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Psychological Factors and Post-Traumatic Stress Disorder (PTSD) Risk in Stroke Survivors: A Cross-Sectional Study.
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2025-03-02 eCollection Date: 2025-01-01 DOI: 10.52965/001c.129914
Ngoc Huy Nguyen, Son Dinh Thanh Le, Ha Thi Thu Bui, Viet Quoc Hoang, Cuong Cao Do

Introduction: As of 2023, stroke is the second leading cause of death and the third leading cause of death and disability globally, with an expected rise by 2030. While traditional risk factors like demographics, smoking, inactivity, diabetes, and hypertension are well-known, post-traumatic stress disorder (PTSD) remains under-studied despite its 13% incidence rate and link to stroke risk.

Methods: This cross-sectional study, conducted from 1st November, 2023 to 30th January, 2024 in Doanhung, Phutho Province, involved stroke patients over 18 years old diagnosed within the past year. A 56-question questionnaire assessed demographics, clinical characteristics, the Barthel Index, and the PTSD Checklist for DSM-5 (PCL-5). Multivariable logistic regression using Stepwise AIC identified optimal models related to PTSD.

Results: A cohort of 397 participants, with a mean age of 67.98 years and 54.9% female, had a PTSD prevalence of 10.8%. Significant PTSD predictors included regular alcohol consumption (OR=11.43, 95% CI: 1.30-99.15, p=0.027), slight memory decrease (OR=3.59, 95% CI: 1.28-10.62, p=0.017), female gender (OR=3.15, 95% CI: 1.08-10.44, p=0.045), extroverted personality (OR=4.36, 95% CI: 1.73-11.86, p=0.003), and Barthel Index scores (OR=0.85, 95% CI: 0.80-0.90, p<0.001). However, age showed marginally significant association with PTSD (OR=0.97, 95% CI: 0.94-1.00, p=0.067), and unconsciousness during stroke (yes) had an OR of 2.43 (95% CI: 0.96-6.04, p=0.056).

Conclusion: This study highlights the complex interplay of demographic, lifestyle, and clinical factors influencing PTSD risk in stroke survivors. Addressing these factors in interventions is crucial to reduce the psychological burden and improve rehabilitation outcomes.

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引用次数: 0
Methadone for Chronic Pain: A Review of Pharmacology, Efficacy, and Safety Concerns.
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2025-03-02 eCollection Date: 2025-01-01 DOI: 10.52965/001c.129552
Patrick Brown, Alexa Ryder, Christopher Robinson, Kayla Valenti, Katie Phung, Jamal Hasoon

Purpose of review: Methadone is a synthetic opioid extensively used in opioid use disorder management but is gaining recognition for its unique pharmacological properties that make it a viable alternative for chronic pain management. This review aims to explore methadone's pharmacokinetics, pharmacodynamics, efficacy, and safety profile to assess its potential role in managing chronic pain conditions.

Recent findings: Methadone's dual action as a mu-opioid receptor agonist and NMDA receptor antagonist positions it as an effective option for managing both nociceptive and neuropathic pain. It has shown promising results in cancer pain management, refractory pain, and opioid rotation strategies. Despite its therapeutic advantages, concerns regarding its narrow therapeutic window, variable pharmacokinetics, QT interval prolongation, and risk of respiratory depression highlight the need for careful patient selection and monitoring. New evidence also sheds light on its affordability and efficacy in low-resource settings, as well as its controversial role in mitigating opioid-induced hyperalgesia.

Summary: Methadone offers a unique therapeutic option in chronic pain management due to its multifaceted pharmacological properties. While it provides significant benefits for patients with complex pain syndromes, clinicians must exercise caution due to its safety concerns and variability in individual metabolism. A personalized approach, combined with rigorous monitoring, is essential to optimize its benefits while minimizing risks. Further research is needed to better define its role in chronic pain treatment and address unresolved safety concerns.

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引用次数: 0
Effectiveness of Distant/Remote Blessing Treatment on Cognitive-motor Function: A Randomized Double-blind Placebo-controlled Trial. 远距离/远程祝福治疗对认知运动功能的有效性:一项随机双盲安慰剂对照试验。
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.52965/001c.128098
Alice Branton, Mahendra Kumar Trivedi, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

Background: Biofield therapies can be administered in person (hands-on treatment) or remotely, and this study focuses on the latter. A literature review did not find any reports on the effectiveness of remote biofield energy /blessing therapy in enhancing cognition and motor function performance in adults.

