The identification of cardiac progenitor cells in mammals raises the possibility that the human heart contains a population of stem cells capable of generating cardiomyocytes and coronary vessels. Several recent studies now show that the different cell types that characterize the adult human heart arise from a common ancestor. Human cardiac stem cells differentiate into cardiomyocytes, and, in lesser extent, into smooth muscle and endothelial cells. The characterization of human cardiac stem cells (CSCs) has important clinical implications. In recent years, CD117 (c-kit) has been reported to mark a subtype of stem/progenitor cells in the human heart, with stem cell-like properties, including the ability to self-renewal and clonogenicity multipotentiality. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano
哺乳动物心脏祖细胞的鉴定提高了人类心脏含有能够产生心肌细胞和冠状血管的干细胞群的可能性。最近的几项研究表明，成年人心脏的不同细胞类型来自一个共同的祖先。人类心脏干细胞分化为心肌细胞，并在较小程度上分化为平滑肌细胞和内皮细胞。人类心脏干细胞(CSCs)的表征具有重要的临床意义。近年来，CD117 (c-kit)被报道标记人类心脏中的一种干细胞/祖细胞亚型，具有干细胞样特性，包括自我更新能力和克隆原性多潜能。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分·2015年10月26日至31日)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano
{"title":"Stem cell markers in the heart of the human newborn","authors":"A. Faa, E. Podda, V. Fanos","doi":"10.7363/050204","DOIUrl":"https://doi.org/10.7363/050204","url":null,"abstract":"The identification of cardiac progenitor cells in mammals raises the possibility that the human heart contains a population of stem cells capable of generating cardiomyocytes and coronary vessels. Several recent studies now show that the different cell types that characterize the adult human heart arise from a common ancestor. Human cardiac stem cells differentiate into cardiomyocytes, and, in lesser extent, into smooth muscle and endothelial cells. The characterization of human cardiac stem cells (CSCs) has important clinical implications. In recent years, CD117 (c-kit) has been reported to mark a subtype of stem/progenitor cells in the human heart, with stem cell-like properties, including the ability to self-renewal and clonogenicity multipotentiality. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71291118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Zaffanello, G. Piacentini, E. Gasperi, C. Maffeis, C. Fava, S. Bonafini, A. Tagetti, F. Antoniazzi
Purpose of the study: Frequency of habitual snoring is significantly higher in obese than in normal-weight subjects. Obesity and adeno-tonsillar size are risk factors of snoring. Other factors, such as fat distribution and upper airway collapsibility, could explain the relationship between obesity, snoring and obtructive sleep apneas. The aim of the study was to investigate clinical and instrumental significance of snoring in exogenous obese children referred to our department. Methodology: This preliminary study takes part of a larger prospective respiratory sleep study. In 36 consecutive obese children (18 males), body mass index (BMI), BMI Z score and neck circumference were calculated according to age and sex. Nasal patency, tonsil size, palate position scoring were also recorded. An overnight polygraphy was performed using a portable ambulatory device. Statistical analysis was done using SPSS® Statistics 19.0 software for Windows®. Main findings: Snoring, objectively measured by polygraphy, was associated with palate position and with oxygen desaturation index (ODI). The correlation between snoring and ODI completely disappeared when adjusting for palate position scoring. Key conclusions: Low palate position can be identified as an adjunctive, although not unique, factor that can contribute to making snoring and increased desaturation events possibly related to increased risk of upper airway collapsibility during sleep in obese children.
