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Antibiotic-loaded Bone Cement Combined with Vacuum-assisted Closure Facilitating Wound Healing in Wagner 3-4 Diabetic Foot Ulcers. 抗生素骨水泥结合真空辅助闭合术促进瓦格纳 3-4 型糖尿病足溃疡的伤口愈合
IF 1.3 3区 社会学 Q3 SOCIOLOGY Pub Date : 2025-09-01 Epub Date: 2022-06-15 DOI: 10.1177/15347346221109045
Yan-Wei Sun, Liang Li, Zhi-Hua Zhang

This study explored the clinical effectiveness of antibiotic-loaded bone cement (ALBC) combined with vacuum-assisted closure (VAC) on the treatment of Wagner 3-4 diabetic foot ulcers (DFUs). This is a retrospective study, including 32 patients with Wagner 3-4 DFUs who had undergone treatment between August 2019 and June 2021. Patient age, sex, Hemoglobin A1c (HbA1c), body mass index (BMI), ankle brachial index (ABI), white blood cells (WBC), C-reactive protein (CRP) levels, comorbidities and wound closure methods were recorded. Patients were divided into the study group and control group according to the treatment modality. Patients in the study group received the combination treatment of ALBC and VAC, while patients in the control group received single VAC treatment. Clinical endpoints were assessed and compared between the two groups, including wound complete healing time and complications after operation. All patients were followed-up 6 months postoperation. Results showed that the mean healing time of the study group (44.20 ± 16.72 days) was shorter than that of the control group (64.00 ± 29.85 days) (P < .05). The infection rate of the study group on the 10th day postoperation was lower than that of the control group (6.67%, 47.06%, P < .05). And there were no significant statistical differences between the two groups in terms of bleeding and necrosis complications postoperation (P = .603, P = .603). Based on the findings, we conclude that the application of ALBC combined with VAC can facilitate wound healing in Wagner 3-4 DFUs patients. It can help to control wound infections and shorten wound healing time.

本研究探讨了抗生素骨水泥(ALBC)联合真空辅助闭合(VAC)治疗瓦格纳3-4型糖尿病足溃疡(DFUs)的临床疗效。这是一项回顾性研究,包括在2019年8月至2021年6月期间接受治疗的32名瓦格纳3-4型DFU患者。研究记录了患者的年龄、性别、血红蛋白A1c(HbA1c)、体重指数(BMI)、踝肱指数(ABI)、白细胞(WBC)、C反应蛋白(CRP)水平、合并症和伤口闭合方法。根据治疗方式将患者分为研究组和对照组。研究组患者接受 ALBC 和 VAC 联合治疗,对照组患者接受单一 VAC 治疗。对两组患者的临床终点进行评估和比较,包括伤口完全愈合时间和术后并发症。所有患者均在术后 6 个月接受随访。结果显示,研究组的平均愈合时间(44.20 ± 16.72 天)短于对照组(64.00 ± 29.85 天)(P P = .603, P = .603)。根据研究结果,我们得出结论:应用 ALBC 联合 VAC 可以促进 Wagner 3-4 DFUs 患者的伤口愈合。它有助于控制伤口感染并缩短伤口愈合时间。
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引用次数: 0
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S. Mau
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IF 1.1 3区 社会学 Q3 SOCIOLOGY Pub Date : 2023-05-08 DOI: 10.1007/s11609-023-00497-x
L. Wacquant
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IF 1.1 3区 社会学 Q3 SOCIOLOGY Pub Date : 2023-02-23 DOI: 10.1007/s11609-023-00492-2
G. Wagner, Juan S. Guse, Monika Hasenbruch
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Nora Waitkus
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Berliner Journal Fur Soziologie
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