Pub Date : 2024-07-15DOI: 10.30651/jqm.v8i02.21060
Ahmad Ikliluddin, Adey Rahmat Saputra
Smartphones today have been used to support human activities. It makes the human eye always exposed to smartphone screens that use light-emitting diodes (LEDs) that emit light with a blue electromagnetic spectrum known as blue light. The effect of blue light on human eyes is still being studied. This study aims to determine the effect of using smartphone blue light filter features on tear production. This was a quasi-experimental, pre-post study, involving 40 samples who met the inclusion and exclusion criteria. Subjects were asked to use a smartphone within 1 week without activating a blue light filter. After this, tear production was measured using the Schirmer test under topical anesthesia. Then, subjects were asked to use a smartphone again within 1 week by activating the blue light filter and being measured again using the Schirmer test under topical anesthesia. Data obtained were analyzed using SPSS 25 software. There was a statistically significant (sig=0.000) difference in Schirmer test values before and after the usage of smartphone blue light filters. Each increase in the duration of smartphone usage for one minute will decrease Schirmer test results by 0.000625 mm, and so will the multiplication. The duration of smartphone usage has a 21.6% contribution of influence on the results of the Schirmer test. In conclusion, there is an effect of using the blue light filter feature on tear production between the use of a smartphone without activating the blue light filter with the use of a smartphone that activates the blue light filter feature.
{"title":"The effect of using the smartphone blue light filter feature on tear production","authors":"Ahmad Ikliluddin, Adey Rahmat Saputra","doi":"10.30651/jqm.v8i02.21060","DOIUrl":"https://doi.org/10.30651/jqm.v8i02.21060","url":null,"abstract":"Smartphones today have been used to support human activities. It makes the human eye always exposed to smartphone screens that use light-emitting diodes (LEDs) that emit light with a blue electromagnetic spectrum known as blue light. The effect of blue light on human eyes is still being studied. This study aims to determine the effect of using smartphone blue light filter features on tear production. This was a quasi-experimental, pre-post study, involving 40 samples who met the inclusion and exclusion criteria. Subjects were asked to use a smartphone within 1 week without activating a blue light filter. After this, tear production was measured using the Schirmer test under topical anesthesia. Then, subjects were asked to use a smartphone again within 1 week by activating the blue light filter and being measured again using the Schirmer test under topical anesthesia. Data obtained were analyzed using SPSS 25 software. There was a statistically significant (sig=0.000) difference in Schirmer test values before and after the usage of smartphone blue light filters. Each increase in the duration of smartphone usage for one minute will decrease Schirmer test results by 0.000625 mm, and so will the multiplication. The duration of smartphone usage has a 21.6% contribution of influence on the results of the Schirmer test. In conclusion, there is an effect of using the blue light filter feature on tear production between the use of a smartphone without activating the blue light filter with the use of a smartphone that activates the blue light filter feature.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"91 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.30651/jqm.v8i02.22603
N. Lutfiana, A. F. Purnomo, Nur Aisah Ibrahimiyah
Genetic mutations in the androgen receptor (AR) gene have been identified as the cause of androgen insensitivity syndrome. These mutations are linked to inconsistent development of the Wolffian duct and may result in conditions such as micropenis, hypospadias, and cryptorchidism. The androgen receptor has two polymorphic sites located in exon 1, which consists of varying amounts of CAG and GGN repeats. These repetitions lead to the formation of polyglutamine and polyglycine stretches of varied lengths. Increased CAG repeats lead to a decrease in androgen receptor transcriptional activity, but the impact of GGN triplets is less well understood. This research examined the CAG and GGN repeat lengths in males who had a past medical record of cryptorchidism. Prospective and retrospective observational studies from PubMed, Science Direct, and Embase were systematically searched up to 15th November 2020. Primary outcomes were analyzed using a fixed or random effect model regarding its heterogeneity and continued with multilevel modeling of each polymorphism and ethnicity. CAG and GGN repeat polymorphism was found to be significantly different compared to control in contributing to cryptorchidism (CAG: 0.55 [CI 95%=0.19-0.91]; p-value=0.003 and GGN 0.90 [CI95%=0.65-1.15]; p value<0.000). In conclusion, CAG and GGN repeat polymorphism have an essential role in the incidence of cryptorchidism.
