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Synovial Fluid Biomarkers in the Contralateral Knee Predict Patient-Reported Outcomes After Injury at Long-term Follow-up 对侧膝关节滑液生物标志物在长期随访中预测损伤后患者报告的预后
Pub Date : 2026-01-13 DOI: 10.1177/03635465251401555
Emily Berzolla, Vishal Sundaram, Bradley A. Lezak, Nicole Rynecki Baker, Izabel Powers, Daniel J. Kaplan, Thorsten Kirsch, Eric J. Strauss
Background: Inflammatory biomarkers in an injured knee have been shown to predict outcomes, yet the role of the subsequent systemic inflammatory response to injury remains poorly understood. Purpose: To investigate whether synovial fluid (SF) biomarkers from the contralateral uninjured knee could predict long-term patient-reported outcomes (PROs) for the operative knee in patients undergoing arthroscopic knee surgery. Study Design: Case series; Level of evidence, 4. Methods: This retrospective analysis included patients undergoing knee SF aspiration before arthroscopy with ≥8 years of follow-up. SF was aspirated from both the injured and healthy contralateral knees, and concentrations of 10 pro- and anti-inflammatory biomarkers were quantified. Patients completed visual analog scale (VAS) for pain score, Lysholm, Tegner, and Knee injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS) surveys preoperatively and at the final follow-up. Stepwise linear regression was performed to identify the most significant predictor(s) of PRO scores utilizing log-normalized contralateral biomarker concentration, age, body mass index, injury type, and Outerbridge grade as covariates. Concentrations from the contralateral knee were also compared with the injured knee to assess for correlations. Results: A total of 32 patients with a mean age 49.6 ± 12.3 years and follow-up of 10.0 ± 1.4 years were included. Elevated anti-inflammatory tissue inhibitor of metalloproteinase 1 (TIMP-1) in the contralateral knee was associated with improved VAS pain score ( P = .002) and KOOS-PS ( P < .001) at long-term follow-up. Increased levels of contralateral pro-inflammatory matrix metalloproteinase 3 ( P = .004) and regulated on activation normal T cell expressed and secreted ( P = .035) were associated with worse KOOS-PS, while elevated interleukin 1 receptor antagonist was associated with worse VAS pain ( P = .006), Lysholm ( P = .005), and Tegner ( P = .006) score at the final follow-up. Contralateral concentrations of monocyte chemotactic protein 1, macrophage inflammatory protein 1β, vascular endothelial growth factor, and TIMP-1 were correlated with levels in the operative knee but at significantly lower concentrations. Conclusion: SF biomarker levels in the contralateral uninjured knee at the time of arthroscopy were predictive of long-term outcomes for the operative knee. Increased levels of pro-inflammatory biomarkers were predictive of worse outcomes, while anti-inflammatory cytokines predicted improved scores. These results suggest that unilateral knee injury can result in a broader systemic inflammatory response that influences long-term outcomes in patients.
研究背景:损伤膝盖的炎症生物标志物已被证明可以预测预后,但随后的全身炎症反应对损伤的作用仍然知之甚少。目的:研究对侧未损伤膝关节的滑液(SF)生物标志物是否可以预测关节镜下膝关节手术患者手术膝关节的长期预后(PROs)。研究设计:病例系列;证据等级,4级。方法:回顾性分析在关节镜检查前接受膝关节SF抽吸的患者,随访≥8年。从受伤和健康的对侧膝关节均抽吸SF,并量化10种促炎和抗炎生物标志物的浓度。患者在术前和最后随访时完成视觉模拟量表(VAS)疼痛评分、Lysholm、Tegner、膝关节损伤和骨关节炎结局评分生理功能短表(KOOS-PS)调查。采用对数归一化的对侧生物标志物浓度、年龄、体重指数、损伤类型和Outerbridge分级作为协变量,进行逐步线性回归,以确定PRO评分最显著的预测因子。对侧膝关节的浓度也与受伤的膝关节进行了比较,以评估相关性。结果:共纳入32例患者,平均年龄49.6±12.3岁,随访10.0±1.4年。长期随访时,对侧膝关节抗炎组织抑制剂金属蛋白酶1 (TIMP-1)升高与VAS疼痛评分(P = 0.002)和KOOS-PS (P < 0.001)改善相关。对侧促炎基质金属蛋白酶3水平升高(P = 0.004)和正常T细胞表达和分泌受到调节(P = 0.035)与KOOS-PS加重相关,而白细胞介素1受体拮抗剂水平升高与VAS疼痛(P = 0.006)、Lysholm (P = 0.005)和Tegner (P = 0.006)评分加重相关。对侧单核细胞趋化蛋白1、巨噬细胞炎症蛋白1β、血管内皮生长因子和TIMP-1的浓度与手术膝关节的水平相关,但浓度显著降低。结论:关节镜检查时对侧未损伤膝关节SF生物标志物水平可预测手术膝关节的长期预后。促炎生物标志物水平的增加预示着更糟糕的结果,而抗炎细胞因子预示着得分的提高。这些结果表明,单侧膝关节损伤可导致更广泛的全身炎症反应,影响患者的长期预后。
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引用次数: 0
Where Sex Matters for Perioperative and Postoperative Anterior Cruciate Ligament Reconstruction Outcomes: A Systematic Review of MOON Literature 性别对围手术期和术后前交叉韧带重建结果的影响:MOON文献的系统回顾
Pub Date : 2026-01-13 DOI: 10.1177/03635465251386027
Martina E. Hale, Michael S. Ramos, Riley A. O’Toole, Shelley Ivary, Kurt P. Spindler, Michael J. Scarcella
Background: Females are 2 to 8 times more likely than males to sustain an initial anterior cruciate ligament (ACL) tear. However, after ACL reconstruction (ACLR), it remains less certain how males and females differ in other ACLR-related outcomes. Purpose: To summarize Multicenter Orthopaedic Outcomes Network (MOON) studies reporting on ACLR-related outcome differences between sexes. Study Design: Systematic review; Level of evidence, 3. Methods: A systematic literature review based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was conducted utilizing the Embase, MEDLINE, and Cochrane Library databases. Studies were included if they analyzed the MOON knee cohort and reported sex-specific outcomes for perioperative or postoperative primary ACLR outcomes. Results: This review included 28 studies. Six of 6 studies (100%) found no difference between sexes for graft tear at 2 and 6 years of follow-up. Three of 3 studies (100%) found no difference between sexes for contralateral native ACL tear at 2 and 6 years of follow-up. Six of 6 studies (100%) found that female sex correlated with worse Marx activity scores at 2, 6, and 10 years of follow-up. Three of 5 studies (60%) found female sex correlated with worse International Knee Documentation Committee (IKDC) scores at 6 and 10 years of follow-up. Conclusion: There was 100% agreement on the following: sex is not associated with differences in graft tear or contralateral native ACL tear at 2 and 6 postoperative years; female sex is associated with worse Marx activity scores at 2, 6, and 10 years; and female sex is associated with worse return-to-play percentages at 2 and 7 years. There was 60% agreement that female sex is associated with worse IKDC scores at 2 and 6 years.
