Giacomo Garibotto, Pasquale Esposito, D. Picciotto, D. Verzola, F. Costigliolo, V. Zanetti, Michela Saio, E. Russo, F. Viazzi
Cellular senescence is a condition where cells undergo a permanent cell cycle arrest, accompanied by a unique set of functional and morphological changes. While initial studies of senescence have largely focused on its role as a barrier to extended cell division and tumorigenesis, in recent years cell senescence has emerged as an important driver of aging and age-related disease in different tissues, including the kidney. Accelerated cell senescence may decrease kidney repair capacity because of cell cycle arrest; in addition cell senescence promotes glomerulosclerosis and tubulointerstitial fibrosis via the production and release of proinflammatory and matrix-degrading molecules. Although almost all glomerular and tubular cells may undergo senescent changes, the glomerular podocytes and proximal tubule cells are the most commonly affected cells. In these days, treating cell senescence is moving his steps from the preclinical to the clinical stage. While cell senescence appears to be well accepted as a new mechanism for kidney damage and chronic kidney disease [CKD] progression, there still are many unanswered questions regarding how to dectect it in kidney biopsies, which is prognostic meaning of individual kidney senescnce markers, which the role of different cells involved, as well as the efficacy of the emerging senescence-targeted therapies on the progression and complications of CKD.
{"title":"Targeting kidney cell senescence: a new paradigm for the treatment of chronic kidney disease?","authors":"Giacomo Garibotto, Pasquale Esposito, D. Picciotto, D. Verzola, F. Costigliolo, V. Zanetti, Michela Saio, E. Russo, F. Viazzi","doi":"10.62684/fjdt9733","DOIUrl":"https://doi.org/10.62684/fjdt9733","url":null,"abstract":"Cellular senescence is a condition where cells undergo a permanent cell cycle arrest, accompanied by a unique set of functional and morphological changes. While initial studies of senescence have largely focused on its role as a barrier to extended cell division and tumorigenesis, in recent years cell senescence has emerged as an important driver of aging and age-related disease in different tissues, including the kidney. Accelerated cell senescence may decrease kidney repair capacity because of cell cycle arrest; in addition cell senescence promotes glomerulosclerosis and tubulointerstitial fibrosis via the production and release of proinflammatory and matrix-degrading molecules. Although almost all glomerular and tubular cells may undergo senescent changes, the glomerular podocytes and proximal tubule cells are the most commonly affected cells. In these days, treating cell senescence is moving his steps from the preclinical to the clinical stage. While cell senescence appears to be well accepted as a new mechanism for kidney damage and chronic kidney disease [CKD] progression, there still are many unanswered questions regarding how to dectect it in kidney biopsies, which is prognostic meaning of individual kidney senescnce markers, which the role of different cells involved, as well as the efficacy of the emerging senescence-targeted therapies on the progression and complications of CKD.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"77 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The SARS-CoV-2 pandemic has caused an unprecedented health and social crisis worldwide. In this paper we summarized the different therapeutic actions planned from the two sides of the Atlantic Ocean (USA and Europe) to fight the initial phase of COVID-19 pandemic, with an emphasis on passive immunotherapies such as convalescent plasma and anti-Spike monoclonal antibodies. The lessons derived from the critical analysis of that period could drive our treatment decisions for the next pandemics.
