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CD8-positive T-cell lymphoproliferative disorder of the uterus: a new subtype of indolent extranodal T-cell neoplasm? 子宫 CD8 阳性 T 细胞淋巴组织增生性疾病:一种新的非淋巴结外 T 细胞肿瘤亚型?
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI: 10.1007/s12308-024-00589-4
Reham Ahmed, Andrew L Feldman

A 51-year-old female with menorrhagia was found to have a cervical polyp. Polypectomy and endometrial curettage showed an atypical lymphoid infiltrate. Hysterectomy was performed, showing extensive myometrial infiltration by small, cytologically bland CD3-positive αβ T cells with a non-activated cytotoxic phenotype and a low proliferative rate. PCR showed clonal TCR-β gene rearrangement. Lymph nodes were uninvolved. PET-CT was negative. A diagnosis of CD8-positive T-cell lymphoproliferative disorder (T-LPD) was made. At 6 months, the patient was asymptomatic with a negative repeat PET-CT. A critical recent advance in the classification of lymphoid neoplasms is the recognition of indolent extranodal T-LPDs, including those of the gastrointestinal tract (T-cell and NK-cell types) and skin (small/medium CD4-positive and acral CD8-positive). However, T-LPDs of the uterus are rare. Two indolent T-LPDs of the uterus have been reported, both showing a CD8-positive, nonactivated cytotoxic phenotype, low proliferative rate, and clonal TCR rearrangement. Neither developed systemic disease nor recurrence. The etiology of indolent T-LPDs and their relationship to overt T-cell lymphomas remain poorly understood. T-LPDs of the uterus may arise from effector memory T-cells that establish long-term, tissueresident immunologic memory following exposure to fetal extravillous trophoblastic cell alloantigens during a previous pregnancy. Neither our patient nor the 2 previously reported had a current pregnancy or a known recent infection or toxic exposure, and the event(s) triggering evolution into T-LPD are unknown. Indolent T-LPDs can be encountered at new and unusual extranodal sites; knowledge of their clinicopathological features will help avoid unnecessary cytotoxic chemotherapy and improve understanding of this group of disorders.

一名 51 岁女性因月经过多被发现患有宫颈息肉。息肉切除术和子宫内膜刮宫术显示有非典型淋巴细胞浸润。进行了子宫切除术,结果显示子宫肌层广泛浸润了小的、细胞学上无CD3阳性的αβ T细胞,这些细胞无活化细胞毒性表型,增殖率低。PCR 显示克隆 TCR-β 基因重排。淋巴结未受累。PET-CT 呈阴性。诊断结果为 CD8 阳性 T 细胞淋巴增生性疾病(T-LPD)。6 个月后,患者无症状,PET-CT 复查阴性。最近在淋巴肿瘤分类方面取得的一个重要进展是,人们认识到了包括胃肠道(T 细胞和 NK 细胞类型)和皮肤(小/中型 CD4 阳性和尖锐型 CD8 阳性)在内的不太活跃的结节外 T-LPD 肿瘤。然而,子宫 T-LPD 却十分罕见。曾有报道称,有两种子宫惰性 T-LPDs 均表现为 CD8 阳性、非活化细胞毒性表型、低增殖率和克隆 TCR 重排。两者均未出现全身性疾病或复发。人们对不活跃的T-LPD的病因及其与显性T细胞淋巴瘤的关系仍然知之甚少。子宫T-LPD可能源于效应记忆T细胞,这些T细胞在前次妊娠中暴露于胎儿绒毛外滋养细胞异体抗原后建立了长期的组织内免疫记忆。我们的患者和之前报道的 2 例患者均未妊娠,也没有已知的近期感染或毒性暴露,因此引发 T-LPD 演变的事件尚不清楚。在新的和不寻常的结外部位可能会出现惰性T-LPD;了解它们的临床病理特征将有助于避免不必要的细胞毒化疗,并增进对这类疾病的了解。
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引用次数: 0
WNT inhibitory factor 1 (WIF1) is a novel fusion partner of RUNX family transcription factor 1 (RUNX1) in acute myeloid leukemia with t(12;21)(q14;q22) 在患有 t(12;21)(q14;q22)的急性髓性白血病患者中,WNT 抑制因子 1 (WIF1) 是 RUNX 家族转录因子 1 (RUNX1) 的新型融合伙伴
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-07-27 DOI: 10.1007/s12308-024-00597-4
Shaobin Yang, Ming Sun, Long Chen, Hong Zhang, Lidan Sun, Enbin Liu, Xin Tian, Xiaoju Hou, Yani Lin, Mize Lu

