Pub Date : 2021-04-01DOI: 10.1007/s12410-021-09554-6
K. Stout, Kostantinos D. Boudoulas, T. Povsic, S. E. Altin, Aravdeep S Jhand, S. Bailey, Andrew M. Goldsweig
{"title":"The Evolution of Virtual Physiologic Assessments and Virtual Coronary Intervention to Optimize Revascularization","authors":"K. Stout, Kostantinos D. Boudoulas, T. Povsic, S. E. Altin, Aravdeep S Jhand, S. Bailey, Andrew M. Goldsweig","doi":"10.1007/s12410-021-09554-6","DOIUrl":"https://doi.org/10.1007/s12410-021-09554-6","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89108732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-01DOI: 10.1007/s12410-021-09553-7
M. Alasnag, K. Al-Shaibi, G. Stanković
{"title":"Computational Simulation, Bench Testing, and Modeling: Novel Tools to Strategize and Optimize Interventional Procedures","authors":"M. Alasnag, K. Al-Shaibi, G. Stanković","doi":"10.1007/s12410-021-09553-7","DOIUrl":"https://doi.org/10.1007/s12410-021-09553-7","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86042353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01Epub Date: 2021-02-26DOI: 10.1007/s12410-021-09552-8
Yi Lu, Jenny Huang, Natalia V Neverova, Kim-Lien Nguyen
Purpose of review: We aim to discuss the diagnostic use of ultra-small superparamagnetic iron oxide (USPIOs) including ferumoxytol in targeted cardiovascular magnetic resonance imaging (MRI).
Recent findings: Ferumoxytol is the only USPIO clinically available in the U.S. and is a negatively charged USPIO that has potential use for tracking and characterization of macrophage-infiltrated cardiovascular structures. As an iron supplement that is approved for treatment of iron deficiency anemia, the iron core of ferumoxytol is incorporated into the body once it is phagocytosed by macrophages. In organs or tissues with high inflammatory cellular infiltration, such as atherosclerotic plaques and myocardial infarction, localization of iron-laden macrophages can be visualized on delayed MRI. The iron core of ferumoxytol alters the magnetic susceptibility and results in shortening of T2* and T2 relaxation rates. Areas with high concentration appear hypointense (negative contrast) on T2 and T2* MRI. Recently, in vitro findings support the potential specificity of ferumoxytol interactions with macrophage subtypes, which has implications for therapeutic interventions. With increasing concerns about gadolinium retention in the brain and other tissues, the value of ferumoxytol-enhanced MR for targeted clinical imaging is aided by its positive safety profile in patients with impaired renal function.
Summary: This paper discusses pharmacokinetic properties of USPIOs with a focus on ferumoxytol, and summarizes relevant in vitro, animal, and human studies investigating the diagnostic use of USPIOs in targeted contrast-enhanced imaging. We also discuss future directions for USPIOs as targeted imaging agents and associated challenges.
综述目的：我们旨在讨论包括铁氧体在内的超小型超顺磁性氧化铁（USPIO）在心血管磁共振成像（MRI）中的诊断用途：Ferumoxytol 是美国临床上唯一可用的 USPIO，它是一种带负电荷的 USPIO，可用于跟踪和描述巨噬细胞浸润的心血管结构。作为一种获准用于治疗缺铁性贫血的铁质补充剂，铁氧拓的铁核一旦被巨噬细胞吞噬，就会融入体内。在动脉粥样硬化斑块和心肌梗死等炎症细胞浸润较多的器官或组织中，延迟核磁共振成像可观察到含铁巨噬细胞的定位。铁氧拓醇的铁核会改变磁感应强度，导致 T2* 和 T2 弛豫速率缩短。高浓度区域在 T2 和 T2* 磁共振成像上呈现低密度（负对比）。最近，体外研究结果支持铁氧体与巨噬细胞亚型相互作用的潜在特异性，这对治疗干预具有重要意义。随着人们越来越关注钆在大脑和其他组织中的滞留问题，铁氧体在肾功能受损患者中的安全性有助于提高铁氧体增强 MR 在临床定向成像中的价值。摘要：本文讨论了 USPIO 的药代动力学特性，重点是铁氧体，并总结了调查 USPIO 在定向对比增强成像中的诊断用途的相关体外、动物和人体研究。我们还讨论了 USPIO 作为靶向成像剂的未来发展方向和相关挑战。
{"title":"USPIOs as targeted contrast agents in cardiovascular magnetic resonance imaging.","authors":"Yi Lu, Jenny Huang, Natalia V Neverova, Kim-Lien Nguyen","doi":"10.1007/s12410-021-09552-8","DOIUrl":"10.1007/s12410-021-09552-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>We aim to discuss the diagnostic use of ultra-small superparamagnetic iron oxide (USPIOs) including ferumoxytol in targeted cardiovascular magnetic resonance imaging (MRI).</p><p><strong>Recent findings: </strong>Ferumoxytol is the only USPIO clinically available in the U.S. and is a negatively charged USPIO that has potential use for tracking and characterization of macrophage-infiltrated cardiovascular structures. As an iron supplement that is approved for treatment of iron deficiency anemia, the iron core of ferumoxytol is incorporated into the body once it is phagocytosed by macrophages. In organs or tissues with high inflammatory cellular infiltration, such as atherosclerotic plaques and myocardial infarction, localization of iron-laden macrophages can be visualized on delayed MRI. The iron core of ferumoxytol alters the magnetic susceptibility and results in shortening of T2* and T2 relaxation rates. Areas with high concentration appear hypointense (negative contrast) on T2 and T2* MRI. Recently, in vitro findings support the potential specificity of ferumoxytol interactions with macrophage subtypes, which has implications for therapeutic interventions. With increasing concerns about gadolinium retention in the brain and other tissues, the value of ferumoxytol-enhanced MR for targeted clinical imaging is aided by its positive safety profile in patients with impaired renal function.