{"title":"Polymorphic CAG and GGN repeats in Cryptorchidism patient risk: A meta-analytical study","authors":"N. Lutfiana, A. F. Purnomo, Nur Aisah Ibrahimiyah","doi":"10.30651/jqm.v8i02.22603","DOIUrl":"https://doi.org/10.30651/jqm.v8i02.22603","url":null,"abstract":"Genetic mutations in the androgen receptor (AR) gene have been identified as the cause of androgen insensitivity syndrome. These mutations are linked to inconsistent development of the Wolffian duct and may result in conditions such as micropenis, hypospadias, and cryptorchidism. The androgen receptor has two polymorphic sites located in exon 1, which consists of varying amounts of CAG and GGN repeats. These repetitions lead to the formation of polyglutamine and polyglycine stretches of varied lengths. Increased CAG repeats lead to a decrease in androgen receptor transcriptional activity, but the impact of GGN triplets is less well understood. This research examined the CAG and GGN repeat lengths in males who had a past medical record of cryptorchidism. Prospective and retrospective observational studies from PubMed, Science Direct, and Embase were systematically searched up to 15th November 2020. Primary outcomes were analyzed using a fixed or random effect model regarding its heterogeneity and continued with multilevel modeling of each polymorphism and ethnicity. CAG and GGN repeat polymorphism was found to be significantly different compared to control in contributing to cryptorchidism (CAG: 0.55 [CI 95%=0.19-0.91]; p-value=0.003 and GGN 0.90 [CI95%=0.65-1.15]; p value<0.000). In conclusion, CAG and GGN repeat polymorphism have an essential role in the incidence of cryptorchidism.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.30651/jqm.v8i02.20427
Mira Kusuma Wardhani, Harry Kurniawan Gondo
Around the world, preeclampsia (PE) influences five to eight percent of pregnancies and contributes significantly to maternal mortality. This study applies a scientific observational cross-sectional review to examine how TNF-α, TNF-R1, and TNF-R2 play their roles in normal pregnancy, preeclampsia, and preeclampsia associated with sepsis. Blood tests were gathered from subjects at a local medical clinic in Malang, Indonesia, and TNF-α, TNF-R1, and TNF-R2 levels were surveyed utilizing the Enzyme-linked Immunosorbent Assay (ELISA) strategy. The results demonstrate raised TNF-α levels in both preeclampsia and preeclampsia with sepsis, along with expanded TNF-R1 and TNF-R2 receptor levels, signifying their association in these circumstances. Validation through bigger scope studies is basic, possibly situating TNF-α as an early indicative biomarker for sepsis. This study highlights the importance of TNF-α in pregnant mothers with preeclampsia and preeclampsia muddled by sepsis, uncovering possible analytic and remedial avenues.
