I. Coutinho, Catarina Pedrosa, M. Mota, S. Azeredo-Lopes, Cristina Santos, G. Pires, Susana Teixeira, M. Cunha
Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina of preterm newborns and is an important and preventable cause of visual impairment in childhood. This study aimed to assess the incidence and main risk factors associated with the development of ROP in the last 10 years at Hospital Prof. Doutor Fernando Fonseca in Lisbon, Portugal. Methods: Observational and retrospective study conducted between 2005 and 2014 at Hospital Prof. Doctor Fernando Fonseca. The study included newborns of gestational age < 32 weeks. We analyzed maternal, prenatal and neonatal factors associated with the development of ROP. Statistical analysis were performed with Statistical Package for Social Sciences (SPSS®) software. Univariate and multivariate analyses were performed and a multiple logistic regression model was carried out with a significance level α = 0.05. Results: 527 premature infants with a gestational age < 32 weeks were studied, of which 165 developed ROP. 60 of these patients needed treatment. In the univariate analysis, the risk factors for the development of ROP were maternal infection in pregnancy, low birth weight, low gestational age, low Apgar score at 5 minutes, need for oxygen therapy until the 28 th day of life, a high score on the CRIB and SNAPPE2 scales, use of surfactant, respiratory distress syndrome, persistence of patent ductus arteriosus, peri-intraventricular hemorrhage and neonatal sepsis. In the multiple logistic regression analysis, risk factors for ROP were the presence of neonatal sepsis, respiratory distress syndrome, persistence of patent ductus arteriosus and a high score on the neonatal SNAPPE2 scale. Conclusions: We found a ROP incidence rate of 31.3%, with risk factors similar to those observed in other studies.
早产儿视网膜病变(Retinopathy of prematurity, ROP)是一种早产儿视网膜血管增殖性疾病，是儿童期视力损害的重要且可预防的原因。本研究旨在评估葡萄牙里斯本的dooutor Fernando Fonseca教授医院在过去10年中与ROP发展相关的发病率和主要危险因素。方法:2005年至2014年在医院Fernando Fonseca教授进行的观察性和回顾性研究。研究对象为胎龄< 32周的新生儿。我们分析了与ROP发展相关的母体、产前和新生儿因素。采用SPSS®(Statistical Package for Social Sciences)软件进行统计分析。进行单因素和多因素分析，采用多元logistic回归模型，显著性水平α = 0.05。结果:527例胎龄< 32周早产儿发生ROP 165例。其中60名患者需要治疗。在单因素分析中，发生ROP的危险因素为妊娠期母体感染、低出生体重、低胎龄、5分钟时Apgar评分低、需要吸氧治疗至28天、CRIB和SNAPPE2评分高、使用表面活性物质、呼吸窘迫综合征、持续动脉导管未闭、脑室周围出血和新生儿败血症。在多元logistic回归分析中，新生儿脓毒症、呼吸窘迫综合征、动脉导管未闭持续存在以及新生儿SNAPPE2评分较高是发生ROP的危险因素。结论:我们发现ROP的发生率为31.3%，其危险因素与其他研究相似。
{"title":"Retinopathy of prematurity: Results from 10 years in a single neonatal intensive care unit","authors":"I. Coutinho, Catarina Pedrosa, M. Mota, S. Azeredo-Lopes, Cristina Santos, G. Pires, Susana Teixeira, M. Cunha","doi":"10.7363/060122","DOIUrl":"https://doi.org/10.7363/060122","url":null,"abstract":"Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina of preterm newborns and is an important and preventable cause of visual impairment in childhood. This study aimed to assess the incidence and main risk factors associated with the development of ROP in the last 10 years at Hospital Prof. Doutor Fernando Fonseca in Lisbon, Portugal. Methods: Observational and retrospective study conducted between 2005 and 2014 at Hospital Prof. Doctor Fernando Fonseca. The study included newborns of gestational age < 32 weeks. We analyzed maternal, prenatal and neonatal factors associated with the development of ROP. Statistical analysis were performed with Statistical Package for Social Sciences (SPSS®) software. Univariate and multivariate analyses were performed and a multiple logistic regression model was carried out with a significance level α = 0.05. Results: 527 premature infants with a gestational age < 32 weeks were studied, of which 165 developed ROP. 60 of these patients needed treatment. In the univariate analysis, the risk factors for the development of ROP were maternal infection in pregnancy, low birth weight, low gestational age, low Apgar score at 5 minutes, need for oxygen therapy until the 28 th day of life, a high score on the CRIB and SNAPPE2 scales, use of surfactant, respiratory distress syndrome, persistence of patent ductus arteriosus, peri-intraventricular hemorrhage and neonatal sepsis. In the multiple logistic regression analysis, risk factors for ROP were the presence of neonatal sepsis, respiratory distress syndrome, persistence of patent ductus arteriosus and a high score on the neonatal SNAPPE2 scale. Conclusions: We found a ROP incidence rate of 31.3%, with risk factors similar to those observed in other studies.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2017-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46822419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Miranda, C. Alviggi, G. Nazzaro, E. Salzano, A. Conforti, M. Locci, G. Placido
