Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-2-339-348
S.N. Zheregelya, S. Glushkov, A. I. Karpishchenko
{"title":"Deficiency of glucose-6-phosphate dehydrogenase activity in the development of contrast-induced acute kidney injury","authors":"S.N. Zheregelya, S. Glushkov, A. I. Karpishchenko","doi":"10.28996/2618-9801-2022-2-339-348","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-2-339-348","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69400740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-3-457-472
I. Vasilieva
Health-related quality of life (QoL) is one of the main patient-reported outcomes. Monitoring QoL in patients with chronic kidney disease (CKD) can be considered one of the approaches to the implementation of the principles of personalized medicine in clinical nephrology. The review provides a brief description of the questionnaires most used to assess QoL in patients with CKD and summarizes the results of studies of factors related to QoL at predialysis stages. It is customary to distinguish sociodemographic, clinical, and psychological factors associated with health-related QoL. Being female, smoking, low levels of education and income, the presence of coronary heart or cerebrovascular diseases, depression, and anxiety were shown to be associated with a decrease in QoL of patients with predialysis CKD. As for other clinical and socio-demographic factors, the literature data are not so unambiguous. Thus, several studies have demonstrated that a decrease in glomerular filtration rate, albumin and hemoglobin levels, the presence of diabetes, and an increase in age and creatinine level negatively affect the parameters of the physical component of QoL. At the same time, a significant number of studies have not found a relationship between these variables and the parameters of the psychosocial component of QoL, which is explained by the dependence of this QoL component primarily on the characteristics of the emotional state and personality. Of the psychological factors associated with QoL in patients with CKD treated conservatively, the attention of researchers was focused mainly on the level of depression. Only a few studies have analyzed other psychological variables (personality traits, coping strategies, effects of psychosocial interventions) related to QoL in patients with predialysis CKD. Identification and systematization of potentially modifiable factors affecting patients’ QoL set the directions for the prevention and correction of reduced QoL
{"title":"Factors associated with quality of life in predialysis chronic kidney disease. Review of literature","authors":"I. Vasilieva","doi":"10.28996/2618-9801-2022-3-457-472","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-3-457-472","url":null,"abstract":"Health-related quality of life (QoL) is one of the main patient-reported outcomes. Monitoring QoL in patients with chronic kidney disease (CKD) can be considered one of the approaches to the implementation of the principles of personalized medicine in clinical nephrology. The review provides a brief description of the questionnaires most used to assess QoL in patients with CKD and summarizes the results of studies of factors related to QoL at predialysis stages. It is customary to distinguish sociodemographic, clinical, and psychological factors associated with health-related QoL. Being female, smoking, low levels of education and income, the presence of coronary heart or cerebrovascular diseases, depression, and anxiety were shown to be associated with a decrease in QoL of patients with predialysis CKD. As for other clinical and socio-demographic factors, the literature data are not so unambiguous. Thus, several studies have demonstrated that a decrease in glomerular filtration rate, albumin and hemoglobin levels, the presence of diabetes, and an increase in age and creatinine level negatively affect the parameters of the physical component of QoL. At the same time, a significant number of studies have not found a relationship between these variables and the parameters of the psychosocial component of QoL, which is explained by the dependence of this QoL component primarily on the characteristics of the emotional state and personality. Of the psychological factors associated with QoL in patients with CKD treated conservatively, the attention of researchers was focused mainly on the level of depression. Only a few studies have analyzed other psychological variables (personality traits, coping strategies, effects of psychosocial interventions) related to QoL in patients with predialysis CKD. Identification and systematization of potentially modifiable factors affecting patients’ QoL set the directions for the prevention and correction of reduced QoL","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-4-875-883
T. Kirsanova, N. Kozlovskaya, A. Balakireva, T. Fedorova
{"title":"Renal dysfunction and current biomarkers of renal damage in HELLP syndrome and obstetric atypical hemolytic uremic syndrome","authors":"T. Kirsanova, N. Kozlovskaya, A. Balakireva, T. Fedorova","doi":"10.28996/2618-9801-2022-4-875-883","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-4-875-883","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69402273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-4-884-891
I.G. Kim, L. Novikova, N. Frolova, E. Volodina, C.C. Bochkareva, V. Vinogradov, I. Ostrovskaya, E. Ivanova, V. Berdinsky, M.E. Maltseva, I. Skryabina, A. Stolbova