背景:女性维持初始前交叉韧带(ACL)撕裂的可能性是男性的2至8倍。然而,在ACL重建(ACLR)后,男性和女性在其他ACLR相关结果上的差异仍然不太确定。目的:总结多中心骨科结局网络(MOON)研究报告aclr相关结局的性别差异。研究设计:系统评价;证据水平,3。方法:利用Embase、MEDLINE和Cochrane图书馆数据库,根据PRISMA(系统评价和荟萃分析的首选报告项目)指南进行系统文献综述。如果研究分析了MOON膝关节队列并报告了围手术期或术后原发性ACLR结果的性别特异性结果,则纳入研究。结果:本综述纳入28项研究。6项研究中的6项(100%)在2年和6年的随访中发现移植物撕裂没有性别差异。3项研究中的3项(100%)在随访2年和6年时发现对侧原生ACL撕裂在性别上没有差异。6项研究中的6项(100%)发现,女性在2年、6年和10年的随访中与较差的马克思活动得分相关。5项研究中有3项(60%)发现女性与随访6年和10年的国际膝关节文献委员会(IKDC)评分较差相关。结论:在以下方面100%一致:术后2年和6年,性别与移植物撕裂或对侧原生ACL撕裂的差异无关;女性在2岁、6岁和10岁时马克思活动得分较差;女性在2岁和7岁时重返赛场的比例更低。有60%的人同意女性与2岁和6岁时较差的IKDC分数有关。
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引用次数: 0
Toward an Integrated Perspective Regarding Clinically Significant Labral Injuries in Overhead Throwing Athletes: Form Follows Function 对顶抛运动员临床上重要的唇部损伤的综合观点:形式服从功能
Pub Date : 2026-01-13 DOI: 10.1177/03635465251390549
W. Ben Kibler, Aaron D. Sciascia
Inconsistent outcomes of treatment of labral injuries in the overhead athlete suggest that deficiencies exist in the current knowledge about the roles of the labrum in overhead throwing athletes. These may include inadequate knowledge of labral anatomy and optimum glenohumeral joint (GHJ) mechanics, inadequate knowledge of the pathoanatomy and pathomechanics that create the clinical dysfunction and symptoms, or use of nonanatomic surgical techniques. These deficiencies suggest that a different perspective regarding labral anatomy and GHJ mechanics may provide a basis for examination and guidance for further scholarship and treatment. This perspective is based on the principle of form follows function, which states that the form, the shape or structure of an object, should be based on its intended function, or purpose, and can be utilized to address these deficiencies. It integrates anatomy/form and mechanics/function to provide more effective knowledge and resources for evaluation and treatment. Based on this perspective, this clinical commentary will review and discuss the mechanical function of the GHJ—to optimize task-specific ball-and-socket kinematics, concavity/compression, and dynamic GHJ stability in the overhead throwing athlete; the form of the glenoid labrum, its 3-component mechanical anatomy, and associated biceps tendon–labral complex, which exists to achieve that function; and the demonstrated alterations to the form that result in alteration of function. Alterations to the form, representing various types of labral injury, produce mechanical consequences in GHJ kinematics and contact pressures that can be associated with clinical symptoms and dysfunction. Surgical techniques that address restoring and optimizing the form by re-creating the 3-component mechanical anatomy have been demonstrated to restore the joint kinematics and contact pressures to the intact state. This perspective also provides implications regarding evaluation techniques and treatment guidelines and may serve to provide insights into the development of more effective techniques for restoration of the form that can optimize the function.
头顶运动员唇部损伤的治疗结果不一致,表明目前关于头顶投掷运动员唇部作用的知识存在不足。这些问题可能包括对阴唇解剖和最佳盂肱关节(GHJ)力学知识的不足,对造成临床功能障碍和症状的病理解剖和病理力学知识的不足,或使用非解剖性手术技术。这些缺陷表明,对唇部解剖和GHJ力学的不同观点可能为进一步的研究和治疗提供基础和指导。这种观点基于形式服从功能的原则,即物体的形式、形状或结构应该基于其预期的功能或目的,并且可以用来解决这些缺陷。它整合了解剖学/形态和力学/功能,为评估和治疗提供了更有效的知识和资源。基于这一观点,本临床评论将回顾和讨论GHJ的机械功能,以优化高球投掷运动员特定任务的球窝运动学、凹度/压缩和GHJ的动态稳定性;盂唇的形状,它的三组分机械解剖,以及相关的肱二头肌肌腱-唇复合体,它的存在是为了实现这一功能;形式的改变导致了功能的改变。形状的改变,代表了各种类型的唇部损伤,在GHJ运动学和接触压力方面产生机械后果,这可能与临床症状和功能障碍有关。通过重建三组分机械解剖结构来修复和优化关节形态的外科技术已被证明可以将关节运动学和接触压力恢复到完整状态。这一观点也为评估技术和治疗指南提供了启示,并可能为开发更有效的技术来恢复可以优化功能的形式提供见解。
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引用次数: 0
Preoperative Nonopioid Analgesia Reduces Postoperative Opioid Consumption After Arthroscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials 术前非阿片类镇痛减少关节镜手术后阿片类药物的消耗:随机对照试验的系统回顾和荟萃分析
Pub Date : 2026-01-13 DOI: 10.1177/03635465251396164
Joshua Dworsky-Fried, Ryley Fowler, Prushoth Vivekanantha, Dan Cohen, Nicole Simunovic, Darren de SA, Olufemi R. Ayeni
Background: Orthopaedic surgeons frequently overprescribe opioids after arthroscopic surgery. Previous research has shown reductions in postoperative opioid consumption and pain scores with multimodal nonopioid analgesics. However, the clinical effect of preoperative analgesic strategies has not been fully uncovered. Purpose: To assess the outcomes of arthroscopic surgery associated with preoperative treatment with nonopioid medications. Study Design: Systematic review and meta-analysis; Level of evidence, 1. Methods: Three online databases (PubMed, MEDLINE, Embase) were searched on December 12, 2024, to identify randomized controlled trials investigating the effect of preoperative intervention on pain management following arthroscopic surgery. Extracted data included patient demographics, surgery type, analgesic protocols (ie, type, dosing, timing), adverse effects, postoperative opioid consumption, and pain scores. Postoperative opioid consumption was standardized and converted to oral morphine equivalents. Pain scores were assessed using the visual analog scale (VAS). Weighted means and meta-analyses were conducted to compare postoperative outcomes. Subgroup analyses were performed by analgesic class (COX-2 inhibitors, gabapentin) and surgery type. The quality of studies was assessed with the Risk of Bias 2 tool. Results: A total of 22 studies were included in this review. The overall pooled mean reduction in postoperative opioid consumption with any preoperative medication type was 4.3 mg of oral morphine equivalents (95% CI, –6.1 to –2.5; <jats:italic toggle="yes">P</jats:italic> < .001; <jats:italic toggle="yes">I</jats:italic> <jats:sup>2</jats:sup> = 96%) at 24 hours. The pooled mean reduction associated with preoperative COX-2 administration and gabapentin was 4.2 mg (95% CI, –7.9 to –0.5; <jats:italic toggle="yes">P</jats:italic> = .03; <jats:italic toggle="yes">I</jats:italic> <jats:sup>2</jats:sup> = 93%) and 6.3 mg (95% CI, –9.6 to –3.0; <jats:italic toggle="yes">P</jats:italic> < .001; <jats:italic toggle="yes">I</jats:italic> <jats:sup>2</jats:sup> = 90%) at 24 hours, respectively. Preoperative COX-2 inhibitors also yielded a statistically significant VAS pain reduction of 0.3 cm (95% CI, –0.5 to –0.02; <jats:italic toggle="yes">P</jats:italic> = .04). Patients undergoing anterior cruciate ligament reconstruction had higher postoperative opioid consumption as compared with general knee or shoulder arthroscopies. Conclusion: This systematic review demonstrated that preoperative treatment with nonopioid medications, particularly COX-2 inhibitors and gabapentin, is associated with statistically significant reductions in postoperative opioid consumption after arthroscopic surgery. Despite statistically significant findings, observed reductions in postoperative opioid consumption and VAS pain scores may not represent clinically meaningful improvements. The current available literature is highly heterogeneous, indicating the need f
