首页 > 最新文献

Herzschrittmachertherapie und Elektrophysiologie最新文献

英文 中文
[eCardiology in cardiac electrophysiology]. [心脏电生理学中的电子心电图]。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI: 10.1007/s00399-024-01024-y
David Duncker, Dominik Linz
{"title":"[eCardiology in cardiac electrophysiology].","authors":"David Duncker, Dominik Linz","doi":"10.1007/s00399-024-01024-y","DOIUrl":"10.1007/s00399-024-01024-y","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial intelligence-enhanced electrocardiography : Will it revolutionize diagnosis and management of our patients?] [人工智能增强型心电图:它能否彻底改变我们对患者的诊断和管理?]
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-02-15 DOI: 10.1007/s00399-024-00997-0
Wilhelm Haverkamp, Nils Strodthoff

The use of artificial intelligence (AI) in healthcare has made significant progress in the last 10 years. Many experts believe that utilization of AI technologies, especially deep learning, will bring about drastic changes in how physicians understand, diagnose, and treat diseases. One aspect of this development is AI-enhanced electrocardiography (ECG) analysis. It involves not only optimizing the traditional ECG analysis by the physician and improving the accuracy of automatic interpretation by the ECG device but also introducing entirely new diagnostic options enabled by AI. Examples include assessing left ventricular function, predicting atrial fibrillation, and diagnosing both cardiac and noncardiac conditions. Through AI, the ECG becomes a comprehensive tool for screening, diagnosis, and patient management, potentially revolutionizing clinical practices. This paper provides an overview of the current state of this development, discusses existing limitations, and explores the challenges that may arise for healthcare professionals in this context.

人工智能(AI)在医疗保健领域的应用在过去 10 年中取得了重大进展。许多专家认为,人工智能技术,尤其是深度学习技术的应用,将为医生理解、诊断和治疗疾病的方式带来翻天覆地的变化。人工智能增强型心电图(ECG)分析就是这一发展的一个方面。这不仅涉及优化医生的传统心电图分析,提高心电图设备自动判读的准确性,还涉及引入由人工智能实现的全新诊断选项。例如,评估左心室功能、预测心房颤动以及诊断心脏和非心脏疾病。通过人工智能,心电图成为筛查、诊断和患者管理的综合工具,有可能彻底改变临床实践。本文概述了这一发展的现状,讨论了现有的局限性,并探讨了在此背景下医疗保健专业人员可能面临的挑战。
{"title":"[Artificial intelligence-enhanced electrocardiography : Will it revolutionize diagnosis and management of our patients?]","authors":"Wilhelm Haverkamp, Nils Strodthoff","doi":"10.1007/s00399-024-00997-0","DOIUrl":"10.1007/s00399-024-00997-0","url":null,"abstract":"<p><p>The use of artificial intelligence (AI) in healthcare has made significant progress in the last 10 years. Many experts believe that utilization of AI technologies, especially deep learning, will bring about drastic changes in how physicians understand, diagnose, and treat diseases. One aspect of this development is AI-enhanced electrocardiography (ECG) analysis. It involves not only optimizing the traditional ECG analysis by the physician and improving the accuracy of automatic interpretation by the ECG device but also introducing entirely new diagnostic options enabled by AI. Examples include assessing left ventricular function, predicting atrial fibrillation, and diagnosing both cardiac and noncardiac conditions. Through AI, the ECG becomes a comprehensive tool for screening, diagnosis, and patient management, potentially revolutionizing clinical practices. This paper provides an overview of the current state of this development, discusses existing limitations, and explores the challenges that may arise for healthcare professionals in this context.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Life-saving fall detection by a smartwatch in a case of ventricular fibrillation. 智能手表在心室颤动病例中的跌倒探测功能挽救了生命。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-05-13 DOI: 10.1007/s00399-024-01026-w
Steffen Grautoff, Michael Watol

New smart devices that have the potential to support the health and well-being of their owners have become available. In particular, smart watches are able to identify a fall by the person who is wearing the watch and report it to pre-defined contacts and the local emergency control center. Falls in older people are common and only rarely caused by malignant cardiac arrhythmia. The case of an elderly male whose smart watch automatically reported his fall due to ventricular fibrillation to the local emergency control center is described. Through the intervention of the wearer's device, the activated dispatcher called the patient's wife, who found her husband lying unresponsive on the floor. Emergency medical services responded immediately and were able to successfully resuscitate the patient. A hospital discharge without any long-term complications was achieved.

