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Associating Insulin Instillation with Negative Pressure Wound Therapy Reduces Insulin Resistance in Diabetic Patients with Infected Foot Wounds 将胰岛素滴注与负压伤口治疗相关联可降低糖尿病足部感染患者的胰岛素抵抗
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-12-31 DOI: 10.24966/ETS-8798/100056
Xin-long Chen
In this work we investigated whether a joint treatment with insulin instillation and negative pressure wound therapy (NPWT) would reduce insulin resistance (IR) in diabetic patients with infected diabetic foot ulcers (DFUs) and improve their healing. We also studied the effects of insulin+NPWT treatment on the inflammatory response coupled with wound healing. Seventy-five diabetic patients with infected DFUs were recruited and randomly divided into equal (n=25) groups treated respectively with NPWT alone, NPWT+insulin, and conventional dressings (controls). Thereafter, the ulcers’ healing progress was assessed. The serum levels of Tumor Necrosis Factor-α (TNF-α), Interleukin-2 (IL-2), and Interleukin-6 (IL-6) were measured at 1 day before and at 7, 14, and 21 days after each treatment using specific double-antibody sandwich enzyme-linked immunosorbent assays (ELISA). Serum glucose was measured via a glucose-oxidase method, and serum insulin via radioimmunoassay. In each patient, IR was appraised via the Homeostasis Model Assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI). Our results showed that at 7, 14 and 21 days post-treatment, with respect to the control group the two NPWT-treated groups had (i) significantly (p < 0.05) lower serum levels of TNF-α, IL-2 and IL-6; (ii) a significantly (p < 0.01) greater reduction in IR; and (iii) significantly (p < 0.05) higher wound healing rates. Moreover, at 14- and 21-days post-treatment, the NPWT+insulin-treated group had a significantly (p < 0.05) higher wound healing rate than the NPWT alone-treated group. In conclusion, the combined NPWT+insulin instillation treatment gave superior results by improving wound healing, decreasing inflammation at the wounds surface, and reducing IR in diabetic patients with infected DFUs.
在这项工作中,我们研究了胰岛素滴注和负压伤口治疗(NPWT)的联合治疗是否会降低糖尿病足溃疡(DFU)感染患者的胰岛素抵抗(IR)并改善其愈合。我们还研究了胰岛素+NPWT治疗对炎症反应和伤口愈合的影响。招募75名感染DFU的糖尿病患者,并随机分为相等(n=25)组,分别用NPWT单独治疗、NPWT+胰岛素治疗和常规敷料治疗(对照)。之后,评估溃疡的愈合进展。使用特异性双抗体夹心酶联免疫吸附试验(ELISA)在每次治疗前1天和治疗后7、14和21天测量血清肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)和白细胞介素-6(IL-6)的水平。通过葡萄糖氧化酶法测定血清葡萄糖,通过放射免疫法测定血清胰岛素。在每个患者中,通过稳态模型评估(HOMA-IR)和定量胰岛素敏感性检查指数(QUICKI)评估IR。我们的结果显示,在治疗后7、14和21天,与对照组相比,两个NPWT治疗组(i)血清TNF-α、IL-2和IL-6水平显著降低(p<0.05);(ii)IR显著(p<0.01)降低;和(iii)显著(p<0.05)较高的伤口愈合率。此外,在治疗后14天和21天,NPWT+胰岛素治疗组的伤口愈合率显著高于(p<0.05)NPWT单独治疗组。总之,在感染DFU的糖尿病患者中,NPWT+胰岛素滴注联合治疗通过改善伤口愈合、减少伤口表面炎症和减少IR而产生了优越的效果。
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引用次数: 0
Mass testing and containment of Covid-19 新冠肺炎的大规模检测和遏制
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-10-31 DOI: 10.24966/ETS-8798/S1001
M. Xiong
Urgent public health interventions to mitigate the spread of Covid-19 curtailed most social activities and work. Meanwhile, maintaining social distancing and lockdown will cause substantial economic loss and social damage. Now the critical question is how to reopen the economy while containing the COVID-19 pandemic without social distancing restrictions? The solution is mass testing. Alternative public health intervention strategies such as shelter-in-place and social distancing policies that may halt economic activities may be curtailed if virus testing which is an effective way to contain Covid-19 is expanded. Although the U.S. still has a longer path ahead, we have estimated that if the number of daily tests is 581,000 per day, i.e., the current number of daily tests would need to be doubled in order for Covid-19 to be contained and social distancing measures to be lifted.
