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Sclerosing angiomatoid nodular transformation of spleen: a rare case report. 脾脏硬化性血管瘤样结节变性1例。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025543
M Cernat, L Antoci, I Chemencedji, A Suman, I Mishin

Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a relatively rare non-neoplastic proliferative mass of vascular origin arising from the red pulp of the spleen accounting for less than 1% of all splenic tumors. Accurate preoperative diagnosis is difficult due to the rarity of the pathology and lack of specific clinical and radiologic features, and final diagnosis of SANT is based on histopathologic and immunohistochemical studies. A 34-year-old male patient who presented with an incidentally found tumor of the spleen discovered on a routine CT examination. The patient underwent classic splenectomy. Pathological examination with immunohistochemical staining confirmed SANT of the spleen. SANT should be included in the differential diagnosis of focal pathology of the spleen due to the rarity of this disease and should be treated by further open or laparoscopic splenectomy with pathologic examination including mandatory immunohistochemical staining.

脾脏硬化性血管瘤样结节转化(SANT)是一种相对罕见的非肿瘤性增生性肿瘤,起源于脾脏红髓,占所有脾脏肿瘤的不到1%。由于病理罕见,缺乏具体的临床和影像学特征,术前难以准确诊断,最终诊断SANT是基于组织病理学和免疫组织化学研究。一位34岁男性患者,在常规CT检查中发现偶然发现的脾脏肿瘤。患者行经典脾切除术。病理检查免疫组化染色证实脾脏SANT。SANT由于罕见,应纳入脾脏局灶性病理的鉴别诊断,并应通过进一步的开放或腹腔镜脾切除术治疗,病理检查包括强制性免疫组织化学染色。
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引用次数: 0
Robotic vs. uniportal lobectomy: a prospective analysis of postoperative pain, analgesic requirements, and individual risk factors. 机器人与单门肺叶切除术:术后疼痛、镇痛需求和个体危险因素的前瞻性分析。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025533
L Tulinský, N Jarošová, D Adamica, P Bujok, M Mitták, L Martínek

Introduction: Lung carcinoma represents a malignancy with the highest global mortality rate. Surgical treatment remains the cornerstone of curative therapy, with minimally invasive techniques currently dominating the field. This study aimed to compare post-operative pain in patients undergoing lobectomy for lung cancer via uniportal video-assisted thoracoscopic surgery (UVATS) vs. robotic-assisted thoracic surgery (RATS).

Methods: This prospective study included 140 patients (70 RATS, 70 UVATS) undergoing lobectomy with mediastinal lymphadenectomy. Patients assessed their pain using the Short-Form McGill Pain Questionnaire and visual analogue scale (VAS) on the 3rd and 14th postoperative days. We also analyzed the influence of age, gender, and BMI on pain perception and analgesic requirements.

Results: Patients following RATS exhibited significantly higher pain intensity compared to UVATS on both the 3rd (VAS 5.8 ± 2.0 vs. 3.8 ± 1.6; P < 0.00001) and 14th postoperative days (VAS 2.7 ± 1.1 vs. 2.2 ± 1.1; P = 0.00133). Combined analgesic therapy was more frequently required in the RATS group. Female patients demonstrated markedly higher pain intensity and analgesic requirements in both surgical approaches. Age and BMI had no significant impact on pain perception.

Conclusion: Robotic-assisted surgery is associated with higher postoperative pain compared to uniportal video-assisted thoracoscopy, with differences being more pronounced in female patients. We recommend implementing targeted analgesic strategies for robotic procedures and considering the use of 8-mm ports instead of standard 12-mm ports to reduce chest wall trauma.