As a member of the core transcription factor family, RUNX1 plays an important role in stem cell differentiation. RUNX1 rearrangements are common in myeloid and lymphoid tumors [1]. (Blood 129(15):2070-2082, 2017). One of the most commonly detected abnormalities in acute myeloid leukemia (AML) is the translocation t(8;21)(q22;q22) (Blood Adv 4(1):229–238, 2020), resulting in a RUNX1::RUNX1T1 fusion. Occasionally, RUNX1 is translocated with other genes. This article describes an AML patient with a specific chromosomal translocation involving the RUNX1 gene and the identification of the RUNX1::WIF1 fusion. Chromosomal abnormalities were detected through karyotype analysis, break gene involved was identified via fluorescence in situ hybridization (FISH), and the novel fusion was identified through transcriptome sequencing and subsequently confirmed through reverse transcription-polymerase chain reaction (RT-PCR) and Sanger sequencing. A 79-year-old female patient diagnosed with AML was found to have a t(12;21)(q14;q12) translocation. FISH analysis provided evidence of RUNX1 gene rearrangement. Additionally, transcriptomic sequencing revealed a novel fusion known as RUNX1::WIF1, which consists of RUNX1 exon 2 and WIF1 exon 3. The novel fusion was further confirmed through RT-PCR and Sanger sequencing. We identified WIF1 as a novel fusion partner of RUNX1 in AML. Additionally, this is the first report of a RUNX1 fusion gene with the break point in intron 2, resulting in an out-of-frame fusion. Further research is needed to investigate the impact of this novel fusion on the establishment and progression of the disease.

作为核心转录因子家族的成员,RUNX1在干细胞分化中发挥着重要作用。RUNX1重排在骨髓和淋巴肿瘤中很常见[1]。(Blood 129(15):2070-2082,2017)。急性髓性白血病(AML)中最常检测到的异常之一是t(8;21)(q22;q22)易位(Blood Adv 4(1):229-238,2020),导致RUNX1::RUNX1T1融合。偶尔,RUNX1也会与其他基因发生易位。本文描述了一名患有涉及RUNX1基因的特定染色体易位的急性髓细胞性白血病患者,以及RUNX1::WIF1融合的鉴定。通过核型分析发现了染色体异常,通过荧光原位杂交(FISH)确定了涉及的断裂基因,通过转录组测序确定了新型融合基因,随后通过反转录聚合酶链反应(RT-PCR)和桑格测序进行了确认。一名被诊断为急性髓细胞性白血病的 79 岁女性患者被发现患有 t(12;21)(q14;q12)易位。FISH 分析提供了 RUNX1 基因重排的证据。此外,转录组测序发现了一个名为RUNX1::WIF1的新型融合基因,它由RUNX1第2外显子和WIF1第3外显子组成。通过 RT-PCR 和 Sanger 测序进一步证实了这种新型融合。我们发现 WIF1 是急性髓细胞白血病中 RUNX1 的新型融合伙伴。此外,这是首次报道RUNX1融合基因的断裂点位于内含子2,从而导致框架外融合。我们需要进一步研究这种新型融合对疾病的形成和发展的影响。
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引用次数: 0
Gamma-delta T-cell acute lymphoblastic lymphoma/leukemia: a report of a rare entity. γ-δT细胞急性淋巴细胞淋巴瘤/白血病:一份罕见病例的报告。
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1007/s12308-024-00578-7
Giby V George, Maggie Kajstura, Andrew G Evans, Chauncey R Syposs