新的智能设备已经问世,它们有可能为佩戴者的健康和福祉提供支持。特别是,智能手表能够识别佩戴手表的人是否跌倒,并向预先设定的联系人和当地紧急控制中心报告。老年人摔倒很常见,但很少由恶性心律失常引起。本报告描述了一名老年男性因心室颤动而跌倒,智能手表自动向当地紧急控制中心报告的案例。通过佩戴者设备的干预,启动的调度员呼叫了病人的妻子,她发现丈夫躺在地板上毫无反应。紧急医疗服务人员立即做出反应,成功地对病人进行了抢救。病人顺利出院,没有出现任何长期并发症。
{"title":"Life-saving fall detection by a smartwatch in a case of ventricular fibrillation.","authors":"Steffen Grautoff, Michael Watol","doi":"10.1007/s00399-024-01026-w","DOIUrl":"10.1007/s00399-024-01026-w","url":null,"abstract":"<p><p>New smart devices that have the potential to support the health and well-being of their owners have become available. In particular, smart watches are able to identify a fall by the person who is wearing the watch and report it to pre-defined contacts and the local emergency control center. Falls in older people are common and only rarely caused by malignant cardiac arrhythmia. The case of an elderly male whose smart watch automatically reported his fall due to ventricular fibrillation to the local emergency control center is described. Through the intervention of the wearer's device, the activated dispatcher called the patient's wife, who found her husband lying unresponsive on the floor. Emergency medical services responded immediately and were able to successfully resuscitate the patient. A hospital discharge without any long-term complications was achieved.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A long-standing conundrum: an unusual case of 2:1 atrioventricular block with conflicting findings. 一个长期存在的难题:一个不寻常的 2:1 房室传导阻滞病例,却有相互矛盾的发现。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-05-22 DOI: 10.1007/s00399-024-01022-0
Hakan Gökalp Uzun, Selim Ekinci

A 2:1 atrioventricular (AV) block can occur anywhere within the conduction system, and noninvasive measurements may not always predict the exact site of the block. Although localization of the block is critical for deciding any treatment, patients should also be carefully questioned about symptoms both at rest and during exertion. A case of 2:1 AV block that was symptomatic only during exertion, appeared infranodal by noninvasive diagnostic methods, but was found to be intranodal on electrophysiological study is reported.

2:1 房室(AV)传导阻滞可发生在传导系统的任何部位,无创测量不一定能准确预测阻滞部位。虽然阻滞的定位对于决定任何治疗都至关重要,但也应仔细询问患者在休息和劳累时的症状。本文报告了一例 2:1 房室传导阻滞患者,该患者仅在用力时出现症状,非侵入性诊断方法显示其为结内阻滞,但在电生理研究中发现其为结内阻滞。
{"title":"A long-standing conundrum: an unusual case of 2:1 atrioventricular block with conflicting findings.","authors":"Hakan Gökalp Uzun, Selim Ekinci","doi":"10.1007/s00399-024-01022-0","DOIUrl":"10.1007/s00399-024-01022-0","url":null,"abstract":"<p><p>A 2:1 atrioventricular (AV) block can occur anywhere within the conduction system, and noninvasive measurements may not always predict the exact site of the block. Although localization of the block is critical for deciding any treatment, patients should also be carefully questioned about symptoms both at rest and during exertion. A case of 2:1 AV block that was symptomatic only during exertion, appeared infranodal by noninvasive diagnostic methods, but was found to be intranodal on electrophysiological study is reported.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitteilungen aus der Arbeitsgruppe Elektrophysiologie und Rhythmologie (AGEP). 电生理学和心律失常工作组(AGEP)的通讯。
Q4 Medicine Pub Date : 2024-06-01 DOI: 10.1007/s00399-024-01017-x
{"title":"Mitteilungen aus der Arbeitsgruppe Elektrophysiologie und Rhythmologie (AGEP).","authors":"","doi":"10.1007/s00399-024-01017-x","DOIUrl":"https://doi.org/10.1007/s00399-024-01017-x","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrogating a biventricular pacemaker: the importance of 12-lead electrocardiogram. 询问双心室起搏器:12 导联心电图的重要性。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-06-03 DOI: 10.1007/s00399-024-01021-1
Konstantinos Iliodromitis, Bernd Lemke, Sebastian Robl, Harilaos Bogossian
{"title":"Interrogating a biventricular pacemaker: the importance of 12-lead electrocardiogram.","authors":"Konstantinos Iliodromitis, Bernd Lemke, Sebastian Robl, Harilaos Bogossian","doi":"10.1007/s00399-024-01021-1","DOIUrl":"10.1007/s00399-024-01021-1","url":null,"abstract":"","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Digital competence in rhythmology : Training and education]. [节律学中的数字化能力:培训与教育]。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-01-18 DOI: 10.1007/s00399-024-00990-7
Mahdi Emrani, Matthias Daniel Zink

Background: The digital transformation in medicine, particularly in technology-orientated areas such as rhythmology, is leading to a rapid change in diagnostic and therapeutic options. Digital skills are helpful and need to keep up with this pace of change.