Objective: The aim of this study was to examine the effect of distant/remote blessing (biofield energy) therapy on the cognitive and motor functions in adults with self-reported neuropsychological impairments using NIH Toolbox®.

Methods: The present study was a randomized, double-blind clinical trial involving 117 participants with self-reported neuropsychological impairments. These participants were stratified into three distinct groups: control, sham control, and blessing/biofield treatment as the intervention. At baseline (day 0), day 90, and day 180, NIH Toolbox® was employed to evaluate all participants' cognitive and motor function scores.

Results: In the blessing treatment group, language function score (p <0.01), working memory (p <0.0001), and episodic memory (p <0.0001) scores exhibited statistically significant differences compared to both the naïve control and sham control groups. Moreover, in the blessing intervention group, a substantial improvement was observed in locomotion (p <0.0001), standing balance (p <0.01), dexterity (p <0.01), grip strength (p <0.05), and muscle endurance (p <0.05) compared to the naïve control and sham control groups. Importantly, no adverse effects were reported during the study period.

Conclusion: The study outcomes revealed that distant/remote blessing/biofield energy therapy is safe, non-invasive, and less expensive. It enhances cognitive-motor functions in adults with perceived neuropsychological impairments.

Clinical trial registration: CTRI/2022/07/043736.

背景:生物场疗法可以亲自(动手治疗)或远程给药,本研究的重点是后者。文献综述未发现远程生物场能量/祝福疗法在提高成人认知和运动功能表现方面的有效性的任何报道。目的:本研究的目的是检查远程祝福(生物场能量)治疗对自我报告神经心理障碍的成人认知和运动功能的影响。方法:本研究是一项随机双盲临床试验,涉及117名自我报告神经心理障碍的参与者。这些参与者被分为三个不同的组:对照组,假对照组和祝福/生物场治疗作为干预。在基线(第0天)、第90天和第180天,采用NIH Toolbox®评估所有参与者的认知和运动功能评分。结果:祝福治疗组语言功能评分(p p p p p p p p p p)结论:研究结果显示远程祝福/生物场能量治疗安全、无创、费用较低。它能增强有认知神经心理障碍的成年人的认知运动功能。临床试验注册:CTRI/2022/07/043736。
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引用次数: 0
Prevalence of Undiagnosed Attention Deficit Hyperactivity Disorder. 未确诊的注意缺陷多动障碍的患病率。
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.52965/001c.128096
Carissa Du, Daniel Zongliang Zhao, Latha Ganti

Background: Attention deficit/hyperactivity disorder (ADHD) is a disorder characterized by inattention, hyperactivity, and impulsivity. Primary pharmacologic interventions include stimulants and non-stimulants. Diagnosing ADHD is typically more difficult in women due to a range of different symptoms between the sexes. Although ADHD has had more advocacy recently, misdiagnoses are still common, resulting in ADHD being mistaken for other disorders. This study aims to decipher the prevalence of undiagnosed ADHD.

Methods: A web-based survey was administered, comprising of a questionnaire derived from the Adult ADHD Self-Report Scale (ASRS-V1.1), and two additional questions formulated to determine whether the individual was initially diagnosed with ADHD and whether they take medications for it. The Adult ADHD Self-Report Scale is split into two parts where part A determines the symptoms and part B further probes into specific symptoms.

Results: Amongst the cohort of 200, the percentage undiagnosed ADHD was 14%. 61% were women, while 39% were men. The first two questions on the ASRS-V1.1, pertaining to task completion, were the most statistically significant results.

Conclusion: Although advocacy for ADHD has increased in the last twenty years, our study found that 14% of a layperson cohort are undiagnosed with ADHD. It appears that undiagnosed ADHD is more prevalent in women compared to men.