Gamma delta (γδ) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is a rare, aggressive subtype of T-lymphoid leukemia that accounts for only 9-12% of all T-ALL cases. Herein, we report the case of an 8-year-old boy who presented with facial swelling, shortness of breath, and progressive cervical and axillary lymphadenopathy. Pathological examination, flow cytometry (Navios, Beckman Coulter ClearLLab 10C 10-color T-cell panel [containing FITC-labeled TCR γδ antibody]), chromosomal analysis, interphase FISH, and targeted DNA-based NGS (34-gene Illumina TruSeq Myeloid Panel) were performed. Flow cytometry evaluation of a lymph node biopsy specimen revealed an immature T-cell population positive for CD4, CD3, CD2 (subset positive), CD5, CD7, CD38, CD1a, cytoplasmic terminal deoxynucleotidyl transferase (cyto-TdT), CD30 (subset positive), and T-cell receptor (TCR) gamma delta (γδ). Microscopic examination of an enlarged lymph node and bone marrow showed involvement by a dense, diffuse, neoplastic infiltrate. Interphase FISH revealed a copy number loss of PDGFRB (5q32) in 90.5% of interphase nuclei. Targeted DNA-based NGS detected a tier II oncogenic variant in NOTCH1 (c.7375C > T, p.Gln2459Ter) at a VAF of 21%. This case of γδ T-ALL highlights a rare entity and adds to the literature, albeit scant, which may aid in better recognition and classification.

γδ(γδ)T 细胞急性淋巴细胞白血病/淋巴瘤(T-ALL)是 T 淋巴细胞白血病中一种罕见的侵袭性亚型,仅占所有 T-ALL 病例的 9-12%。在此,我们报告了一例 8 岁男孩的病例,他出现面部肿胀、呼吸急促、进行性颈部和腋窝淋巴结病变。病理检查、流式细胞术(Navios、Beckman Coulter ClearLLab 10C 10 色 T 细胞面板[含 FITC 标记的 TCR γδ 抗体])、染色体分析、间期 FISH 和基于 DNA 的靶向 NGS(34 基因 Illumina TruSeq 髓系面板)均已完成。淋巴结活检标本的流式细胞术评估显示,未成熟T细胞群的CD4、CD3、CD2(亚群阳性)、CD5、CD7、CD38、CD1a、细胞质末端脱氧核苷酸转移酶(cyto-TdT)、CD30(亚群阳性)和T细胞受体(TCR)γδ(γδ)阳性。对肿大的淋巴结和骨髓进行的显微镜检查显示,肿瘤呈密集、弥漫性浸润。相间荧光原位杂交(FISH)发现,90.5%的相间核中存在 PDGFRB(5q32)拷贝数缺失。基于DNA的靶向NGS检测出NOTCH1的二级致癌变异(c.7375C > T, p.Gln2459Ter),VAF为21%。这例γδ T-ALL病例突显了一种罕见的实体,并增加了文献(尽管很少),这可能有助于更好地识别和分类。
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引用次数: 0
Cytogenetic and pathologic characterization of MYC-rearranged B-cell lymphomas in pediatric and young adult patients. 儿童和年轻成人 MYC 重排 B 细胞淋巴瘤的细胞遗传学和病理学特征。
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-06-01 Epub Date: 2024-04-02 DOI: 10.1007/s12308-024-00579-6
Marie-France Gagnon, Frido K Bruehl, Daniel R Sill, Reid G Meyer, Patricia T Greipp, Nicole L Hoppman, Xinjie Xu, Linda B Baughn, Jess F Peterson, Ellen D McPhail, Rhett P Ketterling, Rebecca L King

