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Comparison of the efficacy Talc solution injection through Chest Tube and Talcum Powder through Pleuroscopy for the Treatment of Malignant Pleural Effusion: a randomized clinical trial 通过胸腔插管注射滑石粉溶液和通过胸腔镜注射滑石粉治疗恶性胸腔积液的疗效比较:随机临床试验
Pub Date : 2024-01-17 DOI: 10.18502/ajs.v6i1.14712
Nima Taghizadeh, Reza Ershadi, A. Notash, Behnam Molavi, Ali Ghorbani Abdgah, Mahsa Najafi Kandovan
Background: The aim of the present study was to compare the different outcomes and response rates of talc powder injection via chest tube and talc spray through thoracoscopy in the treatment of malignant pleural effusion in patients. Methods: In this randomized controlled trial, patients with malignant pleural effusion, who were hospitalized in the surgery and hematology-oncology departments of Shariati and Imam Khomeini Hospitals, were enrolled. The patients were randomly divided into two groups: chest tube and pleuroscopy, using simple randomization. The mean and standard deviation, frequency and percentage, independent sample t-tests, chi-square, and Fisher’s exact tests were used for data analysis. A p-value of less than 0.05 was considered statistically significant. Results: No significant difference was observed between the two groups in the incidences of chest pain, fever, and both symptoms (p > 0.05). The treatment success rates among the chest tube and pleuroscopy cases were 83.3% and 100%, respectively, and there was no significant difference between the two groups (p = 0.05). Among the five patients who had a recurrence, four (80%) had lung cancer, and one (20%) had liver cancer, and this difference was significant (P = 0.003). Regarding the rate of response to the treatment according to the side with effusion, among the people who had a relapse, two people (40%) had right-sided effusion, and three others (60%) had left-sided effusion (P = 0.623). Conclusions: Both techniques were safe, had minor side effects, were transient, and easy to manage. However, the recurrence of the disease in the thoracoscopic pleurodesis method was significantly less than in the chest tube.  
研究背景本研究旨在比较经胸管注射滑石粉和经胸腔镜喷洒滑石粉治疗恶性胸腔积液患者的不同疗效和反应率。研究方法在这项随机对照试验中,沙里亚蒂医院和伊玛目霍梅尼医院外科和血液肿瘤科住院的恶性胸腔积液患者被纳入研究对象。采用简单随机法将患者随机分为两组:胸腔插管组和胸腔镜检查组。数据分析采用平均值和标准差、频率和百分比、独立样本 t 检验、卡方检验和费雪精确检验。P 值小于 0.05 即为具有统计学意义。结果两组患者的胸痛、发热和两种症状的发生率无明显差异(P>0.05)。胸腔插管和胸腔镜检查病例的治疗成功率分别为 83.3% 和 100%,两组间无明显差异(P = 0.05)。在复发的五例患者中,四例(80%)为肺癌,一例(20%)为肝癌,差异有学意义(P = 0.003)。关于有渗出的一侧对治疗的反应率,在复发的患者中,2 人(40%)为右侧渗出,另外 3 人(60%)为左侧渗出(P = 0.623)。结论两种技术都很安全,副作用小,都是一过性的,易于处理。不过,胸腔镜胸膜腔穿刺法的疾病复发率明显低于胸导管法。
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引用次数: 0
Comparative Study of Quality of Life After Surgery in Sigmoid and Rectal Cancers: A Single-Center Prospective Study 乙状结肠癌和直肠癌术后生活质量比较研究:单中心前瞻性研究
Pub Date : 2024-01-17 DOI: 10.18502/ajs.v6i1.14715
Anvar Elyasi, Mohammad Sadeq Najafi, Seyed Mohsen Ahmad Tafti, A. Kazemeini, S. M. Meshkati Yazd, M. Dashtkuhi, B. Behboudi, M. Fazeli, A. Keshvari, M. Keramati
Background: Sigmoid and rectal cancers are common malignancies that necessitate surgical resection as the primary treatment modality. However, surgery can significantly impact the quality of life (QoL) of patients, particularly in terms of bowel function, sexual function, and psychological well-being. This study aimed to compare the QoL of patients who underwent surgery for sigmoid and rectal cancers Methods: A prospective study was conducted on 90 patients who underwent elective surgery for sigmoid or rectal cancer between January 2019 and December 2021 at the center. The QLQ-C30 and QLQ-CR29 questionnaires were utilized to assess the QoL of patients post-surgery. The QoL scores between the two groups were compared using t-tests and repeated measures ANOVA. Results: The average age of the patients was years, and 57.8% were females. The sigmoid group comprised 44 patients (48.8%) who underwent sigmoid colectomy, and the rectal group consisted of 46 patients (51.2%) who underwent low anterior resection. There were no significant differences in the baseline characteristics and QLQ-C30 scores between the two groups and also in other categories (sex, age groups, and cancer stages) (p > 0.05). However, a significant difference was observed between the QLQ-CR29 scores of the two surgical groups (p < 0.05). QLQ-CR29 was not significantly different between sex and age groups and cancer stages (p > 0.05). Conclusions: The study demonstrated that surgery for sigmoid and rectal cancers deteriorated the QoL of patients, irrespective of the type of surgery or the location of the tumor. There was no significant difference in the QoL between the sigmoid and rectal groups measured by QLQ-C30. However, QLQ-CR29 showed significantly better QoL for the rectal group.