简介:肺癌是全球死亡率最高的恶性肿瘤。手术治疗仍然是治愈性治疗的基石,微创技术目前在该领域占主导地位。本研究旨在比较通过单门视频辅助胸腔镜手术(UVATS)和机器人辅助胸腔镜手术(RATS)进行肺癌肺叶切除术患者的术后疼痛。方法:本前瞻性研究纳入140例(大鼠70例,UVATS 70例)行肺叶切除术合并纵隔淋巴结切除术。患者在术后第3天和第14天使用短格式McGill疼痛问卷和视觉模拟量表(VAS)评估疼痛。我们还分析了年龄、性别和BMI对疼痛感知和镇痛需求的影响。结果:大鼠术后第3天(VAS 5.8±2.0比3.8±1.6;P < 0.00001)和第14天(VAS 2.7±1.1比2.2±1.1;P = 0.00133)疼痛强度明显高于UVATS。大鼠组更需要联合镇痛治疗。在两种手术入路中,女性患者表现出明显更高的疼痛强度和镇痛需求。年龄和BMI对疼痛感知无显著影响。结论:与单门视频胸腔镜手术相比,机器人辅助手术术后疼痛更高,在女性患者中差异更明显。我们建议在机器人手术中实施有针对性的镇痛策略,并考虑使用8mm端口而不是标准的12mm端口来减少胸壁创伤。
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引用次数: 0
Surprising finding of desmoid in a young man by an urologist. 泌尿科医生在一名年轻男子身上发现了令人惊讶的硬纤维瘤。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch202561
J Marešová, J Kočárek-, M Čermák, L Plincelnerová

We present a case report of a 26-year-old patient with an incidental finding of intra-abdominal fibromatosis (desmoid) in the small pelvis who presented to the urology outpatient clinic for erectile dysfunction. Ultrasound examination revealed hydronephrosis of the right kidney with parenchymal reduction, and a bulky tumor was detected in the small pelvis, which was compressing the right-sided ureter. The patient was followed up with a CT scan which confirmed a solid tumour in the small pelvis of unclear origin, the nature of the tumour and the treatment were discussed by the multidisciplinary team and a decision was made to resect the tumour. Pathologist confirmed sporadic variant of desmoid. Desmoid tumors are characterized by both locally aggressive carcinomas mimicking growth and frequent recurrences after resection, which may require subsequent oncological treatment. For these reasons, patients with desmoids should be fol-lowed up by an oncologist, ideally at centers experienced in treating this rare disease.

我们提出一个26岁的病例报告,病人偶然发现腹腔内纤维瘤病(硬纤维瘤)在小骨盆谁提出了泌尿科门诊勃起功能障碍。超声检查显示右肾肾水肿,实质减少,小骨盆内发现一大块肿瘤,压迫右侧输尿管。患者进行了CT扫描,证实小骨盆内有一个来源不明的实体瘤,多学科小组讨论了肿瘤的性质和治疗方法,并决定切除肿瘤。病理证实为散发性硬纤维瘤。硬纤维瘤的特点是局部侵袭性癌模拟生长和切除后经常复发,这可能需要后续的肿瘤治疗。由于这些原因,硬纤维瘤患者应该由肿瘤学家随访,最好是在治疗这种罕见疾病经验丰富的中心。
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引用次数: 0
Acute examination to rule out cervical spine injuries in adults. 急性检查排除成人颈椎损伤。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025295
J Konečný, M Reška, J Habr, R Hasara, L Veverková

This paper provides a brief overview of current information and recommendations regard-ing acute imaging of adult patients to rule out cervical spine injuries. It summarizes the possibilities of plain X-ray examination of the cervical spine, which is technically demand-ing and has low diagnostic yield. Therefore, it is no longer recommended. Exceptions are locations where CT is not available and patients for whom exposure to medium or high doses of ionizing radiation is contraindicated. Routinely performed CT examinations of the cervical spine to rule out injury have a significant medical and financial impact. For this reason, internationally recognized criteria sets NEXUS (National Emergency X-Radiography Utilization Study) and CCR (Canadian C-spine Rule) have been introduced. These include information from the patient's history and clinical examination and are used to indicate the need for cervical spine CT to exclude trauma. Both systems are described and compared. According to some recommendations and in the opinion of the authors, combining the two systems could further improve their effectiveness.

