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Facial palsy reconstruction. 面瘫重建
Q2 Medicine Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.7181/acfs.2023.00528
Soo Hyun Woo, Young Chul Kim, Tae Suk Oh

The facial nerve stimulates the muscles of facial expression and the parasympathetic nerves of the face. Consequently, facial nerve paralysis can lead to facial asymmetry, deformation, and functional impairment. Facial nerve palsy is most commonly idiopathic, as with Bell palsy, but it can also result from a tumor or trauma. In this article, we discuss traumatic facial nerve injury. To identify the cause of the injury, it is important to first determine its location. The location and extent of the damage inform the treatment method, with options including primary repair, nerve graft, cross-face nerve graft, nerve crossover, and muscle transfer. Intracranial proximal facial nerve injuries present a challenge to surgical approaches due to the complexity of the temporal bone. Surgical intervention in these cases requires a collaborative approach between neurosurgery and otolaryngology, and nerve repair or grafting is difficult. This article describes the treatment of peripheral facial nerve injury. Primary repair generally offers the best prognosis. If primary repair is not feasible within 6 months of injury, nerve grafting should be attempted, and if more than 12 months have elapsed, functional muscle transfer should be performed. If the affected nerve cannot be utilized at that time, the contralateral facial nerve, ipsilateral masseter nerve, or hypoglossal nerve can serve as the donor nerve. Other accompanying symptoms, such as lagophthalmos or midface ptosis, must also be considered for the successful treatment of facial nerve injury.

面神经刺激面部表情肌和面部副交感神经。因此,面神经麻痹会导致面部不对称、变形和功能障碍。面神经麻痹最常见的是特发性的,如贝尔麻痹,但也可能由肿瘤或外伤引起。本文将讨论外伤性面神经损伤。要确定损伤的原因,首先要确定损伤的位置。损伤的位置和程度决定了治疗方法,包括初次修复、神经移植、交叉面神经移植、神经交叉和肌肉转移。由于颞骨的复杂性,颅内近端面神经损伤给手术方法带来了挑战。这些病例的手术干预需要神经外科和耳鼻喉科的合作,而神经修复或移植是很困难的。本文介绍了周围面神经损伤的治疗方法。初次修复一般可获得最佳预后。如果在受伤后 6 个月内无法进行初次修复,则应尝试神经移植;如果超过 12 个月,则应进行功能性肌肉转移。如果当时无法使用受影响的神经,则可使用对侧面神经、同侧颌下神经或舌下神经作为供体神经。要成功治疗面神经损伤,还必须考虑其他伴随症状,如眼睑下垂或面中部下垂。
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引用次数: 0
Demographic review of aesthetic surgery for patients with facial palsy. 面瘫患者美容手术的人口统计学回顾。
Q2 Medicine Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.7181/acfs.2023.00591
Min Young Lee, Yun Jung Kim, Young Seok Kim, Tai Suk Roh, In Sik Yun

Background: This study analyzed the demographic characteristics of patients with facial palsy who were treated using either dynamic or static procedures. This study aimed to compare the frequency of procedure implementation and age distribution between the two groups.

Methods: This study retrospectively analyzed the medical records of patients treated for facial palsy at a single institution from 2014 to 2022. Among cases included in our study, dynamic procedures involved cross-facial nerve graft and latissimus dorsi or gracilis muscle flap transfer. Static procedures included gold weight insertion, canthopexy, browlift, and thread lift/static slings.

Results: Among the 31 patients included in our study, eight (25.8%) incorporated dynamic techniques, and the average age of patients was 44.75 years (range, 24-68 years) with a male to female ratio of 1:4. The remaining 23 patients (74.2%) underwent a static procedure, of which the average age was 59.17 years (range, 23-81 years) which was statistically significantly higher than the average age of 44.75 of dynamic patients (p= 0.013). Regarding the timing of treatment after diagnosis, no patient underwent dynamic procedures more than 20 years after initial diagnosis. A greater diversity in the timing of treatment was observed in the static group. All patients who underwent dynamic procedures were treated using static procedures during the study period.