{"title":"Controversies in COVID-19 pandemic: the case of convalescent plasma","authors":"Massimo Franchini, Daniele Focosi","doi":"10.62684/tksz2015","DOIUrl":"https://doi.org/10.62684/tksz2015","url":null,"abstract":"The SARS-CoV-2 pandemic has caused an unprecedented health and social crisis worldwide. In this paper we summarized the different therapeutic actions planned from the two sides of the Atlantic Ocean (USA and Europe) to fight the initial phase of COVID-19 pandemic, with an emphasis on passive immunotherapies such as convalescent plasma and anti-Spike monoclonal antibodies. The lessons derived from the critical analysis of that period could drive our treatment decisions for the next pandemics.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"321 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141386253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felice Petraglia, S. Vannuccini, Angela Gallone, Virginia Manzi, Francesco La Torre, Federico Toscano, Nicolò Buffi, F. Sorbi, Massimiliano Fambrini
The development of new medical diagnostic technologies and procedures and the drop in the birth rate observed in the last decades represent the main causes of increased incidence of uterine disorders. Endometriosis, adenomyosis and uterine fibroids are benign uterine disorders whose understanding have greatly increased and clinical management have improved in recent times. Molecular pathogenetic aspects, new imaging technologies (transvaginal ultrasound and magnetic resonance), biochemical markers, hormonal drugs, minimally invasive surgical technologies were studied for diagnosis and treatment of endometriosis, adenomyosis and uterine fibroids. Sex steroid hormones, inflammation and fibrosis are key pathogenetic mechanisms of uterine disorders. Endometriosis is characterized by endometrial cells migrating outside the uterus and implanting in the pelvis, associated with inflammation, neuroangiogenesis and fibrosis causing dysmenorrhea, pelvic pain, dysuria and dyschezia. The painful symptoms may activate central sensitization and stress responses. Adenomyosis is caused by the presence of endometrial cells within the myometrium, characterized by pelvic pain, abundant menstrual bleeding and infertility. Heavy menstrual bleeding can cause the reduction of iron reserves and consequently iron deficiency anemia. Uterine fibroids are the most common benign tumors of the uterus in women of reproductive age. They can be asymptomatic, but they frequently manifest with abnormal uterine bleeding, pelvic discomfort, and challenges with fertility. Submucosal or intramural fibroids can hinder embryo implantation and potentially lead to pregnancy-related complications such as miscarriage, placenta previa, preterm labor, or postpartum hemorrhage. The increased incidence of uterine disorders has a major clinical impact on women’s health and a very poor quality of life is often reported. Therefore, prompt diagnosis and effective management are mandatory.
{"title":"Uterine disorders in reproductive life","authors":"Felice Petraglia, S. Vannuccini, Angela Gallone, Virginia Manzi, Francesco La Torre, Federico Toscano, Nicolò Buffi, F. Sorbi, Massimiliano Fambrini","doi":"10.62684/qpnc8303","DOIUrl":"https://doi.org/10.62684/qpnc8303","url":null,"abstract":"The development of new medical diagnostic technologies and procedures and the drop in the birth rate observed in the last decades represent the main causes of increased incidence of uterine disorders. Endometriosis, adenomyosis and uterine fibroids are benign uterine disorders whose understanding have greatly increased and clinical management have improved in recent times. Molecular pathogenetic aspects, new imaging technologies (transvaginal ultrasound and magnetic resonance), biochemical markers, hormonal drugs, minimally invasive surgical technologies were studied for diagnosis and treatment of endometriosis, adenomyosis and uterine fibroids. Sex steroid hormones, inflammation and fibrosis are key pathogenetic mechanisms of uterine disorders. Endometriosis is characterized by endometrial cells migrating outside the uterus and implanting in the pelvis, associated with inflammation, neuroangiogenesis and fibrosis causing dysmenorrhea, pelvic pain, dysuria and dyschezia. The painful symptoms may activate central sensitization and stress responses. Adenomyosis is caused by the presence of endometrial cells within the myometrium, characterized by pelvic pain, abundant menstrual bleeding and infertility. Heavy menstrual bleeding can cause the reduction of iron reserves and consequently iron deficiency anemia. Uterine fibroids are the most common benign tumors of the uterus in women of reproductive age. They can be asymptomatic, but they frequently manifest with abnormal uterine bleeding, pelvic discomfort, and challenges with fertility. Submucosal or intramural fibroids can hinder embryo implantation and potentially lead to pregnancy-related complications such as miscarriage, placenta previa, preterm labor, or postpartum hemorrhage. The increased incidence of uterine disorders has a major clinical impact on women’s health and a very poor quality of life is often reported. Therefore, prompt diagnosis and effective management are mandatory.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"47 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141381797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandro Gallo, Salvatore Fregola, Filomena Talarico, Stella Fragkiadaki, D. Kontaxopoulou, Evangelia Stanitsa, Katarina Vukojević, Danira Matijaca, Alessio Merola, Ivan Radević, Katjia Matesan, Amanda Gigliotti, Miodrag Miljković, Srdjan Kojaetinac, Vlado Dimovski, Anamarija Kejar, Danica Stevovic, Roberta Matkovic, Elena Sodano, Guido Piccoli, Nicola Mayera, E. Pedace, Darja Šemrov, Pietro Hiram Guzzi
The improvement of health and social care needs the introduction of shared solution at transnational level. The SI4CARE (Social Inno- vation for Integrated Health Care) project is a transnational initiative within the Adriatic-Ionian regions aiming to develop strategies to improve the current status of health and social care. The project member Municipality of Miglierina, a small rural town in Calabria, is developing a pilot action related to the use of wearable device for monitoring people affected by dementia together with the project partner Ra.Gi.. Ra.Gi. is a non-profit organization dedicated to assisting people with dementia in day care centers and so-called dementia-friendly communities. The pilot is based on the use of smart wearable devices to monitor these patients during their daily lifetime. This paper focuses on the design and implementation of the system discussing the proposed application, the strengths and weaknesses. We report results from a pilot experiment showing the effectiveness of this approach. Finally, the possibility of extending the experiment to the other Adriatic-Ionian region is presented.
