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Small Fiber Neuropathy in Veterans With Gulf War Illness 海湾战争退伍军人的小纤维神经病变
Pub Date : 2024-05-01 DOI: 10.12788/fp.0470
Edward Shadiack
Background: Gulf War veterans deployed to operations Desert Shield and Desert Storm returned with chronic multisystemic symptoms. This Gulf War Illness (GWI) has defied attempts to identify an underlying etiology. Pain and other symptoms attributable to autonomic nervous system (ANS) dysfunction are common, which may suggest a pathophysiologic underpinning. Small fiber neuropathy (SFN) presents with similar symptoms. Toxic exposures have been implicated in both SFN and GWI. Methods: A retrospective chart review of clinical data at the New Jersey War Related Illness and Injury Study Center addressed the following questions: (1) how common was biopsy-confirmed SFN in veterans with GWI; (2) do veterans with GWI and SFN report more symptoms attributable to ANS dysfunction as compared to veterans with GWI and no SFN; and (3) can SFN in veterans with GWI and SFN be explained by conditions commonly associated with SFN? Chart review abstracted GWI status, skin biopsy results, and ANS symptom burden. For veterans with GWI and SFN, additional chart abstraction was explored for commonly reported contributing conditions. Results: From March 1, 2015, to January 31, 2019, 51 Gulf War veterans evaluated at the War Related Illness and Injury Study center had a skin biopsy. Of these, 42 (83%) were diagnosed with GWI and 24 of 42 (57%) also had SFN. No differences were observed in ANS symptoms when compared with veterans with GWI and no SFN. A potential etiology for SFN was identified in 16 of 24 (67%) veterans with GWI and SFN, increasing to 19 (79%) when hyperlipidemia was included. Our analysis did not identify an explanation in 5 of 24 (21%) veterans with GWI and SFN. Conclusions: SFN was common in this clinical sample of veterans diagnosed with GWI. A well-established potential etiology was identified in most cases of SFN. About 20% of veterans with GWI in our clinical sample had idiopathic SFN, and it is plausible that deployment-related exposures could have contributed to this condition. Symptoms of ANS are prevalent in GWI, though SFN cannot solely account for this. Our study does not generally support SFN as etiologic for GWI, though this may still be relevant for some. Additional research is required to explore relationships between Gulf War exposures and SFN.
背景:参加过 "沙漠盾牌 "和 "沙漠风暴 "行动的海湾战争退伍老兵在返回时出现了慢性多系统症状。这种海湾战争疾病(GWI)一直无法确定其病因。自律神经系统(ANS)功能障碍导致的疼痛和其他症状很常见,这可能暗示了其病理生理基础。小纤维神经病(SFN)也有类似症状。有毒暴露与 SFN 和 GWI 都有关联。研究方法对新泽西州战争相关疾病和伤害研究中心的临床数据进行回顾性病历审查,以解决以下问题:(1) 在患有 GWI 的退伍军人中,活检证实 SFN 的发生率有多高;(2) 与患有 GWI 但没有 SFN 的退伍军人相比,患有 GWI 和 SFN 的退伍军人是否报告了更多可归因于 ANS 功能障碍的症状;(3) GWI 和 SFN 退伍军人中的 SFN 是否可以用通常与 SFN 相关的病症来解释?病历审查抽取了 GWI 状态、皮肤活检结果和自律神经系统症状负担。对于患有 GWI 和 SFN 的退伍军人,我们还对病历摘要进行了补充,以了解常见的相关病症。结果:从 2015 年 3 月 1 日到 2019 年 1 月 31 日,在战争相关疾病和伤害研究中心接受评估的 51 名海湾战争退伍军人进行了皮肤活检。其中 42 人(83%)被诊断为 GWI,42 人中有 24 人(57%)同时患有 SFN。与患有 GWI 和未患有 SFN 的退伍军人相比,在 ANS 症状方面未发现任何差异。在 24 名患有 GWI 和 SFN 的退伍军人中,有 16 人(67%)发现了 SFN 的潜在病因,如果将高脂血症也包括在内,则人数增加到 19 人(79%)。在 24 名患有 GWI 和 SFN 的退伍军人中,有 5 人(21%)的病因未在我们的分析中找到解释。结论:在被诊断为 GWI 的退伍军人临床样本中,SFN 很常见。大多数 SFN 病例的潜在病因已得到确认。在我们的临床样本中,约 20% 的 GWI 退伍军人患有特发性 SFN,与部署相关的暴露可能是导致这种情况的原因。自律神经失调的症状在 GWI 中很普遍,但 SFN 并不能完全解释这一点。我们的研究总体上并不支持将自律神经网络作为 GWI 的病因,尽管这可能与某些人的情况仍然相关。还需要进行更多的研究来探讨海湾战争暴露与 SFN 之间的关系。
