Berliner Journal Fur Soziologie最新文献

Glycogen storage disease type Ib (GSD-Ib), characterized by impaired glucose homeostasis, neutropenia, and neutrophil dysfunction, is caused by a deficiency in glucose-6-phosphate transporter (G6PT). Neutropenia in GSD-Ib has been known to result from enhanced apoptosis of neutrophils. However, it has also been raised that neutrophil maturation arrest in the bone marrow would contribute to neutropenia. We now show that G6pt^-/- mice exhibit severe neutropenia and impaired neutrophil differentiation in the bone marrow. To investigate the role of G6PT in myeloid progenitor cells, the G6PT gene was mutated using CRISPR/Cas9 system, and single cell-derived G6PT^-/- human promyelocyte HL-60 cell lines were established. The G6PT^-/- HL-60s exhibited impaired neutrophil differentiation, which is associated with two mechanisms: (i) abnormal lipid metabolism causing a delayed metabolic reprogramming and (ii) reduced nuclear transcriptional activity of peroxisome proliferator-activated receptor-γ (PPARγ) in G6PT^-/- HL-60s. In this study, we demonstrated that G6PT is essential for neutrophil differentiation of myeloid progenitor cells and regulates PPARγ activity.

The economic difficulties following the COVID-19 pandemic have seemingly reinforced the need for geographic restructuring and a reshoring of production, as they have demonstrated the vulnerability of globalized production. This article provides an assessment of the impact of COVID-19 on the geographies of production. Criticizing overly simplified perspectives on globalization, the article argues that global production networks are multiscalar and politically shaped phenomena. Based on these theoretical considerations and case studies on the automotive, electronics and clothing industries, the article concludes that the COVID-19 pandemic cannot be interpreted as a trigger for a general retreat from global manufacturing, but it reinforced longer-standing shifts toward more multipolar production and consumption structures. While the issue of global production network resilience has attracted greater attention in corporate strategies and industrial policies, the localization and regionalization of production networks is only one of several strategies, and it has hardly been implemented so far. Ongoing disruptions of supply chains, increased transport costs, and, above all, geopolitically and environmentally motivated policies could well lead to greater re- or nearshoring. Political efforts in this direction are, however, limited by pre-existing global economic development paths and the balance of power associated with them. In the conclusions, the article stresses the necessity of a politically motivated restructuring of global production networks in the context of an urgently needed social-ecological transformation.

The term "globalization" doesn't refer to a current epoch of world history, but to an undulated process interrupted by harsh setbacks. Its phases of upswing are characterized by exponential growth. They end when tipping points arrive. For globalization inevitably has its winners and losers, these phases are paralleled by processes of fragmentation in other countries, macro-regions and societies. The article provides a sketch of both types of processes, illustrated by examples from world history. It thereby shows that they must not be considered mere byproducts of technological development in transport and communication, but also depend on institutions that guarantee "International Public Goods" (IPGs), above all safety, stability and connectivity. Only great powers can provide this type of goods, for only they have the resources to do so, then again for only they are confronted with a volunteer's dilemma. Moreover globalization depends on a grand narrative that marginalizes competing schools of thought. Crises emerge either when transactions driving the process reach a tipping point, or when great powers decline and are no longer ready or able to provide IPGs. Now critical discourses emerge and become hegemonic in the face of successive crises undermining the grand narrative. This results in social division between cosmopolitans and populists. Both "big players" currently face different dilemmas conditioned by their positions as hegemonic power (USA) and freerider (China), in each case causing them to act neo-isolationist. The result: IPGs are no longer guaranteed, globalization is in crisis. This development has been catalysed by the Corona-pandemic.