{"title":"Features of COVID-19 vaccine prophylaxis in renal graft recipients","authors":"I.G. Kim, L. Novikova, N. Frolova, E. Volodina, C.C. Bochkareva, V. Vinogradov, I. Ostrovskaya, E. Ivanova, V. Berdinsky, M.E. Maltseva, I. Skryabina, A. Stolbova","doi":"10.28996/2618-9801-2022-4-884-891","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-4-884-891","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69402416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-2-279-291
N. Frolova, N. Tomilina, K. E. Loss, E. Stolyarevich, R. Iskhakov, G. Arbolishvili, M. Frolov, S. S. Usatiuk, Yu.V. Streltsov, L. Artyukhina, M. Zubkin, O. Kotenko, G. Volgina, M. Lysenko
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-3-441-456
L. I. Anikonova, O. Vorobyeva, N. Bakulina
ATTR amyloidosis (transthyretin amyloidosis) is a progressive, fatal disease characterized by the accumulation of transthyretin amyloid mainly in the peripheral nervous system (somatic and autonomic) and heart, as well as in the kidneys, gastrointestinal tract, eyeballs, and ligaments, which impairs the normal function of organs and systems. The hereditary form of ATTR amyloidosis, or ATTRv amyloidosis, is found all over the world and is characterized by broad genetic and phenotypic heterogeneity, resulting in late diagnosis. The kidneys are a potential target organ in ATTRv amyloidosis. Clinically, nephropathy is manifested by albuminuria, proteinuria, nephrotic syndrome, or decreased renal function. A nephrologist may be involved in the diagnosis of amyloid nephropathy/ATTRv amyloidosis in a patient with symptoms of renal damage in an endemic region or with a family history of ATTRv amyloidosis, or, more difficult, in the diagnosis of a sporadic case of ATTRv amyloidosis when symptoms of nephropathy were detected in a patient in a non-endemic region without a known family history of amyloidosis. The diagnosis of amyloidosis, especially is sporadic cases, requires the nephrologist to know the specific symptoms, the so-called "red flags" of ATTR amyloidosis that allow suspecting amyloidosis, and methods to confirm the diagnosis. Kidney biopsy in the presence of nephropathy is the gold standard in the diagnosis of amyloidosis. Congo-red staining of biopsy specimens with subsequent visualization of the apple-green birefringence of congophilic masses with polarized light is crucial for histological confirmation of the diagnosis. Immunohistochemistry is used for amyloid typing. The less available method for typing is mass spectrometry of affected tissue. Detection of "red flags" of amyloidosis in a patient with nephropathy makes it possible to diagnose ATTR amyloidosis in some cases without a biopsy, by TTR gene sequencing or myocardial scintigraphy with 99mTc-pyrophosphate. After amyloidosis is diagnosed, it is necessary to conduct a detailed examination for assessing the damage to potential target organs, which requires an interdisciplinary approach. Early diagnosis and disease-modifying therapies can slow the progression of neuropathy and cardiomyopathy, and presumably nephropathy.
{"title":"ATTR-amyloidosis - a systemic disease involving the kidneys","authors":"L. I. Anikonova, O. Vorobyeva, N. Bakulina","doi":"10.28996/2618-9801-2022-3-441-456","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-3-441-456","url":null,"abstract":"ATTR amyloidosis (transthyretin amyloidosis) is a progressive, fatal disease characterized by the accumulation of transthyretin amyloid mainly in the peripheral nervous system (somatic and autonomic) and heart, as well as in the kidneys, gastrointestinal tract, eyeballs, and ligaments, which impairs the normal function of organs and systems. The hereditary form of ATTR amyloidosis, or ATTRv amyloidosis, is found all over the world and is characterized by broad genetic and phenotypic heterogeneity, resulting in late diagnosis. The kidneys are a potential target organ in ATTRv amyloidosis. Clinically, nephropathy is manifested by albuminuria, proteinuria, nephrotic syndrome, or decreased renal function. A nephrologist may be involved in the diagnosis of amyloid nephropathy/ATTRv amyloidosis in a patient with symptoms of renal damage in an endemic region or with a family history of ATTRv amyloidosis, or, more difficult, in the diagnosis of a sporadic case of ATTRv amyloidosis when symptoms of nephropathy were detected in a patient in a non-endemic region without a known family history of amyloidosis. The diagnosis of amyloidosis, especially is sporadic cases, requires the nephrologist to know the specific symptoms, the so-called \"red flags\" of ATTR amyloidosis that allow suspecting amyloidosis, and methods to confirm the diagnosis. Kidney biopsy in the presence of nephropathy is the gold standard in the diagnosis of amyloidosis. Congo-red staining of biopsy specimens with subsequent visualization of the apple-green birefringence of congophilic masses with polarized light is crucial for histological confirmation of the diagnosis. Immunohistochemistry is used for amyloid typing. The less available method for typing is mass spectrometry of affected tissue. Detection of \"red flags\" of amyloidosis in a patient with nephropathy makes it possible to diagnose ATTR amyloidosis in some cases without a biopsy, by TTR gene sequencing or myocardial scintigraphy with 99mTc-pyrophosphate. After amyloidosis is diagnosed, it is necessary to conduct a detailed examination for assessing the damage to potential target organs, which requires an interdisciplinary approach. Early diagnosis and disease-modifying therapies can slow the progression of neuropathy and cardiomyopathy, and presumably nephropathy.","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-3-473-479
A. Litun, Z. Simonova, E. Kolmakova