背景:骨科医生经常在关节镜手术后过量使用阿片类药物。先前的研究表明,使用多模式非阿片类镇痛药可减少术后阿片类药物的消耗和疼痛评分。然而,术前镇痛策略的临床效果尚未完全揭示。目的:评估关节镜手术与术前非阿片类药物治疗相关的结果。研究设计:系统评价和荟萃分析;证据等级:1。方法:于2024年12月12日检索PubMed, MEDLINE, Embase三个在线数据库,以确定调查术前干预对关节镜手术后疼痛管理影响的随机对照试验。提取的数据包括患者人口统计、手术类型、镇痛方案(即类型、剂量、时间)、不良反应、术后阿片类药物消耗和疼痛评分。术后阿片类药物消耗量标准化并转化为口服吗啡当量。疼痛评分采用视觉模拟量表(VAS)评定。采用加权平均数和荟萃分析比较术后结果。根据镇痛药类别(COX-2抑制剂、加巴喷丁)和手术类型进行亚组分析。使用风险偏倚2工具评估研究质量。结果:本综述共纳入22项研究。在24小时内,任何术前药物类型的术后阿片类药物消耗的总体汇总平均减少量为4.3 mg口服吗啡当量(95% CI, -6.1至-2.5;P < .001; I 2 = 96%)。术前给药COX-2和加巴喷丁在24小时的综合平均减少量分别为4.2 mg (95% CI, -7.9至-0.5;P = 0.03; i2 = 93%)和6.3 mg (95% CI, -9.6至-3.0;P < 0.001; i2 = 90%)。术前COX-2抑制剂也使VAS疼痛减少0.3 cm,具有统计学意义(95% CI, -0.5至-0.02;P = 0.04)。接受前交叉韧带重建的患者术后阿片类药物消耗高于普通膝关节或肩关节镜检查。结论:本系统综述表明,术前使用非阿片类药物治疗,特别是COX-2抑制剂和加巴喷丁,与关节镜术后阿片类药物消耗的统计学显著降低相关。尽管有统计学上的显著发现,但术后阿片类药物消耗和VAS疼痛评分的减少可能并不代表有临床意义的改善。目前可获得的文献是高度异质性的,这表明需要高质量的前瞻性研究来更准确地评估疼痛管理的最佳方法。
{"title":"Preoperative Nonopioid Analgesia Reduces Postoperative Opioid Consumption After Arthroscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials","authors":"Joshua Dworsky-Fried, Ryley Fowler, Prushoth Vivekanantha, Dan Cohen, Nicole Simunovic, Darren de SA, Olufemi R. Ayeni","doi":"10.1177/03635465251396164","DOIUrl":"https://doi.org/10.1177/03635465251396164","url":null,"abstract":"Background: Orthopaedic surgeons frequently overprescribe opioids after arthroscopic surgery. Previous research has shown reductions in postoperative opioid consumption and pain scores with multimodal nonopioid analgesics. However, the clinical effect of preoperative analgesic strategies has not been fully uncovered. Purpose: To assess the outcomes of arthroscopic surgery associated with preoperative treatment with nonopioid medications. Study Design: Systematic review and meta-analysis; Level of evidence, 1. Methods: Three online databases (PubMed, MEDLINE, Embase) were searched on December 12, 2024, to identify randomized controlled trials investigating the effect of preoperative intervention on pain management following arthroscopic surgery. Extracted data included patient demographics, surgery type, analgesic protocols (ie, type, dosing, timing), adverse effects, postoperative opioid consumption, and pain scores. Postoperative opioid consumption was standardized and converted to oral morphine equivalents. Pain scores were assessed using the visual analog scale (VAS). Weighted means and meta-analyses were conducted to compare postoperative outcomes. Subgroup analyses were performed by analgesic class (COX-2 inhibitors, gabapentin) and surgery type. The quality of studies was assessed with the Risk of Bias 2 tool. Results: A total of 22 studies were included in this review. The overall pooled mean reduction in postoperative opioid consumption with any preoperative medication type was 4.3 mg of oral morphine equivalents (95% CI, –6.1 to –2.5; &lt;jats:italic toggle=\"yes\"&gt;P&lt;/jats:italic&gt; &lt; .001; &lt;jats:italic toggle=\"yes\"&gt;I&lt;/jats:italic&gt; &lt;jats:sup&gt;2&lt;/jats:sup&gt; = 96%) at 24 hours. The pooled mean reduction associated with preoperative COX-2 administration and gabapentin was 4.2 mg (95% CI, –7.9 to –0.5; &lt;jats:italic toggle=\"yes\"&gt;P&lt;/jats:italic&gt; = .03; &lt;jats:italic toggle=\"yes\"&gt;I&lt;/jats:italic&gt; &lt;jats:sup&gt;2&lt;/jats:sup&gt; = 93%) and 6.3 mg (95% CI, –9.6 to –3.0; &lt;jats:italic toggle=\"yes\"&gt;P&lt;/jats:italic&gt; &lt; .001; &lt;jats:italic toggle=\"yes\"&gt;I&lt;/jats:italic&gt; &lt;jats:sup&gt;2&lt;/jats:sup&gt; = 90%) at 24 hours, respectively. Preoperative COX-2 inhibitors also yielded a statistically significant VAS pain reduction of 0.3 cm (95% CI, –0.5 to –0.02; &lt;jats:italic toggle=\"yes\"&gt;P&lt;/jats:italic&gt; = .04). Patients undergoing anterior cruciate ligament reconstruction had higher postoperative opioid consumption as compared with general knee or shoulder arthroscopies. Conclusion: This systematic review demonstrated that preoperative treatment with nonopioid medications, particularly COX-2 inhibitors and gabapentin, is associated with statistically significant reductions in postoperative opioid consumption after arthroscopic surgery. Despite statistically significant findings, observed reductions in postoperative opioid consumption and VAS pain scores may not represent clinically meaningful improvements. The current available literature is highly heterogeneous, indicating the need f","PeriodicalId":517411,"journal":{"name":"The American Journal of Sports Medicine","volume":"243 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145955122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No Significant Difference in Return-to-Sport Rates Between Anterior Cruciate Ligament Reconstruction With Lateral Extra-Articular Tenodesis and Isolated Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis. 前交叉韧带重建与外侧关节外肌腱固定术与孤立前交叉韧带重建在恢复运动率上无显著差异:一项系统回顾和荟萃分析。
Pub Date : 2026-01-12 DOI: 10.1177/03635465251386013
Viraj A Deshpande,Abhay Mathur,Isabel Barnett,Jordan Frausto,Patrick Saunders,David S Gazzaniga,Kevin C Parvaresh
BACKGROUNDAlthough anterior cruciate ligament (ACL) reconstruction (ACLR) remains the standard to treat ACL ruptures, athletes remain at higher risk of graft rerupture. Concomitant lateral extra-articular tenodesis (LET) has gained popularity by improving rotatory stability, yet no synthesis of expected return-to-sport (RTS) rates in athletes undergoing ACLR with LET (ACLR+LET) exists.PURPOSESTo synthesize RTS outcomes in athletes undergoing ACLR+LET and compare RTS rates, patient-reported outcome measures, and adverse event rates between isolated ACLR (iACLR) and ACLR+LET in the athletic population.STUDY DESIGNSystematic review and meta-analysis; Level of evidence 4.METHODSStudies reporting RTS after primary single-bundle iACLR and ACLR+LET using an iliotibial band autograft at a minimum 12-month clinical follow-up were included. Primary outcomes were RTS and return to previous level (RTPL), while secondary outcomes were patient-reported outcomes and adverse events. Study quality was assessed using the Cochrane Risk of Bias 2 and Methodological Index for Non-Randomized Studies tools, while RTS criteria were assessed using the Return to Play Quality of Evidence tool. Meta-analyses and sensitivity analyses were performed using R with the "Metafor" package.RESULTSFourteen studies were included, encompassing 1791 patients (38% female; mean age, 23.5 ± 8.5 years); 840 patients (709 athletes) underwent iACLR and 951 patients (901 athletes) underwent ACLR+LET. Grafts, surgical techniques, and rehabilitation protocols varied, and athletes participated in a variety of competitive and noncompetitive sports. Patients with iACLR reported a mean overall RTS rate of 88.2% ± 1.8% (344/390) and mean RTPL rate of 79% ± 16.2% (264/334), while patients with ACLR+LET reported a mean RTS rate of 88.2% ± 10.4% (591/670) and RTPL rate of 76.9% ± 16.5% (333/433). RTS did not significantly differ between the iACLR and ACLR+LET groups (OR, 0.84; 95% CI, 0.55-1.27; I2 = 0%; P = .41), nor did RTPL (OR, 1.20; 95% CI, 0.78-1.84; I2 0%; P = .40). Patients with ACLR+LET reported superior side-to-side laxity and flexion differential (both P < .001) and reduced graft rerupture risk (OR, 0.31; 95% CI, 0.17-0.57; I2 = 0%; P < .001).CONCLUSIONThere is no significant difference in RTS rates between the iACLR and ACLR+LET groups. However, ACLR+LET is associated with superior rotational stability and significantly lower graft rupture risk in an athletic population, supporting its use in high-risk patients where durability is critical.