{"title":"MOSCHCOWITZ SYNDROME IN TWIN PREGNANT WOMEN AFTER OOCYTES DONOR CYCLES: A CASE REPORT","authors":"M. Miranda, C. Alviggi, G. Nazzaro, E. Salzano, A. Conforti, M. Locci, G. Placido","doi":"10.7363/060125","DOIUrl":"https://doi.org/10.7363/060125","url":null,"abstract":"","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"531 1","pages":"1-51"},"PeriodicalIF":0.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Raimondi, F. Migliaro, L. Verdoliva, Diego Gragnaniello, G. Poggi, Carlo Sansone, R. Kosova, L. Capasso
{"title":"Can we assess the severity of neonatal respiratory distress by ultrasound? A comparison of three methods.","authors":"F. Raimondi, F. Migliaro, L. Verdoliva, Diego Gragnaniello, G. Poggi, Carlo Sansone, R. Kosova, L. Capasso","doi":"10.7363/060236","DOIUrl":"https://doi.org/10.7363/060236","url":null,"abstract":"","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"6 1","pages":"12-13"},"PeriodicalIF":0.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this retrospective review, premature neonates less than 34 weeks gestation admitted to a tertiary neonatal intensive care unit (NICU) in Nairobi, Kenya from February 2012 to October 2015 were identified from medical records and database. There were 88 neonates admitted to the neonatal unit, out of which 78 survived. There were 10 pairs of twins and 1 set of triplets. The gestational age ranged from 26 weeks to 33.7 weeks gestation, with a mean gestation of 30.3 (± 1.8) weeks, and a mean birth weight of 1,508 (± 381) g. The smallest neonate who survived weighed 800 g. Smaller babies needed mechanical ventilation for a longer duration and stayed longer in NICU. Less than half of the neonates in our cohort received antenatal dexamethasone. We plan to have further discussion with the obstetricians to increase antenatal steroid use. Ten babies died during this period. With improved perinatal care in Kenya, we anticipate better survival and outcome of these preterm babies.
{"title":"Outcome of premature neonates born in a tertiary neonatal intensive care unit in Nairobi, Kenya","authors":"Atul Patel, Y. Kandasamy","doi":"10.7363/060113","DOIUrl":"https://doi.org/10.7363/060113","url":null,"abstract":"In this retrospective review, premature neonates less than 34 weeks gestation admitted to a tertiary neonatal intensive care unit (NICU) in Nairobi, Kenya from February 2012 to October 2015 were identified from medical records and database. There were 88 neonates admitted to the neonatal unit, out of which 78 survived. There were 10 pairs of twins and 1 set of triplets. The gestational age ranged from 26 weeks to 33.7 weeks gestation, with a mean gestation of 30.3 (± 1.8) weeks, and a mean birth weight of 1,508 (± 381) g. The smallest neonate who survived weighed 800 g. Smaller babies needed mechanical ventilation for a longer duration and stayed longer in NICU. Less than half of the neonates in our cohort received antenatal dexamethasone. We plan to have further discussion with the obstetricians to increase antenatal steroid use. Ten babies died during this period. With improved perinatal care in Kenya, we anticipate better survival and outcome of these preterm babies.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Silva, F. Flôr-de-Lima, G. Rocha, Inês Alves, H. Guimarães
Introduction: Pneumothorax occurs more frequently in the neonatal period than in any other period of life and is associated with increased mortality and morbidity. Several risk factors for pneumothorax, including respiratory pathology, invasive and non-invasive respiratory support, and predictors of mortality have been described.Objective: To evaluate the prevalence of pneumothorax, to assess risk factors and to describe the clinical characteristics, management and outcome of newborn infants with pneumothorax, as well as to identify predictors of mortality in these newborns.Methods: This retrospective case-control study included all newborns hospitalized in the Neonatal Intensive Care Unit (NICU) of “Centro Hospitalar Sao Joao”, Porto, Portugal, between 2003 and 2014, with the diagnosis of pneumothorax. A control group was selected among the newborns without pneumothoraces, admitted to the same NICU during the same period. The collected data included: demographics and perinatal data, pneumothorax characteristics, classification, treatment and clinical outcomes.Results: Our study included 240 neonates (80 with pneumothoraces and 160 controls), of whom 145 were male (60.4%). Median gestational age was 37 (24-40) weeks and median birthweight 2,613 (360-4,324) grams. The prevalence in our NICU was 1.5%. Pneumothorax was