本文提供了一个简要的概述,目前的信息和建议,关于急性影像学成人患者排除颈椎损伤。本文总结了颈椎x线平片检查的可能性,这种检查技术要求高,诊断率低。因此,不再推荐使用。例外情况是不能使用CT的地方,以及暴露于中剂量或高剂量电离辐射的患者是禁忌。对颈椎进行常规CT检查以排除损伤具有重大的医疗和经济影响。因此,引入了国际公认的标准集NEXUS(国家紧急x射线摄影利用研究)和CCR(加拿大颈椎规则)。这些信息包括来自患者病史和临床检查的信息,并用于指示是否需要进行颈椎CT检查以排除创伤。对两种系统进行了描述和比较。根据一些建议和作者的观点,将两个系统结合起来可以进一步提高其有效性。
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引用次数: 0
SSIs - analysis of self-report data and economic impact. ssi -自我报告数据和经济影响的分析。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025289
L Veverková, P Doležal, J Habr, M Reška, P Vlček, J Konečný, I Čapov, J Žák, I Penka

Background: Surgical site infections (SSIs) are a major health and economic problem. Increased morbidity, prolonged hospital stay and the need for additional treatments increase the financial costs of healthcare institutions. The aim of this article is to analyze the incidence of SSIs, their impact on hospital length of stay and economic burden under Czech conditions.

Methods: We analyzed hospitalizations in the period from 1st January 2021 to 31st December 2024 that were classified as SSI according to the CZ-DRG. A total of 2,134 hospitalizations were included, of which 212 (9.93%) were complicated by SSI. We recorded the length of hospital stay, number of reoperations and their duration.

Results: SSI hospitalizations accounted for 9.93% of all cases but 25.3% of hospital days. The economic impact of SSIs was expressed as a case-mix of 24.07%. SSI cases required 19.66% of all operations and 16.43% of total operating time.

Conclusion: It is evident from the findings of this study that SSIs are not only a medical problem, but also an economic one. The economic analysis conducted in this study demonstrates that, even with higher reimbursement for SSI cases, this reimbursement does not cover the additional costs associated with prolonged hospitalization and the necessity for reoperations.

背景:手术部位感染(ssi)是一个主要的健康和经济问题。发病率增加、住院时间延长以及需要额外治疗增加了医疗机构的财务成本。本文的目的是分析在捷克条件下ssi的发生率,其对住院时间和经济负担的影响。方法:分析2021年1月1日至2024年12月31日期间根据CZ-DRG分类为SSI的住院情况。共纳入住院2134例,其中212例(9.93%)合并SSI。记录住院时间、再手术次数及持续时间。结果:SSI住院占全部病例的9.93%,占住院天数的25.3%。ssi的经济影响表示为24.07%的病例组合。SSI病例需要19.66%的手术和16.43%的总手术时间。结论:从本研究结果可以明显看出,ssi不仅是一个医学问题,也是一个经济问题。本研究进行的经济分析表明,即使对SSI病例有更高的报销,这种报销也不包括与长期住院和必须再次手术有关的额外费用。
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引用次数: 0
Surgical therapy of congenital stomach diverticulum. 先天性胃憩室的外科治疗。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025549
J Pažin, Š O Schütz, P Kolek, Radek Pohnán

Introduction: Gastric diverticulum is a very rare condition and, in most cases, asymptomatic. Its diagnosis is challenging for diagnostic departments. Symptomatology of the larger gastric diverticula can imitate other illnesses for some time. Initially we can treat it like abdominal pain, gallbladder or kidney colic, back pain, or gastroesophageal, or duodenogastric reflux disease. Common use diagnostic examinations like X-ray of the abdomen or thorax, or ultrasound of the abdominal cavity often cannot find the origin of the problems. It is the least common gastrointestinal diverticulum, therefore its presence can be lost from the minds of the examination specialists. In case of successful diagnosis of the gastric diverticulum the next therapy is led due to clinical state of the patient and according to symptomatology. Almost all gastric diverticula are set for conservative therapy. We can decide for surgery when complications such as bleed-ing or signs of the perforation occur and according to some problems, which can limit the patient in common life (such as pain, dysphagia, odynophagia or reflux disease).