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引用次数: 0
Persistent Flu-Like Symptoms in a Patient With Glaucoma and Osteoporosis 青光眼和骨质疏松症患者的持续流感样症状
Pub Date : 2024-05-01 DOI: 10.12788/fp.0477
Timothy Bodnar
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引用次数: 0
Robotic Pet Therapy in the Intensive Care Unit 重症监护室的机器人宠物疗法
Pub Date : 2024-05-01 DOI: 10.12788/fp.0468
Andrew Franck
Background: Robotic pet therapy could aid in the nonpharmacologic treatment of pain, agitation, delirium, immobility, and sleep disruption (PADIS) in the intensive care unit (ICU), similar to traditional pet therapy. Observations: The North Florida/South Georgia Veterans Health System implemented a robotic pet therapy program for patients requiring ICU care. Details of this program are described in this article, including evaluating its impact on PADIS management. Conclusions: Robotic pet therapy can be successfully implemented in the ICU and could be a simple, safe, and beneficial nonpharmacologic intervention for PADIS.
背景:机器人宠物疗法与传统宠物疗法类似,可帮助重症监护病房(ICU)对疼痛、躁动、谵妄、不动和睡眠障碍(PADIS)进行非药物治疗。观察结果北佛罗里达州/南乔治亚州退伍军人医疗系统为需要重症监护室护理的病人实施了一项机器人宠物治疗计划。本文将详细介绍该计划,包括评估其对 PADIS 管理的影响。结论:机器人宠物疗法可在重症监护室成功实施,是治疗 PADIS 的一种简单、安全、有益的非药物干预措施。
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引用次数: 0
Remembering the Dead in Unity and Peace 在团结与和平中缅怀逝者
Pub Date : 2024-05-01 DOI: 10.12788/fp.0482
Cynthia Geppert
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引用次数: 0
Association of Atrial Fibrillation and/or Flutter With Adverse Cardiac Outcomes and Mortality in Patients With Wolff-Parkinson-White Syndrome 心房颤动和/或扑动与沃尔夫-帕金森-怀特综合征患者不良心脏预后和死亡率的关系
Pub Date : 2024-04-01 DOI: 10.12788/fp.0471
John Chin
Background: Wolff-Parkinson-White (WPW) syndrome is characterized by the presence of accessory pathways and development of potentially malignant arrhythmias that can lead to sudden cardiac death. We aimed to determine the impact of atrial fibrillation and/or flutter (AF/AFL) on adverse cardiac outcomes and mortality in patients with WPW syndrome. Methods: This study identified a cohort of Military Health System patients with WPW syndrome from January 1, 2014, to December 31, 2019. The cohort was divided into 2 subgroups by the presence or absence of AF/AFL. Cardiac composite outcome and mortality were assessed. Kaplan-Meier curves were constructed to assess the bivariate association between exposure and these 2 study outcomes. Cox proportional models were used to estimate the hazard ratios and 95% CIs associated with the cardiac composite outcome and mortality. Results: Of 35,539 patients included in the study, 19,961 were female (56.2%), the mean (SD) age was 62.9 (18.0) years, and 5291 patients (14.9%) had AF/AFL. The cardiac composite outcome and mortality incidence rates per 100 person-years in the AF/AFL vs non-AF/AFL subgroups were 8.18 vs 4.90, and 4.09 vs 2.13, respectively ( P < .001). There were 3130 (8.8%) deaths. After adjusting for confounding variables, the AF/AFL subgroup maintained a 12% and 16% higher association with the composite outcome and mortality, respectively. Conclusions: Patients with WPW syndrome and AF/AFL have a higher association with adverse cardiac outcomes and death. Consideration for more aggressive electrophysiology screening and ablation strategies may be warranted in this population.