Research question: Which digital technologies and resources with rhythmological relevance play a role today and in the future?

Methods: Review of the various digital technologies for rhythm detection and monitoring, as well as current digital resources for training and education.

Results: Rhythm detection and monitoring can be optimized with smart devices and telemedicine, while digital platforms such as social media and virtual reality offer new perspectives in the training of rhythmology specialists.

Conclusion: Acquiring digital skills will be the basis for future work in rhythmology.

背景:医学领域的数字化转型,尤其是心律学等技术导向型领域的数字化转型,正在导致诊断和治疗方案的快速变化。研究问题:哪些与心律学相关的数字技术和资源将在未来发挥作用?研究问题:哪些与心律学相关的数字技术和资源在当今和未来发挥作用?方法:回顾用于心律检测和监测的各种数字技术,以及当前用于培训和教育的数字资源:结果:智能设备和远程医疗可以优化心律检测和监测,而社交媒体和虚拟现实等数字平台则为心律学专家的培训提供了新的视角:结论:掌握数字化技能将是未来心律学工作的基础。
{"title":"[Digital competence in rhythmology : Training and education].","authors":"Mahdi Emrani, Matthias Daniel Zink","doi":"10.1007/s00399-024-00990-7","DOIUrl":"10.1007/s00399-024-00990-7","url":null,"abstract":"<p><strong>Background: </strong>The digital transformation in medicine, particularly in technology-orientated areas such as rhythmology, is leading to a rapid change in diagnostic and therapeutic options. Digital skills are helpful and need to keep up with this pace of change.</p><p><strong>Research question: </strong>Which digital technologies and resources with rhythmological relevance play a role today and in the future?</p><p><strong>Methods: </strong>Review of the various digital technologies for rhythm detection and monitoring, as well as current digital resources for training and education.</p><p><strong>Results: </strong>Rhythm detection and monitoring can be optimized with smart devices and telemedicine, while digital platforms such as social media and virtual reality offer new perspectives in the training of rhythmology specialists.</p><p><strong>Conclusion: </strong>Acquiring digital skills will be the basis for future work in rhythmology.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lead placement in cardiac implantable electronic devices]. [心脏植入式电子设备的引线置放]。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-05-15 DOI: 10.1007/s00399-024-01019-9
Jonas Wörmann, David Duncker, Till Althoff, Christian Heeger, Roland Tilz, Heidi Estner, Andreas Rillig, Philipp Sommer, Leon Iden, Victoria Johnson, K R Julian Chun, Henning Jansen, Tilman Maurer, Sonia Busch, Daniel Steven

The implantation of electrodes for cardiac implantable electronic devices (CIED) requires profound technical understanding and precise execution. The positioning of electrodes in the right ventricle and atrium has significant implications for patient safety and the effectiveness of CIED therapy. Particular focus is given to the distinction between apical and septal stimulation in ventricular positioning. Based on current data, this article provides a practice-oriented guide that leads implanters through the individual steps of electrode positioning. The implantation of electrodes for physiological stimulation (cardiac resynchronization therapy, CRT, and conduction system pacing, CSP) is not addressed in this article.