Case report: Authors present a case of a 64-years-old patient, which was examined for abdominal pain in the epigastrium with night episodes of gastroesophageal reflux and cough for 2 years. Contrast examination of the upper gastrointestinal tract was performed in the past, but did not reveal any pathology. Therefore, a recent gastrofi-broscopic examination of the stomach followed. The results were unclear and showed the possibility of the presence of hiatal hernia or stomach diverticulum untill computer tomography scans gave clear diagnosis of stomach diverticulum. It was located in the fundus area in the rear stomach wall and it was in intimate contact with the spleen and left adrenal gland. Because of patient's symptoms, robotic resection of the diverticulum was indicated after consultation.

Conclusion: Stomach diverticulum is a very rare anatomic abnormality in general. Surgical treatment is indicated in the low range of all stomach diverticula. Literature reviews show mostly single case reports or small groups of patients with stomach diverticula. There is no recommendation for treating management. Surgical approach should be individual and based on symptoms and complications connected to diverticulum presence.

胃憩室是一种非常罕见的疾病,在大多数情况下,无症状。其诊断对诊断部门具有挑战性。胃大憩室的症状在一段时间内可模仿其他疾病。最初我们可以把它当作腹痛、胆囊或肾绞痛、背痛、胃食管病或十二指肠胃反流病来治疗。常用的诊断检查,如腹部或胸部x光片或腹腔超声检查,往往找不到问题的根源。它是最不常见的胃肠道憩室,因此它的存在可以从检查专家的头脑中消失。在成功诊断胃憩室的情况下,根据患者的临床状态和症状进行下一步治疗。几乎所有胃憩室均采用保守治疗。当出现出血或穿孔迹象等并发症时,根据一些限制患者日常生活的问题(如疼痛、吞咽困难、吞咽困难或反流性疾病),我们可以决定是否进行手术。病例报告:作者报告了一例64岁的患者,因上腹部腹痛并伴有夜间胃食管反流和咳嗽2年而接受检查。上胃肠道造影检查过去曾进行过,但未发现任何病理。因此,最近对胃进行了胃镜检查。结果不明确,显示可能存在裂孔疝或胃憩室,直到计算机断层扫描明确诊断胃憩室。位于胃后壁底区,与脾、左肾上腺密切接触。由于患者的症状,咨询后建议采用机器人切除憩室。结论:胃憩室是一种非常罕见的解剖异常。手术治疗适用于所有胃憩室的低范围。文献综述显示胃憩室多为单例报告或小群体患者。没有治疗管理的建议。手术方法应该是个体化的,并基于与憩室存在相关的症状和并发症。
{"title":"Surgical therapy of congenital stomach diverticulum.","authors":"J Pažin, Š O Schütz, P Kolek, Radek Pohnán","doi":"10.48095/ccrvch2025549","DOIUrl":"10.48095/ccrvch2025549","url":null,"abstract":"<p><strong>Introduction: </strong>Gastric diverticulum is a very rare condition and, in most cases, asymptomatic. Its diagnosis is challenging for diagnostic departments. Symptomatology of the larger gastric diverticula can imitate other illnesses for some time. Initially we can treat it like abdominal pain, gallbladder or kidney colic, back pain, or gastroesophageal, or duodenogastric reflux disease. Common use diagnostic examinations like X-ray of the abdomen or thorax, or ultrasound of the abdominal cavity often cannot find the origin of the problems. It is the least common gastrointestinal diverticulum, therefore its presence can be lost from the minds of the examination specialists. In case of successful diagnosis of the gastric diverticulum the next therapy is led due to clinical state of the patient and according to symptomatology. Almost all gastric diverticula are set for conservative therapy. We can decide for surgery when complications such as bleed-ing or signs of the perforation occur and according to some problems, which can limit the patient in common life (such as pain, dysphagia, odynophagia or reflux disease).</p><p><strong>Case report: </strong>Authors present a case of a 64-years-old patient, which was examined for abdominal pain in the epigastrium with night episodes of gastroesophageal reflux and cough for 2 years. Contrast examination of the upper gastrointestinal tract was performed in the past, but did not reveal any pathology. Therefore, a recent gastrofi-broscopic examination of the stomach followed. The results were unclear and showed the possibility of the presence of hiatal hernia or stomach diverticulum untill computer tomography scans gave clear diagnosis of stomach diverticulum. It was located in the fundus area in the rear stomach wall and it was in intimate contact with the spleen and left adrenal gland. Because of patient's symptoms, robotic resection of the diverticulum was indicated after consultation.</p><p><strong>Conclusion: </strong>Stomach diverticulum is a very rare anatomic abnormality in general. Surgical treatment is indicated in the low range of all stomach diverticula. Literature reviews show mostly single case reports or small groups of patients with stomach diverticula. There is no recommendation for treating management. Surgical approach should be individual and based on symptoms and complications connected to diverticulum presence.</p>","PeriodicalId":52413,"journal":{"name":"Rozhledy v Chirurgii","volume":"104 12","pages":"549-554"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteroatmospheric fistula - literature review and current recommendations. 肠-大气瘘-文献回顾和目前的建议。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025191
J Šturma, Z Šubrt, J Gojda, M Laboš