Conclusion: Because aesthetics-based static techniques are typically quick outpatient procedures that can be performed under local anesthesia, our study shows that these are often preferred treatments for all age groups, especially for debilitated or older patients. Further research is required to investigate the long-term functional outcomes of these surgical techniques in a wider population of patients.

研究背景本研究分析了采用动态或静态手术治疗的面瘫患者的人口统计学特征。该研究旨在比较两组患者实施手术的频率和年龄分布:本研究回顾性分析了2014年至2022年在一家机构接受治疗的面瘫患者的病历。在纳入研究的病例中,动态手术包括交叉面神经移植和背阔肌或擒拿肌肌皮瓣转移。静态手术包括黄金重量植入、眦角成形术、提眉术和线性上提/静态吊带术:在纳入研究的 31 位患者中,有 8 位(25.8%)采用了动态技术,患者的平均年龄为 44.75 岁(24-68 岁),男女比例为 1:4。其余 23 名患者(74.2%)接受了静态手术,其中患者的平均年龄为 59.17 岁(23-81 岁),在统计学上明显高于动态患者 44.75 岁的平均年龄(P= 0.013)。关于确诊后的治疗时间,没有患者在初次确诊后超过 20 年才接受动态治疗。静态组患者的治疗时间差异更大。所有接受动态手术的患者在研究期间都接受了静态手术:由于以美学为基础的静态技术通常是快速的门诊手术,可在局部麻醉下进行,我们的研究表明,这些技术通常是所有年龄组患者的首选治疗方法,尤其是对于体弱或年长的患者。还需要进一步研究这些手术技术在更多患者中的长期功能效果。
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引用次数: 0
Transdermal scopolamine for the treatment of recurrent parotid sialocele: a case report. 经皮东莨菪碱治疗复发性腮腺鞘膜积液:病例报告。
Q2 Medicine Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.7181/acfs.2023.00360
Chi Hyun Lee, Changryul Claud Yi, Yong Chan Bae, Jae Woo Lee, Byung-Joo Lee, Joo Hyoung Kim

Recurrent parotid sialocele is rare and challenging to treat. Treatment options are limited for cases of parotid sialocele that recur despite ductal ligation. This case study presents a patient who underwent wide excision of the right buccal mucosa due to squamous cell carcinoma. During the wide excision, a segment of the parotid duct was excised, and ductal ligation was performed to prevent the occurrence of a sialocele, followed by reconstruction using a folded anterolateral thigh free flap. Twenty-two days after surgery, parotid sialocele occurred despite the initial ductal ligation and subsequent ductal ligation was performed; however, the sialocele recurred. As an alternative therapeutic option, a transdermal scopolamine patch was applied for 3 weeks, with one patch used every 3 days. The results were encouraging, with complete resolution of the sialocele. A transdermal scopolamine offers a noninvasive, convenient method of treating parotid sialocele with minimal side effects. The successful outcome of this case suggests that a transdermal scopolamine can be an effective therapeutic option for recurrent parotid sialocele in conjunction with surgical treatment.

复发性腮腺鞘膜积液非常罕见,治疗难度很大。对于结扎导管后仍复发的腮腺鞘膜积液病例,治疗方案十分有限。本病例研究介绍了一名因鳞状细胞癌而接受右侧口腔粘膜广泛切除术的患者。在大范围切除术中,切除了一段腮腺导管,并进行了导管结扎以防止发生咽峡炎,随后使用折叠的大腿前外侧游离皮瓣进行了重建。术后 22 天,尽管最初进行了腮腺导管结扎,但还是出现了腮腺鞘膜积液,随后又进行了导管结扎,但鞘膜积液再次出现。作为一种替代疗法,患者使用了经皮东莨菪碱贴片,每 3 天贴一片,连续使用了 3 周。结果令人鼓舞,霰粒肿完全消退。透皮东莨菪碱贴片是治疗腮腺鞘膜积液的一种非侵入性、方便且副作用极小的方法。本病例的成功结果表明,经皮东莨菪碱可作为复发性腮腺霰粒肿的一种有效治疗方法,并与手术治疗相结合。
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引用次数: 0
Clinical characteristics of pediatric nasal bone fractures by age group. 按年龄组划分的小儿鼻骨骨折临床特征。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-12-20 DOI: 10.7181/acfs.2023.00514
Jun Woo Kim, Dong Gil Han

Background: The clinical characteristics of pediatric nasal fractures can vary depending on the child's age, social activities, and environment. Therefore, this study aimed to analyze these characteristics in different age groups.