significantly associated with respiratory distress syndrome (RDS) (p = 0.010) and transient tachypnea of the newborn (TTN) (p < 0.001). Invasive mechanical ventilation (MV) (p = 0.016) and FiO2 ≥ 0.4 (p = 0.003), were independent risk factors for the development of pneumothoraces. The mortality rate was 13.8%. Hypotension, MV and thoracentesis followed by a chest tube insertion were found to be predictors of mortality in newborns with pneumothoraces, but pneumothorax per se was not a predictor of mortality.Conclusion: Pneumothorax is relatively frequent in the NICU. Its risk factors and predictors of mortality should be known in order to prevent and treat this critical situation. Pneumothorax itself was not a predictor of mortality, probably due to the adequate and prompt management used in the NICU.
{"title":"Pneumothorax in neonates: a level III Neonatal Intensive Care Unit experience","authors":"I. Silva, F. Flôr-de-Lima, G. Rocha, Inês Alves, H. Guimarães","doi":"10.7363/050220","DOIUrl":"https://doi.org/10.7363/050220","url":null,"abstract":"Introduction: Pneumothorax occurs more frequently in the neonatal period than in any other period of life and is associated with increased mortality and morbidity. Several risk factors for pneumothorax, including respiratory pathology, invasive and non-invasive respiratory support, and predictors of mortality have been described.Objective: To evaluate the prevalence of pneumothorax, to assess risk factors and to describe the clinical characteristics, management and outcome of newborn infants with pneumothorax, as well as to identify predictors of mortality in these newborns.Methods: This retrospective case-control study included all newborns hospitalized in the Neonatal Intensive Care Unit (NICU) of “Centro Hospitalar Sao Joao”, Porto, Portugal, between 2003 and 2014, with the diagnosis of pneumothorax. A control group was selected among the newborns without pneumothoraces, admitted to the same NICU during the same period. The collected data included: demographics and perinatal data, pneumothorax characteristics, classification, treatment and clinical outcomes.Results: Our study included 240 neonates (80 with pneumothoraces and 160 controls), of whom 145 were male (60.4%). Median gestational age was 37 (24-40) weeks and median birthweight 2,613 (360-4,324) grams. The prevalence in our NICU was 1.5%. Pneumothorax was significantly associated with respiratory distress syndrome (RDS) (p = 0.010) and transient tachypnea of the newborn (TTN) (p < 0.001). Invasive mechanical ventilation (MV) (p = 0.016) and FiO2 ≥ 0.4 (p = 0.003), were independent risk factors for the development of pneumothoraces. The mortality rate was 13.8%. Hypotension, MV and thoracentesis followed by a chest tube insertion were found to be predictors of mortality in newborns with pneumothoraces, but pneumothorax per se was not a predictor of mortality.Conclusion: Pneumothorax is relatively frequent in the NICU. Its risk factors and predictors of mortality should be known in order to prevent and treat this critical situation. Pneumothorax itself was not a predictor of mortality, probably due to the adequate and prompt management used in the NICU.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Correia, A. Graça, I. Sampaio, C. Moniz, M. Machado
This study aims to assess the adequacy of temperature control during transport of patients referred for therapeutic hypothermia at our centre and to evaluate the occurrence of complications when temperature control is not adequate. Transport data of patients (n = 37) referred during a period of 30 months was reviewed retrospectively, as well as our prospectively collected database of infants treated with hypothermia. We evaluated duration of transport, incidence of excessive cooling on admission and associated complications. Distance from the referring hospital and duration of the transport were not associated with excessive cooling. We then divided patients into two groups according to adequacy of temperature control during transport depending on the presence or absence of regular temperature recordings and compared study variables between the groups. A significant correlation was found between the lack of adequate temperature records during transport (n = 19) and excessive hypothermia on admission (42% vs. 11% for the group with adequate temperature monitoring). There was a trend towards increased incidence of coagulation problems for infants who had admission temperatures below 32.0°C. Passive cooling is simple and effective to ensure early achievement of neuroprotective temperature, but continuous temperature monitoring during transportation is mandatory in order to avoid excessive cooling.