背景:沃尔夫-帕金森-怀特(Wolff-Parkinson-White,WPW)综合征的特点是存在附属通路和可能导致心脏性猝死的潜在恶性心律失常。我们旨在确定心房颤动和/或扑动(AF/AFL)对 WPW 综合征患者不良心脏预后和死亡率的影响。方法:本研究确定了 2014 年 1 月 1 日至 2019 年 12 月 31 日期间患有 WPW 综合征的军事卫生系统患者队列。根据有无房颤/AFL,将患者分为两个亚组。对心脏综合结果和死亡率进行了评估。构建了 Kaplan-Meier 曲线,以评估暴露与这两种研究结果之间的二元关联。采用 Cox 比例模型估算与心脏综合结果和死亡率相关的危险比和 95% CI。结果:在纳入研究的 35539 名患者中,有 19961 名女性(56.2%),平均(标清)年龄为 62.9(18.0)岁,5291 名患者(14.9%)患有房颤/自发性心力衰竭。心房颤动/心力衰竭亚组与非心房颤动/心力衰竭亚组的心脏综合结果和每百人年死亡率分别为 8.18 vs 4.90 和 4.09 vs 2.13(P < .001)。死亡人数为 3130 人(8.8%)。对混杂变量进行调整后,房颤/AFL 亚组与综合结果和死亡率的相关性分别高出 12% 和 16%。结论WPW综合征和房颤/AFL患者与不良心脏预后和死亡的相关性较高。在这一人群中,可能需要考虑更积极的电生理学筛查和消融策略。
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引用次数: 0
Nasal Cannula Dislodgement During Sleep in Veterans Recovering Long-term Oxygen Therapy for Hypoxemic Chronic Respiratory Failure 因低氧血症慢性呼吸衰竭而长期接受氧气治疗的退伍军人睡眠期间鼻导管脱落的情况
Pub Date : 2024-04-01 DOI: 10.12788/fp.0473
Z. Elfessi
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引用次数: 0
Graduate Medical Education Financing in the US Department of Veterans Affairs 美国退伍军人事务部的研究生医学教育融资
Pub Date : 2024-04-01 DOI: 10.12788/fp.0472
John Byrne
Background: The US Department of Veterans Affairs (VA) partners with 250 sponsors of graduate medical education (GME), annually providing $850 million for 11,000 full-time equivalent resident positions that support veteran patient care and provide educational opportunities for trainees from affiliated academic programs. Knowledge of VA GME financing is vital to maintain these partnerships. Observations: In response to increased scrutiny from several federal oversight bodies, the VA revised its GME reimbursement policy and procedures, including implementing new resident tracking and auditing mechanisms. This article describes the VA GME reimbursement policies and procedures and, to facilitate understanding, compares GME financing policies of the VA and Centers for Medicare and Medicaid Services. Similarities include counting full-time equivalent positions for reimbursable resident activities (eg, patient care and didactics) and ensuring reimbursement is limited to 1 payment per resident. Differences include funding of resident salaries and benefits, indirect funding to support education, and the calculations to determine reimbursement. Conclusions: The VA continues to refine its GME financing policies and procedures to maintain compliance with laws and regulations, and to provide accurate reimbursement to academic affiliates. This endeavor is essential to support the vital GME partnerships between the VA and its affiliate institutions.
