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Interprofessional team-based primary care practice and preventive cancer screening: evidence from Family Health Teams in Ontario, Canada. 基于专业团队的初级保健实践和预防性癌症筛查:来自加拿大安大略省家庭健康团队的证据。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-09 DOI: 10.1007/s10198-024-01745-4
Yihong Bai, Jennifer Reid, Steven Habbous, Rose Anne Devlin, Liisa Jaakkimainen, Sisira Sarma

Health care reforms introduced interprofessional team-based primary care to optimize access to health care and preventive services. In this context, preventive cancer screening represents an important measure as it is essential for the early detection of cancer and treatment. We investigated the effects of Family Health Teams (FHTs), an interprofessional team-based primary care practice setting, on cancer screening rates in Ontario, Canada. By utilizing comprehensive health administrative data from April 1st 2011 to March 31st 2023, we determined the effect of FHT on screening rates for breast, cervical, and colorectal cancer while controlling for relevant physician and patient characteristics. Our analytical framework employs fractional probit models, including the Mundlak procedure, and generalized estimating equations to assess the impact of practicing in FHTs on cancer screening rates, while accounting for unobserved physician heterogeneity. Our results indicate that compared to non-FHTs, physicians practicing in FHTs have higher breast (2.4%), cervical (2%), and colon (0.8%) cancer screening rates per physician per year. The effectiveness of FHTs in promoting cancer screenings is particularly pronounced in smaller practices and among populations in rural and economically deprived areas. Our findings highlight the role of teams in enhancing preventive health care services potentially through task shifting mechanisms and suggest that such models may offer a pathway to improving access to preventive health care, especially in marginalized populations. Our research contributes to the literature by providing empirical evidence on the benefits of interprofessional team-based primary care in improving cancer screening.

保健改革引入了以专业团队为基础的初级保健,以优化获得保健和预防服务的机会。在这种情况下,预防性癌症筛查是一项重要措施,因为它对癌症的早期发现和治疗至关重要。我们调查了家庭健康团队(FHTs)对加拿大安大略省癌症筛查率的影响,这是一个基于跨专业团队的初级保健实践环境。通过利用2011年4月1日至2023年3月31日的综合健康管理数据,在控制相关医生和患者特征的情况下,我们确定了FHT对乳腺癌、宫颈癌和结直肠癌筛查率的影响。我们的分析框架采用分数概率模型(包括Mundlak程序)和广义估计方程来评估FHTs执业对癌症筛查率的影响,同时考虑到未观察到的医师异质性。我们的研究结果表明,与非FHTs相比,FHTs执业医师每年的乳腺癌(2.4%)、宫颈癌(2%)和结肠癌(0.8%)筛查率更高。FHTs在促进癌症筛查方面的有效性在规模较小的诊所以及农村和经济贫困地区的人群中尤为明显。我们的研究结果强调了团队在加强预防保健服务方面的作用,可能通过任务转移机制,并表明这种模式可能为改善获得预防保健的途径,特别是在边缘化人群中。我们的研究通过提供基于跨专业团队的初级保健在改善癌症筛查方面的益处的经验证据,为文献做出了贡献。
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引用次数: 0
Can wage changes solve the labour crisis in the National Health Service? 工资变化能解决英国国民医疗服务体系的劳工危机吗?
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-09 DOI: 10.1007/s10198-024-01737-4
Xingzuo Zhou, Jolene Skordis, Junjian Yi, Yiang Li, Jonathan Clarke, Hongkun Zhang

This study aimed to examine the healthcare labour demand and supply elasticity regarding wage in the National Health Service (NHS) in England amid a labour crisis. A simultaneous error-correction regression analysis was conducted using secondary data from the NHS and Office for National Statistics from 2009 Q3 to 2022 Q1. Findings indicate both labour demand and supply of HCHS doctors in the NHS are highly inelastic with respect to real wages, with only a 0.1% decrease in NHS staff hiring and a 0.8% rise in NHS staff's willingness to work as full-time equivalents per 10% wage increase. Approximately 22% of the wage disequilibrium adjusts quarterly, indicating moderate speed of wage adjustment. Our results suggest that wage setting is not a sufficient solution to the labour crisis. Innovative and sustainable solutions are needed to reduce the demand for skilled health labour and increase the supply of health labour.