背景:乙状结肠癌和直肠癌是常见的恶性肿瘤,必须以手术切除作为主要治疗方式。然而,手术会严重影响患者的生活质量(QoL),尤其是在排便功能、性功能和心理健康方面。本研究旨在比较接受乙状结肠癌和直肠癌手术患者的生活质量:对该中心在2019年1月至2021年12月期间接受乙状结肠癌或直肠癌择期手术的90名患者进行了前瞻性研究。采用 QLQ-C30 和 QLQ-CR29 问卷评估患者手术后的 QoL。采用t检验和重复测量方差分析比较两组患者的QoL得分。结果患者平均年龄岁,57.8%为女性。乙状结肠组有 44 名患者(48.8%)接受了乙状结肠切除术,直肠组有 46 名患者(51.2%)接受了低位前切除术。两组患者的基线特征和 QLQ-C30 评分以及其他类别(性别、年龄组和癌症分期)均无明显差异(P > 0.05)。不过,两组手术者的 QLQ-CR29 评分有明显差异(P < 0.05)。QLQ-CR29 在性别、年龄组和癌症分期之间没有明显差异(P > 0.05)。结论研究表明,无论手术类型或肿瘤位置如何,乙状结肠癌和直肠癌手术都会使患者的 QoL 下降。根据 QLQ-C30 测量,乙状结肠组和直肠组的 QoL 无明显差异。不过,QLQ-CR29 显示直肠组的 QoL 明显更好。
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引用次数: 0
Identifying the discriminative value of leukocytes, CRP and Procalcitonin serum level in detecting the anastomosis leakage after gastrointestinal surgery 确定白细胞、CRP 和降钙素原血清水平在检测胃肠道手术后吻合口渗漏方面的鉴别价值
Pub Date : 2024-01-17 DOI: 10.18502/ajs.v6i1.14710
Ehsan Sobhanian, A. Notash, Zahra Moghimi, H. Amoli, Ali Sobhanian, Ehsan Sadeghian
Background: Anastomosis leakage is a pivotal post colorectal surgery, threatening patient survival. Unspecific clinical presentations prolong the diagnostic process, potentially reducing the effectiveness of interventions. This situation has highlighted the need for a biomarker that enables early prediction of anastomosis leakage (AL). Previous studies suggest the potential utility of serum levels of white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) as biomarkers for early detection of AL. Consequently, the present study was conducted with the aim of investigating the potential correlation of these markers with the occurrence of AL. Methods: Patients who were referred to the hospitals of Tehran University of Medical Sciences from November 2018 to January 2020 were evaluated for inclusion in the study. After obtaining informed consents, 277 cases were enrolled in the study. Serum levels of WBC, CRP, and PCT were measured preoperatively and up to five days postoperation. A statistical correlation analysis was conducted using SPSS software (version 24). Results: Among the 277 cases, 14 exhibited AL. The highest sensitivity and specificity for AL were observed for CRP on the second and third post-operative days. PCT, however, showed higher utility on the fourth post-operative day with 57% sensitivity, 56% specificity (p-value = 0.001 for the second day and 0.002 on the third day), and a negative predictive value of 96%. These values changed to 36%, 64%, and 95% respectively on the fifth postoperative day, which remains within the acceptable range (p-value = 0.018). Conclusions: Both CRP and PCT have potential utility as diagnostic biomarkers for the presence of AL and can significantly accelerate the diagnosis period. For the highest sensitivity and specificity, CRP should be used on the second and third post-operative days. The optimal utility for PCT, however, is on the fourth post-operative day.