Methods: We retrospectively reviewed of a series of patients aged under 12 years who received treatment between 2013 and 2021. The initial study design involved dividing the patients into four age groups, corresponding to different developmental ages, but there were no cases in infants aged 0 to 1 year. Therefore, the patients were divided into three groups: group I, between 2 and 5; group II, between 6 and 9; and group III, between 10 and 12 years of age. The following parameters were evaluated: sex, age, etiology, fracture type and severity, and the incidence of septal injuries.

Results: In total, 98 patients were included in this study. In group III, the ratio of boys to girls was 3.88:1, exceeding the overall ratio of 1.97:1. The most common cause varied with age: slipping down in group I, bumping accidents in group II, and sports accidents in group III. Concomitant septal injuries were present in 4.17% of patients in group I, 5.71% of patients in group II, and 28.21% of patients in group III.

Conclusion: Increasing age was accompanied by a greater tendency for male predominance and a higher prevalence of sports-related causes and septal injuries. Violence was infrequent but started to become a contributing factor during school age. These varying environmental factors across age groups can offer valuable insights into the epidemiology and clinical characteristics of pediatric nasal bone fractures.

背景:小儿鼻骨骨折的临床特征会因儿童的年龄、社会活动和环境而有所不同。因此,本研究旨在分析不同年龄组的这些特征:方法:我们回顾性研究了 2013 年至 2021 年期间接受治疗的一系列 12 岁以下患者。最初的研究设计是将患者分为四个年龄组,分别对应不同的发育年龄,但没有 0 至 1 岁婴儿的病例。因此,患者被分为三组:第一组,2 至 5 岁;第二组,6 至 9 岁;第三组,10 至 12 岁。对以下参数进行了评估:性别、年龄、病因、骨折类型和严重程度以及室间隔损伤的发生率:本研究共纳入 98 名患者。在第三组中,男孩与女孩的比例为 3.88:1,超过了 1.97:1 的总体比例。最常见的原因因年龄而异:第一组为滑倒,第二组为磕碰事故,第三组为运动事故。第一组有 4.17% 的患者合并鼻中隔损伤,第二组有 5.71% 的患者合并鼻中隔损伤,第三组有 28.21% 的患者合并鼻中隔损伤:随着年龄的增长,男性占多数的趋势越来越明显,与运动有关的原因和房间隔损伤的发生率也越来越高。暴力并不常见,但在学龄期开始成为诱因。这些不同年龄组的环境因素可为了解小儿鼻骨骨折的流行病学和临床特征提供宝贵的见解。
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引用次数: 0
Facial artery: anatomical variations in the perioral region in cadavers. 面部动脉:尸体口周的解剖变化。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-12-20 DOI: 10.7181/acfs.2023.00493
Vu Hoang Nguyen, Lin Cheng-Kuan, Tuan Anh Nguyen, Trang Huu Ngoc Thao Cai

Background: In recent years, there has been an increase in reports of perioral vascular complications resulting from filler injections, such as necrosis of the lip or alar rim, occlusion, and in severe cases, blindness. Conversely, the use of perioral arterial flaps is becoming more prevalent in the treatment of cleft lips, cancer, and trauma. A thorough understanding of perioral arteries is essential to minimize complications and maximize the success of these flaps. However, the course of the facial artery (FA) in the perioral region remains incompletely understood. The aim of this study was to describe the variations of the FA in the perioral region.