虽然前交叉韧带(ACL)重建(ACLR)仍然是治疗ACL破裂的标准方法,但运动员仍然有较高的移植物再破裂风险。伴随的外侧关节外肌腱固定术(LET)通过改善旋转稳定性而得到了广泛的应用,但目前还没有关于接受ACLR和LET (ACLR+LET)的运动员预期恢复运动(RTS)率的综合研究。目的:综合接受ACLR+LET的运动员的RTS结果,比较运动员人群中孤立ACLR (iACLR)和ACLR+LET的RTS率、患者报告的结果测量和不良事件发生率。研究设计:系统评价和荟萃分析;证据等级4。方法纳入了在至少12个月的临床随访中报告原发性单束iACLR和ACLR+LET后使用髂胫束自体移植物的RTS研究。主要结局是RTS和恢复到先前水平(RTPL),而次要结局是患者报告的结局和不良事件。研究质量使用Cochrane Risk of Bias 2和Methodological Index for non - random Studies工具进行评估,RTS标准使用证据质量回归工具进行评估。meta分析和敏感性分析使用R和“meta”软件包进行。结果纳入14项研究,共纳入1791例患者(女性38%,平均年龄23.5±8.5岁);840例患者(709名运动员)接受了iACLR, 951例患者(901名运动员)接受了ACLR+LET。移植物、手术技术和康复方案各不相同,运动员参加了各种竞技和非竞技运动。iACLR患者报告的平均总RTS率为88.2%±1.8%(344/390),平均RTPL率为79%±16.2%(264/334),而ACLR+LET患者报告的平均RTS率为88.2%±10.4% (591/670),RTPL率为76.9%±16.5%(333/433)。iACLR组和ACLR+LET组的RTS无显著差异(OR, 0.84; 95% CI, 0.55-1.27; I2 = 0%; P = 0.41), RTPL组也无显著差异(OR, 1.20; 95% CI, 0.78-1.84; I2 0%; P = 0.40)。ACLR+LET患者报告了更好的侧到侧松弛和屈曲差异(均P < 0.001),并降低了移植物再破裂风险(OR, 0.31; 95% CI, 0.17-0.57; I2 = 0%; P < 0.001)。结论iACLR组与ACLR+LET组的RTS发生率无显著性差异。然而,在运动人群中,ACLR+LET具有优越的旋转稳定性和显著降低移植物破裂风险,支持其用于对耐久性至关重要的高风险患者。
{"title":"No Significant Difference in Return-to-Sport Rates Between Anterior Cruciate Ligament Reconstruction With Lateral Extra-Articular Tenodesis and Isolated Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis.","authors":"Viraj A Deshpande,Abhay Mathur,Isabel Barnett,Jordan Frausto,Patrick Saunders,David S Gazzaniga,Kevin C Parvaresh","doi":"10.1177/03635465251386013","DOIUrl":"https://doi.org/10.1177/03635465251386013","url":null,"abstract":"BACKGROUNDAlthough anterior cruciate ligament (ACL) reconstruction (ACLR) remains the standard to treat ACL ruptures, athletes remain at higher risk of graft rerupture. Concomitant lateral extra-articular tenodesis (LET) has gained popularity by improving rotatory stability, yet no synthesis of expected return-to-sport (RTS) rates in athletes undergoing ACLR with LET (ACLR+LET) exists.PURPOSESTo synthesize RTS outcomes in athletes undergoing ACLR+LET and compare RTS rates, patient-reported outcome measures, and adverse event rates between isolated ACLR (iACLR) and ACLR+LET in the athletic population.STUDY DESIGNSystematic review and meta-analysis; Level of evidence 4.METHODSStudies reporting RTS after primary single-bundle iACLR and ACLR+LET using an iliotibial band autograft at a minimum 12-month clinical follow-up were included. Primary outcomes were RTS and return to previous level (RTPL), while secondary outcomes were patient-reported outcomes and adverse events. Study quality was assessed using the Cochrane Risk of Bias 2 and Methodological Index for Non-Randomized Studies tools, while RTS criteria were assessed using the Return to Play Quality of Evidence tool. Meta-analyses and sensitivity analyses were performed using R with the \"Metafor\" package.RESULTSFourteen studies were included, encompassing 1791 patients (38% female; mean age, 23.5 ± 8.5 years); 840 patients (709 athletes) underwent iACLR and 951 patients (901 athletes) underwent ACLR+LET. Grafts, surgical techniques, and rehabilitation protocols varied, and athletes participated in a variety of competitive and noncompetitive sports. Patients with iACLR reported a mean overall RTS rate of 88.2% ± 1.8% (344/390) and mean RTPL rate of 79% ± 16.2% (264/334), while patients with ACLR+LET reported a mean RTS rate of 88.2% ± 10.4% (591/670) and RTPL rate of 76.9% ± 16.5% (333/433). RTS did not significantly differ between the iACLR and ACLR+LET groups (OR, 0.84; 95% CI, 0.55-1.27; I2 = 0%; P = .41), nor did RTPL (OR, 1.20; 95% CI, 0.78-1.84; I2 0%; P = .40). Patients with ACLR+LET reported superior side-to-side laxity and flexion differential (both P < .001) and reduced graft rerupture risk (OR, 0.31; 95% CI, 0.17-0.57; I2 = 0%; P < .001).CONCLUSIONThere is no significant difference in RTS rates between the iACLR and ACLR+LET groups. However, ACLR+LET is associated with superior rotational stability and significantly lower graft rupture risk in an athletic population, supporting its use in high-risk patients where durability is critical.","PeriodicalId":517411,"journal":{"name":"The American Journal of Sports Medicine","volume":"3 1","pages":"3635465251386013"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anterior Cruciate Ligament Reconstruction With a Quadriceps Tendon Autograft in Female Patients Shows Equivalent Graft Failure But Lower Activity Scores and Slower Quadriceps Strength Recovery Compared With Male Patients: A Systematic Review and Meta-analysis. 与男性患者相比,自体四头肌肌腱移植重建前交叉韧带的女性患者表现出相同的移植物衰竭,但活动评分较低,四头肌力量恢复较慢:一项系统回顾和荟萃分析。
Pub Date : 2026-01-12 DOI: 10.1177/03635465251376649
Anirudh Sharma,Muaaz Tahir,Osama Aweid,Tarek Boutefnouchet,Tamer Sweed,Amit Meena,Darren L de Sa,Rachel M Frank,Peter D'Alessandro,Shahbaz S Malik
BACKGROUNDThe use of a quadriceps tendon (QT) autograft has gained popularity in recent years, and it has been called the "graft of the future." However, there is limited evidence of its sex-specific outcomes in female patients.PURPOSETo assess the outcomes of anterior cruciate ligament reconstruction (ACLR) with a QT autograft specifically in female patients and to elucidate any differences in sex-specific outcomes compared with male patients.STUDY DESIGNSystematic review; Level of evidence, 2.METHODSThis systematic review was conducted in accordance with PRISMA guidelines using 4 online databases for a review of the literature. Studies using a QT autograft for ACLR but not reporting female-specific outcomes were excluded. Outcomes assessed included patient-reported outcomes, objective functional outcomes, and complications. A meta-analysis was performed in which data allowed for a comparison of outcomes with male patients.RESULTSThere were 9 studies included in this review, with a total of 714 female knees (mean age, 23.0 years) that underwent ACLR with a QT autograft. No difference was observed in the pooled graft failure rate between male and female patients at ≥24 months (8.8% vs 7.4%, respectively; P = .50). Female patients had lower Tegner scores at 24 months (P = .0007) and a lower quadriceps strength limb symmetry index at 6 months (P < .0001). No significant difference was seen in the side-to-side difference in instrumented laxity measurements at 6 months (P = .44) or in Lysholm scores at 24 months (P = .52). The mean extension loss in female patients was 0.07° (range, -0.22° to 0.58°) at 24 months. The return-to-sport rate in female patients ranged from 71.4% to 82.7%.CONCLUSIONEvidence from currently available literature suggests that there is no difference in graft failure rates between the sexes after ACLR with a QT autograft. Additionally, female patients have lower activity scores and slower quadriceps recovery compared with male patients.