{"title":"Using Smart Wearable Devices for Supporting Patients Affected by Dementia in Rural Areas of Calabria","authors":"Alessandro Gallo, Salvatore Fregola, Filomena Talarico, Stella Fragkiadaki, D. Kontaxopoulou, Evangelia Stanitsa, Katarina Vukojević, Danira Matijaca, Alessio Merola, Ivan Radević, Katjia Matesan, Amanda Gigliotti, Miodrag Miljković, Srdjan Kojaetinac, Vlado Dimovski, Anamarija Kejar, Danica Stevovic, Roberta Matkovic, Elena Sodano, Guido Piccoli, Nicola Mayera, E. Pedace, Darja Šemrov, Pietro Hiram Guzzi","doi":"10.62684/ulhy8584","DOIUrl":"https://doi.org/10.62684/ulhy8584","url":null,"abstract":"The improvement of health and social care needs the introduction of shared solution at transnational level. The SI4CARE (Social Inno- vation for Integrated Health Care) project is a transnational initiative within the Adriatic-Ionian regions aiming to develop strategies to improve the current status of health and social care. The project member Municipality of Miglierina, a small rural town in Calabria, is developing a pilot action related to the use of wearable device for monitoring people affected by dementia together with the project partner Ra.Gi.. Ra.Gi. is a non-profit organization dedicated to assisting people with dementia in day care centers and so-called dementia-friendly communities. The pilot is based on the use of smart wearable devices to monitor these patients during their daily lifetime. This paper focuses on the design and implementation of the system discussing the proposed application, the strengths and weaknesses. We report results from a pilot experiment showing the effectiveness of this approach. Finally, the possibility of extending the experiment to the other Adriatic-Ionian region is presented.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"281 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141386806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A DFT study of the photochemical dimerization on 4-nitro-2-phenylindone has been performed. The reaction was performed by Marussia Bakunin in 1911 but the reaction products were not identified. Calculations allow us to know that the reaction occurred through the first excited singlet state. The nature of the first excited singlet state allowed the formation of both head-to-head and head-to-tail dimers. Finally, the main product was the syn-trans head-to-tail dimer, while the other two compounds found by Bakunin in lower yields were the syn-trans head-to-head dimer and the syn-cis head-to-tail dimer. The results described by Bakunin can not be interpreted assuming the reaction occurred through the formation of the excited triplet state.
{"title":"The Photochemical Dimerization of 4-Nitro-2-Phenylindone. A DFT Study","authors":"Maurizio D’Auria, Lucia Emanuele, R. Racioppi","doi":"10.62684/eyvj9669","DOIUrl":"https://doi.org/10.62684/eyvj9669","url":null,"abstract":"A DFT study of the photochemical dimerization on 4-nitro-2-phenylindone has been performed. The reaction was performed by Marussia Bakunin in 1911 but the reaction products were not identified. Calculations allow us to know that the reaction occurred through the first excited singlet state. The nature of the first excited singlet state allowed the formation of both head-to-head and head-to-tail dimers. Finally, the main product was the syn-trans head-to-tail dimer, while the other two compounds found by Bakunin in lower yields were the syn-trans head-to-head dimer and the syn-cis head-to-tail dimer. The results described by Bakunin can not be interpreted assuming the reaction occurred through the formation of the excited triplet state.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"51 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present Editorial deals with the highly pathogenic avian influenza (HPAI) virus A(H5N1), whose clade 2.3.4.4b has been identified in several domestic and wild bird and mammalian species, both terrestrial and aquatic, with mass mortality outbreaks also affecting South American sea lions. Within this fast evolving scenario, the progressively and consistently expanding range of virus-susceptible host species alongside the prominent viral neurotropism and neuropathogenicity are a matter of concern, with A(H5N1) virus having additionally spread among USA cattle, which may also shed it through their milk. Although it is not happening at the moment, the possibility A(H5N1) virus may sooner or later become easily transmissible between people appears to be largely plausible. A collaborative, intersectorial and multidisciplinary approach, based upon the "One Health" concept/principle is strongly needed in order to properly counteract the global menace brought about by the HPAI A(H5N1) virus, thereby taking inspiration from the lessons learned during the COVID-19 pandemic.