{"title":"Snoring in a cohort of obese children: association with palate position and nocturnal desaturations","authors":"M. Zaffanello, G. Piacentini, E. Gasperi, C. Maffeis, C. Fava, S. Bonafini, A. Tagetti, F. Antoniazzi","doi":"10.7363/050134","DOIUrl":"https://doi.org/10.7363/050134","url":null,"abstract":"Purpose of the study: Frequency of habitual snoring is significantly higher in obese than in normal-weight subjects. Obesity and adeno-tonsillar size are risk factors of snoring. Other factors, such as fat distribution and upper airway collapsibility, could explain the relationship between obesity, snoring and obtructive sleep apneas. The aim of the study was to investigate clinical and instrumental significance of snoring in exogenous obese children referred to our department. Methodology: This preliminary study takes part of a larger prospective respiratory sleep study. In 36 consecutive obese children (18 males), body mass index (BMI), BMI Z score and neck circumference were calculated according to age and sex. Nasal patency, tonsil size, palate position scoring were also recorded. An overnight polygraphy was performed using a portable ambulatory device. Statistical analysis was done using SPSS® Statistics 19.0 software for Windows®. Main findings: Snoring, objectively measured by polygraphy, was associated with palate position and with oxygen desaturation index (ODI). The correlation between snoring and ODI completely disappeared when adjusting for palate position scoring. Key conclusions: Low palate position can be identified as an adjunctive, although not unique, factor that can contribute to making snoring and increased desaturation events possibly related to increased risk of upper airway collapsibility during sleep in obese children.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":"050134-050134"},"PeriodicalIF":0.4,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Reali, M. Puddu, Maria Cristina Pintus, M. A. Marcialis, G. Pichiri, P. Coni, D. Manus, A. Dessì, G. Faa, V. Fanos
In recent years the presence of stem cells (hBSCs: human breastmilk-derived stem cells) and epithelial progenitors has been demonstrated in mother’s milk (MM). Stem cells present in samples of fresh MM exhibit a high degree of vitality and this makes possible the performance of cell cultures and to evaluate the differentiation capacity of the hBSCs. The most important datum that expresses the enormous potential of the use of MM stem cells is the presence of a cell population capable of differentiating into the three mesoderm, endoderm and ectoderm lines. The small number of studies and MM samples analyzed and the different sampling methods applied suggest standardization in the collection, analysis and culture of MM in future studies, in consideration of the well-known extreme variability of MM composition, also from the standpoint of cells. The analysis of literature data confirms the uniqueness of MM and its enormous potential. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano
近年来，已证实母乳中存在干细胞(hBSCs:人母乳来源的干细胞)和上皮祖细胞。新鲜MM样品中的干细胞表现出高度的活力，这使得细胞培养的性能和评估hBSCs的分化能力成为可能。表达MM干细胞巨大潜力的最重要的数据是存在能够分化为三种中胚层、内胚层和外胚层系的细胞群。考虑到众所周知的MM成分的极端可变性，从细胞的角度来看，研究和分析的MM样本数量少，采用的采样方法不同，建议在未来的研究中对MM的收集、分析和培养进行标准化。通过对文献数据的分析，证实了MM的独特性及其巨大的潜力。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分·2015年10月26日至31日)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano
{"title":"Multipotent stem cells of mother's milk","authors":"A. Reali, M. Puddu, Maria Cristina Pintus, M. A. Marcialis, G. Pichiri, P. Coni, D. Manus, A. Dessì, G. Faa, V. Fanos","doi":"10.7363/050103","DOIUrl":"https://doi.org/10.7363/050103","url":null,"abstract":"In recent years the presence of stem cells (hBSCs: human breastmilk-derived stem cells) and epithelial progenitors has been demonstrated in mother’s milk (MM). Stem cells present in samples of fresh MM exhibit a high degree of vitality and this makes possible the performance of cell cultures and to evaluate the differentiation capacity of the hBSCs. The most important datum that expresses the enormous potential of the use of MM stem cells is the presence of a cell population capable of differentiating into the three mesoderm, endoderm and ectoderm lines. The small number of studies and MM samples analyzed and the different sampling methods applied suggest standardization in the collection, analysis and culture of MM in future studies, in consideration of the well-known extreme variability of MM composition, also from the standpoint of cells. The analysis of literature data confirms the uniqueness of MM and its enormous potential. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Dessì, S. Marras, Giorgia Locci, A. D. Magistris, V. Fanos, G. Faa
