc.), respectively.

Results

The results show that the texts read with a refractive error caused increased orbicularis oculi EMG power and reduced aperture size (P < 0.001). There was no statistically significant difference between the conditions for pulse rate, pupil diameter, or EMG activity of the frontalis and trapezius muscles with either visual or cognitive stress presented in this experiment.

Conclusion

Visual stress experienced due to reading under an induced refractive error is potentially mediated by a local mechanism, different from the mechanism underlying reading under low contrast or high cognitive demand.

本研究的目的是评估不同视觉和认知难度水平下长时间阅读的眼部和肌肉反应。方法35例视力20/20,无眼部病理史和认知障碍的受试者参加研究。受试者在不同的视觉和认知难度水平下阅读6(30分钟)。采用表面肌电图(EMG)记录上下眼轮匝肌、额肌和斜方肌的活动。分别用摄像机、脉搏计和ISCAN眼动仪记录受试者的光圈大小、瞳孔直径和脉搏率。结果屈光不正时阅读文本会导致眼轮匝肌电图功率增加,孔径减小(P <0.001)。在本实验中,无论是视觉压力还是认知压力,额肌和斜方肌的脉搏率、瞳孔直径、肌电图活动均无统计学差异。结论屈光不正诱发的视觉压力与低对比度或高认知需求下的阅读不同,可能是由局部机制介导的。
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引用次数: 16
Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration 萎缩性年龄相关性黄斑变性患者玉米黄质与视觉功能的随机、双盲、安慰剂对照研究
Pub Date : 2011-11-01 DOI: 10.1016/j.optm.2011.08.008
Stuart P. Richer O.D., Ph.D. , William Stiles M.D., J.D. , Kelly Graham-Hoffman PsyD , Marc Levin M.D., J.D. , Dennis Ruskin O.D. , James Wrobel DPM , Dong-Wouk Park , Carla Thomas

Background

The purpose of this study is to evaluate whether dietary supplementation with the carotenoid zeaxanthin (Zx) raises macula pigment optical density (MPOD) and has unique visual benefits for patients with early atrophic macular degeneration having visual symptoms but lower-risk National Institute of Health/National Eye Institute/Age-Related Eye Disease Study characteristics.

Methods

This was a 1-year, n = 60 (57 men, 3 women), 4-visit, intention-to-treat, prospective, randomized controlled clinical trial of patients (74.9 years, standard deviation [SD] 10) with mild-to-moderate age-related macular degeneration (AMD) randomly assigned to 1 of 2 dietary supplement carotenoid pigment intervention groups: 8 mg Zx (n = 25) and 8 mg Zx plus 9 mg lutein (L) (n = 25) or 9 mg L (“Faux Placebo,” control group, n = 10). Analysis was by Bartlett’s test for equal variance, 3-way repeated factors analysis of variance, independent t test (P < 0.05) for variance and between/within group differences, and post-hoc Scheffé's tests. Estimated foveal heterochromic flicker photometry, 1° macular pigment optical density (MPOD QuantifEye®), low- and high-contrast visual acuity, foveal shape discrimination (Retina Foundation of the Southwest), 10° yellow kinetic visual fields (KVF), glare recovery, contrast sensitivity function (CSF), and 6° blue cone ChromaTest® color thresholds were obtained serially at 4, 8, and 12 months.

Results

Ninety percent of subjects completed ≥ 2 visits with an initial Age-Related Eye Disease Study report #18 retinopathy score of 1.4 (1.0 SD)/4.0 and pill intake compliance of 96% with no adverse effects. There were no intergroup differences in 3 major AMD risk factors: age, smoking, and body mass index as well as disease duration and Visual Function Questionnaire 25 composite score differences. Randomization resulted in equal MPOD variance and MPOD increasing in each of the 3 groups from 0.33 density units (du) (0.17 SD) baseline to 0.51 du (0.18 SD) at 12 m, (P = 0.03), but no between-group differences (Analysis of Variance; P = 0.47). In the Zx group, detailed high-contrast visual acuity improved by 1.5 lines, Retina Foundation of the Southwest shape discrimination sharpened from 0.97 to 0.57 (P = 0.06, 1-tail), and a larger percentage of Zx patients experienced clearing of their KVF central scotomas (P = 0.057). The “Faux Placebo” L group was superior in terms of low-contrast visual acuity, CSF, and glare recovery, whereas Zx showed a trend toward significance.