{"title":"Profiling of sodium and ultrafiltration at patients on a program hemodialysis: Focus on quality of life","authors":"A. Litun, Z. Simonova, E. Kolmakova","doi":"10.28996/2618-9801-2022-3-473-479","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-3-473-479","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-3-494-501
O. Gordeeva, N. Karpina
{"title":"Risk factors identification of respiratory tuberculosis progression in patients with end-stage renal disease","authors":"O. Gordeeva, N. Karpina","doi":"10.28996/2618-9801-2022-3-494-501","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-3-494-501","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.28996/2618-9801-2022-3-519-528
A. Yankovoy, A. Zulkarnaev
The need for central venous catheters in patients on hemodialysis is very high. Even though complications of catheter implantation are rare (on average about 0.5% of cases, according to own data - 0.37%), their treatment is extremely difficult and, in most cases, requires a large surgery. We present four clinical observations. In the first case, during the puncture was damaged the left subclavian vein in the area of its fixation to the first rib and confluence with the internal jugular vein. The resulting heavy bleeding required a thoracotomy, the bleeding was stopped. The patient was discharged. In the second case, there was damage to the left common carotid artery. The defect was eliminated during the operation. The patient was discharged. In the third case, the right common carotid artery was damaged. During the first hours after the injury, the local hematoma did not grow, the condition remained stable. Four hours after physical exertion (stool), there was a rapid increase in hematoma, compression of the trachea, and suffocation. Attempts to intubate were unsuccessful. An emergency tracheostomy was performed. Despite this, the patient died. In the fourth case, the upper vena cava was damaged. In this case, the catheter was located in the projection of the right atrium on the frontal x-ray. The pleural cavity was drained. In connection with the ongoing bleeding on the pleural drainage, an emergency computer tomography was performed, where it was found that the catheter perforates the vein and was located in the pleural cavity. An emergency thoracotomy was performed, the vein defect was eliminated. The patient was discharged after long-term treatment. Thus, a series of clinical observations demonstrate that the diagnosis of severe complications of large vessel damage during the dialysis catheters implantation is difficult due to several factors: the patient's condition, anatomical features, comorbid background, and many localizations of possible damage to vessels. Complicated catheter implantation requires mandatory ultrasound control, observation in the intensive care unit, mandatory x-ray examination, and, if necessary, computer tomography for early detection of life-threatening conditions.
{"title":"Trauma of the central vessels, which led to profuse bleeding, after tunneled dialysis catheter insertion in patients treated with hemodialysis","authors":"A. Yankovoy, A. Zulkarnaev","doi":"10.28996/2618-9801-2022-3-519-528","DOIUrl":"https://doi.org/10.28996/2618-9801-2022-3-519-528","url":null,"abstract":"The need for central venous catheters in patients on hemodialysis is very high. Even though complications of catheter implantation are rare (on average about 0.5% of cases, according to own data - 0.37%), their treatment is extremely difficult and, in most cases, requires a large surgery. We present four clinical observations. In the first case, during the puncture was damaged the left subclavian vein in the area of its fixation to the first rib and confluence with the internal jugular vein. The resulting heavy bleeding required a thoracotomy, the bleeding was stopped. The patient was discharged. In the second case, there was damage to the left common carotid artery. The defect was eliminated during the operation. The patient was discharged. In the third case, the right common carotid artery was damaged. During the first hours after the injury, the local hematoma did not grow, the condition remained stable. Four hours after physical exertion (stool), there was a rapid increase in hematoma, compression of the trachea, and suffocation. Attempts to intubate were unsuccessful. An emergency tracheostomy was performed. Despite this, the patient died. In the fourth case, the upper vena cava was damaged. In this case, the catheter was located in the projection of the right atrium on the frontal x-ray. The pleural cavity was drained. In connection with the ongoing bleeding on the pleural drainage, an emergency computer tomography was performed, where it was found that the catheter perforates the vein and was located in the pleural cavity. An emergency thoracotomy was performed, the vein defect was eliminated. The patient was discharged after long-term treatment. Thus, a series of clinical observations demonstrate that the diagnosis of severe complications of large vessel damage during the dialysis catheters implantation is difficult due to several factors: the patient's condition, anatomical features, comorbid background, and many localizations of possible damage to vessels. Complicated catheter implantation requires mandatory ultrasound control, observation in the intensive care unit, mandatory x-ray examination, and, if necessary, computer tomography for early detection of life-threatening conditions.","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69401944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：