为缓解新冠肺炎传播而采取的紧急公共卫生干预措施减少了大多数社会活动和工作。与此同时,保持社交距离和封锁将造成巨大的经济损失和社会损害。现在的关键问题是,在没有社交距离限制的情况下,如何在遏制新冠肺炎疫情的同时重新开放经济?解决方案是大规模测试。如果扩大病毒检测(这是遏制新冠肺炎的有效途径),可能会停止经济活动的替代公共卫生干预策略,如庇护和保持社交距离政策,可能会被削减。尽管美国还有更长的路要走,但我们估计,如果每天的检测数量为58.1万次,即目前的每日检测数量需要增加一倍,才能控制新冠肺炎并取消社交距离措施。
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引用次数: 0
Unplanned Reoperation And Interventional Radiology Post Appendicectomy: A Meta-Analysis 阑尾切除术后的意外再手术和介入放射学:一项荟萃分析
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-10-31 DOI: 10.24966/ets-8798/100049
M. Sugrue
Introduction: Optimizing delivery of care to patients with appendicitis as part of an emergency general surgery care program is important. Appendicitis is one of commonest emergency surgical presentations and has significant potential morbidity and occasional mortality. Meta-analysis of reinterventions following appendicectomy has not been published. This meta-analysis evaluated the prevalence and potential predictors of reoperation and interventional radiological (IR) procedures post appendicectomy. Methods: A PROSPERO-registered (ID CRD42017069040) meta-analysis following PRISMA guidelines using databases PubMed and Scopus for studies between June 2012 to May 2017 was undertaken. Headings included “reoperation”, “return to operation theatre”, “complication”, “appendicectomy”, “outcome”, “abscess drainage”. Articles scoring ≥16 for comparative and ≥10 for non-comparative using MINORS criteria were included. Results: 2810 articles reviewed were reduced to 52 qualifying studies for a final analysis of 319,053 appendicectomies. Overall, 0.9% (range 0.0% to 14.2%) underwent some form of reintervention. The reoperation rate was 0.6% (range 0.0 to 14.2%) and radiologic drainage rate 1.5% (range 0.0% to 11.1%). Reoperations were significantly associated with a laparoscopic approach, earlier grade of appendicitis and not using drains. Laparoscopy conversion to open and the grade of surgeon performing the appendicectomy did not affect reintervention. Conclusion: This meta-analysis identified a small but notable reoperation and IR rate, significantly increased by complexity of appendicitis and open surgery. Strategies promoting for earlier presentation and diagnosis with laparoscopic approaches may improve overall outcomes.
引言:作为急诊普通外科护理计划的一部分,优化阑尾炎患者的护理非常重要。阑尾炎是最常见的急诊外科表现之一,具有显著的潜在发病率和偶尔的死亡率。阑尾切除术后再干预的荟萃分析尚未发表。这项荟萃分析评估了阑尾切除术后再次手术和介入放射学(IR)手术的发生率和潜在预测因素。方法:在2012年6月至2017年5月期间,根据PRISMA指南,使用PubMed和Scopus数据库进行PROSPERO注册(ID CRD42017069040)荟萃分析。标题包括“再次手术”、“重返手术室”、“并发症”、“阑尾切除术”、“结果”、“脓肿引流”。纳入了使用MINORS标准评分≥16的比较文章和≥10的非比较文章。结果:2810篇综述的文章减少到52篇符合条件的研究,对319053例阑尾切除术进行最终分析。总体而言,0.9%(0.0%-14.2%)接受了某种形式的再干预。再次手术率为0.6%(0.0-14.2%),放射学引流率为1.5%(0.0%-11.1%)。再次手术与腹腔镜入路、早期阑尾炎和不使用引流管显著相关。腹腔镜手术转为开放手术和阑尾切除术的外科医生级别不影响再干预。结论:这项荟萃分析确定了一个小但显著的再手术和IR率,因阑尾炎和开放手术的复杂性而显著增加。促进腹腔镜入路早期表现和诊断的策略可能会改善整体结果。
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引用次数: 1
Solid Pseudopapillary Neoplasm of the Pancreas: Case Report 胰腺实性假乳头状肿瘤1例报告
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-10-31 DOI: 10.24966/ets-8798/100051
M. Kukučka
Solid pseudopapillary neoplasm of the pancreas is a rare pancreatic tumor with low malignant potential, typically affecting young women. In literature this tumor may be referred to as Frantz tumor, solid tumor, cystic tumor, papillary-cystic tumor or solid pseudopapillary tumor. According to the current WHO classification from 2010 these tumors are considered low-grade malignant epithelial tumors of pancreas. In this case report we present a case of 19-years old women with cystic lesion located in left hypogastrium. After thorough evaluation and subsequent multidisciplinary consultation, the patient was indicated to radical resection of the lesion. Final histological evaluation of the surgical specimen revealed the diagnosis of solid-pseudopapillary neoplasm.