Conclusion

In older male patients with AMD, Zx-induced foveal MPOD elevation mirrored that of L and provided compl

本研究的目的是评估膳食补充类胡萝卜素玉米黄质(Zx)是否能提高黄斑色素光密度(MPOD),并对有视觉症状但风险较低的早期萎缩性黄斑变性患者具有独特的视觉益处。方法:这是一项为期1年,n = 60(57名男性,3名女性),4次随访,意向治疗,前瞻性,随机对照的临床试验,患者(74.9岁,标准差[SD] 10)患有轻度至中度年龄相关性黄斑变性(AMD),随机分配到2个膳食补充剂类胡萝卜素干预组中的一个:8mg Zx (n = 25), 8mg Zx加9mg叶黄素(L) (n = 25)或9mg L(“假安慰剂”,对照组,n = 10)。分析采用Bartlett 's等方差检验、3-way重复因子方差分析、独立t检验(P <0.05)的方差和组间/组内差异,以及事后scheff检验。在4、8和12个月时,分别获得估计的中央凹异色闪烁光度、1°黄斑色素光学密度(MPOD QuantifEye®)、低对比度和高对比度视力、中央凹形状辨别(西南视网膜基金会)、10°黄色动态视野(KVF)、眩光恢复、对比灵敏度函数(CSF)和6°蓝锥chrorestest®颜色阈值。结果90%的受试者完成≥2次就诊,初始年龄相关性眼病研究报告#18视网膜病变评分为1.4 (1.0 SD)/4.0,服药依从性为96%,无不良反应。年龄、吸烟、体质指数3个主要AMD危险因素以及病程、视觉功能问卷25项综合评分组间差异无统计学意义。随机化导致MPOD方差相等,3组的MPOD从基线0.33密度单位(du) (0.17 SD)增加到12 m时的0.51密度单位(0.18 SD), (P = 0.03),但组间无差异(方差分析;P = 0.47)。在Zx组中,详细的高对比度视力提高了1.5线,视网膜基础的西南形状辨别从0.97提高到0.57 (P = 0.06, 1尾),Zx患者的KVF中心暗斑清除率更高(P = 0.057)。“假安慰剂”L组在低对比视力、脑脊液和眩光恢复方面具有优势,而Zx组则有显著性趋势。结论在老年男性AMD患者中,zx诱导的中央凹MPOD升高反映了L的作用,并通过改善中央凹锥体视觉参数提供了互补的明显的视觉益处,而L则增强了与粗细杆视觉相关的参数,两种类胡萝卜素之间存在相当大的重叠。等剂量(非典型膳食比例)Zx加L组在提高MPOD方面表现较差,可能是因为十二指肠、肝脂蛋白或视网膜类胡萝卜素的竞争。基于视网膜分布和Zx中央凹优势,这些结果具有生物学意义。
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引用次数: 102
Updating the practice for the better 为了更好地更新实践
Pub Date : 2011-11-01 DOI: 10.1016/j.optm.2011.09.006
Gary Gerber O.D.
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引用次数: 0
Microtropia: clinical findings and management for the primary eye care practitioner 斜视:初级眼保健医生的临床表现和管理
Pub Date : 2011-11-01 DOI: 10.1016/j.optm.2011.02.020
Josephine O. Ibironke O.D., MPH

Background

Microtropia is a small-angle strabismus with a highly developed degree of binocular cooperation. It is a unilateral comitant horizontal deviation less than 5 prism diopters (PD) in the presence of anomalous retinal correspondence (ARC), amblyopia, some motor fusion, and reduced stereoacuity.

Case report

A 7-year-old white girl presented for a second opinion concerning unexplained vision loss in the left eye. Visual acuities were 20/20 in the right eye and 20/200 in the left eye. Ocular evaluation found normal eye health with a 4-PD constant left esotropia at near and a 3-PD constant left esotropia at distance on unilateral cover test. A diagnosis of steady nasal eccentric fixation microtropia without identity with strabismic amblyopia in the left eye was made. Over the follow-up period, visual acuity improved but the alignment did not.

Conclusion

Microtropia can defy detection, resulting in a reduced chance of achieving near-normal visual potential in children. It is important for clinicians to understand the possible etiologies, related entities, proper testing, differential diagnoses, and the goals of treatment. This case report reviews the clinical findings, diagnoses, and management of patients with microtropia.

背景:微斜视是一种双眼合作高度发达的小角度斜视。它是一种单侧伴随水平偏差小于5棱镜屈光度(PD),存在视网膜异常对应(ARC),弱视,一些运动融合和立体视敏度降低。病例报告:一名7岁白人女孩因左眼不明原因的视力丧失而求诊。右眼视力20/20,左眼视力20/200。眼部评估发现眼睛健康正常,近处4-PD恒定左侧内斜视,远处3-PD恒定左侧内斜视。诊断为稳定型鼻偏心固定性微斜视,与左眼斜视弱视不一致。在随访期间,视力有所改善,但对齐没有。结论儿童微斜视不易被发现,使其达到接近正常视电位的机会降低。临床医生了解可能的病因、相关实体、适当的检测、鉴别诊断和治疗目标是很重要的。本病例报告回顾了小斜视患者的临床表现、诊断和治疗。
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引用次数: 4
期刊
Optometry
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