{"title":"Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy: temperature control during transport","authors":"S. Correia, A. Graça, I. Sampaio, C. Moniz, M. Machado","doi":"10.7363/050222","DOIUrl":"https://doi.org/10.7363/050222","url":null,"abstract":"This study aims to assess the adequacy of temperature control during transport of patients referred for therapeutic hypothermia at our centre and to evaluate the occurrence of complications when temperature control is not adequate. Transport data of patients (n = 37) referred during a period of 30 months was reviewed retrospectively, as well as our prospectively collected database of infants treated with hypothermia. We evaluated duration of transport, incidence of excessive cooling on admission and associated complications. Distance from the referring hospital and duration of the transport were not associated with excessive cooling. We then divided patients into two groups according to adequacy of temperature control during transport depending on the presence or absence of regular temperature recordings and compared study variables between the groups. A significant correlation was found between the lack of adequate temperature records during transport (n = 19) and excessive hypothermia on admission (42% vs. 11% for the group with adequate temperature monitoring). There was a trend towards increased incidence of coagulation problems for infants who had admission temperatures below 32.0°C. Passive cooling is simple and effective to ensure early achievement of neuroprotective temperature, but continuous temperature monitoring during transportation is mandatory in order to avoid excessive cooling.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ambu, C. Gerosa, Giorgia Locci, Eleonora Obinu, A. Ravarino, A. D. Magistris, A. Reali, P. Eyken, G. Faa, Silvia Nati, L. Vinci
In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in the crypt base in the regulation of ISC proliferation and self-renewal; Wnt, Notch, BMP, Ephrin, JAK/STAT1, PTEN, AKT, PI3K and many more. Numerous investigators are involved in studying the location, number, and behavior of ISCs within the base of the intestinal crypts. Several markers are espressed by ISCs. Among these, Leucine-rich-repeat-containing G-protein-coupled receptor-5 (Lgr5), Sox9, Prominin-1, DCAMKL-1, EphB2, p-PTEN, p-AKT, Fgfr3, m-TER, and CD44. Stem cell therapy has shown promise for the treatment of some diseases characterized by tissue damage with ischemic and inflammatory lesions like inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano
{"title":"The small intestinal mucosa and its stem cells","authors":"R. Ambu, C. Gerosa, Giorgia Locci, Eleonora Obinu, A. Ravarino, A. D. Magistris, A. Reali, P. Eyken, G. Faa, Silvia Nati, L. Vinci","doi":"10.7363/050224","DOIUrl":"https://doi.org/10.7363/050224","url":null,"abstract":"In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in the crypt base in the regulation of ISC proliferation and self-renewal; Wnt, Notch, BMP, Ephrin, JAK/STAT1, PTEN, AKT, PI3K and many more. Numerous investigators are involved in studying the location, number, and behavior of ISCs within the base of the intestinal crypts. Several markers are espressed by ISCs. Among these, Leucine-rich-repeat-containing G-protein-coupled receptor-5 (Lgr5), Sox9, Prominin-1, DCAMKL-1, EphB2, p-PTEN, p-AKT, Fgfr3, m-TER, and CD44. Stem cell therapy has shown promise for the treatment of some diseases characterized by tissue damage with ischemic and inflammatory lesions like inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neonatal pain treatment requires personalization, and pain assessment should be contextualized to be effective. Here we summarize the available tools in neonatal analgesia, paying a special attention to highlight the personalization of antalgic behavior, both in assessment and in treatment of neonatal pain. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)
新生儿疼痛的治疗需要个性化，疼痛评估应该是有效的背景。在这里，我们总结了新生儿镇痛的可用工具，特别注意强调在新生儿疼痛的评估和治疗中止痛行为的个性化。第11届国际新生儿学与卫星会议会议记录·卡利亚里(意大利)·2015年10月26日-31日·从子宫到成人客座编辑:Vassilios Fanos(意大利卡利亚里)，Michele Mussap(意大利热那亚)，Antonio Del Vecchio(意大利巴里)，Bo Sun(中国上海)，Dorret I. Boomsma(荷兰阿姆斯特丹)，Gavino Faa(意大利卡利亚里)，Antonio Giordano(美国费城)