背景:美国退伍军人事务部(VA)与 250 家研究生医学教育(GME)赞助商合作,每年提供 8.5 亿美元用于 11,000 个相当于全日制住院医师的职位,以支持退伍军人的患者护理,并为附属学术项目的受训人员提供教育机会。了解退伍军人事务部的 GME 融资情况对于维持这些合作关系至关重要。意见:为了应对多个联邦监督机构日益严格的审查,退伍军人事务部修订了其住院医师培训报销政策和程序,包括实施新的住院医师跟踪和审计机制。本文介绍了退伍军人事务部的继续医学教育补偿政策和程序,并对退伍军人事务部和医疗保险与医疗补助服务中心的继续医学教育资助政策进行了比较,以便于理解。相似之处包括计算可报销住院医师活动(如病人护理和教学)的全职等效职位,并确保报销仅限于每位住院医师一次。不同之处包括对住院医师工资和福利的资助、支持教育的间接资助以及确定报销额度的计算方法。结论:退伍军人事务部将继续完善其继续医学教育资助政策和程序,以保持符合法律法规,并向学术附属机构提供准确的报销。这项工作对于支持退伍军人事务部与其附属机构之间重要的继续医学教育合作关系至关重要。
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引用次数: 0
Moral Injury in Health Care: A Unified Definition and its Relationship to Burnout 医疗保健中的道德伤害:统一定义及其与职业倦怠的关系
Pub Date : 2024-04-01 DOI: 10.12788/fp.0467
Wendy Dean
Background: Moral injury had been discussed by health care professionals as a cause of occupational distress prior to COVID-19, but the pandemic expanded the appeal and investigation of the term. Moral injury incorporates more than the transdiagnostic symptoms of exhaustion and cynicism and goes beyond operational, demand-resource mismatches of corporatized systems. Observations: Moral injury describes the frustration, anger, and helplessness associated with existential threats to a clinician’s professional identity as business interests erode their ability to put patients’ needs ahead of corporate and health system obligations. We propose a framework that combines 2 moral injury definitions. An individual who experiences a betrayal by a legitimate authority has an opportunity to choose their response. Moral injury arises when a superior’s actions or a system’s policies and practices undermine one’s professional obligations to prioritize the patient’s best interest. Perceived as inescapable, the resignation or helplessness of moral injury may present with emotional exhaustion, ineffectiveness, and depersonalization, all hallmarks of burnout. Both moral injury and burnout can mediate and moderate the relationship between triggers for workplace distress and the resulting psychological, existential, and physical harm. Conclusions : Moral injury is increasingly recognized as a source of distress among health care professionals. It emerges from structural constraints on the ability of health care professionals to deliver optimal care and stand up for patients, their oaths, and their professions. A unified definition of moral injury must be integrated into the framing of clinician distress alongside burnout, recentering health care on ethical decision making rather than profit.
背景:在 COVID-19 之前,医护专业人员已将精神伤害作为职业困扰的一个原因进行过讨论,但这一流行病扩大了这一术语的吸引力和调查范围。精神伤害不仅包括疲惫和愤世嫉俗等跨诊断症状,还超越了公司化系统的业务和需求资源不匹配问题。意见:当商业利益削弱了临床医生将患者需求置于企业和医疗系统义务之上的能力时,临床医生的职业身份就会受到生存威胁,道德伤害描述了与此相关的沮丧、愤怒和无助。我们提出了一个结合两种道德伤害定义的框架。遭遇合法权威背叛的个人有机会选择自己的回应。当上级的行为或系统的政策和实践损害了个人优先考虑患者最佳利益的职业义务时,就会产生道德伤害。道德伤害被认为是不可避免的,道德伤害带来的不甘或无助可能表现为情绪衰竭、效率低下和人格解体,这些都是职业倦怠的特征。道德伤害和职业倦怠都可以调解和缓和工作场所困扰的诱因与由此造成的心理、生存和身体伤害之间的关系。结论 :越来越多的人认识到,道德伤害是医疗保健专业人员的痛苦根源。医护专业人员在提供最佳护理和维护患者、他们的誓言和他们的职业时,会受到结构性限制。道德伤害的统一定义必须与职业倦怠一起被纳入临床医生痛苦的框架中,将医疗保健重新置于道德决策而非盈利之上。
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引用次数: 0