{"title":"Exploring cytokine levels in pregnancy, preeclampsia, and sepsis-complicated preeclampsia","authors":"Mira Kusuma Wardhani, Harry Kurniawan Gondo","doi":"10.30651/jqm.v8i02.20427","DOIUrl":"https://doi.org/10.30651/jqm.v8i02.20427","url":null,"abstract":"Around the world, preeclampsia (PE) influences five to eight percent of pregnancies and contributes significantly to maternal mortality. This study applies a scientific observational cross-sectional review to examine how TNF-α, TNF-R1, and TNF-R2 play their roles in normal pregnancy, preeclampsia, and preeclampsia associated with sepsis. Blood tests were gathered from subjects at a local medical clinic in Malang, Indonesia, and TNF-α, TNF-R1, and TNF-R2 levels were surveyed utilizing the Enzyme-linked Immunosorbent Assay (ELISA) strategy. The results demonstrate raised TNF-α levels in both preeclampsia and preeclampsia with sepsis, along with expanded TNF-R1 and TNF-R2 receptor levels, signifying their association in these circumstances. Validation through bigger scope studies is basic, possibly situating TNF-α as an early indicative biomarker for sepsis. This study highlights the importance of TNF-α in pregnant mothers with preeclampsia and preeclampsia muddled by sepsis, uncovering possible analytic and remedial avenues. \u0000 ","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"21 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.30651/jqm.v8i02.20561
Fery Setiawan, Ahmad Yudianto, Arif Rahman Nurdianto, J. Sunariani, Latief Mooduto
Criminal acts often leave traces analyzed by law enforcement, especially by the Indonesian National Police (POLRI). Sometimes, various items were found and analyzed to link the victim and the perpetrator. Blood, the most abundant body fluid, found in crime scenes, consists of cellular and liquid elements. The forensic focuses on red blood, which can be wet or dried at the crime scene. Sometimes, there was no blood or bloodstains found, but objects related to other body fluids, such as: condoms, toothbrushes, the mouth of glass cups, straws, etc, could be found. Blood group analysis could still be carried out based on secretor gene (Se) considering that 80% of the population was of the secretor group. There are two chromosomes related to blood regulation, namely: chromosomes no. 9 and 19. The former relates to the ABO blood group and the latter relates to the secretory phenotype. The basic principle of secretors was antigens found on the surface of red blood cells and all body fluids, except cerebrospinal fluid. The pattern of inheritance on chromosomes 9 and 19 is based on the probability law by Mendell. It stated that all of genotypes (homozygous dominant-recessive or heterozygous) would be passed on to their offspring.
{"title":"Determination of ABO blood group based on secretors or non-secretors analysis in body fluids","authors":"Fery Setiawan, Ahmad Yudianto, Arif Rahman Nurdianto, J. Sunariani, Latief Mooduto","doi":"10.30651/jqm.v8i02.20561","DOIUrl":"https://doi.org/10.30651/jqm.v8i02.20561","url":null,"abstract":"Criminal acts often leave traces analyzed by law enforcement, especially by the Indonesian National Police (POLRI). Sometimes, various items were found and analyzed to link the victim and the perpetrator. Blood, the most abundant body fluid, found in crime scenes, consists of cellular and liquid elements. The forensic focuses on red blood, which can be wet or dried at the crime scene. Sometimes, there was no blood or bloodstains found, but objects related to other body fluids, such as: condoms, toothbrushes, the mouth of glass cups, straws, etc, could be found. Blood group analysis could still be carried out based on secretor gene (Se) considering that 80% of the population was of the secretor group. There are two chromosomes related to blood regulation, namely: chromosomes no. 9 and 19. The former relates to the ABO blood group and the latter relates to the secretory phenotype. The basic principle of secretors was antigens found on the surface of red blood cells and all body fluids, except cerebrospinal fluid. The pattern of inheritance on chromosomes 9 and 19 is based on the probability law by Mendell. It stated that all of genotypes (homozygous dominant-recessive or heterozygous) would be passed on to their offspring.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.30651/jqm.v8i02.22152
Ratna Kusumawati, E. Koendhori, N. Mertaniasih, Irfan Arif Ikhwani, Dimas Firman Hidayat, Yelvi Levani, Ayu Lidya Paramitha
The prevalence of Multidrug antibiotic-resistant Pseudomonas aeruginosa (MDRPA) has been increasing during the decade And has become attention in hospital patients. This retrospective descriptive descriptive aimed to determine the prevalence of MDRPA and its sensitivity patterns. Data were taken from results of bacterial culture and antibiotic resistance tests from various clinical specimens from patients at Dr. Soetomo General Academic Hospital throughout 2022-2023. The resistance test was carried out using a Vitek 2 compact instrument. MDRPA is defined as Pseudomonas aeruginosa that is not sensitive to three or more of the following classes of antibiotics: meropenem or imipenem, ciprofloxacin, gentamicin or amikacin, ceftazidime or cefepime, and piperacillin/ tazobactam. The prevalence of MDRPA was 57.0%. MDRPA isolates were also the most common origin from the burn unit and HCU A (high care unit A), mostly from pus specimens and sputum. Pseudomonas aeruginosa sensitivity was best with piperacillin/tazobactam (55.5%), meropenem (54.8%), amikacin (47.5%), gentamicin (46.5%), cefepime (46.3%), ceftazidime (45.0%), ciprofloxacin (44.7%) and aztreonam (43.2%). The sensitivity of MDRPA to antibiotics is much lower than that of Pseudomonas aeruginosa. This study showed high number of MDRPA specifically in Surabaya and the pattern sensitivity of Pseudomonas aeruginosa can become guidelines in choosing antibiotics treatment for patients.