MYC-rearranged B-cell lymphoma (BCL) in the pediatric/young adult (YA) age group differs substantially in disease composition from adult cohorts. However, data regarding the partner genes, concurrent rearrangements, and ultimate diagnoses in these patients is scarce compared to that in adult cohorts. We aimed to characterize the spectrum of MYC-rearranged (MYC-R) mature, aggressive BCL in the pediatric/YA population. A retrospective study of morphologic, immunophenotypic, and fluorescence in situ hybridization (FISH) results of patients age ≤ 30 years with suspected Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL), and a MYC-R by FISH between 2013-2022 was performed. Two-hundred fifty-eight cases (129 (50%) pediatric (< 18 years) and 129 (50%) YA (18-30 years)) were included. Most MYC-R BCL in pediatric (89%) and YA (66%) cases were BL. While double-hit (DH) cytogenetics (MYC with BCL2 and/or BCL6-R, HGBCL-DH) was rare in the pediatric population (2/129, 2%), HGBCL-DH increased with age and was identified in 17/129 (13%) of YA cases. Most HGBCL-DH had MYC and BCL6-R, while BCL2-R were rare in both groups (3/258, 1%). MYC-R without an IG partner was more common in the YA group (14/116 (12%) vs 2/128 (2%), p = 0.001). The pediatric to YA transition is characterized by decreasing frequency in BL and increasing genetic heterogeneity of MYC-R BCL, with emergence of DH-BCL with MYC and BCL6-R. FISH to evaluate for BCL2 and BCL6 rearrangements is likely not warranted in the pediatric population but should continue to be applied in YA BCL.

儿科/青壮年(YA)年龄组的MYC重排B细胞淋巴瘤(BCL)在疾病构成上与成人组有很大不同。然而,与成人组相比,有关这些患者的伴侣基因、并发重排和最终诊断的数据却很少。我们的目的是描述儿童/青少年群体中MYC重排(MYC-R)成熟、侵袭性BCL的谱系特征。我们对 2013-2022 年间年龄小于 30 岁、疑似伯基特淋巴瘤(Burkitt lymphoma,BL)、弥漫大 B 细胞淋巴瘤(DLBCL)或高级别 B 细胞淋巴瘤(Highgrade B-cell lymphoma,HGBCL)患者的形态学、免疫表型和荧光原位杂交(FISH)结果进行了回顾性研究。258 例病例(129 例(50%)小儿淋巴瘤(BL
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引用次数: 0
In honor of Prof. Dr. José Vassallo, MD, PhD (1957-2024). 纪念医学博士何塞-瓦萨洛教授(1957-2024)。
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-06-01 Epub Date: 2024-03-07 DOI: 10.1007/s12308-024-00576-9
Guilherme Rossi Assis-Mendonça
{"title":"In honor of Prof. Dr. José Vassallo, MD, PhD (1957-2024).","authors":"Guilherme Rossi Assis-Mendonça","doi":"10.1007/s12308-024-00576-9","DOIUrl":"10.1007/s12308-024-00576-9","url":null,"abstract":"","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":" ","pages":"47-48"},"PeriodicalIF":0.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The first case of six-way complex translocation of t(4;7;9;22;8;14) in a patient with chronic myeloid leukemia. 首例慢性粒细胞白血病患者的 t(4;7;9;22;8;14)六向复合易位。
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-06-01 Epub Date: 2024-03-16 DOI: 10.1007/s12308-024-00577-8
Xiaoyu Bi, Chao Li, Miao Shang, Bingbing Han, Hongyu Li, Lidan Sun, Yani Lin, Shaobin Yang