为心脏植入式电子设备(CIED)植入电极需要深刻的技术理解和精确的操作。电极在右心室和心房的定位对患者的安全和 CIED 治疗的有效性具有重要影响。本文特别关注心室定位中心尖和室间隔刺激的区别。本文以当前数据为基础,提供了一份以实践为导向的指南,引导植入者完成电极定位的各个步骤。本文不涉及生理刺激(心脏再同步化治疗、CRT 和传导系统起搏)电极的植入。
{"title":"[Lead placement in cardiac implantable electronic devices].","authors":"Jonas Wörmann, David Duncker, Till Althoff, Christian Heeger, Roland Tilz, Heidi Estner, Andreas Rillig, Philipp Sommer, Leon Iden, Victoria Johnson, K R Julian Chun, Henning Jansen, Tilman Maurer, Sonia Busch, Daniel Steven","doi":"10.1007/s00399-024-01019-9","DOIUrl":"10.1007/s00399-024-01019-9","url":null,"abstract":"<p><p>The implantation of electrodes for cardiac implantable electronic devices (CIED) requires profound technical understanding and precise execution. The positioning of electrodes in the right ventricle and atrium has significant implications for patient safety and the effectiveness of CIED therapy. Particular focus is given to the distinction between apical and septal stimulation in ventricular positioning. Based on current data, this article provides a practice-oriented guide that leads implanters through the individual steps of electrode positioning. The implantation of electrodes for physiological stimulation (cardiac resynchronization therapy, CRT, and conduction system pacing, CSP) is not addressed in this article.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful catheter ablation of atrial tachycardia initiated with orthodromic capture of superior vena cava potentials. 成功导管消融以正交捕获上腔静脉电位引发的房性心动过速。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-05-10 DOI: 10.1007/s00399-024-01023-z
Kohei Ukita, Yasuyuki Egami, Yasuharu Matsunaga-Lee, Masamichi Yano, Masami Nishino

A case of successful catheter ablation of paroxysmal atrial fibrillation and atrial tachycardia is reported. After pulmonary vein isolation, atrial tachycardia was induced by the use of isoproterenol and burst pacing from the catheter in the right atrium. An attempt was made to create a three-dimensional (3D) map of the atrial tachycardia, but the atrial tachycardia was terminated in the middle of the mapping. The 3D map was insufficient but indicated that the superior vena cava was involved in the circuit. When the intracardiac electrograms were reviewed, it was found that the atrial tachycardia was initiated with orthodromic capture of superior vena cava potentials and it was considered that the atrial tachycardia involved the superior vena cava-right atrium junction. Accordingly, superior vena cava isolation was performed. After that, atrial fibrillation and atrial tachycardias were not induced by the use of isoproterenol and burst pacing. In this case, an intracardiac electrogram at the time of induction of the tachycardia was helpful for understanding the circuit of the tachycardia.

报告了一例成功导管消融阵发性心房颤动和房性心动过速的病例。肺静脉隔离后,使用异丙肾上腺素诱发房性心动过速,并从右心房的导管进行脉冲起搏。尝试绘制房性心动过速的三维(3D)图,但房性心动过速在绘制过程中终止。三维图不够充分,但显示上腔静脉参与了回路。复查心内电图时发现,房性心动过速是在上腔静脉电位的正向捕获下开始的,因此认为房性心动过速涉及上腔静脉-右心房交界处。因此,进行了上腔静脉隔离。此后,使用异丙肾上腺素和脉冲起搏均未诱发心房颤动和房性心动过速。在该病例中,诱发心动过速时的心内电图有助于了解心动过速的回路。
{"title":"Successful catheter ablation of atrial tachycardia initiated with orthodromic capture of superior vena cava potentials.","authors":"Kohei Ukita, Yasuyuki Egami, Yasuharu Matsunaga-Lee, Masamichi Yano, Masami Nishino","doi":"10.1007/s00399-024-01023-z","DOIUrl":"10.1007/s00399-024-01023-z","url":null,"abstract":"<p><p>A case of successful catheter ablation of paroxysmal atrial fibrillation and atrial tachycardia is reported. After pulmonary vein isolation, atrial tachycardia was induced by the use of isoproterenol and burst pacing from the catheter in the right atrium. An attempt was made to create a three-dimensional (3D) map of the atrial tachycardia, but the atrial tachycardia was terminated in the middle of the mapping. The 3D map was insufficient but indicated that the superior vena cava was involved in the circuit. When the intracardiac electrograms were reviewed, it was found that the atrial tachycardia was initiated with orthodromic capture of superior vena cava potentials and it was considered that the atrial tachycardia involved the superior vena cava-right atrium junction. Accordingly, superior vena cava isolation was performed. After that, atrial fibrillation and atrial tachycardias were not induced by the use of isoproterenol and burst pacing. In this case, an intracardiac electrogram at the time of induction of the tachycardia was helpful for understanding the circuit of the tachycardia.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital twins for cardiac electrophysiology: state of the art and future challenges. 心脏电生理学数字双胞胎:技术现状与未来挑战。
Q4 Medicine Pub Date : 2024-06-01 Epub Date: 2024-04-12 DOI: 10.1007/s00399-024-01014-0
Matthijs J M Cluitmans, Gernot Plank, Jordi Heijman