本研究的目的是检查医疗保健劳动力的需求和供应弹性关于工资在英国国家医疗服务(NHS)在劳工危机。使用2009年第三季度至2022年第一季度NHS和国家统计局的二手数据进行同步误差校正回归分析。研究结果表明,就实际工资而言,NHS中HCHS医生的劳动力需求和供应都高度缺乏弹性,每增加10%的工资,NHS员工招聘只减少0.1%,NHS员工全职工作的意愿增加0.8%。大约22%的工资不均衡按季度调整,表明工资调整的速度适中。我们的研究结果表明,工资设定并不能充分解决劳动力危机。需要创新和可持续的解决办法,以减少对熟练保健劳动力的需求并增加保健劳动力的供应。
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引用次数: 0
The effect of workload on primary care doctors on referral rates and prescription patterns: evidence from English NHS. 初级保健医生工作量对转诊率和处方模式的影响:来自英国NHS的证据。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-07 DOI: 10.1007/s10198-024-01742-7
Hanifa Pilvar, Toby Watt

This paper investigates the impact of workload pressure on primary care outcomes using a unique dataset from English general practices. Leveraging the absence of General Practitioner (GP) colleagues as an instrumental variable, we find that increased workload leads to an increase in prescription rates of antibiotics as well as in the share of assessment referrals. On the other hand, the quantity and frequency of psychotropics decreases. When there is an absence, workload is intensified mostly on GP partners, and the mode of consultation shifts toward remote interactions as a response to higher workload pressure. The effects are more pronounced for patients above 65 years-old and those in Short-staffed practices. Our study sheds light on the intricate relationship between workload pressure and patient care decisions in primary care settings.

本文使用来自英语全科实践的独特数据集调查了工作量压力对初级保健结果的影响。利用全科医生(GP)同事的缺席作为一个工具变量,我们发现工作量的增加导致抗生素处方率的增加以及评估转诊的份额。另一方面,精神药物的数量和频率减少。当医生缺席时,工作量主要集中在全科医生身上,作为对更高工作量压力的回应,咨询模式转向远程互动。对于65岁以上的患者和人手不足的患者,这种影响更为明显。我们的研究揭示了工作压力和患者护理决策之间的复杂关系在初级保健设置。
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引用次数: 0
Expensive today but cheaper tomorrow: lifetime costs of an active middle ear implant compared to alternative treatment options. 今天昂贵,但明天更便宜:与其他治疗方案相比,主动中耳植入的终身成本。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-06 DOI: 10.1007/s10198-024-01743-6
Markus Krohn, Klaas Kiesewetter, Annika Buchholz, Bettina Schlick, Susan Busch, Thomas Lenarz, Anke Lesinski-Schiedat, Hannes Maier, Cornelia Batsoulis, Michael Urban, Steffen Flessa

Background: When choosing between different treatment options, implants often appear too costly. However, this perspective does not take future costs into account. This article evaluates lifetime costs for different surgical interventions to treat hearing loss.

Methods: The analysis focused on three groups from the perspective of health insurers. Group 1 comprises patients who have only been implanted with a middle ear implant. Patients in Group 2 had already undergone middle ear surgery to improve hearing prior to the implantation of a middle ear implant. Group 3 consists of patients who were treated exclusively with hearing-improvement surgeries (no implant). The lifetime costs were calculated using the Monte Carlo simulation. The inputs were based on medical data from a maximum-care hospital and data from the German healthcare system.

Results: Based on an average observation period of 26.73 years, the lifetime costs amounted to 28,325€ for group 1, 32,187€ for group 2 and 28,381€ for group 3. While the mean values between groups 1 and 3 appear comparable, group 1 has a significantly lower standard deviation (G1 vs. G3: 6120€ vs. 10,327€).

Discussion/conclusion: Choosing a treatment option can be a complex medical decision and impose a substantial economic burden for the statutory health insurance. Hence, treatment decisions should be patient-centred at first but also including a shared-decision making on economic feasibility, whether proposed treatment alternatives are likely to be successful and economically reasonable.