背景:吻合口漏是结直肠手术后的关键问题,威胁着患者的生存。无特异性的临床表现延长了诊断过程,可能会降低干预措施的有效性。这种情况凸显了对能早期预测吻合口漏(AL)的生物标志物的需求。之前的研究表明,血清中的白细胞(WBC)、C 反应蛋白(CRP)和降钙素原(PCT)水平可作为早期检测 AL 的生物标志物。因此,本研究旨在调查这些标志物与 AL 发生的潜在相关性。研究方法对 2018 年 11 月至 2020 年 1 月期间转诊至德黑兰医科大学医院的患者进行评估,将其纳入本研究。在获得知情同意后,277 例患者被纳入研究。对术前和术后五天内的血清白细胞、CRP 和 PCT 水平进行了测量。使用 SPSS 软件(24 版)进行了统计相关性分析。结果在 277 例病例中,有 14 例表现为 AL。术后第二和第三天的 CRP 对 AL 的敏感性和特异性最高。然而,PCT 在术后第四天显示出更高的效用,敏感性为 57%,特异性为 56%(第二天的 P 值 = 0.001,第三天为 0.002),阴性预测值为 96%。术后第五天,这些数值分别变为 36%、64% 和 95%,仍在可接受范围内(p 值 = 0.018)。结论CRP 和 PCT 作为诊断 AL 存在的生物标记物具有潜在的实用性,可显著缩短诊断时间。为了获得最高的灵敏度和特异性,CRP 应在术后第二和第三天使用。而 PCT 的最佳使用时间是术后第四天。
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引用次数: 0
An investigation on causes of delayed referral of patients with pleural empyema 关于胸腔积液患者延迟转诊原因的调查
Pub Date : 2024-01-17 DOI: 10.18502/ajs.v6i1.14713
Ali Biharas Monfared, F. S. Beigee, Niloufar Alizadeh, M. Dizaji, Parizad Sinaei
Background: In the treatment of pleural empyema, medical therapy is typically sufficient for the 1st or 2nd stage. However, surgical intervention becomes the optimal modality in the 3rd stage. A significant number of patients experience delayed diagnosis and treatment, leading to the conversion of non-surgical pleural empyema into complicated surgical empyema Methods: A cross-sectional study was conducted on patients with pleural empyema who were admitted to NRITLD in Tehran from 2015 to 2016. Initially, 66 patients were selected; however, after the exclusion of 12 patients, a total of 54 patients were included in the study Results: Delays were attributed to the medical system in 62% of cases and to the patient in 29% of cases. The median (IQR) of the total delay time attributed to the system was 38 (25) days. No significant difference was found in the median of delayed referrals between genders. A significant correlation was observed between the interval of the first and last visit and the interval between the onset of symptoms and chest x-ray (CXR), as well as the interval between the performance of CXR and the insertion of chest tube drainage (CTD). Conclusions: The delay in referral and treatment can be attributed to the patient, practitioners, or both. In this study, it was found that the medical system is the primary cause of delay, primarily due to the long waiting times for admission and operation in hospitals. Patients who experience a delay in CXR and CTD insertion will face a significant delay in referral and their course of treatment. It is suggested that delayed referral could be prevented by providing patients with basic medical education, offering specialized training to general practitioners for early referral, and managing waiting lists effectively.
背景:在治疗胸腔积液时,药物疗法通常足以应付第一或第二阶段。然而,在第三阶段,手术干预成为最佳方式。大量患者因诊断和治疗延误,导致非手术治疗的胸膜腔积液转变为复杂的手术治疗的胸膜腔积液:对2015年至2016年德黑兰NRITLD收治的胸膜腔积液患者进行了横断面研究。最初选取了 66 名患者,但在排除了 12 名患者后,共有 54 名患者被纳入研究结果:62%的延误归因于医疗系统,29%的延误归因于患者。医疗系统造成的总延误时间的中位数(IQR)为 38(25)天。转诊延误时间的中位数在性别间没有明显差异。首次就诊和最后一次就诊的时间间隔与症状出现和胸部 X 光检查(CXR)之间的时间间隔以及胸部 X 光检查和插入胸管引流术(CTD)之间的时间间隔之间存在明显的相关性。结论转诊和治疗的延误可归因于患者、医生或两者。本研究发现,医疗系统是造成延误的主要原因,这主要是由于入院和手术的等待时间过长。如果患者在进行心肺功能检查和 CTD 插入手术时遇到延误,那么他们在转诊和治疗过程中将面临严重的延误。建议通过为患者提供基本医疗教育、为全科医生提供早期转诊的专门培训以及有效管理候诊名单来防止转诊延误。
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引用次数: 0
Unveiling the Hidden Peril: A Rare Case of Gossypiboma in an Elderly Woman 揭开隐藏的危险:一个罕见的老年妇女膀胱疱疹病例
Pub Date : 2024-01-17 DOI: 10.18502/ajs.v6i1.14714
Vinay H G, Naveen N, Ramprashanth M P
Background: Revolutionary developments in the surgical field have led to a comparative reduction in surgeryassociated complications than in the past. However, some complications, which directly indicate surgeon’s negligence, should not be underestimated. Gossypibomas, a rare but horrifying complication of surgeries, occur when cotton foreign bodies are retained in the patient and are only discovered after long periods of time. Methods: A 46-year-old diabetic anemic female, with a previous history of operative management for cancer of the cervix (stage IA2), presented with features suggesting sub-acute intestinal obstruction. Results: Contrast Enhanced Computed Tomography (CECT) of the abdomen revealed a linear hyper-attenuating string-like structure in the distal bowel loop, suggesting a Retained Foreign Body. The patient was immediately taken up for exploratory laparotomy, and the retained foreign body was removed. Conclusions: Although the diagnosis of Gossypibomas can be challenging at times, it is imperative to manage patients with this rare complication swiftly and precisely to prevent permanent future disabilities. Young surgeons should be made aware of the legal consequences of such a dreaded complication and should anticipate the diagnosis in bizarre surgical circumstances.