In chronic myeloid leukemia (CML), patients exhibit the t(9;22)(q34.1;q11.2) translocation, resulting in the formation of a Philadelphia chromosome (Ph). However, a subset of CML patients display variant complex translocations, characterized by three-way, four-way, and five-way translocations, which have been occasionally associated with a poor prognosis. This case report presents the first case of a t(9;22) variant six-way complex translocation in CML. The R banding chromosome karyotyping technique was used to obtain preliminary karyotyping results, and the multi-probe FISH technique was used to assist in the verification of chromosome results. Both FISH and PCR proved the existence of fusion genes. A 45-year-old male patient admitted to our hospital due to elevated WBC and anemia. Bone marrow smears revealed a significant proliferation of mature granulocytes, accompanied by an increase in eosinophils and basophils. Karyotype analysis indicated abnormalities in six chromosomes, including 4, 7, 8, 9, 14, and 22. Further analysis using FISH technology demonstrated the presence of the BCR::ABL1 fusion gene, as well as the mapping of the BCR (22q11), MYC (8q24), IGH (14q32), D4S163 (4q35.1), and D7S486 (7q31) genes to new chromosomes. Ultimately, the karyotype findings were described as t(4;7;9;22;8;14)(q27;q22;q34;q11;q22;q12). PCR showed that BCR::ABL1 was p210. After treatment with imatinib for 4 months, the patient achieved complete cytogenetic response (CCyR) and early molecular response (EMR). This is the first report of complex chromosomal karyotype involving six-way translocation in CML; the combination of chromosome analysis and FISH techniques is an effective strategy in determining the karyotype result.

慢性髓性白血病(CML)患者会出现 t(9;22)(q34.1;q11.2)易位,从而形成费城染色体(Ph)。然而,也有一部分 CML 患者表现出变异的复杂易位,其特点是三向、四向和五向易位,偶尔与不良预后有关。本病例报告了首例 t(9;22)变异六向复合易位的 CML 患者。该病例使用 R 带染色体核型技术获得初步核型结果,并使用多探针 FISH 技术协助验证染色体结果。FISH 和 PCR 均证明了融合基因的存在。一名 45 岁男性患者因白细胞升高和贫血入住我院。骨髓涂片显示成熟粒细胞明显增生,同时嗜酸性粒细胞和嗜碱性粒细胞增多。核型分析表明有六条染色体异常,包括 4、7、8、9、14 和 22。使用 FISH 技术进行的进一步分析表明存在 BCR::ABL1 融合基因,以及 BCR(22q11)、MYC(8q24)、IGH(14q32)、D4S163(4q35.1)和 D7S486(7q31)基因在新染色体上的映射。最终,核型结果被描述为 t(4;7;9;22;8;14)(q27;q22;q34;q11;q22;q12)。PCR 显示,BCR::ABL1 为 p210。伊马替尼治疗 4 个月后,患者获得了完全细胞遗传学应答(CCyR)和早期分子应答(EMR)。这是首次报道CML中涉及六向易位的复杂染色体核型;染色体分析和FISH技术相结合是确定核型结果的有效策略。
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引用次数: 0
Hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1 in a young adult: a case report with literature review. 由单纯疱疹病毒 1 型引起的嗜血细胞淋巴组织细胞增多症:病例报告与文献综述。
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-06-01 Epub Date: 2024-02-29 DOI: 10.1007/s12308-024-00575-w
Hanqing Zhang, Peng Zhang, Zhifang Xiao, Yang Gao, Na Han, Xianjun He, Jinfeng Zhang, Yonghua Li

Hemophagocytic lymphohistiocytosis is a severe hyperinflammatory syndrome that can be potentially life-threatening without appropriate treatment. Although viral infection is the most common trigger of hemophagocytic lymphohistiocytosis, cases of herpes simplex virus type 1-induced hemophagocytic lymphohistiocytosis are rare in adults. This study aims to provide a comprehensive overview of the clinical characteristics and treatment outcomes associated with HSV-1-induced HLH. We herein report an adult case of hemophagocytic lymphohistiocytosis caused by herpes simplex virus type 1, diagnosed on the basis of peripheral blood metagenomic next-generation sequencing results. The patient exhibited a favorable response to treatment, involving dexamethasone, intravenous immunoglobulin, and acyclovir. Notably, etoposide administration was deemed unnecessary, and there has been no recurrence of the disease within the year following treatment. Early and sensitive recognition, rapid and precise diagnosis, and timely and appropriate treatment facilitated the successful treatment of this case.

