In this study, the most recent American Time Use Surveys containing reported activity-based emotions and sensations information before (10,378 respondents in 2013) and during (6,902 respondents in 2021) the COVID-19 pandemic are used to assess if time use related individuals’ subjective wellbeing (SWB) decreased in the pandemic. Given that the coronavirus has been shown to strongly influence activity decisions and social interactions, sequence analysis is applied to find daily time allocation patterns and changes in daily time allocation. Then, those derived daily patterns and other activity-travel factors, as well as social and demographic, temporal, spatial, and other contextual characteristics are added as explanatory variables in regression models of SWB measures. This provides a holistic framework of exploring the direct and indirect effects (via activity-travel schedules) of the recent pandemic on SWB while controlling for contexts such as the life assessments, daily schedule of activities, and living environment. The results show that respondents in the COVID year reported a new time allocation pattern that has a substantial amount of time at home, and they experienced more negative emotions. Three relatively happier daily patterns in 2021 contained substantial amounts of outdoor and indoor activities. In addition, no significant correlation was observed between metropolitan areas and individuals’ SWB in 2021. However, comparisons among states show Texas and Florida residents experienced more positive wellbeing presumably due to fewer COVID-related restrictions.