背景:注意缺陷/多动障碍(ADHD)是一种以注意力不集中、多动和冲动为特征的障碍。主要的药物干预包括兴奋剂和非兴奋剂。诊断ADHD对女性来说通常更困难,因为男女之间有一系列不同的症状。尽管多动症最近得到了更多的宣传,但误诊仍然很常见,导致多动症被误认为是其他疾病。这项研究的目的是破译未确诊的ADHD的患病率。方法:进行了一项基于网络的调查,包括一份来自成人ADHD自我报告量表(ASRS-V1.1)的问卷,以及制定的两个附加问题,以确定个体是否最初被诊断为ADHD以及是否服用药物治疗。成人ADHD自我报告量表分为两部分,其中A部分确定症状,B部分进一步探讨具体症状。结果:在200名队列中,未确诊ADHD的比例为14%。61%是女性,39%是男性。ASRS-V1.1的前两个问题与任务完成有关,是统计上最显著的结果。结论:尽管在过去的二十年中对ADHD的倡导有所增加,但我们的研究发现,14%的外行队列未被诊断为ADHD。与男性相比,未确诊的ADHD在女性中更为普遍。
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引用次数: 0
The Psych Behind Psychedelics: Exploring Hallucinogen Use as a Marker for Untreated Mental Health Disorders. 致幻剂背后的心理学:探索致幻剂的使用作为未治疗的精神健康障碍的标志。
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.52965/001c.127794
Liyana Ahmed, Sanjana Konda, Latha Ganti

Objective: Are individuals who use hallucinogens self-medicating their mental illness and are they more likely to abuse other illegal substances?

Design setting participants: Data from the National Survey on Drug Use and Health (NSDUH), collected by the Substance Abuse and Mental Health Services Administration (SAMHSA) database was queried for correlations with hallucinogen use. Using age group as a control variable, different variables were run through a crosstab in order to find significant data pointing to the implications of hallucinogen use.

Results: The data from the crosstab analysis showed three key findings about hallucinogen use: Those with mental illness or substance abuse issues were substantially more likely to use hallucinogens, the hallucinogen use greatly increased with the pandemic along with further mental health issues, and those who used hallucinogens were more significantly likely to abuse other illegal substances, primarily in a younger population.

Conclusion: The positive correlation between mental health issues and hallucinogen use emphasizes the need for better mental health services, especially after the COVID-19 pandemic.The positive correlation between hallucinogen use and other drug use indicates the widespread drug abuse problem, especially within a younger population in which drugs pose a larger neurological threat.

目的:使用致幻剂的人是否会自我治疗他们的精神疾病,他们是否更有可能滥用其他非法药物?设计设置参与者:从药物滥用和精神健康服务管理局(SAMHSA)数据库收集的全国药物使用和健康调查(NSDUH)数据中查询与致幻剂使用的相关性。使用年龄组作为控制变量,不同的变量通过交叉表来运行,以找到指向致幻剂使用影响的重要数据。结果:交叉表分析的数据显示了关于致幻剂使用的三个主要发现:有精神疾病或药物滥用问题的人更有可能使用致幻剂,致幻剂的使用随着流行病的流行以及进一步的精神健康问题而大大增加,使用致幻剂的人更有可能滥用其他非法药物,主要是在较年轻的人群中。结论:精神健康问题与致幻剂使用呈正相关关系,强调了加强精神卫生服务的必要性,特别是在COVID-19大流行之后。致幻剂使用与其他药物使用之间的正相关关系表明,药物滥用问题普遍存在,特别是在药物对神经系统构成更大威胁的年轻人群中。
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引用次数: 0
Does TikTok Addiction exist? A qualitative study. 抖音成瘾真的存在吗?定性研究。
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.52965/001c.127796
Pasquale Caponnetto, Ines Lanzafame, Graziella Chiara Prezzavento, Abdulnaser Fakhrou, Vittorio Lenzo, Alberto Sardella, Mahmoud Ali Moussa, Maria C Quattropani

Background: Problematic TikTok Use (PTU) is a psychological condition marked by compulsive and excessive engagement with the app, often characterized by prolonged scrolling, content interaction, and seeking user feedback.

Methods: This qualitative study, conducted from February to March 2024, explored factors driving TikTok addiction, its consequences, and strategies for mitigation. Data were collected through in-depth interviews and surveys with 56 participants (23 men, 33 women).

Results: Thematic analysis identified key addiction-related factors, including excessive time spent on the app, emotional attachment, and cognitive rumination over viewed content. Women demonstrated a higher likelihood of developing PTU, particularly when using TikTok for over six hours daily and displaying significant emotional and cognitive ties to its content. Despite its addictive potential, participants acknowledged positive aspects of TikTok, such as its capacity to disseminate cultural, educational, and artistic content. However, negative effects, including procrastination, attention deficits, and exposure to harmful content, were also noted.