The existence of stem cells within the adult pancreas is supported by the ability of this organ to regenerate its endocrine component in various conditions such as pregnancy and following partial pancreatectomy. Several studies have shown that progenitor or adult stem cells may reside within the pancreas and particularly in the pancreatic ducts, including acinar cells and islets of Langerhans. The discovery of human pluripotent stem cells in the pancreas, and the possibility of development of strategies for generating these, represented a turning point for the therapeutic interventions of type 1 diabetes.Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano
成人胰腺中干细胞的存在是由该器官在各种情况下(如怀孕和部分胰腺切除术后)再生其内分泌成分的能力所支持的。几项研究表明，祖细胞或成体干细胞可能存在于胰腺内，特别是胰管中，包括腺泡细胞和朗格汉斯岛。胰腺中人类多能干细胞的发现，以及产生这些干细胞的策略发展的可能性，代表了1型糖尿病治疗干预的一个转折点。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano
{"title":"Stem cells and the pancreas: from discovery to clinical approach","authors":"A. Dessì, S. Marras, Giorgia Locci, A. D. Magistris, V. Fanos, G. Faa","doi":"10.7363/050130","DOIUrl":"https://doi.org/10.7363/050130","url":null,"abstract":"The existence of stem cells within the adult pancreas is supported by the ability of this organ to regenerate its endocrine component in various conditions such as pregnancy and following partial pancreatectomy. Several studies have shown that progenitor or adult stem cells may reside within the pancreas and particularly in the pancreatic ducts, including acinar cells and islets of Langerhans. The discovery of human pluripotent stem cells in the pancreas, and the possibility of development of strategies for generating these, represented a turning point for the therapeutic interventions of type 1 diabetes.Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stem cells (SC) look like to be the possible solution to a number of human pathologies, including those involving the heart. In fact, some studies based on animal models suggest that SC can be used to repair the damaged cardiac tissue, such as in case of myocardial infarction. In fact it has been demonstrated that it would be possible to produce a quantity of SC sufficient to repair an animal heart having physiology and dimensions as the human heart. The aim of this short review is to examine the different subtypes of SC potentially involved in the heart repair (autologous and heterologous) processes as well as the serious concerns that have still to be overcome before considering SC a sure therapy for the heart diseases: rejections, oncogenesis due to SC high proliferative activity, difficult in ruling their differentiation, massive SC death when introducing them in an ischemic environment, ethical problems when SC are derived from embryos. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano
干细胞(SC)似乎是解决许多人类疾病的可能方法，包括那些涉及心脏的疾病。事实上，一些基于动物模型的研究表明，SC可以用于修复受损的心脏组织，例如心肌梗死。事实上，已经证明有可能产生足够数量的SC来修复具有人类心脏生理学和尺寸的动物心脏。这篇简短综述的目的是研究可能参与心脏修复(自体和异体)过程的SC的不同亚型，以及在考虑SC作为心脏病的可靠治疗方法之前仍需克服的严重问题:排斥反应，由于SC高增殖活性导致的肿瘤发生，难以控制其分化，在缺血环境中引入SC时大量死亡，胚源性SC时的伦理问题。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分·2015年10月26日至31日)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano
{"title":"Stem cells and heart: an open future or a mirage?","authors":"P. Bassareo, G. Mercuro","doi":"10.7363/050102","DOIUrl":"https://doi.org/10.7363/050102","url":null,"abstract":"Stem cells (SC) look like to be the possible solution to a number of human pathologies, including those involving the heart. In fact, some studies based on animal models suggest that SC can be used to repair the damaged cardiac tissue, such as in case of myocardial infarction. In fact it has been demonstrated that it would be possible to produce a quantity of SC sufficient to repair an animal heart having physiology and dimensions as the human heart. The aim of this short review is to examine the different subtypes of SC potentially involved in the heart repair (autologous and heterologous) processes as well as the serious concerns that have still to be overcome before considering SC a sure therapy for the heart diseases: rejections, oncogenesis due to SC high proliferative activity, difficult in ruling their differentiation, massive SC death when introducing them in an ischemic environment, ethical problems when SC are derived from embryos. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandra Culurgioni, F. Carta, A. Olla, E. Gioia, N. Chuchueva, R. Puxeddu