Enteroatmospheric fistula (EAF) is one of the most severe and life-threatening surgical complications, significantly increasing the cost of patient treatment. It is classified as a postoperative complication, collectively referred to as abdominal catastrophes. EAF is a specific type of intestinal fistula that occurs when the intestinal lumen opens into an unhealed defect in the abdominal wall, leading to continuous wound contamination that complicates healing. Treatment of this complication is challenging, prolonged, and requires a multidisciplinary approach in three distinct phases. In the first phase, the goal is aggressive therapy of abdominal sepsis and management of its source. -After stabilizing the patient, the second, chronic phase focuses on care for the defect and reversing the nutritional status from catabolism to anabolism. Following the maturation of adhesions in the abdominal cavity, healing of the wound around the EAF, and adequate nutritional preparation, the patient undergoes the reconstructive phase, which involves restoring the continuity of the digestive tract and reconstructing the abdominal wall. Throughout all phases, the patient is at risk for numerous secondary complications related to malnutrition and prolonged hospitalization. Therefore, preventing the development of EAF is of paramount importance. The aim of this paper is to summarize current recommendations for the treatment of EAF and discuss some of the modern approaches to managing this condition.

肠大气瘘(EAF)是最严重和危及生命的外科并发症之一,显著增加了患者的治疗成本。它被归类为术后并发症,统称为腹部灾难。EAF是一种特殊类型的肠瘘,发生在肠管打开进入腹壁未愈合的缺陷时,导致伤口持续污染,使愈合复杂化。治疗这种并发症是具有挑战性的,长期的,需要在三个不同的阶段多学科的方法。在第一阶段,目标是积极治疗腹部败血症并控制其来源。-稳定病人后,第二个慢性阶段侧重于对缺陷的护理,并将营养状态从分解代谢逆转到合成代谢。随着腹腔粘连的成熟,EAF周围伤口的愈合,以及足够的营养准备,患者进入重建阶段,包括恢复消化道的连续性和重建腹壁。在所有阶段,患者都面临着与营养不良和长期住院有关的许多继发性并发症的风险。因此,预防EAF的发展至关重要。本文的目的是总结目前对EAF治疗的建议,并讨论一些现代方法来管理这种情况。
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引用次数: 0
View of current vascular surgery on asymptomatic carotid stenosis. 无症状颈动脉狭窄的血管外科治疗现状。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch2025252
R Vlachovský, T Novotný, R Staffa

In recent years, the significant progress in the outcomes of conservative treatment for patients with asymptomatic carotid stenosis has sparked discussions about the most effective invasive treatment. The necessity of such treatment is still being debated in certain cases. Several studies have already been conducted to find the most appropriate approach for asymptomatic patients with carotid stenosis, while others are still randomizing and awaiting results. A major unanswered question is whether revascularization is more beneficial than intensive conservative treatment, particularly in view of the lower stroke rates achieved in recent years without conventional or endovascular intervention. The long-term goal should be to identify a subset of patients who would benefit from conservative treatment. In this text, we summarize the issue in the context of the results of two recently completed pivotal studies.