{"title":"Prevalence And Pattern Sensitivity Multidrug Antibiotics Resistant Pseudomonas aeruginosa in the High Care Unit at Dr. Soetomo General Academic Hospital Period 2022-2023","authors":"Ratna Kusumawati, E. Koendhori, N. Mertaniasih, Irfan Arif Ikhwani, Dimas Firman Hidayat, Yelvi Levani, Ayu Lidya Paramitha","doi":"10.30651/jqm.v8i02.22152","DOIUrl":"https://doi.org/10.30651/jqm.v8i02.22152","url":null,"abstract":"The prevalence of Multidrug antibiotic-resistant Pseudomonas aeruginosa (MDRPA) has been increasing during the decade And has become attention in hospital patients. This retrospective descriptive descriptive aimed to determine the prevalence of MDRPA and its sensitivity patterns. Data were taken from results of bacterial culture and antibiotic resistance tests from various clinical specimens from patients at Dr. Soetomo General Academic Hospital throughout 2022-2023. The resistance test was carried out using a Vitek 2 compact instrument. MDRPA is defined as Pseudomonas aeruginosa that is not sensitive to three or more of the following classes of antibiotics: meropenem or imipenem, ciprofloxacin, gentamicin or amikacin, ceftazidime or cefepime, and piperacillin/ tazobactam. The prevalence of MDRPA was 57.0%. MDRPA isolates were also the most common origin from the burn unit and HCU A (high care unit A), mostly from pus specimens and sputum. Pseudomonas aeruginosa sensitivity was best with piperacillin/tazobactam (55.5%), meropenem (54.8%), amikacin (47.5%), gentamicin (46.5%), cefepime (46.3%), ceftazidime (45.0%), ciprofloxacin (44.7%) and aztreonam (43.2%). The sensitivity of MDRPA to antibiotics is much lower than that of Pseudomonas aeruginosa. This study showed high number of MDRPA specifically in Surabaya and the pattern sensitivity of Pseudomonas aeruginosa can become guidelines in choosing antibiotics treatment for patients.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"17 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Congenital pseudarthrosis of the tibia (CPT) is an infrequently observed condition. However, it is considered to be one of the most complex ailments in the field of pediatric orthopedics. In cases where a tibial fracture is absent, the conventional treatment approach involves using bracing as a preventive measure against fractures. Various surgical modalities have been proposed for the management of CPT, including intramedullary (IM) rod fixation, external fixators, on-lay grafts, cancellous grafts, periosteal grafts, Paley cross-union, amputation, vascularized fibula grafts, and induced membrane techniques. These modalities can be used in different combinations and permutations. The need for repetitive surgical interventions due to unsuccessful therapeutic outcomes or modifications in secondary treatments can significantly disrupt the childhood experience, resulting in prolonged and recurrent functional limitations. In certain instances, amputation may be required as a primary or secondary treatment modality. This literature review will clarify the current surgical interventions for CPT disease based on a summary of research data. The surgery the patient receives significantly impacts their general health and capacity to heal.