Conclusion: This study highlights the dual nature of TikTok's impact, emphasizing the need for balanced use and targeted interventions to reduce addiction while leveraging its positive features.

背景:问题TikTok使用(PTU)是一种强迫性和过度使用应用程序的心理状态,通常以长时间滚动、内容交互和寻求用户反馈为特征。方法:这项定性研究于2024年2月至3月进行,探讨了导致TikTok成瘾的因素、后果和缓解策略。数据收集通过深度访谈和调查56名参与者(23名男性,33名女性)。结果:主题分析确定了与成瘾相关的关键因素,包括在应用程序上花费的过多时间、情感依恋和对观看内容的认知反思。女性患PTU的可能性更高,特别是当每天使用抖音超过6小时,并对其内容表现出显著的情感和认知联系时。尽管TikTok有让人上瘾的潜力,但参与者也承认了它的积极方面,比如它传播文化、教育和艺术内容的能力。然而,负面影响,包括拖延症、注意力缺陷和接触有害内容,也被注意到了。结论:这项研究强调了TikTok影响的双重性质,强调了平衡使用和有针对性的干预的必要性,以减少成瘾,同时利用其积极特性。
{"title":"Does TikTok Addiction exist? A qualitative study.","authors":"Pasquale Caponnetto, Ines Lanzafame, Graziella Chiara Prezzavento, Abdulnaser Fakhrou, Vittorio Lenzo, Alberto Sardella, Mahmoud Ali Moussa, Maria C Quattropani","doi":"10.52965/001c.127796","DOIUrl":"10.52965/001c.127796","url":null,"abstract":"<p><strong>Background: </strong>Problematic TikTok Use (PTU) is a psychological condition marked by compulsive and excessive engagement with the app, often characterized by prolonged scrolling, content interaction, and seeking user feedback.</p><p><strong>Methods: </strong>This qualitative study, conducted from February to March 2024, explored factors driving TikTok addiction, its consequences, and strategies for mitigation. Data were collected through in-depth interviews and surveys with 56 participants (23 men, 33 women).</p><p><strong>Results: </strong>Thematic analysis identified key addiction-related factors, including excessive time spent on the app, emotional attachment, and cognitive rumination over viewed content. Women demonstrated a higher likelihood of developing PTU, particularly when using TikTok for over six hours daily and displaying significant emotional and cognitive ties to its content. Despite its addictive potential, participants acknowledged positive aspects of TikTok, such as its capacity to disseminate cultural, educational, and artistic content. However, negative effects, including procrastination, attention deficits, and exposure to harmful content, were also noted.</p><p><strong>Conclusion: </strong>This study highlights the dual nature of TikTok's impact, emphasizing the need for balanced use and targeted interventions to reduce addiction while leveraging its positive features.</p>","PeriodicalId":51865,"journal":{"name":"Health Psychology Research","volume":"13 ","pages":"127796"},"PeriodicalIF":2.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional Competence of Healthcare Workers and Its Impact on Patient Loyalty in Vietnamese Hospitals. 越南医院医护人员情绪能力及其对患者忠诚的影响
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2024-12-21 eCollection Date: 2024-01-01 DOI: 10.52965/001c.127128
Phuoc Thien Mai, Nah Pi Sa, Triet Dinh Luu, Nam Khoa Ly, Phi Duong Nguyen

Objective: To evaluate the effect of healthcare employees' emotional competence (EC) on patient loyalty in public and private hospitals in Ho Chi Minh City, with a focus on the mediating roles of respect, trust, and rapport.

Method: A survey of 244 patients measured respect, trust, rapport, EC, and patient loyalty using a 5-point Likert scale. Structural equation modeling (SEM) was applied to assess the relationships between EC and patient loyalty, comparing results between public and private hospitals.

Results: EC significantly enhanced patient loyalty, with respect and rapport serving as key mediators. Private hospitals showed higher EC levels among staff, leading to greater patient loyalty, while public hospitals, impacted by staff fatigue and high patient loads, demonstrated lower EC and reduced loyalty. EC accounted for 58% of service quality variance and 65% of loyalty variance.

