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Comparing clusterings using combination of the kappa statistic and entropy-based measure 使用kappa统计量和基于熵的度量相结合的聚类比较
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-11-16 DOI: 10.1007/s40300-019-00162-5
Evženie Uglickich, I. Nagy, Dominika Vlčková
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引用次数: 1
Robust small area estimation in generalized linear mixed models 广义线性混合模型的鲁棒小面积估计
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-10-30 DOI: 10.1007/s40300-019-00161-6
S. Sinha
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引用次数: 3
The relationship between Gini terminology and the ROC curve 基尼术语与ROC曲线的关系
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-10-25 DOI: 10.1007/s40300-019-00160-7
E. Schechtman, G. Schechtman
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引用次数: 10
Priors via imaginary training samples of sufficient statistics for objective Bayesian hypothesis testing 先验通过虚构的训练样本获得足够的统计量进行客观的贝叶斯假设检验
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-09-28 DOI: 10.1007/s40300-019-00159-0
D. Fouskakis
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引用次数: 1
Plateau proposal distributions for adaptive component-wise multiple-try metropolis 自适应分量多重尝试大都市的高原方案分布
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-09-06 DOI: 10.1007/s40300-022-00235-y
F. Din-Houn, D. Lau, S. Krumscheid
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引用次数: 0
Bayesian treatment of non-standard problems in test analysis 检验分析中非标准问题的贝叶斯处理
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-08-17 DOI: 10.1007/s40300-019-00158-1
Rajitha M. Silva, Yuping Guan, T. Swartz
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引用次数: 0
Unsupervised separation of dynamics from pixels 动态与像素的无监督分离
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-07-20 DOI: 10.1007/s40300-019-00155-4
S. Chiappa, U. Paquet
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引用次数: 4
A recursive approach for determining matrix inverses as applied to causal time series processes 用于确定矩阵逆的递归方法,应用于因果时间序列过程
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-01-18 DOI: 10.1007/s40300-019-00147-4
S. Provost, John N. Haddad
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引用次数: 0
A continuous-time hidden Markov model for cancer surveillance using serum biomarkers with application to hepatocellular carcinoma. 基于血清生物标志物的肿瘤监测的连续时间隐马尔可夫模型在肝细胞癌中的应用
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2019-01-01 Epub Date: 2019-05-30 DOI: 10.1007/s40300-019-00151-8
Ruben Amoros, Ruth King, Hidenori Toyoda, Takashi Kumada, Philip J Johnson, Thomas G Bird

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer deaths worldwide, and its early detection is a critical determinant of whether curative treatment is achievable. Early stage HCC is typically asymptomatic. Thus, screening programmes are used for cancer detection in patients at risk of tumour development. Radiological screening methods are limited by imperfect data, cost and associated risks, and additionally are unable to detect lesions until they have grown to a certain size. Therefore, some screening programmes use additional blood/serum biomarkers to help identify individuals in whom to target diagnostic cancer investigations. The GALAD score, combining the levels of several blood biomarkers, age and sex, has been developed to identify patients with early HCC. Here we propose a Bayesian hierarchical model for an individual's longitudinal GALAD scores whilst in HCC surveillance to identify potentially significant changes in the trend of the GALAD score, indicating the development of HCC, aiming to improve early detection compared to standard methods. An absorbent two-state continuous-time hidden Markov model is developed for the individual level longitudinal data where the states correspond to the presence/absence of HCC. The model is additionally informed by the information on the diagnosis by standard clinical practice, taking into account that HCC can be present before the actual diagnosis so that there may be false negatives within the diagnosis data. We fit the model to a Japanese cohort of patients undergoing HCC surveillance and show that the detection capability of this proposal is greater than using a fixed cut-point.

肝细胞癌(HCC)是全球癌症死亡的第四大常见原因,其早期检测是能否实现治疗的关键决定因素。早期HCC通常无症状。因此,筛查方案被用于有肿瘤发展风险的患者的癌症检测。放射筛查方法受到不完善的数据、成本和相关风险的限制,此外,在病变发展到一定大小之前,无法检测病变。因此,一些筛查计划使用额外的血液/血清生物标志物来帮助识别癌症诊断调查的对象。GALAD评分结合了几种血液生物标志物(年龄和性别)的水平,已被开发用于识别早期HCC患者。在这里,我们提出了一个在HCC监测中个体纵向GALAD评分的贝叶斯分层模型,以确定GALAD评分趋势的潜在显著变化,表明HCC的发展,旨在与标准方法相比提高早期检测。针对个体水平的纵向数据,开发了一个吸收的两状态连续时间隐马尔可夫模型,其中状态对应于HCC的存在/不存在。该模型还由标准临床实践的诊断信息告知,考虑到HCC可能在实际诊断之前存在,因此诊断数据中可能存在假阴性。我们将该模型与接受HCC监测的日本患者队列进行了拟合,并表明该方案的检测能力大于使用固定切割点。
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引用次数: 14
Estimation of small area counts with the benchmarking property 用基准属性估计小面积计数
IF 0.8 Q3 STATISTICS & PROBABILITY Pub Date : 2018-11-29 DOI: 10.1007/s40300-018-0146-2
M. Ranalli, G. Montanari, Cecilia Vicarelli
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引用次数: 4
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Metron-International Journal of Statistics
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