{"title":"A literature review of current surgical treatment for congenital pseudoarthrosis of the tibia","authors":"Panji Sananta, Ade Yahya Nasution, Eka Noviya Fuzianingsih","doi":"10.30651/jqm.v8i02.19066","DOIUrl":"https://doi.org/10.30651/jqm.v8i02.19066","url":null,"abstract":"Congenital pseudarthrosis of the tibia (CPT) is an infrequently observed condition. However, it is considered to be one of the most complex ailments in the field of pediatric orthopedics. In cases where a tibial fracture is absent, the conventional treatment approach involves using bracing as a preventive measure against fractures. Various surgical modalities have been proposed for the management of CPT, including intramedullary (IM) rod fixation, external fixators, on-lay grafts, cancellous grafts, periosteal grafts, Paley cross-union, amputation, vascularized fibula grafts, and induced membrane techniques. These modalities can be used in different combinations and permutations. The need for repetitive surgical interventions due to unsuccessful therapeutic outcomes or modifications in secondary treatments can significantly disrupt the childhood experience, resulting in prolonged and recurrent functional limitations. In certain instances, amputation may be required as a primary or secondary treatment modality. This literature review will clarify the current surgical interventions for CPT disease based on a summary of research data. The surgery the patient receives significantly impacts their general health and capacity to heal.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"23 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noise Induced Hearing Loss (NIHL) is sensorineural deafness caused by hearing threshold values in the workplace. According to the Regulation of the Minister of Manpower and Transmigration Number 13 of 2011 it regulates the threshold and chemical factors. The threshold value is 85 dB with 8 hours/day noise exposure time. This study aimed to determine the relationship between work period and the incidence of NIHL in PT. Kayu Perkasa Raya. The type of research used was quantitative with observational analytic methods. Data was obtained from questionnaires and audiometric results. The research design used cross-sectional, a study between measurement and observation variables that were carried out simultaneously. The sampling technique was purposive sampling. The analysis used using chi-square. The distribution was based on a working period. During the working period of ≥ 5 years, there were 10 people (33.3%) who experienced NIHL, and 20 people (66.7%) who did not experience NIHL. During the working period < 5 years, two people (11.1%) experienced NIHL, and 16 people (88.9%) did not experience NIHL (p=0.081). In conclusion, no significant relationship exists between the work period and NIHL at PT.Kayu Perkasa Raya.
{"title":"The relationship between work period and hearing disorder caused by noise in workers of PT. Kayu Perkasa Raya","authors":"Astin prima Sari, Rakhma Auliya Sari, Ika Dyah, Wahju Budi Martono","doi":"10.30651/jqm.v8i01.18942","DOIUrl":"https://doi.org/10.30651/jqm.v8i01.18942","url":null,"abstract":"Noise Induced Hearing Loss (NIHL) is sensorineural deafness caused by hearing threshold values in the workplace. According to the Regulation of the Minister of Manpower and Transmigration Number 13 of 2011 it regulates the threshold and chemical factors. The threshold value is 85 dB with 8 hours/day noise exposure time. This study aimed to determine the relationship between work period and the incidence of NIHL in PT. Kayu Perkasa Raya. The type of research used was quantitative with observational analytic methods. Data was obtained from questionnaires and audiometric results. The research design used cross-sectional, a study between measurement and observation variables that were carried out simultaneously. The sampling technique was purposive sampling. The analysis used using chi-square. The distribution was based on a working period. During the working period of ≥ 5 years, there were 10 people (33.3%) who experienced NIHL, and 20 people (66.7%) who did not experience NIHL. During the working period < 5 years, two people (11.1%) experienced NIHL, and 16 people (88.9%) did not experience NIHL (p=0.081). In conclusion, no significant relationship exists between the work period and NIHL at PT.Kayu Perkasa Raya.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"55 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.30651/jqm.v8i01.18617
N. Meida, Bambang Purwanto, B. Wasita, S. Indrakila, S. Soetrisno
Propolis is an herbal medicinal plant that contains caffeic acid phenethyl ester. This natural polyphenol compound acts as an antioxidant and can reduce blood glucose levels and increase body weight. This study aims to determine the effectiveness of Gunung Lawu propolis in lowering blood glucose levels and increasing body weight in diabetic rats. The Wistar rats were induced with STZ 45 mg/kg BW and nicotinamide 110 mg/kg BW as diabetic model rats. Research subjects were taken randomly and divided into five groups: (1) Normal, (2) DM with no propolis, (3) DM 14 days + propolis 100 mg/kg BW/day (P1), (4) DM 14 days + Propolis 200 mg/kg BW/day (P2), and (5) DM 0 day + Propolis 200 mg/kg BW/day (P3). Propolis extract was given orally once a day for 14 consecutive days (in groups 3 and 4) and 28 consecutive days (in group 5). Blood glucose levels in the treatment group (P1, P2, and P3) decreased significantly (P1: 115.28 ± 4.7 mg/dL; P2: 98.36 ± 4.8 mg/dL; and P3: 87.36 ± 4, 2 mg/dL) compared with that in the DM group (272.07 ± 3.9 mg/dL). The body weight of the treatment group (P1, P2, and P3) increased significantly (P1: 180.60 ± 5.7 g; P2: 180.60 ± 4.2 g; and P3: 208.00 ± 5.1 gr) compared with that in the DM group (160.00 ± 3.2 gr). In conclusion, Propolis is effective in reducing blood glucose levels and improving (increasing) body weight in diabetic model rats.