近年来,自体四头肌肌腱(QT)移植越来越受欢迎,并被称为“未来的移植物”。然而,在女性患者中,其性别特异性结果的证据有限。目的评估女性患者自体QT间期移植前交叉韧带重建术(ACLR)的结果,并阐明与男性患者相比性别特异性结果的差异。研究设计:系统评价;证据等级2。方法根据PRISMA指南,使用4个在线数据库对文献进行系统综述。使用QT自体移植治疗ACLR但未报道女性特异性结果的研究被排除在外。评估的结果包括患者报告的结果、客观功能结果和并发症。进行了一项荟萃分析,其中的数据允许与男性患者的结果进行比较。结果本综述纳入9项研究,共有714例女性膝关节(平均年龄23.0岁)行ACLR合并自体QT移植。≥24个月时,男性和女性患者的移植失败率没有差异(分别为8.8%和7.4%,P = 0.50)。女性患者在24个月时Tegner评分较低(P = 0.0007), 6个月时下股四头肌力量肢体对称指数较低(P < 0.0001)。6个月时仪器松弛测量的侧对侧差异无显著性差异(P = 0.44), 24个月时Lysholm评分无显著性差异(P = 0.52)。女性患者24个月时的平均伸度损失为0.07°(范围为-0.22°至0.58°)。女性患者的恢复运动率从71.4%到82.7%不等。结论:现有文献的证据表明,ACLR合并QT自体移植物后的移植物失败率在性别之间没有差异。此外,与男性患者相比,女性患者的活动评分较低,股四头肌恢复较慢。
{"title":"Anterior Cruciate Ligament Reconstruction With a Quadriceps Tendon Autograft in Female Patients Shows Equivalent Graft Failure But Lower Activity Scores and Slower Quadriceps Strength Recovery Compared With Male Patients: A Systematic Review and Meta-analysis.","authors":"Anirudh Sharma,Muaaz Tahir,Osama Aweid,Tarek Boutefnouchet,Tamer Sweed,Amit Meena,Darren L de Sa,Rachel M Frank,Peter D'Alessandro,Shahbaz S Malik","doi":"10.1177/03635465251376649","DOIUrl":"https://doi.org/10.1177/03635465251376649","url":null,"abstract":"BACKGROUNDThe use of a quadriceps tendon (QT) autograft has gained popularity in recent years, and it has been called the \"graft of the future.\" However, there is limited evidence of its sex-specific outcomes in female patients.PURPOSETo assess the outcomes of anterior cruciate ligament reconstruction (ACLR) with a QT autograft specifically in female patients and to elucidate any differences in sex-specific outcomes compared with male patients.STUDY DESIGNSystematic review; Level of evidence, 2.METHODSThis systematic review was conducted in accordance with PRISMA guidelines using 4 online databases for a review of the literature. Studies using a QT autograft for ACLR but not reporting female-specific outcomes were excluded. Outcomes assessed included patient-reported outcomes, objective functional outcomes, and complications. A meta-analysis was performed in which data allowed for a comparison of outcomes with male patients.RESULTSThere were 9 studies included in this review, with a total of 714 female knees (mean age, 23.0 years) that underwent ACLR with a QT autograft. No difference was observed in the pooled graft failure rate between male and female patients at ≥24 months (8.8% vs 7.4%, respectively; P = .50). Female patients had lower Tegner scores at 24 months (P = .0007) and a lower quadriceps strength limb symmetry index at 6 months (P < .0001). No significant difference was seen in the side-to-side difference in instrumented laxity measurements at 6 months (P = .44) or in Lysholm scores at 24 months (P = .52). The mean extension loss in female patients was 0.07° (range, -0.22° to 0.58°) at 24 months. The return-to-sport rate in female patients ranged from 71.4% to 82.7%.CONCLUSIONEvidence from currently available literature suggests that there is no difference in graft failure rates between the sexes after ACLR with a QT autograft. Additionally, female patients have lower activity scores and slower quadriceps recovery compared with male patients.","PeriodicalId":517411,"journal":{"name":"The American Journal of Sports Medicine","volume":"24 1","pages":"3635465251376649"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis. 前交叉韧带重建后膝关节骨关节炎的危险因素:系统回顾和荟萃分析。
Pub Date : 2026-01-12 DOI: 10.1177/03635465251380285
Lei Zhang,Tianhao Xu,Qianjiang Xiong,Yunan Hu,Lei Fan,Weili Fu
BACKGROUNDThe incidence of knee osteoarthritis (KOA) after anterior cruciate ligament (ACL) reconstruction (ACLR) is high, posing significant challenges to long-term joint health and overall quality of life. Identifying and understanding the risk factors associated with postoperative KOA are crucial for improving surgical outcomes and guiding preventive strategies.PURPOSETo perform a systematic review and meta-analysis to investigate the risk factors for KOA after ACLR.STUDY DESIGNSystematic review; Level of evidence, 4.METHODSA systematic review with meta-analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. There were 3 databases (PubMed, Embase, and Web of Science) searched from inception to September 2024. All prospective and retrospective studies investigating the risk factors for KOA after ACLR were considered. The odds ratio (OR) or weighted mean difference (WMD) was calculated for potential risk factors if ≥2 studies assessed the same risk factor. Variables that could not be subjected to a meta-analysis were qualitatively analyzed.RESULTSA total of 39 studies met the inclusion criteria, with a combined sample size of 46,545, and 35 studies were subjected to a meta-analysis. The incidence of KOA after ACLR ranged from 2.34% to 100.00%, with a mean incidence of 8.29%. Overall, 9 factors were associated with an increase in the risk of KOA after ACLR: older age (WMD, 3.30 [95% CI, 2.33-4.28]), male sex (OR, 1.41 [95% CI, 1.14-1.74]), a higher body mass index (WMD, 1.31 [95% CI, 0.34-2.27]), bone-patellar tendon-bone autografts (OR, 1.66 [95% CI, 1.11-2.50]), a longer interval between ACL injury and surgery (WMD, 1.09 [95% CI, 0.55-1.63]), meniscectomy (OR, 2.42 [95% CI, 2.01-2.91]), meniscal injuries (OR, 3.35 [95% CI, 2.06-5.45]), additional injuries (OR, 3.65 [95% CI, 1.74-7.68]), and chondral lesions at the time of ACLR (OR, 2.15 [95% CI, 1.43-3.24]).CONCLUSIONOlder age, male sex, a higher body mass index, bone-patellar tendon-bone autografts, meniscectomy, a longer interval between ACL injury and surgery, and concomitant other injuries (meniscal or chondral) may increase the risk of KOA after ACLR. An increased awareness of relevant risk factors and targeted preventive strategies for modifiable risk factors can effectively reduce the incidence of KOA after ACLR.