背景:在选择不同的治疗方案时,种植体往往显得过于昂贵。然而,这种观点并没有考虑到未来的成本。本文评估了不同手术干预治疗听力损失的终生成本。方法:从健康保险公司的角度对三组人群进行分析。第一组包括只植入了中耳的患者。第2组患者在植入中耳植入物之前已经接受了中耳手术以改善听力。第三组患者仅接受听力改善手术(无植入物)。使用蒙特卡罗模拟计算了寿命成本。输入的数据基于一家最高护理医院的医疗数据和德国医疗保健系统的数据。结果:基于26.73年的平均观察期,第1组的终生成本为28,325欧元,第2组为32187欧元,第3组为28,381欧元。虽然第1组和第3组之间的平均值具有可比性,但第1组的标准差明显较低(G1 vs G3: 6120欧元vs 10327欧元)。讨论/结论:选择一种治疗方案可能是一个复杂的医疗决定,并对法定健康保险造成巨大的经济负担。因此,治疗决策首先应以患者为中心,但也应包括对经济可行性的共同决策,即所提出的治疗方案是否可能成功,在经济上是否合理。
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引用次数: 0
Exploring the social value and design preferences for a home-based dementia community program in Australia. 探索澳大利亚以家庭为基础的痴呆症社区项目的社会价值和设计偏好。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-05 DOI: 10.1007/s10198-024-01738-3
Sabrina Lenzen, Brenda Gannon, Richard Norman, Sally Bennett, Lindy Clemson, Laura Gitlin

We study the monetary value and the relative importance of several program characteristics for an evidence-based intervention provided at home for people living with dementia and their carers in Australia. Using a discrete choice experiment, advised through an expert and consumer co-design approach, we consider the total number of sessions, the delivery mode, the primary outcome and focus of the program as well as its costs as attributes. Results from a representative sample of the Australian adult population show a high willingness to pay for the program overall, even greater than the actual costs. Choice data from 940 respondents show preferences for in-person sessions over telehealth options and respondents place a high value on improving mood and dementia-related behaviour as well as independence in daily activities. Preference heterogeneity shows that people who have experience with home care services place an even higher monetary value on the program, compared to the rest of the sample. In light of the increased emphasis of governments on expanding home care options over residential care, these results contribute towards the design and implementation of a home-based program for people with dementia and their carers and highlight its social value.

我们研究了在澳大利亚为痴呆症患者及其护理人员提供的基于证据的家庭干预的货币价值和几个项目特征的相对重要性。使用离散选择实验,通过专家和消费者共同设计的方法,我们考虑了会议的总数,交付模式,项目的主要结果和重点以及其成本作为属性。从一个代表性的澳大利亚成年人样本中得出的结果显示,他们非常愿意为这个项目买单,甚至比实际成本还要高。来自940名受访者的选择数据显示,与远程医疗方案相比,受访者更喜欢面对面的会议,受访者高度重视改善情绪和与痴呆症相关的行为以及日常活动的独立性。偏好异质性表明,与其他样本相比,有过家庭护理服务经历的人对该计划的货币价值更高。鉴于政府越来越重视扩大家庭护理选择,而不是寄宿护理,这些结果有助于为痴呆症患者及其护理人员设计和实施以家庭为基础的方案,并突出其社会价值。
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引用次数: 0
Costs attributable to hypercholesterolemia in a single period and over the life cycle. 高胆固醇血症在单个时期和整个生命周期的成本。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-01 Epub Date: 2024-03-22 DOI: 10.1007/s10198-024-01684-0
Stephanie Reitzinger, Miriam Reiss, Thomas Czypionka

Hypercholesterolemia is a major risk factor for atherosclerotic cardiovascular disease leading to reduced (healthy) life years. The aim of this study is to quantify the societal costs associated with hypercholesterolemia. We use epidemiologic data on the distribution of cholesterol levels as well as data on relative risks regarding ischemic heart disease, stroke, and other cardiovascular diseases. The analytical approach is based on the use of population-attributable fractions applied to direct medical, direct non-medical and indirect costs using data of Austria. Within a life-cycle analysis we sum up the costs of hypercholesterolemia for the population of 2019 and, thus, consider future morbidity and mortality effects on this population. Epidemiologic data suggest that approximately half of Austria's population have low-density lipoprotein cholesterol (LDL-C) levels above the target levels (i.e., are exposed to increased risk). We estimate that 8.2% of deaths are attributable to hypercholesterolemia. Total costs amount to about 0.33% of GDP in the single-period view. In the life-cycle perspective, total costs amount to €806.06 million, €312.1 million of which are medical costs, and about €494 million arise due to production loss associated with hypercholesterolemia. The study points out that significant shares of deaths, entries into disability pension and care allowance, full-time equivalents lost to the labor market as well as monetary costs for the health system and the society could be avoided if LDL-C-levels of the population were reduced.