{"title":"A(H5N1) Avian Influenza Virus: A New Pandemic Threat on the Horizon?","authors":"Giovanni Di Guardo","doi":"10.62684/yzzr4829","DOIUrl":"https://doi.org/10.62684/yzzr4829","url":null,"abstract":"The present Editorial deals with the highly pathogenic avian influenza (HPAI) virus A(H5N1), whose clade 2.3.4.4b has been identified in several domestic and wild bird and mammalian species, both terrestrial and aquatic, with mass mortality outbreaks also affecting South American sea lions. Within this fast evolving scenario, the progressively and consistently expanding range of virus-susceptible host species alongside the prominent viral neurotropism and neuropathogenicity are a matter of concern, with A(H5N1) virus having additionally spread among USA cattle, which may also shed it through their milk. Although it is not happening at the moment, the possibility A(H5N1) virus may sooner or later become easily transmissible between people appears to be largely plausible. A collaborative, intersectorial and multidisciplinary approach, based upon the \"One Health\" concept/principle is strongly needed in order to properly counteract the global menace brought about by the HPAI A(H5N1) virus, thereby taking inspiration from the lessons learned during the COVID-19 pandemic.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"15 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141273463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Babbi, Matteo Manfredi, Elisa Bertolini, Castrense Savojardo, P. Martelli, R. Casadio
Next-generation sequencing techniques provide an unprecedented characterisation of human Variants of Unknown Significance (VUS). Single-residue variations are collected in public databases and associated to diseases and phenotypes. However, for detailing at molecular level mechanisms involved in the onset of diseases, variants need structural and functional annotation. Here we propose a new portal called Bioinformatic Sweeties, collecting resources ranging from databases for human protein annotation to computational methods for predicting impact of variants. The tools, included in the portal, allow computing different protein properties, ranging from solvent accessible surface to stability and interactions and do not require login or installation. The portal, speeding up the variant characterisation process, is available at: https://bioinformaticsweeties.biocomp.unibo.it
{"title":"Bioinformatic Sweeties: a unified portal for characterizing human proteins and their variants","authors":"G. Babbi, Matteo Manfredi, Elisa Bertolini, Castrense Savojardo, P. Martelli, R. Casadio","doi":"10.62684/hdyo1899","DOIUrl":"https://doi.org/10.62684/hdyo1899","url":null,"abstract":"Next-generation sequencing techniques provide an unprecedented characterisation of human Variants of Unknown Significance (VUS). Single-residue variations are collected in public databases and associated to diseases and phenotypes. However, for detailing at molecular level mechanisms involved in the onset of diseases, variants need structural and functional annotation. Here we propose a new portal called Bioinformatic Sweeties, collecting resources ranging from databases for human protein annotation to computational methods for predicting impact of variants. The tools, included in the portal, allow computing different protein properties, ranging from solvent accessible surface to stability and interactions and do not require login or installation. The portal, speeding up the variant characterisation process, is available at: https://bioinformaticsweeties.biocomp.unibo.it","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. The role of the Nurse Navigator was developed in order to address the health disparities created by the social determinants of health, , being an expert, specialized and trained nurse who takes charge of the patient diagnosed with cancer and accompanies him throughout the treatment process, helping him to extricate himself from the labyrinth of the healthcare system. This figure was introduced and studied in the general surgery of the Madonna del Soccorso hospital in San Benedetto del Tronto. Objective. Primary outcomes are the reduction of time interval between the first patient contact and each phase of the diagnostic and therapeutic pathway. Secondary outcomes are the assessment of the number and frequency of contacts between the patient and the ONN, as well as of the number and type of organized procedures, and patient satisfaction assessment. Methods. A prospective cohort study was conducted with a historical control group represented by the same number of cancer patients treated in the same surgical unit in the previous year and not followed by an ONN. The patients’ contacts were registered within a dedicated mobile number. A questionnaire on patient satisfaction with cancer care was completed and administered to patients in a blinded manner by a third