{"title":"Contextualized pain management in newborns","authors":"C. Bellieni, M. Tei, G. Buonocore","doi":"10.7363/050209","DOIUrl":"https://doi.org/10.7363/050209","url":null,"abstract":"Neonatal pain treatment requires personalization, and pain assessment should be contextualized to be effective. Here we summarize the available tools in neonatal analgesia, paying a special attention to highlight the personalization of antalgic behavior, both in assessment and in treatment of neonatal pain. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giorgia Locci, A. Pinna, A. Dessì, Eleonora Obinu, C. Gerosa, M. A. Marcialis, Maria Cristina Pintus, M. Angiolucci, V. Fanos, R. Ambu, G. Faa
Early pancreas development, given its complexity, is generally considered as a paradigm for branching morphogenesis and for the development of two organs in one: the Langherans islets, programmed to secrete hormones into the bloodstream, and the exocrine pancreas compartment, composed of two major cell types, acinar and ductal cells, devoid to secrete digestive enzymes into the duodenum through a branched network of ducts. Exocrine and endocrine pancreas are generally presumed to originate from a common multi-lineage progenitor cell (MPC), emerging within the definitive endoderm surrounding the posterior foregut. Bipotential precursors committed to the pancreatic fate originate the MPC, that are considered the progenitors of all pancreatic cells operating in the mature pancreas, including acinar, ductal, endocrine and stromal cell types. Pluripotent stem cells (PSCs) are able to differentiate into several cell types, including acinary cells, duct cells and islet cells, depending on certain transcription factors, which function in a coordinated way during pancreas development. The epidemiological entity of pancreatic diseases such as diabetes mellitus and issues regarding the management of the diabetic patient have constantly stimulated the great current interest aimed at regenerative pancreatic medicine. Several studies in rats have demonstrated the existence of stem/progenitor cells in the adult pancreas and have clarified the mechanism by which pancreatic stem cells differentiate into acinar, ductal and endocrine cells. In this context, the cellular microenvironment called “niche” plays a major role in inducing differentiation of stem/progenitor cells by adequate cellular signals. Within the niche, undifferentiated pluripotent cells give rise to asymmetrically dividing daughter cells. The main purpose of this work was to identify stem cells and progenitor cells in the human pancreas during intrauterine development in relation to what is already known in the adult pancreas and in experimental models. Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano
早期胰腺的发育，由于其复杂性，通常被认为是分支形态发生和两个器官合一发育的范例:朗格朗胰岛，负责向血液中分泌激素;外分泌胰腺室，由两种主要细胞类型，腺泡细胞和导管细胞组成，缺乏通过分支的导管网络向十二指肠分泌消化酶。外分泌和内分泌胰腺通常被认为起源于共同的多系祖细胞(MPC)，出现在后前肠周围的最终内胚层内。参与胰腺命运的双电位前体起源于MPC，它被认为是成熟胰腺中所有胰腺细胞的祖细胞，包括腺泡细胞、导管细胞、内分泌细胞和基质细胞类型。多能干细胞(PSCs)能够分化为多种细胞类型，包括腺细胞、导管细胞和胰岛细胞，这取决于某些转录因子，这些转录因子在胰腺发育过程中以协调的方式起作用。胰腺疾病(如糖尿病)的流行病学特征和糖尿病患者的管理问题不断激发了当前对再生胰腺医学的极大兴趣。几项在大鼠身上进行的研究证实了成年胰腺中存在干细胞/祖细胞，并阐明了胰腺干细胞分化为腺泡细胞、导管细胞和内分泌细胞的机制。在这种情况下，被称为“生态位”的细胞微环境通过充足的细胞信号在诱导干细胞/祖细胞分化中起主要作用。在生态位内，未分化的多能细胞产生不对称分裂的子细胞。这项工作的主要目的是鉴定子宫内发育过程中人类胰腺中的干细胞和祖细胞，并将其与成人胰腺和实验模型中已知的情况进行比较。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano
{"title":"Stem progenitor cells in the human pancreas","authors":"Giorgia Locci, A. Pinna, A. Dessì, Eleonora Obinu, C. Gerosa, M. A. Marcialis, Maria Cristina Pintus, M. Angiolucci, V. Fanos, R. Ambu, G. Faa","doi":"10.7363/050223","DOIUrl":"https://doi.org/10.7363/050223","url":null,"abstract":"Early pancreas development, given its complexity, is generally considered as a paradigm for branching morphogenesis and for the development of two organs in one: the Langherans islets, programmed to secrete hormones into the bloodstream, and the exocrine pancreas compartment, composed of two major cell types, acinar and ductal cells, devoid to secrete digestive enzymes into the duodenum through a branched network of ducts. Exocrine and endocrine pancreas are generally presumed to originate from a common multi-lineage progenitor cell (MPC), emerging within the definitive endoderm surrounding the posterior foregut. Bipotential precursors committed to the pancreatic fate originate the MPC, that are considered the progenitors of all pancreatic cells operating in the mature pancreas, including acinar, ductal, endocrine and stromal cell types. Pluripotent stem cells (PSCs) are able to differentiate into several cell types, including acinary cells, duct cells and islet cells, depending on certain transcription factors, which function in a coordinated way during pancreas development. The epidemiological entity of pancreatic diseases such as