Methods: We dissected 52 embalmed and formaldehyde-fixed Vietnamese cadavers. We then studied the size and distribution of perioral arteries in 102 specimens.

Results: The superior labial artery (SLA) was the most common branch, occurring in 87.25% of cadavers, followed by the inferior labial artery (ILA) at 78.43%. The SLA primarily originated above the mouth corner (cheilion), accounting for 91.01% of cases, and predominantly exhibited a tortuous course within the submucosa (78.65%). The ILA's branching pattern varied, but it was primarily located below the cheilion (91.25%). The ILA also followed a twisted path, generally within the submucosa. The ILA exhibited two patterns: the typical pattern, distributed at the vermilion border of the lower lip (8.82%), and the horizontal labiomental artery pattern, which ran horizontally in the middle of the lower lip area (69.61%). At their origin, the SLA and ILA had average external diameters of 1.29 mm and 1.28 mm, respectively.

Conclusion: Numerous anatomical variations in the FA in the perioral region were found. A detailed anatomic description, suggested landmarks, and angiography before the procedure will be useful to help doctors avoid complications.

背景:近年来,有关注射填充剂导致口周血管并发症的报道越来越多,如唇部或唇颊缘坏死、闭塞,严重的还会导致失明。相反,在治疗唇裂、癌症和外伤时,口周动脉皮瓣的使用也越来越普遍。全面了解口周动脉对减少并发症和最大限度地提高这些皮瓣的成功率至关重要。然而,人们对面动脉(FA)在口周区域的走向仍然不甚了解。本研究的目的是描述面动脉在口周区域的变化:方法:我们解剖了 52 具经防腐处理和甲醛固定的越南尸体。方法:我们解剖了 52 具经防腐处理和甲醛固定的越南尸体,然后研究了 102 具标本口周动脉的大小和分布情况:结果:唇上动脉(SLA)是最常见的分支,出现在 87.25% 的尸体中,其次是唇下动脉(ILA),占 78.43%。SLA 主要起源于口角(cheilion)上方,占 91.01%,主要在粘膜下呈迂曲走向(78.65%)。ILA 的分支模式各不相同,但主要位于口角下方(91.25%)。ILA 的路径也很曲折,一般位于粘膜下层。ILA 表现出两种形态:典型形态,分布在下唇朱缘处(8.82%);水平唇动脉形态,水平分布在下唇中部(69.61%)。SLA和ILA在其起源处的平均外径分别为1.29毫米和1.28毫米:结论:口周区域的 FA 存在许多解剖学变异。手术前详细的解剖描述、建议的地标和血管造影将有助于医生避免并发症。
{"title":"Facial artery: anatomical variations in the perioral region in cadavers.","authors":"Vu Hoang Nguyen, Lin Cheng-Kuan, Tuan Anh Nguyen, Trang Huu Ngoc Thao Cai","doi":"10.7181/acfs.2023.00493","DOIUrl":"10.7181/acfs.2023.00493","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been an increase in reports of perioral vascular complications resulting from filler injections, such as necrosis of the lip or alar rim, occlusion, and in severe cases, blindness. Conversely, the use of perioral arterial flaps is becoming more prevalent in the treatment of cleft lips, cancer, and trauma. A thorough understanding of perioral arteries is essential to minimize complications and maximize the success of these flaps. However, the course of the facial artery (FA) in the perioral region remains incompletely understood. The aim of this study was to describe the variations of the FA in the perioral region.</p><p><strong>Methods: </strong>We dissected 52 embalmed and formaldehyde-fixed Vietnamese cadavers. We then studied the size and distribution of perioral arteries in 102 specimens.</p><p><strong>Results: </strong>The superior labial artery (SLA) was the most common branch, occurring in 87.25% of cadavers, followed by the inferior labial artery (ILA) at 78.43%. The SLA primarily originated above the mouth corner (cheilion), accounting for 91.01% of cases, and predominantly exhibited a tortuous course within the submucosa (78.65%). The ILA's branching pattern varied, but it was primarily located below the cheilion (91.25%). The ILA also followed a twisted path, generally within the submucosa. The ILA exhibited two patterns: the typical pattern, distributed at the vermilion border of the lower lip (8.82%), and the horizontal labiomental artery pattern, which ran horizontally in the middle of the lower lip area (69.61%). At their origin, the SLA and ILA had average external diameters of 1.29 mm and 1.28 mm, respectively.</p><p><strong>Conclusion: </strong>Numerous anatomical variations in the FA in the perioral region were found. A detailed anatomic description, suggested landmarks, and angiography before the procedure will be useful to help doctors avoid complications.</p>","PeriodicalId":52238,"journal":{"name":"Archives of Craniofacial Surgery","volume":"24 6","pages":"266-272"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oronasal fistula reconstruction using tongue flap with simultaneous iliac bone graft: a case report. 舌瓣同时髂骨移植重建口鼻瘘1例报告。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-10-20 DOI: 10.7181/acfs.2022.00948
Da Som Kim, Yi Jun Moon, Ho Jin Park, Seung-Ha Park