高胆固醇血症是动脉粥样硬化性心血管疾病的主要风险因素,会导致(健康)寿命减少。本研究旨在量化与高胆固醇血症相关的社会成本。我们使用了胆固醇水平分布的流行病学数据以及缺血性心脏病、中风和其他心血管疾病的相对风险数据。分析方法是利用奥地利的数据,将人口可归因分数应用于直接医疗、直接非医疗和间接成本。在生命周期分析中,我们总结了高胆固醇血症给 2019 年人口带来的成本,从而考虑了未来发病率和死亡率对这一人口的影响。流行病学数据表明,奥地利约有一半人口的低密度脂蛋白胆固醇(LDL-C)水平高于目标水平(即风险增加)。我们估计,8.2% 的死亡可归因于高胆固醇血症。从单期角度看,总成本约占国内生产总值的 0.33%。从生命周期的角度来看,总成本为 8.0606 亿欧元,其中 3.121 亿欧元为医疗成本,约 4.94 亿欧元为与高胆固醇血症相关的生产损失。研究指出,如果降低人口的低密度脂蛋白胆固醇水平,就可以避免大量死亡、领取伤残抚恤金和护理津贴、丧失相当于全职的劳动力以及卫生系统和社会的货币成本。
{"title":"Costs attributable to hypercholesterolemia in a single period and over the life cycle.","authors":"Stephanie Reitzinger, Miriam Reiss, Thomas Czypionka","doi":"10.1007/s10198-024-01684-0","DOIUrl":"10.1007/s10198-024-01684-0","url":null,"abstract":"<p><p>Hypercholesterolemia is a major risk factor for atherosclerotic cardiovascular disease leading to reduced (healthy) life years. The aim of this study is to quantify the societal costs associated with hypercholesterolemia. We use epidemiologic data on the distribution of cholesterol levels as well as data on relative risks regarding ischemic heart disease, stroke, and other cardiovascular diseases. The analytical approach is based on the use of population-attributable fractions applied to direct medical, direct non-medical and indirect costs using data of Austria. Within a life-cycle analysis we sum up the costs of hypercholesterolemia for the population of 2019 and, thus, consider future morbidity and mortality effects on this population. Epidemiologic data suggest that approximately half of Austria's population have low-density lipoprotein cholesterol (LDL-C) levels above the target levels (i.e., are exposed to increased risk). We estimate that 8.2% of deaths are attributable to hypercholesterolemia. Total costs amount to about 0.33% of GDP in the single-period view. In the life-cycle perspective, total costs amount to €806.06 million, €312.1 million of which are medical costs, and about €494 million arise due to production loss associated with hypercholesterolemia. The study points out that significant shares of deaths, entries into disability pension and care allowance, full-time equivalents lost to the labor market as well as monetary costs for the health system and the society could be avoided if LDL-C-levels of the population were reduced.</p>","PeriodicalId":51416,"journal":{"name":"European Journal of Health Economics","volume":" ","pages":"1595-1603"},"PeriodicalIF":3.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What remains after the money ends? Evidence on whether admission reductions continued following the largest health and social care integration programme in England. 钱花完了,还剩下什么?关于英格兰最大的医疗和社会护理整合计划之后是否继续减少入院人数的证据。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-01 Epub Date: 2024-03-09 DOI: 10.1007/s10198-024-01676-0
Vasudha Wattal, Katherine Checkland, Matt Sutton, Marcello Morciano

We study the long-term effects on hospital activity of a three-year national integration programme. We use administrative data spanning from 24 months before to 22 months after the programme, to estimate the effect of programme discontinuation using difference-in-differences method. Our results show that after programme discontinuation, emergency admissions were slower to increase in Vanguard compared to non-Vanguard sites. These effects were heterogeneous across sites, with greater reductions in care home Vanguard sites and concentrated among the older population. Care home Vanguards showed significant reductions beginning early in the programme but falling away more rapidly after programme discontinuation. Moreover, there were greater reductions for sites performing poorly before the programme. Overall, this suggests the effects of the integration programme might have been lagged but transitory, and more reliant on continued programme support.