party to avoid bias. Results. The study group included 30 cancer patients. The average time from first contact to primary diagnostic test was 8 days versus 20 days in 2022 (control group). All patients underwent discussion by a multidisciplinary team (MDT), and the time to reach the MDT discussion was not different between the 2 groups. Five patients were deemed ineligible for surgery, and the average time to referral to a medical oncologist was 2 days in the study compared to 10 days in the control group. Twenty-five patients were eligible for initial surgery, and the mean time from first contact to surgery was 23 days after ONN establishment compared with 45 days in the control group. Each patient had an average of 10 phone calls with the ONN. For patients with a first diagnosis of cancer, the ONN organized an average of 4 tests. A patient satisfaction questionnaire achieved a response rate of 100%, with an average score of 85.2/90. Conclusion. The data demonstrate that ONN service is effective and may improve the quality and outcomes of the management path of surgical oncology patients. The professional role of the ONN, with predefined technical and non-technical skills, should also be officially recognized by the healthcare system and hospital administration.
{"title":"A new figure in oncology pathways: Oncology Nurse Navigator and his preliminary results in the San Benedetto del Tronto Surgery","authors":"Ilenia Merlini, Salomone Di Saverio","doi":"10.62684/wvqv9876","DOIUrl":"https://doi.org/10.62684/wvqv9876","url":null,"abstract":"Background. The role of the Nurse Navigator was developed in order to address the health disparities created by the social determinants of health, , being an expert, specialized and trained nurse who takes charge of the patient diagnosed with cancer and accompanies him throughout the treatment process, helping him to extricate himself from the labyrinth of the healthcare system. This figure was introduced and studied in the general surgery of the Madonna del Soccorso hospital in San Benedetto del Tronto. Objective. Primary outcomes are the reduction of time interval between the first patient contact and each phase of the diagnostic and therapeutic pathway. Secondary outcomes are the assessment of the number and frequency of contacts between the patient and the ONN, as well as of the number and type of organized procedures, and patient satisfaction assessment. Methods. A prospective cohort study was conducted with a historical control group represented by the same number of cancer patients treated in the same surgical unit in the previous year and not followed by an ONN. The patients’ contacts were registered within a dedicated mobile number. A questionnaire on patient satisfaction with cancer care was completed and administered to patients in a blinded manner by a third party to avoid bias. Results. The study group included 30 cancer patients. The average time from first contact to primary diagnostic test was 8 days versus 20 days in 2022 (control group). All patients underwent discussion by a multidisciplinary team (MDT), and the time to reach the MDT discussion was not different between the 2 groups. Five patients were deemed ineligible for surgery, and the average time to referral to a medical oncologist was 2 days in the study compared to 10 days in the control group. Twenty-five patients were eligible for initial surgery, and the mean time from first contact to surgery was 23 days after ONN establishment compared with 45 days in the control group. Each patient had an average of 10 phone calls with the ONN. For patients with a first diagnosis of cancer, the ONN organized an average of 4 tests. A patient satisfaction questionnaire achieved a response rate of 100%, with an average score of 85.2/90. Conclusion. The data demonstrate that ONN service is effective and may improve the quality and outcomes of the management path of surgical oncology patients. The professional role of the ONN, with predefined technical and non-technical skills, should also be officially recognized by the healthcare system and hospital administration.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"22 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140285339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patent Foramen Ovale (PFO) is a remnant of fetal circulation that could be observed in the 25% of the population worldwide. PFO is associated to numerous clinical conditions as migraines, coronary embolization, transient ischemic attacks, and stroke. The main PFO concerns are related to its correlation to stroke, in particular in young adults. Despite the impact on morbidity that PFO could have, to date there is not clear evidence about its management and treatment. In this narrative review our aim is to summarize the more recent evidence in the literature dealing with PFO, in order to provide an updated overview on this topic.