Cardiac arrhythmias remain a major cause of death and disability. Current antiarrhythmic therapies are effective to only a limited extent, likely in large part due to their mechanism-independent approach. Precision cardiology aims to deliver targeted therapy for an individual patient to maximize efficacy and minimize adverse effects. In-silico digital twins have emerged as a promising strategy to realize the vision of precision cardiology. While there is no uniform definition of a digital twin, it typically employs digital tools, including simulations of mechanistic computer models, based on patient-specific clinical data to understand arrhythmia mechanisms and/or make clinically relevant predictions. Digital twins have become part of routine clinical practice in the setting of interventional cardiology, where commercially available services use digital twins to non-invasively determine the severity of stenosis (computed tomography-based fractional flow reserve). Although routine clinical application has not been achieved for cardiac arrhythmia management, significant progress towards digital twins for cardiac electrophysiology has been made in recent years. At the same time, significant technical and clinical challenges remain. This article provides a short overview of the history of digital twins for cardiac electrophysiology, including recent applications for the prediction of sudden cardiac death risk and the tailoring of rhythm control in atrial fibrillation. The authors highlight the current challenges for routine clinical application and discuss how overcoming these challenges may allow digital twins to enable a significant precision medicine-based advancement in cardiac arrhythmia management.

心律失常仍然是导致死亡和残疾的主要原因。目前的抗心律失常疗法效果有限,这在很大程度上可能是由于其治疗方法与机制无关。精准心脏病学旨在为个体患者提供有针对性的治疗,以最大限度地提高疗效并减少不良反应。为实现精准心脏病学的愿景,硅内数字双胞胎已成为一种前景广阔的策略。虽然数字孪生没有统一的定义,但它通常采用数字工具,包括基于患者特定临床数据的机理计算机模型模拟,以了解心律失常机制和/或进行临床相关预测。在介入心脏病学领域,数字孪生已成为常规临床实践的一部分,商业化服务使用数字孪生来无创确定血管狭窄的严重程度(基于计算机断层扫描的分数血流储备)。虽然在心律失常管理方面尚未实现常规临床应用,但近年来,数字双胞胎在心脏电生理学方面取得了重大进展。与此同时,在技术和临床方面仍然存在重大挑战。本文简要概述了用于心脏电生理学的数字双胞胎的历史,包括最近在预测心脏性猝死风险和调整心房颤动节律控制方面的应用。作者强调了目前常规临床应用所面临的挑战,并讨论了如何克服这些挑战才能让数字孪生在心律失常管理方面取得基于精准医疗的重大进展。
{"title":"Digital twins for cardiac electrophysiology: state of the art and future challenges.","authors":"Matthijs J M Cluitmans, Gernot Plank, Jordi Heijman","doi":"10.1007/s00399-024-01014-0","DOIUrl":"10.1007/s00399-024-01014-0","url":null,"abstract":"<p><p>Cardiac arrhythmias remain a major cause of death and disability. Current antiarrhythmic therapies are effective to only a limited extent, likely in large part due to their mechanism-independent approach. Precision cardiology aims to deliver targeted therapy for an individual patient to maximize efficacy and minimize adverse effects. In-silico digital twins have emerged as a promising strategy to realize the vision of precision cardiology. While there is no uniform definition of a digital twin, it typically employs digital tools, including simulations of mechanistic computer models, based on patient-specific clinical data to understand arrhythmia mechanisms and/or make clinically relevant predictions. Digital twins have become part of routine clinical practice in the setting of interventional cardiology, where commercially available services use digital twins to non-invasively determine the severity of stenosis (computed tomography-based fractional flow reserve). Although routine clinical application has not been achieved for cardiac arrhythmia management, significant progress towards digital twins for cardiac electrophysiology has been made in recent years. At the same time, significant technical and clinical challenges remain. This article provides a short overview of the history of digital twins for cardiac electrophysiology, including recent applications for the prediction of sudden cardiac death risk and the tailoring of rhythm control in atrial fibrillation. The authors highlight the current challenges for routine clinical application and discuss how overcoming these challenges may allow digital twins to enable a significant precision medicine-based advancement in cardiac arrhythmia management.</p>","PeriodicalId":52403,"journal":{"name":"Herzschrittmachertherapie und Elektrophysiologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Herzschrittmachertherapie und Elektrophysiologie
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1