胰腺实性假乳头状肿瘤是一种罕见的胰腺肿瘤,恶性潜能低,通常影响年轻女性。在文献中,这种肿瘤可以被称为Frantz肿瘤、实体瘤、囊性肿瘤、乳头状囊性肿瘤或实体假乳头状肿瘤。根据世界卫生组织2010年的分类,这些肿瘤被认为是胰腺的低级别恶性上皮肿瘤。在本病例报告中,我们报告了一例19岁的女性,其左下腹部有囊性病变。经过彻底的评估和随后的多学科会诊,患者被建议对病变进行彻底切除。手术标本的最终组织学评估显示诊断为实性假乳头状肿瘤。
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引用次数: 2
Groin Abscess: Assessing The Diagnostic Accuracy Of Emergency Department Clinicians And Imaging Modalities 腹股沟脓肿:评估急诊科临床医生和影像学诊断的准确性
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-10-31 DOI: 10.24966/ets-8798/100050
V. Ameh
Objective: To determine the clinical and imaging diagnostic accuracy in adult patients presenting to the Emergency Department with groin abscess. Method: Retrospective chart review of all adult patients presenting to a district general hospital with a provisional diagnosis of groin abscess was undertaken from January 2019 to December 2019. A proforma was used to capture data such as the age, sex, co-morbidities, grade of assessing clinician and imaging profile. Results: 39 patients with a provisional diagnosis of groin abscess were identified; representing approximately 1% of all ED attendances. There were 21 males and 18 females. The age range was from 23 to 73 years (mean age 42). The abscess was located on the left side in 19 patients (49%), 18 (46%) on the right and 2 (5%) were bilateral. The overall rate of correct diagnosis of the ED clinicians compared to CT diagnosis is indicated by a sensitivity of 82%, positive predictive value of 90% and an accuracy of 75%. 22 patients had CT scan which confirmed an abscess in 18 (83%). Conclusion: Groin abscess is a rare presentation to the Emergency department. Most patients were seen by clinicians below the consultant grade. Diagnostic accuracy was highest amongst physicians.
目的:确定在急诊科就诊的成年腹股沟脓肿患者的临床和影像学诊断准确性。方法:对2019年1月至2019年12月在地区综合医院就诊的所有临时诊断为腹股沟脓肿的成年患者进行回顾性图表审查。形式表用于获取年龄、性别、合并症、临床医生评估等级和影像学资料等数据。结果:39例患者经临时诊断为腹股沟脓肿;约占所有急诊就诊人数的1%。男21例,女18例。年龄范围为23至73岁(平均42岁)。脓肿位于左侧19例(49%),右侧18例(46%),双侧2例(5%)。与CT诊断相比,ED临床医生的总体正确诊断率为82%,阳性预测值为90%,准确率为75%。22例患者进行了CT扫描,其中18例(83%)确诊为脓肿。结论:腹股沟脓肿是急诊科罕见的表现。大多数患者由顾问级别以下的临床医生就诊。医生的诊断准确率最高。
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引用次数: 0
A Rare Case of Isolated Sigmoid Colon Perforation in Patient with Blunt Trauma Abdomen 腹部钝伤患者孤立性乙状结肠穿孔一例
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-10-31 DOI: 10.24966/ets-8798/100053
A. Ammar
A 47 years old male presented to emergency department with history of pain abdomen after road traffic accident 6 hours back. He had deceleration injury while driving a minivan when he hit a truck parked on road side. On presentation, his Airway and breathing was intact with GCS 15/15.Pulse was 110/min and blood pressure was 100/70 mmHg. His abdomen was generalized tender, mostly in the hypogastrium. Digital rectal examination was normal. Ultrasound abdomen showed free fluid in the peritoneal cavity and chest and abdominal X-rays were unremarkable. On opening the abdomen there was 7×7 cm isolated perforation in sigmoid colon 5 cm proximal to recto sigmoid junction. Repair of perforation was done and proximal double barrel sigmoid colostomy was made. Patient was discharged on 3rd post-operative day. Later after 4 months reversal of sigmoid colostomy was done and patient was discharged.