我们研究了为期三年的全国一体化计划对医院活动的长期影响。我们利用从计划实施前 24 个月到计划实施后 22 个月的行政数据,采用差分法估算了计划终止的影响。我们的研究结果表明,在计划终止后,"先锋计划 "地区的急诊入院人数增长速度低于非 "先锋计划 "地区。这些影响在不同地点表现不一,护理院先锋计划地点的减少幅度更大,而且主要集中在老年人群中。护理院先锋计划显示,在计划初期,急诊病人数量明显减少,但在计划终止后,急诊病人数量减少的速度更快。此外,在计划实施前表现不佳的地区,减幅更大。总体而言,这表明整合计划的效果可能是滞后的,但也是短暂的,更依赖于持续的计划支持。
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引用次数: 0
The causal effect of early retirement on medication use across sex and occupation: evidence from Danish administrative data. 不同性别和职业提前退休对药物使用的因果效应:来自丹麦行政数据的证据。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-01 Epub Date: 2024-03-13 DOI: 10.1007/s10198-023-01660-0
Jolien Cremers, Torben Heien Nielsen, Claus Thorn Ekstrøm

We examine the causal effect of early retirement on medication use using Danish registry data. A reform in early retirement schemes in 2006 gradually increased eligibility ages from 60 to 64 differentially across birth cohorts. This enables an instrumental variable design that was applied using novel g-estimation methods that alleviate bias in binary outcome IV models. Our data allow studying patterns in the short run (ages 59½-60½) and in the long run (ages 57-63). For those who were eligible already at age 60, retirement did not change overall medication use. However, when investigating medication and population subgroups, we see that painkiller use decreases and hypertension medication as well as mental health medication use increase after retirement in almost all population subgroups. Moreover, males as well as the blue-collar occupation subgroups do show decreases in overall medication use after early retirement. In conclusion, our analyses reveal that retirement can have important heterogeneous health effects across population groups and are potentially informative about the welfare benefits of social insurance more broadly.

我们利用丹麦的登记数据研究了提前退休对药物使用的因果影响。2006 年,提前退休计划进行了改革,不同出生队列的合格年龄从 60 岁逐步提高到 64 岁。因此,我们采用了工具变量设计,并使用新颖的 g-estimation 方法来减轻二元结果 IV 模型的偏差。我们的数据可以研究短期(59½-60½ 岁)和长期(57-63 岁)的模式。对于那些在 60 岁时已经符合条件的人来说,退休并没有改变总体用药情况。然而,在对药物和人口亚群进行调查时,我们发现几乎在所有人口亚群中,退休后止痛药的使用都会减少,而高血压药物和精神疾病药物的使用都会增加。此外,男性和蓝领职业亚群在提前退休后的总体用药量确实有所减少。总之,我们的分析表明,退休会对不同人群的健康产生重要的异质性影响,并有可能为更广泛的社会保险福利提供信息。
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引用次数: 0
Economic value of diastasis repair with the use of mesh compared to no intervention in Italy. 意大利使用网片修复腹膜膨出与不进行干预的经济价值比较。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-01 Epub Date: 2024-03-14 DOI: 10.1007/s10198-024-01685-z
Carla Rognoni, Alessandro Carrara, Micaela Piccoli, Vincenzo Trapani, Nereo Vettoretto, Giorgio Soliani, Rosanna Tarricone

Aim: Rectus abdominal diastasis (RAD) can cause mainly incontinence and lower-back pain. Despite its high incidence, there is no consensus regarding surgical indication. We aimed at comparing RAD repair (minimally invasive technique with mesh implant) with no treatment (standard of care - SOC) through cost-effectiveness and budget impact analyses from both National Healthcare Service (NHS) and societal perspectives in Italy.

Methods: A model was developed including social costs and productivity losses derived by the online administration of a socio-economic questionnaire, including the EuroQol for the assessment of quality of life. Costs for the NHS were based on reimbursement tariffs.

Results: Over a lifetime horizon, estimated costs were 64,115€ for SOC and 46,541€ for RAD repair in the societal perspective; QALYs were 19.55 and 25.75 for the two groups, respectively. Considering the NHS perspective, RAD repair showed an additional cost per patient of 5,104€ compared to SOC, leading to an ICUR of 824€. RAD repair may be either cost-saving or cost-effective compared to SOC depending on the perspective considered. Considering a current scenario of 100% SOC, an increased diffusion of RAD repair from 2 to 10% in the next 5 years would lead to an incremental cost of 184,147,624€ for the whole society (87% borne by the NHS) and to incremental 16,155 QALYs.

Conclusion: In light of the lack of economic evaluations for minimally invasive RAD repair, the present study provides relevant clinical and economic evidence to help improving the decision-making process and allocating scarce resources between competing ends.