The ultimate goal of cleft palate repair is to achieve an intact palate with the separation of the oral and nasal cavities. However, some patients develop an oronasal fistula in the secondary palate after palatoplasty. Postoperatively, a secondary palatal oronasal fistula may develop, leading to functional problems. In this study, we describe a patient with recurrent oronasal fistula and alveolar cleft with multiple failed previous reconstructions at another clinic. The oronasal fistula and alveolar cleft were repaired using a tongue flap and an iliac bone graft, respectively. The patient demonstrated excellent clinical progress with no recurrence of the oronasal fistula at the 1-year follow-up.

腭裂修复的最终目标是实现口腔和鼻腔分离的完整腭裂。然而,一些患者在腭裂成形术后继发腭部出现口鼻瘘。术后,可能会出现继发性腭口鼻瘘,导致功能问题。在这项研究中,我们描述了一名在另一家诊所多次重建失败的复发性口鼻瘘和牙槽裂患者。分别用舌瓣和髂骨移植修复口鼻瘘和牙槽裂。患者在1年的随访中表现出良好的临床进展,没有复发口鼻瘘。
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引用次数: 0
Alar crease as a donor site for the extension limb of modified nasolabial V-Y advancement flap. 将耳皱襞作为改良鼻唇沟 V-Y 推进皮瓣延伸肢的供体部位。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-12-20 DOI: 10.7181/acfs.2023.00402
Yooseok Ha, Yunsung Park, Hyunwoo Kyung, Sang-Ha Oh

Background: The traditional nasolabial V-Y advancement flap is widely used for midface reconstruction, particularly for the lower third of the nose and upper lip, as its color and texture are similar to these areas. However, it provides insufficient tissue to cover large defects and cannot restore the nasal convexity, nasal ala, and adjacent tissues. The purpose of this study is to investigate the modified nasolabial V-Y advancement flap with extension limbs the along alar crease for the reconstruction of complex midface defects.

Methods: A retrospective analysis of 18 patients, who underwent reconstruction with the modified nasolabial V-Y advancement flap, was performed between September 2014 and December 2022. An extension limb was added along the alar crease, adjacent to the defect area, and was hinged down as a transposition flap at the end of the advancement flap.

Results: The extension limb along the alar crease successfully covered large and complicated defects, including those of the ala, the alar rim, the alar base, the nostrils, and the upper lip, with minor complications.

Conclusion: The alar crease is a good donor site for the reconstruction of large and complex nasal and upper lip defects.