{"title":"Patent Foramen Ovale: The Unresolved Questions","authors":"I. Forzano, Gaetano Santulli","doi":"10.62684/dmfz6956","DOIUrl":"https://doi.org/10.62684/dmfz6956","url":null,"abstract":"Patent Foramen Ovale (PFO) is a remnant of fetal circulation that could be observed in the 25% of the population worldwide. PFO is associated to numerous clinical conditions as migraines, coronary embolization, transient ischemic attacks, and stroke. The main PFO concerns are related to its correlation to stroke, in particular in young adults. Despite the impact on morbidity that PFO could have, to date there is not clear evidence about its management and treatment. In this narrative review our aim is to summarize the more recent evidence in the literature dealing with PFO, in order to provide an updated overview on this topic.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"360 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tumors derived from B-lymphocytes at their various stage of maturation and differentiation (human B-cell lymphomas and leukemias) are the commonest hematological malignancies. Previous editions of the World Health Organization (WHO) classification of Hematopoietic and lymphoid neoplasms, edited in 2001, 2008, and 2017, intended to standardize the diagnosis of hemopoietic neoplasms overall. Recent advances in lymphoma research, mostly based on genomic as well as molecular analyses, have dramatically expanded our knowledge of lymphoma biology, this leading to improved diagnostic criteria, upgrading of provisional entities, and identification of new tumor types. In 2022, two frameworks for classifying hematolymphoid neoplasms were proposed: the WHO-HAEM5 and the International Consensus Classification (ICC). Since a common nosography is essential for advancing health science and providing a foundation for precision medicine, it is critical to recognize possible differences and harmonize the diverse approaches. In this article, the Authors summarizes the key differences between the two most recent classifications by focusing on tumors derived from B-lymphocytes and plasma cells.
来自处于不同成熟和分化阶段的 B 淋巴细胞的肿瘤（人类 B 细胞淋巴瘤和白血病）是最常见的血液恶性肿瘤。世界卫生组织（WHO）曾于 2001 年、2008 年和 2017 年编辑了《造血和淋巴肿瘤分类》，旨在规范造血肿瘤的整体诊断。淋巴瘤研究的最新进展主要基于基因组和分子分析，极大地扩展了我们对淋巴瘤生物学的认识，从而改进了诊断标准，提升了临时实体，并确定了新的肿瘤类型。2022 年，提出了两个血淋巴肿瘤分类框架：WHO-HAEM5 和国际共识分类（ICC）。由于共同的分类法对于推动健康科学发展和为精准医疗奠定基础至关重要，因此认识到可能存在的差异并协调不同的方法至关重要。在本文中，作者总结了这两种最新分类法之间的主要差异，重点介绍了源自 B 淋巴细胞和浆细胞的肿瘤。
{"title":"The 2022 classifications of B-cell lymphomas and plasma cell disorders","authors":"P. Piccaluga, Shaimaa S Khattab","doi":"10.62684/pyhq4306","DOIUrl":"https://doi.org/10.62684/pyhq4306","url":null,"abstract":"Tumors derived from B-lymphocytes at their various stage of maturation and differentiation (human B-cell lymphomas and leukemias) are the commonest hematological malignancies. Previous editions of the World Health Organization (WHO) classification of Hematopoietic and lymphoid neoplasms, edited in 2001, 2008, and 2017, intended to standardize the diagnosis of hemopoietic neoplasms overall. Recent advances in lymphoma research, mostly based on genomic as well as molecular analyses, have dramatically expanded our knowledge of lymphoma biology, this leading to improved diagnostic criteria, upgrading of provisional entities, and identification of new tumor types. In 2022, two frameworks for classifying hematolymphoid neoplasms were proposed: the WHO-HAEM5 and the International Consensus Classification (ICC). Since a common nosography is essential for advancing health science and providing a foundation for precision medicine, it is critical to recognize possible differences and harmonize the diverse approaches. In this article, the Authors summarizes the key differences between the two most recent classifications by focusing on tumors derived from B-lymphocytes and plasma cells.","PeriodicalId":517745,"journal":{"name":"Top Italian Scientists Journal","volume":"360 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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