嗜血细胞淋巴组织细胞增多症是一种严重的高炎症综合征,如果得不到适当的治疗,有可能危及生命。虽然病毒感染是嗜血细胞淋巴组织细胞增多症最常见的诱因,但单纯疱疹病毒1型诱发的嗜血细胞淋巴组织细胞增多症在成人中却很少见。本研究旨在全面概述与 HSV-1 诱导的 HLH 相关的临床特征和治疗结果。我们在此报告一例由单纯疱疹病毒 1 型引起的成人嗜血细胞淋巴组织细胞增多症,该病例是根据外周血元基因组新一代测序结果确诊的。患者对包括地塞米松、静脉注射免疫球蛋白和阿昔洛韦在内的治疗反应良好。值得注意的是,该患者无需使用依托泊苷,而且在治疗后的一年内没有复发。早期敏锐的识别、快速准确的诊断以及及时适当的治疗为该病例的成功治疗提供了便利。
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引用次数: 0
What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms? 世界卫生组织成熟 B 细胞和 T/NK 细胞肿瘤及间质肿瘤分类法第五版有哪些新内容?
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-04-29 DOI: 10.1007/s12308-024-00585-8
Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert

The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme of neoplasms and it was updated several times. In this review, we briefly outline the cornerstones of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours on lymphoid neoplasms. As is adopted throughout the 5th edition of the WHO classification of tumors of all organ systems, entities are listed by a hierarchical system. For the first time, tumor-like lesions have been included in the classification, and modifications of nomenclature for some entities, revisions of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities are presented along with mesenchymal lesions specific to the stroma of lymph nodes and the spleen. In addition to specific outlines on constitutional and somatic genetic changes associated with given entities, a separate chapter on germline predisposition syndromes related to hematologic neoplasms has been added.

肿瘤分类对恶性肿瘤患者的诊断和临床治疗至关重要。世界卫生组织(WHO)提供了一个全球适用的肿瘤分类方案,并对其进行了多次更新。在本综述中,我们将简要概述即将发布的第五版《世界卫生组织血液淋巴肿瘤分类》中关于淋巴肿瘤的基石。与世界卫生组织所有器官系统肿瘤分类第五版所采用的方法一样,实体是按等级系统列出的。该分类首次将肿瘤样病变纳入其中,并对某些实体的命名进行了修改,修订了诊断标准或亚型,删除了某些实体,并引入了新的实体以及淋巴结和脾脏基质中特有的间质病变。除了具体概述与特定实体相关的体质和体细胞遗传变化外,还增加了单独一章,介绍与血液肿瘤相关的种系易感综合征。
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引用次数: 0
Secondary plasma cell leukaemia (PCL) with plasmablastic morphology 具有浆细胞形态的继发性浆细胞白血病(PCL)
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-04-06 DOI: 10.1007/s12308-024-00583-w

Abstract

A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.

摘要 一名 71 岁女性患者,因 IgA lambda 骨髓瘤复发而出现进行性全血细胞减少。外周血片显示有 5%的泡状细胞。流式细胞术分析显示为浆细胞。骨髓涂片中充满了浆细胞。靶 CD138 细胞 FISH 和分子核型鉴定发现了一个复杂的基因组。NGS 发现了高风险突变。骨髓组织学证实为骨髓瘤,无急性白血病证据。患者被诊断为浆细胞性骨髓瘤进展和继发性 PCL。继发性 PCL 患者预后较差。识别这一亚型并探索新型治疗方法至关重要。
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引用次数: 0
In memorium: Dr. Zeba Singh 悼念泽巴-辛格博士
IF 0.6 4区 医学 Q4 HEMATOLOGY Pub Date : 2024-04-05 DOI: 10.1007/s12308-024-00580-z
Rima Koka, Michael E. Kallen
{"title":"In memorium: Dr. Zeba Singh","authors":"Rima Koka, Michael E. Kallen","doi":"10.1007/s12308-024-00580-z","DOIUrl":"https://doi.org/10.1007/s12308-024-00580-z","url":null,"abstract":"","PeriodicalId":51320,"journal":{"name":"Journal of Hematopathology","volume":"18 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140597476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Hematopathology
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