一名47岁男性,6小时前发生道路交通事故后,因腹部疼痛史到急诊科就诊。他在驾驶一辆小型货车时,撞上了一辆停在路边的卡车,减速受伤。在介绍中,他的气道和呼吸完整,GCS 15/15。脉搏为110/min,血压为100/70mmHg。他的腹部普遍疼痛,主要在下腹部。直肠指检正常。腹部超声检查显示腹腔内有游离液体,胸部和腹部X光检查不明显。在打开腹部时,乙状结肠直肠-乙状结肠交界处近5cm处有7×7cm的孤立穿孔。对穿孔进行了修复,并进行了近端双管乙状结肠造口术。患者于术后第3天出院。4个月后进行乙状结肠造口术,患者出院。
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引用次数: 2
Fulminant Necrotizing Fasciitis And Myositis With Streptococcal Toxic Shock Syndrome In A Patient With Rheumatoid Arthritis On Tocilizumab: A Case Report Tocilizumab治疗类风湿性关节炎患者并发坏死性筋膜炎和肌炎伴链球菌毒性休克综合征一例报告
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-10-31 DOI: 10.24966/ets-8798/100052
Oana Antal
Introduction: We present the case of a 44-year man with a fulminant necrotizing myositis and fasciitis and streptococcal toxic shock syndrome, the patient being under treatment with tocilizumab and methotrexate for rheumatoid arthritis. Case presentation: He presented to the emergency department with diarrhea, flu-like symptoms and intense progressive pain in the right thigh after having shoveled while doing building work at home. His condition deteriorated within hours, he developed severe rhabdomyolysis, multiple organ dysfunction syndrome, disseminated intravascular coagulopathy and died, despite early treatment. Discussion: A great index of suspicion for severe necrotizing soft tissue infections is necessary in patients on tocilizumab or other biologic immunosuppressive agents. The possible mechanisms in this setting include lowering CRP involved in innate immune responses, decrement of neutrophil count and function, increasing iron availability for infection, as well as high expression of vimentin, the streptococcal binding protein, by regenerating muscle fibers after trauma. Diarrhea due to endotoxins and flu-like symptoms may be early and sometimes they may be the only presenting signs of severe group A streptococcal infection in patients with blunt trauma on biologics. Low initial CRP and white blood cell count may be misleading. A rapid streptococcal strip test may help anticipate and possibly prevent a deleterious evolution in such patients. Conclusion: Biologics may modify the clinical presentation of NF, the LRINEC score, and the pathology decision algorithm. A great index of suspicion for severe soft tissue infections is required in patients on biologics with blunt trauma, especially when presenting with flu-like symptoms, diarrhea, or vomiting.
引言:我们报告一例44岁男性,患有暴发性坏死性肌炎、筋膜炎和链球菌中毒性休克综合征,该患者正在接受托西利珠单抗和甲氨蝶呤治疗类风湿性关节炎。病例介绍:他在家里做建筑工作时铲了铲,出现腹泻、流感样症状和右大腿剧烈进行性疼痛,随后去了急诊室。他的病情在数小时内恶化,出现严重的横纹肌溶解症、多器官功能障碍综合征、弥漫性血管内凝血病,尽管早期治疗,但仍死亡。讨论:对于使用托西利珠单抗或其他生物免疫抑制剂的患者,有必要对严重坏死性软组织感染进行高度怀疑。这种情况下的可能机制包括降低参与先天免疫反应的CRP,减少中性粒细胞计数和功能,增加感染的铁可利用性,以及通过创伤后再生肌肉纤维来高表达波形蛋白,即链球菌结合蛋白。内毒素和流感样症状引起的腹泻可能是早期的,有时它们可能是生物制品钝性创伤患者严重A组链球菌感染的唯一表现。低的初始CRP和白细胞计数可能会产生误导。快速链球菌条带检测可能有助于预测并可能预防此类患者的有害进化。结论:生物制品可以改变NF的临床表现、LRINEC评分和病理学决策算法。使用生物制剂治疗钝性创伤的患者,尤其是出现流感样症状、腹泻或呕吐时,需要对严重软组织感染进行高度怀疑。
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引用次数: 0
Clinical Image - Unexplained Intraluminal Contrast In A Trauma Patient 临床影像:一例创伤患者不明原因腔内造影
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-06-30 DOI: 10.24966/ets-8798/100043
L. Raff
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引用次数: 0
Acetaminophen Poisoning: A Cause Of Acute Liver Failure In Pediatrics (Clinical Case) 对乙酰氨基酚中毒:儿科急性肝衰竭的一个原因(临床病例)
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-06-30 DOI: 10.24966/ets-8798/100039
Pshenisnov Konstantin Viktorovich
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引用次数: 1
Laparoscopic Inguinal Hernia Repair Can Be Judiciously Used In The Acute Setting 腹腔镜腹股沟疝修补术在急诊中的应用
IF 4 2区 教育学 Q1 Social Sciences Pub Date : 2020-06-30 DOI: 10.24966/ets-8798/100044
A. Perez
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引用次数: 0
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