近年来,无症状颈动脉狭窄患者保守治疗结果的显著进展引发了关于最有效的侵入性治疗的讨论。在某些情况下,这种治疗的必要性仍在辩论中。已经进行了几项研究,为无症状颈动脉狭窄患者寻找最合适的方法,而其他研究仍在随机化,等待结果。一个悬而未决的主要问题是血运重建术是否比强化保守治疗更有益,特别是考虑到近年来在没有常规或血管内干预的情况下卒中发生率较低。长期目标应该是确定能从保守治疗中获益的患者亚群。在本文中,我们总结了两个最近完成的关键研究结果的背景下的问题。
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引用次数: 0
Robotic pancreaticoduodenectomy with a portal vein resection. 机器人胰十二指肠切除术联合门静脉切除术。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch202530
M Rousek, P Záruba, K Pončáková, R Pohnán

Introduction: Robotic pancreaticoduodenectomy ranks among the routinely performed surgical procedures in world pancreatic centres. Since 2023, it has also been performed in the Czech Republic.

Case report: We present a case of a 65-year-old patient with accidentally found dilatation of the pancreatic duct. During the examination, a small tumor in the head of the pancreas was diagnosed. A robotic pancreaticoduodenectomy was performed. Due to the perioperative suspicion of invasion into the portal vein, the resection was performed. The operation and the course of hospitalization were uncomplicated, the patient was discharged on the 9th postoperative day.

Conclusion: Robotic pancreaticoduodenectomy is a method that combines the advantages of a minimally invasive approach and meets the requirements for safety and oncological radicality. Suspected venous invasion is not an obstacle to completing robotic surgery.

机器人胰十二指肠切除术是世界胰腺中心的常规外科手术之一。自2023年以来,它也在捷克共和国演出。病例报告:我们报告一例65岁的患者意外发现胰管扩张。在检查过程中,诊断出胰腺头部有一个小肿瘤。进行了机器人胰十二指肠切除术。因围手术期怀疑侵入门静脉,行手术切除。手术及住院过程无并发症,患者于术后第9天出院。结论:机器人胰十二指肠切除术是一种结合微创手术优点,同时满足安全性和肿瘤根治性要求的手术方法。疑似静脉侵入不是完成机器人手术的障碍。
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引用次数: 0
Colon cancer - neoadjuvant treatment of non-metastatic disease. 结肠癌-非转移性疾病的新辅助治疗。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccrvch202597
J Tomášek, L Fiala

Neoadjuvant treatment for colon cancer, unlike rectal cancer, is rarely used. Its position in the treatment algorithm is not precisely defined. This treatment should be considered for locally significantly advanced tumors (cT4) with extensive nodal involvement. The neoadjuvant treatment plan should be determined in a multidisciplinary team setting. We describe the main clinical trials focused on neoadjuvant chemotherapy in colon cancer. A special subgroup is dMMR/MSI-high tumors, patients with such cancers are candidates for immunotherapy treatment. Immunotherapy can induce complete remission, but can also be accompanied by long-term or permanent toxicity of the treat-ment. Neoadjuvant immunotherapy of non-metastatic colon cancer is the subject of a number of clinical trials. Currently, no immunotherapy is registered in the EU for the neoadjuvant treatment of early colon cancer.

与直肠癌不同,结肠癌很少采用新辅助治疗。它在治疗算法中的位置没有精确定义。对于有广泛淋巴结累及的局部晚期肿瘤(cT4),应考虑采用这种治疗方法。新辅助治疗方案应在多学科团队中确定。我们描述了结肠癌新辅助化疗的主要临床试验。一个特殊的亚组是dMMR/ msi高的肿瘤,这类癌症的患者是免疫治疗的候选者。免疫疗法可以诱导完全缓解,但也可能伴随着长期或永久的治疗毒性。非转移性结肠癌的新辅助免疫治疗是许多临床试验的主题。目前,没有免疫疗法在欧盟注册用于早期结肠癌的新辅助治疗。
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引用次数: 0
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Rozhledy v Chirurgii
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