背景:前交叉韧带(ACL)重建(ACLR)后膝关节骨关节炎(KOA)的发生率很高,对关节的长期健康和整体生活质量构成了重大挑战。识别和了解与术后KOA相关的危险因素对于改善手术效果和指导预防策略至关重要。目的通过系统回顾和荟萃分析,探讨ACLR术后KOA的危险因素。研究设计:系统评价;证据等级,4级。方法根据PRISMA(系统评价和荟萃分析首选报告项目)指南进行系统评价和荟萃分析。从成立到2024年9月,检索了3个数据库(PubMed, Embase和Web of Science)。所有调查ACLR术后KOA危险因素的前瞻性和回顾性研究都被考虑在内。如果有≥2项研究评估相同的危险因素,则计算潜在危险因素的优势比(OR)或加权平均差(WMD)。不能进行荟萃分析的变量进行定性分析。结果共有39项研究符合纳入标准,总样本量为46,545项,其中35项研究进行了meta分析。ACLR术后KOA发生率为2.34% ~ 100.00%,平均为8.29%。总体而言,9个因素与ACLR术后KOA风险增加有关:年龄较大(WMD, 3.30 [95% CI, 2.33-4.28]),男性(OR, 1.41 [95% CI, 1.14-1.74]),较高的体重指数(WMD, 1.31 [95% CI, 0.34-2.27]),骨-髌骨肌腱-骨自体移植物(OR, 1.66 [95% CI, 1.11-2.50]),前交叉韧带损伤与手术间隔时间较长(WMD, 1.09 [95% CI, 0.55-1.63]),半月板切除术(OR, 2.42 [95% CI, 2.01-2.91]),半月板损伤(OR, 3.35 [95% CI, 2.06-5.45]),额外损伤(OR, 3.65 [95% CI, 1.74-7.68]), ACLR时的软骨病变(OR, 2.15 [95% CI, 2.15])。1.43 - -3.24])。结论年龄较大、男性、较高的体重指数、自体骨-髌腱-骨移植、半月板切除术、前交叉韧带损伤与手术间隔时间较长以及合并其他损伤(半月板或软骨)可能增加ACLR术后KOA的发生风险。提高对相关危险因素的认识,针对可改变的危险因素采取有针对性的预防策略,可有效降低ACLR术后KOA的发生率。
{"title":"Risk Factors for Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis.","authors":"Lei Zhang,Tianhao Xu,Qianjiang Xiong,Yunan Hu,Lei Fan,Weili Fu","doi":"10.1177/03635465251380285","DOIUrl":"https://doi.org/10.1177/03635465251380285","url":null,"abstract":"BACKGROUNDThe incidence of knee osteoarthritis (KOA) after anterior cruciate ligament (ACL) reconstruction (ACLR) is high, posing significant challenges to long-term joint health and overall quality of life. Identifying and understanding the risk factors associated with postoperative KOA are crucial for improving surgical outcomes and guiding preventive strategies.PURPOSETo perform a systematic review and meta-analysis to investigate the risk factors for KOA after ACLR.STUDY DESIGNSystematic review; Level of evidence, 4.METHODSA systematic review with meta-analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. There were 3 databases (PubMed, Embase, and Web of Science) searched from inception to September 2024. All prospective and retrospective studies investigating the risk factors for KOA after ACLR were considered. The odds ratio (OR) or weighted mean difference (WMD) was calculated for potential risk factors if ≥2 studies assessed the same risk factor. Variables that could not be subjected to a meta-analysis were qualitatively analyzed.RESULTSA total of 39 studies met the inclusion criteria, with a combined sample size of 46,545, and 35 studies were subjected to a meta-analysis. The incidence of KOA after ACLR ranged from 2.34% to 100.00%, with a mean incidence of 8.29%. Overall, 9 factors were associated with an increase in the risk of KOA after ACLR: older age (WMD, 3.30 [95% CI, 2.33-4.28]), male sex (OR, 1.41 [95% CI, 1.14-1.74]), a higher body mass index (WMD, 1.31 [95% CI, 0.34-2.27]), bone-patellar tendon-bone autografts (OR, 1.66 [95% CI, 1.11-2.50]), a longer interval between ACL injury and surgery (WMD, 1.09 [95% CI, 0.55-1.63]), meniscectomy (OR, 2.42 [95% CI, 2.01-2.91]), meniscal injuries (OR, 3.35 [95% CI, 2.06-5.45]), additional injuries (OR, 3.65 [95% CI, 1.74-7.68]), and chondral lesions at the time of ACLR (OR, 2.15 [95% CI, 1.43-3.24]).CONCLUSIONOlder age, male sex, a higher body mass index, bone-patellar tendon-bone autografts, meniscectomy, a longer interval between ACL injury and surgery, and concomitant other injuries (meniscal or chondral) may increase the risk of KOA after ACLR. An increased awareness of relevant risk factors and targeted preventive strategies for modifiable risk factors can effectively reduce the incidence of KOA after ACLR.","PeriodicalId":517411,"journal":{"name":"The American Journal of Sports Medicine","volume":"94 1","pages":"3635465251380285"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthroscopic Primary Labral Reconstruction in the Hip: Minimum 10-Year Outcomes With a Nested Propensity-Matched Control 关节镜下髋关节初级上唇重建:最小10年结果与巢式倾向匹配对照
Pub Date : 2026-01-12 DOI: 10.1177/03635465251392196
Benjamin G. Domb, Drashti Sikligar, Andrew R. Schab, Roger Quesada-Jimenez, Tyler R. McCarroll, Ady H. Kahana-Rojkind
Background: Labral reconstruction demonstrates promising short- and midterm benefits for irreparable labral tears, but long-term outcomes remain understudied. Purpose: To evaluate minimum 10-year patient-reported outcomes (PROs) of primary arthroscopic labral reconstruction compared with a propensity-matched control group. Study Design: Cohort study; Level of evidence, 2. Methods: Data were prospectively collected for all patients who underwent primary arthroscopic labral reconstruction with allograft as treatment for femoroacetabular impingement and labral tears. Patients included had preoperative and 10-year minimum postoperative data for PROs. Patients were propensity-matched to a control group that had undergone primary labral repair in a 1:3 ratio based on age, sex, body mass index, and acetabular Outerbridge grade. Patient characteristics and PROs were reported and compared between the groups. Rates of meeting clinically relevant thresholds, secondary arthroscopy, and survivorship were also compared. Results: A total of 22 hips (22 patients) of 27 eligible hips (81%) that underwent primary labral reconstruction (RECON) were matched to 66 hips (63 patients) that underwent primary repair (REPAIR). Both groups had similar preoperative and postoperative scores for all PROs ( P > .05). The RECON group met the substantial clinical benefit for the Non-Arthritic Hip Score at a lower rate than the REPAIR group ( P < .05). The RECON group underwent secondary arthroscopy at similar rates to the REPAIR group (13.6% vs 10.6%; P > .05) and had similar rates of survivorship (90.9% vs 81.8%; P > .05). Conclusion: Primary labral reconstruction demonstrated favorable outcomes at a minimum 10-year follow-up. When compared with a propensity-matched control group that underwent primary labral repair, both groups achieved similar postoperative PRO scores. Additionally, they met clinically meaningful thresholds and underwent secondary procedures at comparable rates.