{"title":"Propolis effectiveness on the reduction of blood glucose level and improvement of body weight in diabetic model's rat","authors":"N. Meida, Bambang Purwanto, B. Wasita, S. Indrakila, S. Soetrisno","doi":"10.30651/jqm.v8i01.18617","DOIUrl":"https://doi.org/10.30651/jqm.v8i01.18617","url":null,"abstract":"Propolis is an herbal medicinal plant that contains caffeic acid phenethyl ester. This natural polyphenol compound acts as an antioxidant and can reduce blood glucose levels and increase body weight. This study aims to determine the effectiveness of Gunung Lawu propolis in lowering blood glucose levels and increasing body weight in diabetic rats. The Wistar rats were induced with STZ 45 mg/kg BW and nicotinamide 110 mg/kg BW as diabetic model rats. Research subjects were taken randomly and divided into five groups: (1) Normal, (2) DM with no propolis, (3) DM 14 days + propolis 100 mg/kg BW/day (P1), (4) DM 14 days + Propolis 200 mg/kg BW/day (P2), and (5) DM 0 day + Propolis 200 mg/kg BW/day (P3). Propolis extract was given orally once a day for 14 consecutive days (in groups 3 and 4) and 28 consecutive days (in group 5). Blood glucose levels in the treatment group (P1, P2, and P3) decreased significantly (P1: 115.28 ± 4.7 mg/dL; P2: 98.36 ± 4.8 mg/dL; and P3: 87.36 ± 4, 2 mg/dL) compared with that in the DM group (272.07 ± 3.9 mg/dL). The body weight of the treatment group (P1, P2, and P3) increased significantly (P1: 180.60 ± 5.7 g; P2: 180.60 ± 4.2 g; and P3: 208.00 ± 5.1 gr) compared with that in the DM group (160.00 ± 3.2 gr). In conclusion, Propolis is effective in reducing blood glucose levels and improving (increasing) body weight in diabetic model rats.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"63 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.30651/jqm.v8i01.16060
Iswandi Darwis, Anggoro Budi Hartapo, Muhammad Gahan Sarwiko
ST-elevation myocardial infarction is a form of acute coronary syndrome that is the leading cause of death worldwide. Treatment with reperfusion therapy in the form of primary percutaneous intervention is the main treatment to reduce morbidity and mortality. However, reperfusion therapy is not recommended for patients presenting with symptoms onset of more than 48 hours. A 62-year-old male patient was diagnosed with anterior STEMI with symptoms onset of more than 48 hours based on complaints of anginal chest pain and shortness of breath. ST-segment elevation in V1-V4 and pathological Q in V1-V3 on ECG and increased hs-Troponin I was reported. The patient was not treated with reperfusion therapy based on treatment recommendations. The patient was given vasodilators, beta-blockers, statins, heparinization, and comorbid infection control in the cardiac care ward. Clinical improvement was obtained, and the patient was discharged after seven days of hospitalization and then was planned for Dobutamine Stress Echo during the follow-up visit. Conservative management and viability testing are the main options for patient management in STEMI with symptom onset of more than 48 hours without any complaints of chest pain, stable hemodynamics, and no life-threatening arrhythmia.