背景:传统的鼻唇V-Y推进皮瓣被广泛用于中面部重建,尤其是鼻下1/3和上唇,因为其颜色和质地与这些部位相似。然而,它提供的组织不足以覆盖大面积缺损,也无法恢复鼻凸、鼻翼和邻近组织。本研究的目的是探讨改良鼻唇沟 V-Y 推进皮瓣与沿鼻翼皱襞延伸肢体重建复杂中面部缺损的方法:方法:对2014年9月至2022年12月期间接受改良鼻唇沟V-Y推进皮瓣重建术的18例患者进行了回顾性分析。在缺损区附近沿面颊皱襞增加一个延伸肢体,并在推进瓣末端作为转位瓣向下铰链:结果:沿耳廓皱襞的延伸肢体成功覆盖了大面积的复杂缺损,包括耳廓、耳廓边缘、耳廓基底、鼻孔和上唇的缺损,并发症较少:结论:鼻翼下皱襞是重建大型复杂鼻部和上唇缺损的良好供体部位。
{"title":"Alar crease as a donor site for the extension limb of modified nasolabial V-Y advancement flap.","authors":"Yooseok Ha, Yunsung Park, Hyunwoo Kyung, Sang-Ha Oh","doi":"10.7181/acfs.2023.00402","DOIUrl":"10.7181/acfs.2023.00402","url":null,"abstract":"<p><strong>Background: </strong>The traditional nasolabial V-Y advancement flap is widely used for midface reconstruction, particularly for the lower third of the nose and upper lip, as its color and texture are similar to these areas. However, it provides insufficient tissue to cover large defects and cannot restore the nasal convexity, nasal ala, and adjacent tissues. The purpose of this study is to investigate the modified nasolabial V-Y advancement flap with extension limbs the along alar crease for the reconstruction of complex midface defects.</p><p><strong>Methods: </strong>A retrospective analysis of 18 patients, who underwent reconstruction with the modified nasolabial V-Y advancement flap, was performed between September 2014 and December 2022. An extension limb was added along the alar crease, adjacent to the defect area, and was hinged down as a transposition flap at the end of the advancement flap.</p><p><strong>Results: </strong>The extension limb along the alar crease successfully covered large and complicated defects, including those of the ala, the alar rim, the alar base, the nostrils, and the upper lip, with minor complications.</p><p><strong>Conclusion: </strong>The alar crease is a good donor site for the reconstruction of large and complex nasal and upper lip defects.</p>","PeriodicalId":52238,"journal":{"name":"Archives of Craniofacial Surgery","volume":"24 6","pages":"260-265"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated unilateral temporalis muscle hypertrophy of unknown etiology: a case report and literature review. 病因不明的孤立性单侧颞肌肥大:病例报告和文献综述。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-12-20 DOI: 10.7181/acfs.2023.00458
Jun Ho Choi, Seung Yeon Choi, Jae Ha Hwang, Kwang Seog Kim, Sam Yong Lee

The initial instance of isolated unilateral temporalis muscle hypertrophy (IUTMH) was reported in 1990. Since then, only few cases have been documented. The cause of this condition remains ambiguous; however, it is presumed to be linked to compensatory and stress-induced hypertrophy. We introduce a rare case of the diagnosis and treatment of IUTMH. A 39-year-old woman presented with a steadily enlarging pain-free swelling on the left side of her face, first noticed a month ago. Apart from a hyperthyroidism medication regimen her medical history was unremarkable. She had no history of temporomandibular joint disease, bruxism, surgery, or trauma. However, she complained of having been under substantial stress lately. Contrast-enhanced magnetic resonance imaging revealed asymmetric temporalis muscle hypertrophy. The treatment plan consisted of administering type A botulinum toxin injections into left temporalis muscle, supplemented by lifestyle changes and relaxation techniques. At a follow-up visit 9 months after the injections, the muscle contour was normalized both in physical and in radiologic examinations. While further supportive evidence is needed, it can be anticipated that cosmetic treatment with botulinum toxin, rather than surgical interventions, will become the standard treatment of IUTMH.

