Nephrology and Dialysis最新文献

{"title":"A study of cytotoxic effect of the uremic toxin indoxyl sulfate on myoblasts in vitro, the expression of myostatin mRNA in myoblast cell culture, and the possibility of exogenous regulation","authors":"V. A. Furalyov, V. Kukes, A. Gazdanova","doi":"10.28996/2618-9801-2021-2-219-224","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-2-219-224","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69397544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The vitamin D receptor - a new therapeutic target for kidney disease","authors":"G. Volgina, N. A. Michailova, O. Kotenko","doi":"10.28996/2618-9801-2021-3-330-351","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-330-351","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69397839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of renal pathology: a 7-year review of renal biopsy database","authors":"E. Stolyarevich, T. R. Zhilinskaja, V. V. Variasin, Artificial Organs","doi":"10.28996/2618-9801-2021-3-379-389","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-379-389","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69397950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe hypocalcemia - a problem of an early postoperative period after parathyroidectomy for secondary hyperparathyroidism in dialysis-dependent patients","authors":"E. Parshina, P. Kislyy, K. Novokshonov, A. Tolkach, R. Chernikov, I. Karelina","doi":"10.28996/2618-9801-2021-3-390-400","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-390-400","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69399196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperparathyroidism in kidney transplant recipients: a single-center study","authors":"O. Vetchinnikova, M. Clinical, A. Vatazin, M. Ivanova, R. O. Kantariya","doi":"10.28996/2618-9801-2021-3-401-413","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-401-413","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69398775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of acute kidney injury in Covid-19. Review","authors":"L. Maltseva, I. Vasalatii, Y. Isaakyan, O. Morozova","doi":"10.28996/2618-9801-2021-3-352-365","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-352-365","url":null,"abstract":"The most important feature of acute kidney injury (AKI) in COVID-19 is the absence of a single main link of pathogenesis. A thorough understanding of the mechanisms and main links of the pathogenesis of the disease will allow the identifi cation of early markers of AKI, which will contribute to early diagnosis, prognosis, personalized therapy and prevention of kidney damage in patients with COVID-19. Aim: to summarize data from clinical and scientifi c studies on the known mechanisms of AKI in COVID- 19. To identify markers of early kidney injury in COVID-19. Materials and methods. In the Web of Science, Scopus and RSCI databases, 81 sources were selected that contained relevant data from clinical and scientifi c researches on the topic of this review. Results: the main reported mechanisms of kidney damage in COVID-19 patients are as follows: intracellular activity of the virus leading to cell death, excessive release of pro-infl ammatory cytokines and cytokine storm, pathology of the renin-angiotensin-aldosterone system (RAAS), hyperergic infl ammation and immunothrombosis. The main effects of angiotensin II in the case of dysregulation of the RAAS, as well as the spectrum of pro-infl ammatory cytokines and their functions in the development of the cytokine storm, were determined. The possibility of a direct cytopathic effect of SARS-CoV-2 on the renal epithelium as an independent cause of AKI in COVID-19 was considered. The association between the hyperergic infl ammatory response and the process of immunothrombosis, which is mediated by many defense systems, including neutrophils, platelets and proteins of the complement system was presented. The risk of thrombotic complications in the renal vessels in patients with COVID-19 was anaysed. An analysis of potential early biomarkers of kidney injury in COVID-19 were also presented and compared with clinical biomarkers of AKI. Conclusions: AKI is one of the most common complications in critically ill patients with COVID-19, which signifi cantly worsens the prognosis of the disease. The study of the mechanisms of kidney injury contributes to the discovery of new markers necessary for early diagnosis, prognosis of the course of the disease, and further determination of the optimal personalized therapy. © 2021 JSC Vidal Rus. All Rights Reserved.","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69397853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience in applying the contrast-enhanced ultrasonography in successfully operated patient with malignant tumor of kidney transplant. Case Study and Review of Literature","authors":"N. Belavina, R. Trushkin, E. Ivanova, L. Artyukhina, A. E. Lubennikov, D. Kantimerov, O. Manchenko, V. V. Varyasin, E. Stolyarevich, E. E. Berezhnaia, I. K. Maksimov, I. Kesareva, V. N. Smorshchok, N. Frolova, N. Vetsheva, Artificial Organs","doi":"10.28996/2618-9801-2021-3-414-424","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-414-424","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69399294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of «Gam-COVID-Vac» (Sputnik V)","authors":"A. D. Tolkach, Ekaterina Parshina, A. V. Ivanov, Pavel Kislyy","doi":"10.28996/2618-9801-2021-3-434-436","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-3-434-436","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69399302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection in kidney transplant recipients","authors":"I. Kim, L. Artyukhina, N. Frolova, E. Ivanova, I. Ostrovskaya, V. Berdinsky, V. Vinogradov, E. Volodina, M.E. Maltseva, A. Stolbova, T. Buruleva, A. Frolov, E.A. Kalugin, I. Skryabina, D. Titov, N. Tomilina, M. Zubkin","doi":"10.28996/2618-9801-2021-2-174-184","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-2-174-184","url":null,"abstract":"The study aimed to assess the clinical course and risk factors for adverse outcomes, as well as the treatment options for COVID-19 in renal transplant recipient (RTR). Patients and methods: a retrospective study included 279 RTRs (M 60.9%, age 49.9±10.9 years), infected with SARS-CoV-2 from 01.04.2020 to 30.11.2020. After confirmation of COVID-19 by PCR and chest CT, MMF/Aza were canceled. In severe cases, the CNI dose was minimized while that of CS was increased. Observation endpoints: hospital discharge/recovery or death. Results: SARS-CoV-2 was identified in 84.2% of RTRs. In almost 90% of patients, the COVID-19 was confirmed by CT data. Duration after transplantation at the time of infection was 54.0 (14.0;108.0) months, in 17.6% of cases it was 6 months or less. 223/79.9% RTRs were treated in the hospital. The period from the onset of the disease to the hospitalization was 6.8±4.5 days. Severe lung damage (>50%) occurred in 43.1% RTRs;45.3% of patients required respiratory support. Hospital mortality was 13.9%, overall mortality was 11.1%. The most common cause of death (93.5%) was acute respiratory distress syndrome (ARDS). The risk factors associated with an unfavorable outcome were a high comorbidity index, the severity of the pulmonary lesion, the degree of graft dysfunction at the onset of the disease, decreased SpO2 and the use of mechanical ventilation, as well as anemia, leukocytosis, lymphocytopenia, and hypoalbuminemia, increased levels of creatinine, AST, CRP, LDH, and D-dimer, interleukin-6 and procalcitonin. Scr during the course of the disease increased from 171.6±78.0 μM to 221.5±121.3 μM (p<0.01) with no signs of acute rejection. In 2 recipients with severe graft failure at the time of infection with SARS-CoV-2, HD was resumed from the moment of hospitalization. We were unable to identify the effect of hydroxychloroquine on the outcome of COVID-19. At the same time, mortality in patients with hydroxychloroquine use was higher than in recipients treated with immunobiological drugs: 25.6% and 11.4%, respectively, p<0.02. When immunomodulators were combined with dexamethasone, mortality decreased to 4.8%. The independent factors of adverse outcome were high levels of procalcitonin (p<0.019) and mechanical ventilation (p<0.001). Conclusion: COVID-19 in RTRs is characterized by a severe course and high mortality, which necessitates hospitalization of the majority of infected patients. An increase in procalcitonin levels and the need for mechanical ventilation were independent predictors of an unfavorable outcome of COVID-19. © 2021 JSC Vidal Rus. All rights reserved.","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69396278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal dysfunction in patients with stage 1-2 arterial hypertension and its relationship with cardiovascular remodeling and vascular wall stiffness","authors":"E. Grigoricheva, Y. Bondareva, D. Matsuganov, O. Bastrikov, R. A. Abdulaev, E.V. Yarushina, V. V. Evdokimov","doi":"10.28996/2618-9801-2021-2-185-191","DOIUrl":"https://doi.org/10.28996/2618-9801-2021-2-185-191","url":null,"abstract":"","PeriodicalId":52208,"journal":{"name":"Nephrology and Dialysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69397486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}