diabetes mellitus and issues regarding the management of the diabetic patient have constantly stimulated the great current interest aimed at regenerative pancreatic medicine. Several studies in rats have demonstrated the existence of stem/progenitor cells in the adult pancreas and have clarified the mechanism by which pancreatic stem cells differentiate into acinar, ductal and endocrine cells. In this context, the cellular microenvironment called “niche” plays a major role in inducing differentiation of stem/progenitor cells by adequate cellular signals. Within the niche, undifferentiated pluripotent cells give rise to asymmetrically dividing daughter cells. The main purpose of this work was to identify stem cells and progenitor cells in the human pancreas during intrauterine development in relation to what is already known in the adult pancreas and in experimental models. Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Preterm survivors from the neonatal intensive care unit (NICU) are considered as high risk group for some neurobehavioral impairments such as cognitive disabilities, developmental delays, social/emotional limitations, attention-deficit/hyperactivity disorder (ADHD), and academic difficulties. Objective: The current study aimed to investigate the neurobehavioral outcome of premature infants in Saudi Arabia at the school age. Methods: At the school age, preterm children (range 23-29 weeks or ≤ 1.52 kg) born from April, 2006 through September, 2008, and who were admitted following birth to a NICU, were evaluated with several neurobehavioral tools. Results: This study includes 53 preterm children, who were followed up at the chronological age that ranged from 6.4-8.0 years. The results of the neurobehavioral assessments showed in general normal social adaptive levels and cognitive abilities, with mean total score of about 91.0 and 90.0, respectively. The prevalence of ADHD among preterm children was high, with result of 34.0% for the inattentive type and 11.3% for the hyperactive/impulsive type. None of the preterm children repeats a grade, but 22.6% utilize a form of special educational supports. Some of the preterm children showed poor school performance in reading skills, writing skills and mathematics skills, with percentages of 26.4%, 28.3% and 15.1%, respectively. Conclusions: The present results emphasize that preterm children are a group of high-risk children who need regular follow-up to track the developmental conditions and to provide the early developmental intervention for optimal outcome.
{"title":"Neurobehavioral outcomes of school-age children born preterm: a preliminary study in the Arabic community","authors":"M. Alqahtani","doi":"10.7363/050211","DOIUrl":"https://doi.org/10.7363/050211","url":null,"abstract":"Introduction: Preterm survivors from the neonatal intensive care unit (NICU) are considered as high risk group for some neurobehavioral impairments such as cognitive disabilities, developmental delays, social/emotional limitations, attention-deficit/hyperactivity disorder (ADHD), and academic difficulties. Objective: The current study aimed to investigate the neurobehavioral outcome of premature infants in Saudi Arabia at the school age. Methods: At the school age, preterm children (range 23-29 weeks or ≤ 1.52 kg) born from April, 2006 through September, 2008, and who were admitted following birth to a NICU, were evaluated with several neurobehavioral tools. Results: This study includes 53 preterm children, who were followed up at the chronological age that ranged from 6.4-8.0 years. The results of the neurobehavioral assessments showed in general normal social adaptive levels and cognitive abilities, with mean total score of about 91.0 and 90.0, respectively. The prevalence of ADHD among preterm children was high, with result of 34.0% for the inattentive type and 11.3% for the hyperactive/impulsive type. None of the preterm children repeats a grade, but 22.6% utilize a form of special educational supports. Some of the preterm children showed poor school performance in reading skills, writing skills and mathematics skills, with percentages of 26.4%, 28.3% and 15.1%, respectively. Conclusions: The present results emphasize that preterm children are a group of high-risk children who need regular follow-up to track the developmental conditions and to provide the early developmental intervention for optimal outcome.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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