孤立性单侧颞肌肥大(IUTMH)的首次报道是在 1990 年。此后,只有少数病例被记录在案。这种疾病的病因仍不明确,但推测与代偿性肥大和应激性肥大有关。我们介绍一例罕见的 IUTMH 诊断和治疗病例。一名 39 岁的女性患者于一个月前首次发现左侧面部出现持续性肿胀,且无疼痛感。除了甲状腺功能亢进症的药物治疗外,她的病史并无异常。她没有颞下颌关节疾病、磨牙症、手术或外伤史。不过,她抱怨最近压力很大。对比增强磁共振成像显示她的颞肌不对称肥大。治疗方案包括在左侧颞肌注射A型肉毒毒素,并辅以改变生活方式和放松技巧。在注射 9 个月后的随访中,肌肉轮廓在物理和放射检查中均恢复正常。虽然还需要进一步的支持性证据,但可以预见的是,使用肉毒杆菌毒素进行美容治疗,而非手术治疗,将成为 IUTMH 的标准治疗方法。
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引用次数: 0
Genetic determinants of periosteum-mediated craniofacial bone regeneration: a systematic review. 骨膜介导的颅面骨再生的遗传决定因素:系统综述。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-08-16 DOI: 10.7181/acfs.2023.00381
Eyituoyo Okoturo

Background: Periosteum-mediated bone regeneration (PMBR) is a recognized method for mandibular reconstruction. Despite its unpredictable nature and the limited degree to which it is understood, it does not share the concerns of developmental changes to donor and recipient tissues that other treatment options do. The definitive role of the periosteum in bone regeneration in any mammal remains largely unexplored. The purpose of this study was to identify the genetic determinants of PMBR in mammals through a systematic review.

Methods: Our search methodology was designed in accordance with the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. We conducted a quality assessment of each publication, and evaluated the differences in gene expression between days 7 and 15.

Results: A total of four studies satisfied the inclusion criteria. The subjects and tissues examined in these studies were Wistar rat calvaria in two studies, mini-pigs in one study, and calves and mice in one study. Three out of the four studies achieved the necessary quality score of ≥ 3. Gene expression analysis showed increased activity of genes responsible for angiogenesis, cytokine activities, and immune-inflammatory responses on day 7. Additionally, genes related to skeletal development and signaling pathways were upregulated on day 15. Conclusions: The results suggest that skeletal morphogenesis is regulated by genes associated with skeletal development, and the gene expression patterns of PMBR may be characterized by specific pathways.

背景:骨膜介导的骨再生(PMBR)是一种公认的下颌骨重建方法。尽管骨膜介导骨再生具有不可预测性,而且人们对它的了解程度有限,但它并不像其他治疗方法那样会引起供体和受体组织的发育变化。骨膜在任何哺乳动物骨再生中的确切作用在很大程度上仍未被探索。本研究的目的是通过系统综述确定哺乳动物骨膜再生的遗传决定因素:我们的检索方法是根据 PRISMA(系统综述和元分析的首选报告项目)指南设计的。我们对每篇文献进行了质量评估,并评估了第 7 天和第 15 天之间基因表达的差异:共有四项研究符合纳入标准。其中两项研究的研究对象和组织为 Wistar 大鼠小腿,一项研究的研究对象为迷你猪,一项研究的研究对象为小牛和小鼠。四项研究中有三项达到了必要的质量分数≥3。基因表达分析表明,在第 7 天,负责血管生成、细胞因子活性和免疫炎症反应的基因活性增加。此外,与骨骼发育和信号通路相关的基因在第 15 天出现上调。结论结果表明,骨骼形态发生受骨骼发育相关基因的调控,而 PMBR 的基因表达模式可能具有特定通路的特征。
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引用次数: 0
Dear members of the Korean Cleft Palate-Craniofacial Association. 亲爱的韩国腭裂颅面协会成员们。
Q2 Medicine Pub Date : 2023-12-01 Epub Date: 2023-12-20 DOI: 10.7181/acfs.2023.00619
Dong Gil Han
{"title":"Dear members of the Korean Cleft Palate-Craniofacial Association.","authors":"Dong Gil Han","doi":"10.7181/acfs.2023.00619","DOIUrl":"10.7181/acfs.2023.00619","url":null,"abstract":"","PeriodicalId":52238,"journal":{"name":"Archives of Craniofacial Surgery","volume":"24 6","pages":"292"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139099213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Archives of Craniofacial Surgery
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