{"title":"Congenital dacryocystocele: case report","authors":"Alessandra Culurgioni, F. Carta, A. Olla, E. Gioia, N. Chuchueva, R. Puxeddu","doi":"10.7363/050247","DOIUrl":"https://doi.org/10.7363/050247","url":null,"abstract":"","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"62 1","pages":"23-24"},"PeriodicalIF":0.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Antonucci, C. Locci, E. Chicconi, Luca Antonucci
{"title":"VITAMIN D DEFICIENCY: WHAT'S NEW?","authors":"R. Antonucci, C. Locci, E. Chicconi, Luca Antonucci","doi":"10.7363/050246","DOIUrl":"https://doi.org/10.7363/050246","url":null,"abstract":"","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Very low birth weight infants are particularly vulnerable to bacterial and fungal infections. This leads to a common use of antiinfectives, often on a prophylactic basis. Due to the limited available information and the lack of guidelines, the use of antibacterials and antifungals in preterm newborns admitted to Neonatal Intensive Care Units is characterized by a large variability and these drugs are frequently given with different modalities, particularly as regards dosage and frequency, and in an off-label manner. This article provides an updated overview of the current situation on the use of antiinfectives in prematures, by reporting information derived by an analysis of the literature. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)
出生体重过低的婴儿特别容易受到细菌和真菌感染。这导致抗感染药物的普遍使用，通常是在预防的基础上。由于现有信息有限和缺乏指南，在新生儿重症监护病房的早产新生儿中使用抗菌药物和抗真菌药物的特点是差异很大，这些药物经常以不同的方式给予，特别是在剂量和频率方面，并且以非标签方式给予。本文通过对文献分析得出的信息，提供了对早产儿使用抗感染药物现状的最新概述。第11届国际新生儿学与卫星会议会议记录·卡利亚里(意大利)·2015年10月26日-31日·从子宫到成人客座编辑:Vassilios Fanos(意大利卡利亚里)，Michele Mussap(意大利热那亚)，Antonio Del Vecchio(意大利巴里)，Bo Sun(中国上海)，Dorret I. Boomsma(荷兰阿姆斯特丹)，Gavino Faa(意大利卡利亚里)，Antonio Giordano(美国费城)
{"title":"Antibiotics and antifungals in VLBW infants","authors":"L. Cuzzolin","doi":"10.7363/040214","DOIUrl":"https://doi.org/10.7363/040214","url":null,"abstract":"Very low birth weight infants are particularly vulnerable to bacterial and fungal infections. This leads to a common use of antiinfectives, often on a prophylactic basis. Due to the limited available information and the lack of guidelines, the use of antibacterials and antifungals in preterm newborns admitted to Neonatal Intensive Care Units is characterized by a large variability and these drugs are frequently given with different modalities, particularly as regards dosage and frequency, and in an off-label manner. This article provides an updated overview of the current situation on the use of antiinfectives in prematures, by reporting information derived by an analysis of the literature. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"52 1","pages":"81-86"},"PeriodicalIF":0.4,"publicationDate":"2015-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The creation of new medical approaches based on stem cells to treat chronic kidney disease (CKD) and in particular end stage renal disease (ESRD) has become imperative in recent years, due to the significant burdens of patients affected by renal failure and to the limitations of dialysis and kidney transplantation to solve the problem. The initial prospective of utilizing stem cells for regenerating the affected kidney has been at the basis of excitement and hope for all patients affected by ESRD. Unfortunately, too many challenges have halted the possibility to make such regenerative approach a reality, and the vast majority of patients with CKD and renal insufficiency experience a reduced quality of life associated with high mortality. The problem appears particularly severe when ESDR develops in childhood. Children submitted to kidney transplantation have a 95% of survival rate at 5 years, but only 66% of them survive at 20 years after renal transplant. As a result, patients transplanted in childhood will need repeated renal transplants during their life. Renal regenerative medicine might experience a major renaissance in the next years, developing new methodologies stemmed from the previous attempts. Here, we present some major points to be addressed, in order to open a debate on the potential offered by the different regenerative methodologies: the “exogenous” approach; the “endogenous” approach; the “therapeutic” approach; the “prevention” approach. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)
近年来，基于干细胞治疗慢性肾脏疾病(CKD)，特别是终末期肾脏疾病(ESRD)的新医学方法的创造已经变得势在必行，这是由于肾衰竭患者的重大负担以及透析和肾移植解决这一问题的局限性。对于所有ESRD患者来说，利用干细胞再生受损肾脏的最初前景是兴奋和希望的基础。不幸的是，太多的挑战阻止了这种再生方法成为现实的可能性，绝大多数CKD和肾功能不全患者的生活质量下降，死亡率高。当ESDR在儿童期发展时，问题显得尤为严重。接受肾移植的儿童5年生存率为95%，但肾移植后20年生存率仅为66%。因此，儿童时期移植的患者在其一生中需要反复进行肾脏移植。肾再生医学可能会在未来几年经历一次重大的复兴，从以前的尝试中发展出新的方法。在这里，我们提出了一些需要解决的要点，以便就不同再生方法所提供的潜力展开辩论:“外生”方法;“内生”方法;“治疗”方法;“预防”方法。第11届国际新生儿学与卫星会议会议记录·卡利亚里(意大利)·2015年10月26日-31日·从子宫到成人客座编辑:Vassilios Fanos(意大利卡利亚里)，Michele Mussap(意大利热那亚)，Antonio Del Vecchio(意大利巴里)，Bo Sun(中国上海)，Dorret I. Boomsma(荷兰阿姆斯特丹)，Gavino Faa(意大利卡利亚里)，Antonio Giordano(美国费城)
