Pub Date : 2025-12-04DOI: 10.1016/s2213-2600(25)00339-x
Jeng-Sen Tseng, Stephanie PL Saw, Molly SC Li
No Abstract
没有抽象的
{"title":"Dual PD-1 and VEGF blockade in oncogene-negative NSCLC: where do we stand?","authors":"Jeng-Sen Tseng, Stephanie PL Saw, Molly SC Li","doi":"10.1016/s2213-2600(25)00339-x","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00339-x","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"13 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/s2213-2600(25)00426-6
E Haydn Walters, David P Johns, David W Reid, Frank Thien, Chris Ward
No Abstract
没有抽象的
{"title":"Paradigm shifts in asthma: what is old is new again","authors":"E Haydn Walters, David P Johns, David W Reid, Frank Thien, Chris Ward","doi":"10.1016/s2213-2600(25)00426-6","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00426-6","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"25 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-10-22DOI: 10.1016/S2213-2600(25)00365-0
Jonathan Guo, Andrew Hill, Cassandra Fairhead, Benedict Young, Grace Hennessy, Gayle Pledger
{"title":"Elexacaftor-tezacaftor-ivacaftor as an essential medicine: an opportunity for action.","authors":"Jonathan Guo, Andrew Hill, Cassandra Fairhead, Benedict Young, Grace Hennessy, Gayle Pledger","doi":"10.1016/S2213-2600(25)00365-0","DOIUrl":"10.1016/S2213-2600(25)00365-0","url":null,"abstract":"","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":" ","pages":"1048-1050"},"PeriodicalIF":32.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-29DOI: 10.1016/s2213-2600(25)00396-0
Xu Li, Peng Jin, Lili Zhi
No Abstract
没有抽象的
{"title":"Thunderstorm asthma in China: an emerging clinical and public health concern","authors":"Xu Li, Peng Jin, Lili Zhi","doi":"10.1016/s2213-2600(25)00396-0","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00396-0","url":null,"abstract":"No Abstract","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"08 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145613781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1016/s2213-2600(25)00410-2
Michael Klompas, Richard Branson
{"title":"Time to pull the plug on subglottic secretion drainage?","authors":"Michael Klompas, Richard Branson","doi":"10.1016/s2213-2600(25)00410-2","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00410-2","url":null,"abstract":"","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"22 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1016/s2213-2600(25)00294-2
Miriam M Treggiari, Emily S Sharp, Tetsu Ohnuma, Elaine C Fajardo, Ani Aydin, Shamsuddin Akhtar, Michael Kampp, Mona Hashemaghaie, Aartee Potnis, Tom Gugel, Jamarc Simon, Lazaro G Curry, Karen Adams, Bhavin Darji, Soundari Sureshanand, Richard Hintz, Samantha N Lorzano, Chanel Johnson, N David Yanez
<h3>Background</h3>Endotracheal tubes with subglottic ports and a polyurethane cuff are recommended for reducing microaspiration in patients who are ventilated. However, their long-term safety and efficacy after emergency intubation are uncertain.<h3>Methods</h3>In this randomised controlled phase 2 trial conducted at two single centres (Oregon Health and Science University [OHSU, Portland, OR, USA] and Yale New Haven Hospital [YNHH, New Haven, CT, USA]), all patients aged 18 years or older requiring endotracheal intubation either in the emergency department or elsewhere in hospital for acute respiratory distress or failure were randomly assigned to receive a polyurethane-cuffed endotracheal tube with subglottic suction (PU-EVAC) or a polyvinylchloride-cuffed endotracheal tube (PVC). Individuals who were electively intubated in the operating room and protected populations (children [aged younger than 18 years], pregnant women, and prisoners) were ineligible to participate. Patients were randomised 1:1 into the two treatment arms using a fair coin randomisation scheme. Patients assigned to the PVC group were treated according to usual care, and patients assigned to the PU-EVAC group received continuous subglottic suctioning until removal of the endotracheal tube. The coprimary endpoints at 6 months were laryngeal injury, quality of life (Short Form-36 [SF-36] physical component summary [PCS] and mental component summary [MCS] scores), and cognitive function. Secondary endpoints were infection-related ventilator-associated complications (IVAC) and possible ventilator-associated pneumonia (VAP). This trial is registered at <span><span>ClinicalTrials.gov</span><svg aria-label="Opens in new window" focusable="false" height="20" viewbox="0 0 8 8"><path d="M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z"></path></svg></span> (<span><span>NCT03705286</span><svg aria-label="Opens in new window" focusable="false" height="20" viewbox="0 0 8 8"><path d="M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z"></path></svg></span>) and is now completed.