背景:对于无法修复的唇裂,唇部重建显示出有希望的短期和中期益处,但长期结果仍有待研究。目的:与倾向匹配的对照组比较,评估原发性关节镜下唇部重建的最低10年患者报告结果(PROs)。研究设计:队列研究;证据等级2。方法:前瞻性地收集所有接受首次关节镜下同种异体唇瓣重建术治疗股骨髋臼撞击和唇裂的患者的资料。纳入的患者术前和术后10年的最小PROs数据。根据年龄、性别、体重指数和髋臼外桥分级,将患者倾向匹配到接受初级唇部修复术的对照组,比例为1:3。报告两组患者的特征和PROs并进行比较。达到临床相关阈值的比率、二次关节镜检查和生存率也进行了比较。结果:27个符合条件的髋关节(81%)中,22个髋关节(22例患者)接受了初级唇部重建(RECON),与66个髋关节(63例患者)接受了初级修复(repair)。两组术前和术后所有PROs评分相似(P > 0.05)。RECON组在非关节炎髋关节评分方面达到实质性临床获益的比率低于REPAIR组(P < 0.05)。RECON组接受二次关节镜检查的比例与REPAIR组相似(13.6% vs 10.6%; P > 0.05),生存率相似(90.9% vs 81.8%; P > 0.05)。结论:在至少10年的随访中,初级唇部重建显示出良好的结果。与接受初次唇部修复的倾向匹配对照组相比,两组术后PRO评分相似。此外,他们达到了有临床意义的阈值,并以相当的比率接受了二次手术。
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引用次数: 0
Distal Radius Allograft for Posterior Glenoid Bone Loss: A Cadaveric Graft Matching Study and Biomechanical Study. 桡骨远端同种异体移植治疗后盂骨丢失:尸体移植匹配研究和生物力学研究。
Pub Date : 2026-01-11 DOI: 10.1177/03635465251400313
Edward J Testa,Ryan T Fallon,Rohit Badida,Michael J Kutschke,Jonathan Liu,Stephen E Marcaccio,John D Milner,Brett D Owens
BACKGROUNDPosterior glenoid reconstruction for shoulder instability is commonly performed with distal tibia allograft (DTA), but with variable results. Recent evidence shows that distal radius allograft (DRA) has a radius of curvature (ROC) that more closely matches that of the glenoid.HYPOTHESISDRA would more closely match the posterior glenoid than DTA in ROC and bone mineral density (BMD), and DRA would have superior biomechanical characteristics in a posterior instability model.STUDY DESIGNControlled laboratory study.METHODSTen cadaveric shoulders, ankles, and wrists underwent computed tomography scans. ROC and BMD for the glenoid, DRA, and DTA were measured. Biomechanical analysis was performed for each shoulder by translating the humerus 10 mm posterior-inferiorly relative to the glenoid and recording the maximum force (N) required and lateral displacement (mm) of the humeral head. Five conditions were tested for each shoulder: intact, posterior capsulolabral tear, 30% glenoid bone loss, DRA, and DTA.RESULTSTen shoulders were tested (mean age, 58.1 years [SD, 5.9 years]). The mean anterior-posterior ROC was 31.1 mm (SD, 6.9 mm) for the glenoid, compared to 14.0 mm (SD, 1.9 mm; P < .0001) for DRA, and 68.2 mm (SD, 29.1 mm; P < .0001) for DTA. The mean superior-inferior ROC was 30.2 mm (SD, 3.7 mm) for the glenoid, compared to 30.7 mm (SD, 3.2 mm; P = .901) for DRA, and 23.5 mm (SD, 5.4 mm, P < .001) for DTA. For biomechanical testing, DRA demonstrated increased resistance to force compared with the instability and bone loss states (42.1 N [SD, 14.3 N] vs capsulolabral tear 21.5 N [SD, 17.9 N; P = .002] and bone loss 14.3 N [SD, 7.8 N; P < .001], respectively). However, DRA showed no significant difference in force resistance when compared with DTA (36.3 N [SD, 9.3 N]; P = .362).CONCLUSIONThe native glenoid ROC and BMD are more comparable with DRA than DTA. The DRA restores posterior forces comparable to those of the native glenoid and did not result in significantly greater resistance forces when compared with DTA.CLINICAL RELEVANCEThese anatomic data support DRA use in posterior glenoid reconstruction.
背景:肩关节不稳定的后盂重建通常采用胫骨远端同种异体移植(DTA),但结果不一。最近的证据表明,远端桡骨异体移植物(DRA)的曲率半径(ROC)更接近于关节盂的曲率半径。假设在ROC和骨密度(BMD)方面,DRA比DTA更接近后盂关节,并且在后路不稳定模型中,DRA具有更优越的生物力学特征。研究设计:对照实验室研究。方法对尸体肩部、踝关节和手腕进行计算机断层扫描。测量关节盂、DRA和DTA的ROC和BMD。通过将肱骨相对于关节盂向后下方平移10mm,记录所需的最大力(N)和肱骨头的侧向位移(mm),对每个肩部进行生物力学分析。对每个肩膀进行了五种情况的测试:完整,后囊撕裂,30%盂骨丢失,DRA和DTA。结果10例肩部检查(平均年龄58.1岁[SD, 5.9岁])。肩关节的平均前后ROC为31.1 mm (SD, 6.9 mm),而DRA为14.0 mm (SD, 1.9 mm, P < 0.0001), DTA为68.2 mm (SD, 29.1 mm, P < 0.0001)。关节盂的平均优劣ROC为30.2 mm (SD, 3.7 mm),而DRA为30.7 mm (SD, 3.2 mm, P = 0.901), DTA为23.5 mm (SD, 5.4 mm, P < 0.001)。在生物力学测试中,与不稳定和骨质流失状态相比,DRA表现出更大的抗力能力(分别为42.1 N [SD, 14.3 N]和21.5 N [SD, 17.9 N; P = 0.002]和骨质流失14.3 N [SD, 7.8 N; P < 0.001])。然而,与DTA相比,DRA在抗力方面没有显著差异(36.3 N [SD, 9.3 N]; P = .362)。结论与DRA相比,膝关节骨密度和关节关节ROC值更具可比性。与DTA相比,DRA恢复的后侧力量与原有的关节盂相当,并且不会产生明显更大的阻力。临床意义:这些解剖学数据支持DRA在肩关节后路重建中的应用。
{"title":"Distal Radius Allograft for Posterior Glenoid Bone Loss: A Cadaveric Graft Matching Study and Biomechanical Study.","authors":"Edward J Testa,Ryan T Fallon,Rohit Badida,Michael J Kutschke,Jonathan Liu,Stephen E Marcaccio,John D Milner,Brett D Owens","doi":"10.1177/03635465251400313","DOIUrl":"https://doi.org/10.1177/03635465251400313","url":null,"abstract":"BACKGROUNDPosterior glenoid reconstruction for shoulder instability is commonly performed with distal tibia allograft (DTA), but with variable results. Recent evidence shows that distal radius allograft (DRA) has a radius of curvature (ROC) that more closely matches that of the glenoid.HYPOTHESISDRA would more closely match the posterior glenoid than DTA in ROC and bone mineral density (BMD), and DRA would have superior biomechanical characteristics in a posterior instability model.STUDY DESIGNControlled laboratory study.METHODSTen cadaveric shoulders, ankles, and wrists underwent computed tomography scans. ROC and BMD for the glenoid, DRA, and DTA were measured. Biomechanical analysis was performed for each shoulder by translating the humerus 10 mm posterior-inferiorly relative to the glenoid and recording the maximum force (N) required and lateral displacement (mm) of the humeral head. Five conditions were tested for each shoulder: intact, posterior capsulolabral tear, 30% glenoid bone loss, DRA, and DTA.RESULTSTen shoulders were tested (mean age, 58.1 years [SD, 5.9 years]). The mean anterior-posterior ROC was 31.1 mm (SD, 6.9 mm) for the glenoid, compared to 14.0 mm (SD, 1.9 mm; P < .0001) for DRA, and 68.2 mm (SD, 29.1 mm; P < .0001) for DTA. The mean superior-inferior ROC was 30.2 mm (SD, 3.7 mm) for the glenoid, compared to 30.7 mm (SD, 3.2 mm; P = .901) for DRA, and 23.5 mm (SD, 5.4 mm, P < .001) for DTA. For biomechanical testing, DRA demonstrated increased resistance to force compared with the instability and bone loss states (42.1 N [SD, 14.3 N] vs capsulolabral tear 21.5 N [SD, 17.9 N; P = .002] and bone loss 14.3 N [SD, 7.8 N; P < .001], respectively). However, DRA showed no significant difference in force resistance when compared with DTA (36.3 N [SD, 9.3 N]; P = .362).CONCLUSIONThe native glenoid ROC and BMD are more comparable with DRA than DTA. The DRA restores posterior forces comparable to those of the native glenoid and did not result in significantly greater resistance forces when compared with DTA.CLINICAL RELEVANCEThese anatomic data support DRA use in posterior glenoid reconstruction.","PeriodicalId":517411,"journal":{"name":"The American Journal of Sports Medicine","volume":"48 1","pages":"3635465251400313"},"PeriodicalIF":0.0,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Stabilization for Recurrent Shoulder Instability Using Distal Tibial Allograft: Open Technique With Fresh Allograft Versus Arthroscopic Technique With Frozen Allograft, a Cohort Study. 胫骨远端同种异体移植手术稳定复发性肩关节不稳:开放技术与新鲜同种异体移植相比,关节镜技术与冷冻同种异体移植,一项队列研究。
Pub Date : 2026-01-11 DOI: 10.1177/03635465251399165
Ivan Wong,Marco Adriani,Sarah Remedios,Phob Ganokroj,Nate J Dickinson,Annalise M Peebles,Ryan J Whalen,Stephanie K Eble,Justin W Arner,Toufic R Jildeh,Liam A Peebles,Anthony A Romeo,Matthew T Provencher
BACKGROUNDThe distal tibial allograft (DTA) procedure has been described as an effective treatment option for reconstruction of glenoid bone deficiency in the setting of recurrent anterior shoulder instability; however, no comparative data between an arthroscopic or open DTA approach are available.PURPOSETo compare the clinical and radiographic outcomes of patients who underwent open fresh versus arthroscopic frozen DTA stabilization procedures.STUDY DESIGNCohort study; Level of evidence, 4.METHODSA retrospective review was performed of consecutive patients with a minimum of 5% anterior glenoid bone loss (GBL) associated with recurrent anterior shoulder instability who underwent stabilization with either open fresh or arthroscopic frozen DTA glenoid reconstruction and had a minimum 2-year follow-up. Consecutive patients undergoing arthroscopic frozen DTA were matched in a 1-to-1 format to patients undergoing open fresh DTA by age, body mass index, and number of previous shoulder operations. Patients were evaluated postoperatively in terms of the Western Ontario Shoulder Instability Index (WOSI) score, pain relief, and episodes of recurrent instability. All patients also underwent postoperative imaging evaluation with computed tomography (CT) in which graft incorporation and allograft angle were measured.RESULTSA total of 100 patients (50 open fresh DTA, 50 arthroscopic frozen DTA) with a median ± IQR age of 32.0 ± 6.7 and 27.9 ± 15.9 years, respectively, were analyzed at minimum 2-year follow-up. The open fresh DTA group had significantly more male patients than the arthroscopic frozen DTA group (98% vs 70%, respectively; P < .01), and patients in the open fresh DTA group had significantly greater GBL defects (25% ± 6% vs 21% ± 11%, respectively; P < .01). Both groups demonstrated significantly improved WOSI scores (P < .05) and had similar clinical outcomes regarding improvement postoperatively (P = .61), pain relief (P = .09), and recurrence rates (P = .31). Only 1 case of recurrent instability was noted, which occurred in the open fresh DTA cohort. Analysis of CT data at a mean of 15 months postoperatively showed no significant difference between open fresh versus arthroscopic frozen DTA groups.CONCLUSIONOpen fresh and arthroscopic frozen DTA for anatomic glenoid reconstruction in patients with recurrent anterior shoulder instability resulted in a clinically stable joint with comparable outcomes and excellent healing rates. Additional long-term studies are needed to determine whether the surgical technique and type of allograft used influence clinical outcomes and whether these results are maintained over time.
背景:胫骨远端同种异体移植物(DTA)手术被认为是肩关节前部不稳定复发时肩关节骨缺乏重建的有效治疗选择;然而,没有关节镜或开放式DTA入路的比较数据。目的比较开放新鲜与关节镜下冷冻DTA稳定手术患者的临床和影像学结果。研究设计:队列研究;证据等级,4级。方法回顾性分析了至少5%的前肩关节盂骨丢失(GBL)与复发性肩关节前部不稳定相关的连续患者,这些患者接受了开放新鲜或关节镜下冷冻DTA肩关节盂重建的稳定,并进行了至少2年的随访。连续接受关节镜冷冻DTA的患者与接受开放式新鲜DTA的患者按年龄、体重指数和既往肩关节手术次数进行1比1匹配。术后根据西安大略省肩部不稳定指数(WOSI)评分、疼痛缓解和复发性不稳定发作情况对患者进行评估。所有患者还接受了术后计算机断层扫描(CT)成像评估,其中测量了移植物融合和异体移植物角度。结果共100例患者(50例切开新鲜DTA, 50例关节镜下冷冻DTA),随访至少2年,中位±IQR年龄分别为32.0±6.7岁和27.9±15.9岁。切开新鲜DTA组男性患者明显多于关节镜下冷冻DTA组(分别为98%和70%,P < 0.01),切开新鲜DTA组患者GBL缺损显著高于关节镜下冷冻DTA组(分别为25%±6%和21%±11%,P < 0.01)。两组的WOSI评分均有显著改善(P < 0.05),在术后改善(P = 0.61)、疼痛缓解(P = 0.09)和复发率(P = 0.31)方面的临床结果相似。只有1例复发性不稳定,发生在开放式新鲜DTA队列中。术后平均15个月的CT数据分析显示,切开新鲜DTA组与关节镜下冷冻DTA组之间无显著差异。结论开放新鲜和关节镜下冷冻DTA治疗复发性肩关节前失稳患者解剖性肩关节重建术可获得临床稳定的关节,疗效相当,治愈率高。需要进一步的长期研究来确定手术技术和同种异体移植物类型是否会影响临床结果,以及这些结果是否能长期维持。
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The American Journal of Sports Medicine
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