Conclusions: Emotional competence is essential for improving patient loyalty in healthcare settings. Training programs targeting EC, especially in public hospitals, could enhance patient satisfaction and long-term loyalty.

目的:探讨胡志明市公立和私立医院医护人员情绪能力(EC)对患者忠诚的影响,重点研究尊重、信任和融洽的中介作用。方法:对244名患者进行调查,使用5分李克特量表测量尊重、信任、融洽、EC和患者忠诚度。本研究采用结构方程模型(SEM)来评估电子商务与患者忠诚度之间的关系,并比较公立医院与私立医院的结果。结果:电子商务显著提高了患者的忠诚度,其中尊重和融洽是主要的中介因素。私立医院的员工EC水平较高,患者忠诚度较高,而公立医院受员工疲劳和患者负荷高的影响,员工EC水平较低,患者忠诚度降低。服务质量差异占58%,忠诚度差异占65%。结论:情绪能力对提高医疗机构患者忠诚度至关重要。针对EC的培训计划,特别是在公立医院,可以提高患者满意度和长期忠诚度。
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引用次数: 0
Biological, Psychological, And Social Factors Of Flourishing In Chronic Diseases: A Systematic Review Of Research. 慢性疾病蓬勃发展的生物、心理和社会因素:研究的系统回顾。
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2024-12-14 eCollection Date: 2024-01-01 DOI: 10.52965/001c.126453
Amherstia Pasca Rina, Endang R Surjaningrum, Triana Kesuma Dewi

Objectives: Chronic disease is a condition that is susceptible to deterioration both physically, psychologically and socially, so protective measures are needed to control this vulnerability, namely by flourishing. This research is aimed at identifying biological, psychological and social factors that influence the proliferation of chronic health.

Methods and analysis: This research was carried out in five stages by identifying questions according to PCC and searching for qualitative, quantitative and mixed method studies published from 2010 to 2024 that measured the flourishing of various chronic health conditions. The search strategy used the word flourishing and several appropriate terms on Sciencedirect, IEEE Xplore, Emerald, Taylor & Francis, and Oxford Academics as well as Google Scholar as gray literature. 1,550 studies were found from 6 databases and the final selection results found 19 studies to be analyzed. Two reviewers performed data extraction based on the protocol and underwent quality assessment. Results reporting is categorized based on biological, psychological, social and demographic factors that can influence flourishing.

Results: There are biological, psychological and social factors that can influence the proliferation of chronic health, each of which influences the health condition of a person with a chronic health condition.

目的:慢性病是一种在生理、心理和社会方面都容易恶化的疾病,因此需要采取保护措施来控制这种脆弱性,即通过繁荣来控制。本研究旨在找出影响慢性健康扩散的生物、心理和社会因素:本研究分五个阶段进行,首先根据 PCC 确定问题,然后搜索 2010 年至 2024 年期间发表的、衡量各种慢性健康状况蓬勃发展的定性、定量和混合方法研究。搜索策略使用了 flourishing 一词和 Sciencedirect、IEEE Xplore、Emerald、Taylor & Francis 和 Oxford Academics 以及 Google Scholar 上的几个适当术语作为灰色文献。从 6 个数据库中找到了 1,550 项研究,最终筛选出 19 项研究进行分析。两名审稿人根据协议进行了数据提取,并进行了质量评估。结果报告根据可能影响蓬勃发展的生物、心理、社会和人口因素进行分类:有一些生物、心理和社会因素会影响慢性健康的扩散,其中每个因素都会影响慢性健康患者的健康状况。
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引用次数: 0
Advances in Autism: a bibliometric analysis. 自闭症研究进展:文献计量学分析。
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2024-11-23 eCollection Date: 2024-01-01 DOI: 10.52965/001c.125844
Mehreen Chowdhury, Murdoc Gould, Latha Ganti

This paper provides a comprehensive overview of AI treatment research for Autism Spectrum Disorder (ASD) from 2007 to 2023, focusing on global contributions across countries, institutions, authors, and keywords. The United States leads with 164 documents and 4988 citations, highlighting its central role in advancing AI technologies for ASD therapies, followed by significant contributions from China (90 documents, 1190 citations) and India (65 documents, 564 citations). Institutions like Stanford University and McGill University demonstrate substantial research output, while authors such as Dennis Wall are prominent with contributions that make diagnosing Autism much more efficient with the use of AI. Keywords like "Machine learning", "Autism spectrum disorder", and "Children" dominate, reflecting ongoing efforts to leverage technology for ASD interventions. Overall, this analysis underscores a dynamic global effort to enhance ASD treatment methodologies through collaborative research and technological innovations.