Clinical Implications of a Formulary Conversion From Budesonide/formoterol to Fluticasone/salmeterol at a VA Medical Center 退伍军人医疗中心将处方中的布地奈德/福莫特罗转换为氟替卡松/沙美特罗的临床意义
Pub Date : 2024-03-01 DOI: 10.12788/fp.0459
Lindsay Hoke
Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder associated with chronic and slowly progressive systemic inflammation. The Global Initiative for Chronic Obstructive Lung Disease recommends a combination inhaler of a long-acting β -2 agonist and inhaled corticosteroid for patients with a history of frequent exacerbations. In 2021, the US Department of Veterans Affairs transitioned patients who were prescribed budesonide/formoterol inhaler to a fluticasone/ salmeterol inhaler. Methods: The primary objective of this study was to compare clinical outcomes including COPD exacerbations and hospitalizations 6 months before vs 6 months after the inhaler transition. Secondary outcomes included adverse effects, treatment failure, tobacco use, and antimicrobial/systemic corticosteroid use. A retrospective chart review was conducted on patients with a prescription for a budesonide/formoterol or fluticasone/salmeterol inhalers between February 1, 2021, and May 30, 2022, at the Hershel “Woody” Williams Veterans Affairs Medical Center, Huntington, West Virginia. Results: In a convenience sample of 100 patients who transitioned from the budesonide/formoterol inhaler to the fluticasone/salmeterol inhaler, exacerbations increased from 24 before the transition to 29 after the transition, which was not a statistically significant change ( P = .56). There were no statistically significant differences in the secondary endpoints including active tobacco use. Three patients had adverse reactions to fluticasone/ salmeterol, while 18 patients experienced a therapeutic failure to fluticasone/salmeterol. Conclusions: Patients with COPD that transitioned from budesonide/formoterol to fluticasone/salmeterol during the formulary conversion yield no clinical or statistically significant change in their clinical outcomes. Switching between these inhalers in the same therapeutic class may not impact clinical efficacy of the therapy for veterans with COPD but some intolerances and treatment failures should be expected.
背景:慢性阻塞性肺疾病(COPD)是一种与慢性、缓慢进展的全身性炎症相关的呼吸系统疾病。慢性阻塞性肺病全球倡议》建议有频繁加重病史的患者使用长效β-2受体激动剂和吸入皮质类固醇的联合吸入剂。2021 年,美国退伍军人事务部将处方布地奈德/福莫特罗吸入剂的患者转为使用氟替卡松/沙美特罗吸入剂。研究方法本研究的主要目的是比较吸入器过渡前 6 个月和过渡后 6 个月的临床结果,包括慢性阻塞性肺疾病加重和住院情况。次要结果包括不良反应、治疗失败、吸烟和抗菌药/系统性皮质类固醇的使用。该研究对西弗吉尼亚州亨廷顿市赫谢尔-威廉姆斯退伍军人事务医疗中心(Hershel "Woody" Williams Veterans Affairs Medical Center)2021年2月1日至2022年5月30日期间开具布地奈德/福莫特罗或氟替卡松/沙美特罗吸入剂处方的患者进行了回顾性病历审查。研究结果在从布地奈德/福莫特罗吸入剂过渡到氟替卡松/沙美特罗吸入剂的100名患者中,病情恶化从过渡前的24例增加到过渡后的29例,变化无统计学意义(P = .56)。包括主动吸烟在内的次要终点差异无统计学意义。3名患者对氟替卡松/沙美特罗产生了不良反应,18名患者对氟替卡松/沙美特罗治疗失败。结论在处方转换过程中,从布地奈德/福莫特罗过渡到氟替卡松/沙美特罗的慢性阻塞性肺病患者的临床结果没有发生临床或统计学意义上的显著变化。在同一治疗类别的吸入剂之间进行转换可能不会影响慢性阻塞性肺病退伍军人的临床疗效,但预计会出现一些不耐受和治疗失败的情况。
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引用次数: 0
Fighting to Serve: Women in Military Medicine 为服务而战军医中的女性
Pub Date : 2024-03-01 DOI: 10.12788/fp.0465
Cynthia Geppert
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引用次数: 0
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