</p><p><strong>Summary: </strong>This paper discusses pharmacokinetic properties of USPIOs with a focus on ferumoxytol, and summarizes relevant <i>in vitro</i>, animal, and human studies investigating the diagnostic use of USPIOs in targeted contrast-enhanced imaging. We also discuss future directions for USPIOs as targeted imaging agents and associated challenges.</p>","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021129/pdf/nihms-1681140.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25565745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/s12410-020-09551-1
S. Balla, K. Nieman
{"title":"From Inception to 2020: a Review of Dynamic Myocardial CT Perfusion Imaging","authors":"S. Balla, K. Nieman","doi":"10.1007/s12410-020-09551-1","DOIUrl":"https://doi.org/10.1007/s12410-020-09551-1","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86369585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-02DOI: 10.1007/s12410-020-09549-9
H. Lee, T. Emrich, U. Schoepf, Verena Brandt, Tyler J. Leonard, H. Gray, Vincent Giovagnoli, Danielle M. Dargis, J. Burt, C. Tesche
{"title":"Artificial Intelligence in Cardiac CT: Automated Calcium Scoring and Plaque Analysis","authors":"H. Lee, T. Emrich, U. Schoepf, Verena Brandt, Tyler J. Leonard, H. Gray, Vincent Giovagnoli, Danielle M. Dargis, J. Burt, C. Tesche","doi":"10.1007/s12410-020-09549-9","DOIUrl":"https://doi.org/10.1007/s12410-020-09549-9","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85683711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-12DOI: 10.1007/s12410-020-09548-w
A. Asher, A. Wragg, Ceri Davies
{"title":"Review: FFRCT Changing the Face of Cardiac CT","authors":"A. Asher, A. Wragg, Ceri Davies","doi":"10.1007/s12410-020-09548-w","DOIUrl":"https://doi.org/10.1007/s12410-020-09548-w","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84933407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-11DOI: 10.1007/s12410-020-09547-x
Pooja M. Swamy, P. Parwani, M. Mamas, A. Bharadwaj
{"title":"Role of Intravascular Imaging in the Diagnosis and Treatment of Spontaneous Coronary Artery Dissection","authors":"Pooja M. Swamy, P. Parwani, M. Mamas, A. Bharadwaj","doi":"10.1007/s12410-020-09547-x","DOIUrl":"https://doi.org/10.1007/s12410-020-09547-x","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89772530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-01DOI: 10.1007/s12410-020-09546-y
A. Agdamag, P. Velangi, A. Salavati, P. Nijjar
{"title":"CT Imaging of Left Ventricular Assist Devices and Associated Complications","authors":"A. Agdamag, P. Velangi, A. Salavati, P. Nijjar","doi":"10.1007/s12410-020-09546-y","DOIUrl":"https://doi.org/10.1007/s12410-020-09546-y","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78646647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-27DOI: 10.1007/s12410-020-09545-z
P. Velagapudi, J. Abbott, M. Mamas, R. Blankstein, Y. Chatzizisis, E. Brilakis, F. Jaffer
{"title":"Correction to: Role of Coronary Computed Tomography Angiography in Percutaneous Coronary Intervention of Chronic Total Occlusions","authors":"P. Velagapudi, J. Abbott, M. Mamas, R. Blankstein, Y. Chatzizisis, E. Brilakis, F. Jaffer","doi":"10.1007/s12410-020-09545-z","DOIUrl":"https://doi.org/10.1007/s12410-020-09545-z","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72695858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-22DOI: 10.1007/s12410-020-09544-0
E. Simon, M. Ziccardi, Helena Dickens, Michael N Young, A. Shroff
{"title":"Better Is the Evolution of Good: How IVUS and OCT Have Transformed PCI","authors":"E. Simon, M. Ziccardi, Helena Dickens, Michael N Young, A. Shroff","doi":"10.1007/s12410-020-09544-0","DOIUrl":"https://doi.org/10.1007/s12410-020-09544-0","url":null,"abstract":"","PeriodicalId":51842,"journal":{"name":"Current Cardiovascular Imaging Reports","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2020-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82865227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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