目的:腹直肌舒张症(RAD)主要会导致大小便失禁和下背部疼痛。尽管其发病率很高,但在手术适应症方面尚未达成共识。我们从意大利国家医疗服务体系(NHS)和社会角度出发,通过成本效益和预算影响分析,对 RAD 修复术(植入网片的微创技术)和不治疗(标准护理 - SOC)进行了比较:方法:建立了一个包括社会成本和生产力损失的模型,该模型是通过在线进行社会经济问卷调查得出的,其中包括用于评估生活质量的 EuroQol。国家医疗服务体系(NHS)的成本以报销标准为基础:在一生中,从社会角度来看,SOC 的估计成本为 64,115 欧元,RAD 修复的估计成本为 46,541 欧元;两组的 QALY 分别为 19.55 和 25.75。从国家医疗服务体系的角度来看,RAD修复术与SOC相比,每位患者的额外费用为5104欧元,导致ICUR为824欧元。根据考虑的角度不同,RAD 修复术与 SOC 相比,既可能节省成本,也可能具有成本效益。考虑到目前100% SOC的情况,如果在未来5年内将RAD修复术的普及率从2%提高到10%,那么整个社会将增加184,147,624欧元的成本(87%由NHS承担),并增加16,155 QALYs:鉴于缺乏对微创 RAD 修复的经济评估,本研究提供了相关的临床和经济证据,有助于改善决策过程,并在相互竞争的目标之间分配稀缺资源。
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引用次数: 0
Antivirals to prepare for surges in influenza cases: an economic evaluation of baloxavir marboxil for the Netherlands. 抗病毒药物为流感病例激增做准备:对荷兰巴洛沙韦 marboxil 的经济评估。
IF 3.1 3区 医学 Q1 ECONOMICS Pub Date : 2024-12-01 Epub Date: 2024-03-14 DOI: 10.1007/s10198-024-01683-1
Simon van der Pol, Maarten J Postma, Cornelis Boersma

Objectives: We perform a cost-effectiveness analysis (CEA) and budget impact analysis (BIA) of baloxavir marboxil compared to current care in the Netherlands for patients at risk of influenza-related complications, including patients with comorbidities and the elderly.

Methods: In the CEA, a decision tree model was developed to assess the cost-effectiveness of baloxavir marboxil for a cohort of 52-year-olds from a societal perspective. A lifetime horizon was taken by incorporating the quality-adjusted life expectancy. The BIA included different epidemiological scenarios, estimating different plausible epidemiological scenarios for seasonal influenza considering the whole Dutch population with an increased risk of influenza complications.

Results: The base-case ICER was estimated to be €8,300 per QALY. At the willingness-to-pay threshold of €20,000 per QALY, the probability of being cost effective was 58%. The base-case expected budget impact was €5.7 million on average per year, ranging from €1.5 million to €10.5 million based on the severity of the influenza epidemic and vaccine effectiveness.

Conclusion: In the Netherlands, baloxavir is a cost-effective treatment option for seasonal influenza, with a base-case ICER of €8,300 per QALY for the population aged 60 years and over and patients at high risk of influenza-related complications. For a large part, this ICER is driven by the reduction of the illness duration of influenza and productivity gains in the working population.

研究目的在荷兰,我们对有流感相关并发症风险的患者(包括合并症患者和老年人)进行了一项成本效益分析(CEA)和预算影响分析(BIA):在成本效益分析中,我们开发了一个决策树模型,从社会角度评估52岁人群使用巴洛沙韦马来酸盐的成本效益。通过将质量调整预期寿命纳入其中,得出了终生预期寿命。BIA 包括不同的流行病学情景,估计了季节性流感的不同可信流行病学情景,考虑到整个荷兰人口的流感并发症风险增加:基本情况下的 ICER 估计为每 QALY 8,300 欧元。在每 QALY 20,000 欧元的支付意愿阈值下,具有成本效益的概率为 58%。根据流感疫情的严重程度和疫苗的有效性,基础案例的预期预算影响为平均每年570万欧元,从150万欧元到1050万欧元不等:在荷兰,巴洛沙韦是一种具有成本效益的季节性流感治疗方案,对于 60 岁及以上人群和流感相关并发症高风险患者而言,其基础病例 ICER 为每 QALY 8,300 欧元。这一 ICER 很大程度上是由于流感病程的缩短和工作人群生产率的提高。
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引用次数: 0
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