{"title":"Renal endogenous stem cells: a new source for regenerative medicine in preterms?","authors":"G. Faa, V. Fanos","doi":"10.7363/040224","DOIUrl":"https://doi.org/10.7363/040224","url":null,"abstract":"The creation of new medical approaches based on stem cells to treat chronic kidney disease (CKD) and in particular end stage renal disease (ESRD) has become imperative in recent years, due to the significant burdens of patients affected by renal failure and to the limitations of dialysis and kidney transplantation to solve the problem. The initial prospective of utilizing stem cells for regenerating the affected kidney has been at the basis of excitement and hope for all patients affected by ESRD. Unfortunately, too many challenges have halted the possibility to make such regenerative approach a reality, and the vast majority of patients with CKD and renal insufficiency experience a reduced quality of life associated with high mortality. The problem appears particularly severe when ESDR develops in childhood. Children submitted to kidney transplantation have a 95% of survival rate at 5 years, but only 66% of them survive at 20 years after renal transplant. As a result, patients transplanted in childhood will need repeated renal transplants during their life. Renal regenerative medicine might experience a major renaissance in the next years, developing new methodologies stemmed from the previous attempts. Here, we present some major points to be addressed, in order to open a debate on the potential offered by the different regenerative methodologies: the “exogenous” approach; the “endogenous” approach; the “therapeutic” approach; the “prevention” approach. Proceedings of the 11 th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26 th -31 st , 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2015-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aggression inflicts a huge burden on affected children, their families, and society. Estimates for the prevalence of clinical aggression in children range between 2 and 16%, and childhood aggression tends to continue into adulthood. Current psychological treatments and pharmacological interventions are not effective for all children with aggressive behaviors and there is a huge need for more personalized approaches, which requires insight into the heterogeneity and the mechanisms underlying aggression and its associated comorbidities. Here we discuss what is currently known with regard to individual differences in childhood aggression. Studies employing new opportunities in large scale genotyping, epigenetics and metabolomics technology will in future help to explain heterogeneity and highlight pathways from molecule to phenotype. The FP7-ACTION project (Aggression in Children: Unravelling gene-environment interplay to inform Treatment and InterventiON strategies) aims to contribute to knowledge that will help children, their families, teachers and society at large.
{"title":"Aggression in children: unravelling the interplay of genes and environment through (epi)genetics and metabolomics","authors":"D. Boomsma","doi":"10.7363/040251","DOIUrl":"https://doi.org/10.7363/040251","url":null,"abstract":"Aggression inflicts a huge burden on affected children, their families, and society. Estimates for the prevalence of clinical aggression in children range between 2 and 16%, and childhood aggression tends to continue into adulthood. Current psychological treatments and pharmacological interventions are not effective for all children with aggressive behaviors and there is a huge need for more personalized approaches, which requires insight into the heterogeneity and the mechanisms underlying aggression and its associated comorbidities. Here we discuss what is currently known with regard to individual differences in childhood aggression. Studies employing new opportunities in large scale genotyping, epigenetics and metabolomics technology will in future help to explain heterogeneity and highlight pathways from molecule to phenotype. The FP7-ACTION project (Aggression in Children: Unravelling gene-environment interplay to inform Treatment and InterventiON strategies) aims to contribute to knowledge that will help children, their families, teachers and society at large.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2015-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71290600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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