背景:外科领域的革命性发展使得与外科手术相关的并发症比过去大大减少。然而,一些直接表明外科医生疏忽的并发症也不容小觑。棉花异物瘤(Gossypibomas)是一种罕见但可怕的手术并发症,当棉花异物滞留在患者体内,经过很长时间才被发现。手术方法一名 46 岁的贫血糖尿病女性,曾因宫颈癌(IA2 期)接受过手术治疗,其特征显示为亚急性肠梗阻。检查结果腹部对比增强计算机断层扫描(CECT)显示,远端肠襻有一个线状高增强弦样结构,提示有异物残留。患者被立即送往医院进行剖腹探查手术,并取出了残留异物。结论尽管戈西腓骨瘤的诊断有时具有挑战性,但必须迅速、准确地处理这种罕见并发症的患者,以防止将来造成永久性残疾。应让年轻外科医生意识到这种可怕并发症的法律后果,并在怪异的手术环境中预见到这种诊断。
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引用次数: 0
Comparing the outcomes of total thyroidectomy using a harmonic scalpel versus the conventional ligation techniques in Iran 伊朗使用谐波手术刀与传统结扎技术进行全甲状腺切除术的疗效比较
Pub Date : 2024-01-17 DOI: 10.18502/ajs.v6i1.14711
A. Notash, Ali Momen, Ehsan Sadeghian, Rozhina Molavi
Background: Maintaining hemostasis is considered a remarkable challenge during total thyroidectomy. The use of thermal ultrasonic electrocoagulation (harmonic scalpel) for total thyroidectomy was recently introduced to substitute the conventional ligation methods. However, controversies exist on the efficacy of this technique compared to the classic method. Methods: The data regarding this prospective cohort study was gathered between March 2019 to March 2020. Ninety participants were enrolled in the study. Forty-five subjects received harmonic scalpel ligation and the other forty-five participants underwent conventional total thyroidectomy. Afterward, these two groups were statistically compared regarding surgical time, postoperative hypocalcemia, drainage volume, postoperative pain, hospital stay, and recurrent nerve damage. Results: No significant difference was detected in the group undergoing harmonic ligation concerning postoperative pain, postoperative hospital stay, drainage volume, and postoperative hypocalcemia in the first 48 hours post-operation. However, using a harmonic scalpel significantly reduced the surgical time (56 ± 2 minutes in the harmonic scalpel group versus 67 ± 9 in the conventional technique group, p < 0.001). Also, no recurrent nerve damage was detected in the study. Conclusions: Utilizing a harmonic scalpel has a remarkably higher time efficacy in total thyroidectomy. However, the study suggests no further advantage for this method compared to the conventional techniques in total thyroidectomy.
背景:在全甲状腺切除术中,维持止血被认为是一项巨大的挑战。最近,在全甲状腺切除术中使用热超声电凝(谐波手术刀)取代了传统的结扎方法。然而,与传统方法相比,这种技术的疗效还存在争议。方法:这项前瞻性队列研究的数据收集时间为 2019 年 3 月至 2020 年 3 月。共有 90 名参与者参与了这项研究。45名受试者接受了谐波刀结扎术,另外45名受试者接受了传统的甲状腺全切除术。之后,对两组患者的手术时间、术后低钙血症、引流量、术后疼痛、住院时间和复发性神经损伤进行统计比较。结果显示在术后疼痛、术后住院时间、引流量和术后 48 小时内的低钙血症方面,接受谐波结扎术的组没有发现明显差异。不过,使用谐波手术刀大大缩短了手术时间(谐波手术刀组为 56 ± 2 分钟,而传统技术组为 67 ± 9 分钟,P < 0.001)。此外,研究中未发现复发性神经损伤。结论:在甲状腺全切术中使用谐波刀的时间效率明显更高。不过,研究表明,与传统技术相比,这种方法在甲状腺全切术中并无更多优势。
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引用次数: 0
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Academic Journal of Surgery
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