本文对2007年至2023年人工智能治疗自闭症谱系障碍(ASD)的研究进行了全面综述,重点介绍了各国、机构、作者和关键词的全球贡献。美国以164篇文献和4988次引用领先,突出了其在推进人工智能技术用于ASD治疗方面的核心作用,其次是中国(90篇文献,1190次引用)和印度(65篇文献,564次引用)。斯坦福大学(Stanford University)和麦吉尔大学(McGill University)等机构展示了大量的研究成果,而丹尼斯·沃尔(Dennis Wall)等作者的杰出贡献是,利用人工智能提高了自闭症诊断的效率。“机器学习”、“自闭症谱系障碍”和“儿童”等关键词占据主导地位,反映了利用技术干预自闭症谱系障碍的持续努力。总的来说,这一分析强调了通过合作研究和技术创新来加强ASD治疗方法的全球努力。
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引用次数: 0
Prenatal Acetaminophen Exposure and its Associated Risk for Attention Deficit Hyperactivity Disorder.
IF 2 Q3 PSYCHOLOGY, CLINICAL Pub Date : 2024-11-12 eCollection Date: 2024-01-01 DOI: 10.52965/001c.125267
Noah J Spillers, Norris C Talbot, Patrick M Luther, Gianni H Ly, Caylin J Roberts, Shahab Ahmadzadeh, Sahar Shekoohi, Omar Viswanath, Alan D Kaye

Acetaminophen is one of the most commonly used over-the-counter antipyretic and analgesic drugs on the market and has been relevant in the medical world for almost a hundred years. It has maintained an excellent reputation as a safe therapeutic in several types of patient profiles. However, the number of children diagnosed with neurodevelopmental disorders, namely ADHD, have been on the rise. Recent findings have indicated an association between in utero exposure to acetaminophen and an increased risk of developing neurodevelopmental disorders such as ADHD in offspring. The mechanism by which this potential side effect occurs is difficult to pinpoint. However, it is known that the metabolism of acetaminophen is known to cause oxidative stress, which has been shown to influence the developing fetus. This review highlights the epidemiological data indicating the correlation between prenatal acetaminophen exposure and ADHD and discusses several proposed theories by which this phenomenon may occur. While there is not yet enough clinical evidence to prove that acetaminophen may cause ADHD, there is a strong enough correlation to indicate a warning to pregnant patients of the potential risks. The risks and benefits of treatment should be considered so that the patient may continue with the course of action with the most favorable outcome. This review was mainly based on manuscripts pulled from Google Scholar and PubMed. The purpose of this literature review is to assist clinicians to better understand lesser-known risks in acetaminophen usage in pregnant patients.

对乙酰氨基酚是市场上最常用的非处方解热镇痛药之一,在医学界已有近百年的历史。它作为一种安全的治疗药物,在多种类型的患者中一直保持着良好的声誉。然而,被诊断患有神经发育障碍(即多动症)的儿童人数一直在上升。最近的研究结果表明,子宫内接触对乙酰氨基酚与后代罹患神经发育障碍(如多动症)的风险增加之间存在关联。这种潜在副作用的发生机制很难确定。不过,已知对乙酰氨基酚的新陈代谢会导致氧化应激,这已被证明会影响发育中的胎儿。本综述重点介绍了表明产前对乙酰氨基酚暴露与多动症之间存在相关性的流行病学数据,并讨论了可能出现这种现象的几种拟议理论。虽然目前还没有足够的临床证据证明对乙酰氨基酚可能会导致多动症,但两者之间存在着很强的相关性,足以向孕妇发出潜在风险警告。应考虑到治疗的风险和益处,以便患者能够继续采取最有利的治疗方案。本综述主要基于谷歌学术和 PubMed 上的手稿。本文献综述旨在帮助临床医生更好地了解妊娠期患者使用对乙酰氨基酚过程中鲜为人知的风险。
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引用次数: 0
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