{"title":"Management of anterior ST-elevation myocardial infarction presenting more than 48 hours from symptom onset without reperfusion therapy in the cardiac care unit","authors":"Iswandi Darwis, Anggoro Budi Hartapo, Muhammad Gahan Sarwiko","doi":"10.30651/jqm.v8i01.16060","DOIUrl":"https://doi.org/10.30651/jqm.v8i01.16060","url":null,"abstract":"ST-elevation myocardial infarction is a form of acute coronary syndrome that is the leading cause of death worldwide. Treatment with reperfusion therapy in the form of primary percutaneous intervention is the main treatment to reduce morbidity and mortality. However, reperfusion therapy is not recommended for patients presenting with symptoms onset of more than 48 hours. A 62-year-old male patient was diagnosed with anterior STEMI with symptoms onset of more than 48 hours based on complaints of anginal chest pain and shortness of breath. ST-segment elevation in V1-V4 and pathological Q in V1-V3 on ECG and increased hs-Troponin I was reported. The patient was not treated with reperfusion therapy based on treatment recommendations. The patient was given vasodilators, beta-blockers, statins, heparinization, and comorbid infection control in the cardiac care ward. Clinical improvement was obtained, and the patient was discharged after seven days of hospitalization and then was planned for Dobutamine Stress Echo during the follow-up visit. Conservative management and viability testing are the main options for patient management in STEMI with symptom onset of more than 48 hours without any complaints of chest pain, stable hemodynamics, and no life-threatening arrhythmia.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"12 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-09DOI: 10.30651/jqm.v8i01.20763
F. Setianingrum, A. Rozaliyani
Tuberculosis (TB) is the main risk factor for chronic pulmonary aspergillosis, especially in patients with residual cavitary lesions after completion of TB therapy. The body mass index (BMI) is one of the established markers in predicting the mortality of CPA. However, the data regarding BMI profiles of CPA patients in Indonesia is still limited. We evaluated the BMI profiles of CPA patients among post-TB patients. Patients diagnosed as CPA based on clinical, radiology and the Aspergillus IgG test. 50 patients were included with a mean age of 35 years; 13 patients met the criteria of CPA. The overall median of BMI in these patients was 21. The median BMI in the CPA group was 19,3. The lowest (19,8) median BMI value was observed in the positive Aspergillus IgG group (11,5 – 30 mg/L) with a minimum BMI of 14,7 and a maximum BMI of 29,2. The differences in median BMI across CPA and non CPA groups and Aspergillus IgG level were not statistically significant. However, there is a trend that lower BMI were distributed among patients with positive Aspergillus IgG. More than one third of CPA patients in this study were classified as underweight. Future study is necessary to better depict the BMI profiles in larger scale of populations of CPA in Indonesia in order to achieve better diagnosis and management of CPA.
{"title":"The body mass index profiles in chronic pulmonary aspergillosis: trend and variability in post tuberculosis patients","authors":"F. Setianingrum, A. Rozaliyani","doi":"10.30651/jqm.v8i01.20763","DOIUrl":"https://doi.org/10.30651/jqm.v8i01.20763","url":null,"abstract":"Tuberculosis (TB) is the main risk factor for chronic pulmonary aspergillosis, especially in patients with residual cavitary lesions after completion of TB therapy. The body mass index (BMI) is one of the established markers in predicting the mortality of CPA. However, the data regarding BMI profiles of CPA patients in Indonesia is still limited. We evaluated the BMI profiles of CPA patients among post-TB patients. Patients diagnosed as CPA based on clinical, radiology and the Aspergillus IgG test. 50 patients were included with a mean age of 35 years; 13 patients met the criteria of CPA. The overall median of BMI in these patients was 21. The median BMI in the CPA group was 19,3. The lowest (19,8) median BMI value was observed in the positive Aspergillus IgG group (11,5 – 30 mg/L) with a minimum BMI of 14,7 and a maximum BMI of 29,2. The differences in median BMI across CPA and non CPA groups and Aspergillus IgG level were not statistically significant. However, there is a trend that lower BMI were distributed among patients with positive Aspergillus IgG. More than one third of CPA patients in this study were classified as underweight. Future study is necessary to better depict the BMI profiles in larger scale of populations of CPA in Indonesia in order to achieve better diagnosis and management of CPA.","PeriodicalId":516299,"journal":{"name":"Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya","volume":"50 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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