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Allergy Asthma and Clinical Immunology最新文献

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Allergological study in patients vaccinated against COVID-19 with suspected allergic reactions. 对接种新冠肺炎疫苗并出现疑似过敏反应的患者的过敏学研究。
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2022-05-27 DOI: 10.1186/s13223-022-00685-z
Vicente Jover Cerdá, Ramón Rodríguez Pacheco, Joan Doménech Witek, Sonia Alonso Hernández, Rafael Durán García, Marina Real Panisello, Francisco Manuel Marco de la Calle

Background: One of the main barriers to vaccination against SARS-CoV-2 is the fear of developing hypersensitivity reactions to any of its components. Although these reactions are very rare, it is necessary to establish an effective protocol to detect patients at risk of developing them. The aim of this study was to evaluate hypersensitivity reactions in vaccinated patients in order to allow or not to complete the vaccination protocol.

Methods: Descriptive and cross-sectional study in which patients with suspected hypersensitivity to SARS-CoV-2 vaccines were evaluated. All patients underwent skin prick test (SPT) and/or intradermal test (IDT) with the vaccines and their excipients. In patients with positive IDT with the vaccine, a histopathological and immunohistochemical study was performed by skin biopsy. A basophil activation test (BAT) and a lymphoblastic transformation test (LTT) were also performed.

Results: Sixteen patients with suspected hypersensitivity to SARS-CoV-2 vaccine (12 received Comirnaty®, 3 received Vaxzevria®, and 1 received Spikevax®) were evaluated. Half had immediate hypersensitivity reactions and half had delayed reactions. All SPTs to excipients and vaccines were negative. IDTs with all excipients were negative. IDTs with vaccines were positive in 11 patients and negative in 5. The histological and immunohistochemical study of the two selected patients with positive IDT with vaccine showed T-lymphocyte involvement. BAT and LTT were negative in both cases. The vaccination protocol could be completed in 7 of 16 patients (44%) studied. The remaining 9 patients did not receive the second dose: 5 because vaccination was not required and 4 because they refused to be vaccinated.

Conclusions: Thanks to the allergological and immunohistochemical study, the vaccination protocol could be completed in about half of the patients who presented suspected hypersensitivity reactions to SARS-CoV-2 vaccines. IDTs with vaccines could be a valuable method for assessing the immunogenicity of the vaccines.

背景：接种严重急性呼吸系统综合征冠状病毒2型疫苗的主要障碍之一是担心对其任何成分产生超敏反应。尽管这些反应非常罕见，但有必要建立一个有效的方案来检测有发展风险的患者。本研究的目的是评估接种疫苗的患者的超敏反应，以允许或不完成疫苗接种方案。方法：对疑似对严重急性呼吸系统综合征冠状病毒2型疫苗过敏的患者进行描述性和横断面研究。所有患者均接受了疫苗及其赋形剂的皮肤点刺试验（SPT）和/或皮内试验（IDT）。在接种疫苗的IDT阳性患者中，通过皮肤活检进行组织病理学和免疫组织化学研究。还进行了嗜碱性粒细胞活化试验（BAT）和淋巴细胞转化试验（LTT）。结果：对16名疑似对严重急性呼吸系统综合征冠状病毒2型疫苗过敏的患者（12名接受Comirnaty®，3名接受Vaxzevria®，1名接受Spikevax®）进行了评估。一半有立即超敏反应，一半有延迟反应。辅料和疫苗的所有SPT均为阴性。所有赋形剂的IDT均为阴性。接种疫苗的IDT阳性11例，阴性5例。两名接种疫苗的IDT阳性患者的组织学和免疫组织化学研究显示T淋巴细胞受累。BAT和LTT均为阴性。研究的16名患者中有7名（44%）可以完成疫苗接种方案。其余9名患者没有接种第二剂疫苗：5名是因为不需要接种疫苗，4名是因为他们拒绝接种疫苗。结论：由于过敏性和免疫组织化学研究，大约一半对严重急性呼吸系统综合征冠状病毒2型疫苗出现疑似超敏反应的患者可以完成疫苗接种方案。注射疫苗可能是评估疫苗免疫原性的一种有价值的方法。
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引用次数: 4
The effect of the ragweed sublingual immunotherapy tablet MK-3641 on rescue medication use 豚草舌下免疫治疗片MK-3641对抢救用药的影响
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2014-12-18 DOI: 10.1186/1710-1492-10-S2-A32
S. Gawchik, P. Creticos, K. Murphy, G. Berman, D. Bernstein, J. Maloney, A. Kaur, H. Nolte
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引用次数: 1
Peripherally induced Foxp3+ regulatory T cells mediates the immunomodulatory effect of intravenous immunoglobulin in an experimental model of allergic airway disease 外周诱导的Foxp3+调节性T细胞介导静脉注射免疫球蛋白在变应性气道疾病实验模型中的免疫调节作用
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2014-03-03 DOI: 10.1186/1710-1492-10-S1-A50
A. Massoud, Gabriel N Kaufman, M. Taylor, M. Béland, C. Piccirillo, W. Mourad, B. Mazer
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引用次数: 0
Abstract withdrawn 抽象撤销
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2014-03-01 DOI: 10.1186/1710-1492-7-S2-A15
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引用次数: 0
Abstract withdrawn 抽象撤销
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2014-03-01 DOI: 10.1186/1710-1492-7-S2-A14
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引用次数: 2
Abstract withdrawn 抽象撤销
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2014-01-01 DOI: 10.1186/1710-1492-10-S1-A13
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引用次数: 0
Abstract withdrawn 抽象撤销
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2014-01-01 DOI: 10.1186/1710-1492-10-S1-A43
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引用次数: 0
Anaphylaxis deaths in Ontario: a retrospective review of cases from 1986 to 2011 安大略省过敏反应死亡:1986年至2011年病例的回顾性审查
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2012-11-02 DOI: 10.1186/1710-1492-8-S1-A8
Ya S Xu, S. Waserman, L. Harada, M. Kastner
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引用次数: 4
A new insight into FEIA 对FEIA的新见解
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2011-11-14 DOI: 10.1186/1710-1492-7-S2-A32
Jennifer Chen, Jason K. Lee
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引用次数: 0
Abstract withdrawn 抽象撤销
IF 2.7 4区 医学 Q2 ALLERGY
Allergy Asthma and Clinical Immunology
Pub Date : 2011-01-01 DOI: 10.1186/1710-1492-7-S2-A13
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引用次数: 0
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