<h3>Findings</h3>Between May 6, 2019, and July 31, 2019 (Oregon Health and Science University), and Sept 29, 2020, to Feb 11, 2022 (Yale New Haven Hospital), 1074 adult patients were enrolled and 1068 were randomly assigned to either the PVC (n=533) or the PU-EVAC (n=535) endotracheal tube group. Participants had a mean age at intubation of 62·9 years (SD 15·7), were mostly male (671 [63%] of 1068), and mostly White (718 [67%]). IVAC occurred in 43 (8%) of 535 patients in the PU-EVAC group and in 33 (6%) of 533 patients in the PVC group (risk difference 0·02 [95% CI –0·01 to 0·05]); possible VAP occurred in 30 (6%) patients in the PU-EVAC group and 24 (5%) patients in the PVC group (0·01 [–0·02 to 0·04]). At 6-month follow-up, 558 patients had died (274 [51%] in the PU-EVAC group and 284 [53%] in the PVC group). 157 completed the 6-month
{"title":"Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial","authors":"Miriam M Treggiari, Emily S Sharp, Tetsu Ohnuma, Elaine C Fajardo, Ani Aydin, Shamsuddin Akhtar, Michael Kampp, Mona Hashemaghaie, Aartee Potnis, Tom Gugel, Jamarc Simon, Lazaro G Curry, Karen Adams, Bhavin Darji, Soundari Sureshanand, Richard Hintz, Samantha N Lorzano, Chanel Johnson, N David Yanez","doi":"10.1016/s2213-2600(25)00294-2","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00294-2","url":null,"abstract":"<h3>Background</h3>Endotracheal tubes with subglottic ports and a polyurethane cuff are recommended for reducing microaspiration in patients who are ventilated. However, their long-term safety and efficacy after emergency intubation are uncertain.<h3>Methods</h3>In this randomised controlled phase 2 trial conducted at two single centres (Oregon Health and Science University [OHSU, Portland, OR, USA] and Yale New Haven Hospital [YNHH, New Haven, CT, USA]), all patients aged 18 years or older requiring endotracheal intubation either in the emergency department or elsewhere in hospital for acute respiratory distress or failure were randomly assigned to receive a polyurethane-cuffed endotracheal tube with subglottic suction (PU-EVAC) or a polyvinylchloride-cuffed endotracheal tube (PVC). Individuals who were electively intubated in the operating room and protected populations (children [aged younger than 18 years], pregnant women, and prisoners) were ineligible to participate. Patients were randomised 1:1 into the two treatment arms using a fair coin randomisation scheme. Patients assigned to the PVC group were treated according to usual care, and patients assigned to the PU-EVAC group received continuous subglottic suctioning until removal of the endotracheal tube. The coprimary endpoints at 6 months were laryngeal injury, quality of life (Short Form-36 [SF-36] physical component summary [PCS] and mental component summary [MCS] scores), and cognitive function. Secondary endpoints were infection-related ventilator-associated complications (IVAC) and possible ventilator-associated pneumonia (VAP). This trial is registered at <span><span>ClinicalTrials.gov</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> (<span><span>NCT03705286</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>) and is now completed.<h3>Findings</h3>Between May 6, 2019, and July 31, 2019 (Oregon Health and Science University), and Sept 29, 2020, to Feb 11, 2022 (Yale New Haven Hospital), 1074 adult patients were enrolled and 1068 were randomly assigned to either the PVC (n=533) or the PU-EVAC (n=535) endotracheal tube group. Participants had a mean age at intubation of 62·9 years (SD 15·7), were mostly male (671 [63%] of 1068), and mostly White (718 [67%]). IVAC occurred in 43 (8%) of 535 patients in the PU-EVAC group and in 33 (6%) of 533 patients in the PVC group (risk difference 0·02 [95% CI –0·01 to 0·05]); possible VAP occurred in 30 (6%) patients in the PU-EVAC group and 24 (5%) patients in the PVC group (0·01 [–0·02 to 0·04]). At 6-month follow-up, 558 patients had died (274 [51%] in the PU-EVAC group and 284 [53%] in the PVC group). 157 completed the 6-month ","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"207 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1016/s2213-2600(25)00403-5
Shyamali C Dharmage, Gulshan B Ali, Kimberley C W Wang
{"title":"Prematurity-associated lung disease: from survival to breathing well across the life course","authors":"Shyamali C Dharmage, Gulshan B Ali, Kimberley C W Wang","doi":"10.1016/s2213-2600(25)00403-5","DOIUrl":"https://doi.org/10.1016/s2213-2600(25)00403-5","url":null,"abstract":"","PeriodicalId":51307,"journal":{"name":"Lancet Respiratory Medicine","volume":"21 1","pages":""},"PeriodicalIF":76.2,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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