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Time to Include Emotional Intelligence in Medical Curriculum 将情商纳入医学课程的时机
Pub Date : 2022-06-29 DOI: 10.3126/jonmc.v11i1.45716
Reetu Sharma Baral
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不适用
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引用次数: 0
A Study of Serum Uric Acid Level in Patients with Psoriasis at a Tertiary Care Hospital in Eastern Nepal 尼泊尔东部三级医院银屑病患者血清尿酸水平的研究
Pub Date : 2022-06-29 DOI: 10.3126/jonmc.v11i1.45719
M. Pradhan, A. Rai, S. Karki, Rajiv Ratan Singh Yadav, Sanjeev Mani Yadav
Background: Meta-analysis has shown that psoriasis is associated with hyperuricemia and its sequel.  So this study was done with objective to find out the association of serum uric acid level in patient with psoriasis and its correlation with severity of the disease. Materials and Methods: It was a prospective case control study conducted in the department of Dermatology, Nobel Medical College Teaching Hospital in eastern region of Nepal over a period of one year from Jan 2020 to Dec 2022 after approval of Intuitional review committee on Nobel Medical College Teaching Hospital. The diagnosis of the disease for the cases were done by clinical examination and biopsy when needed. 50 cases and 50 control sample were taken for the study. Psoriasis Area Severity Index was calculated for the cases and serum uric level was measured for both cases and control. Results: The mean serum uric level in psoriatic patients was 6.16 ± 1.64mg/dl with range of 4 to 11 mg/dl and that of control group was 5.39 ± 1.60 mg/dl with the range of 2 to 9mg/dl.  Mean serum uric acid level in psoriatic group was significantly higher than in control group with p value of 0.002 and there was positive correlation between severity of psoriasis with serum uric acid level(p=0.001). Conclusion: Psoriasis was associated with hyperuricemia in psoriasis patients.  
背景:荟萃分析显示银屑病与高尿酸血症及其后遗症相关。本研究旨在探讨银屑病患者血清尿酸水平与病情严重程度的关系。材料与方法:经诺贝尔医学院教学医院机构审查委员会批准,于2020年1月至2022年12月在尼泊尔东部地区诺贝尔医学院教学医院皮肤内科进行为期一年的前瞻性病例对照研究。本组病例均通过临床检查及必要时活检确诊。选取50例病例和50例对照样本进行研究。计算病例的银屑病严重程度指数,并测量病例和对照组的血清尿酸水平。结果:银屑病患者血清尿酸均值为6.16±1.64mg/dl,范围为4 ~ 11 mg/dl;对照组为5.39±1.60 mg/dl,范围为2 ~ 9mg/dl。银屑病组患者血清尿酸水平显著高于对照组(p值为0.002),银屑病严重程度与血清尿酸水平呈正相关(p=0.001)。结论:银屑病患者与高尿酸血症相关。
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引用次数: 0
Peripheral Odontogenic Fibroma- Case Series of a Rare Benign Tumor 外周牙源性纤维瘤-罕见良性肿瘤病例系列
Pub Date : 2022-01-02 DOI: 10.3126/jonmc.v10i2.41794
A. Dawadi, S. Lamichhane, M. Humagain, P. Poudel, Sita Bhusal
Peripheral odontogenic fibroma (POdF) is a rare benign odontogenic tumor of ectomesenchymal origin which is composed of fibrous connective tissue containing islands, strands or cords of odontogenic epithelium. The lesion is more common among females, commonly seen between the second to fourth decades of life, mostly affecting the anterior region of mandible. Clinically, it may present similar characteristics with other more common gingival lesions such as pyogenic granuloma, peripheral ossifying fibroma and peripheral giant cell granuloma. So, histopathological examination is required for accurate diagnosis. We present here three rare clinical cases of peripheral odontogenic fibroma and their management by complete excision of the lesion with good postoperative outcomes.
外周牙源性纤维瘤(POdF)是一种罕见的良性牙源性肿瘤,起源于外牙间质,由纤维结缔组织组成,含有岛状、股状或索状牙源性上皮。这种病变在女性中更为常见,常见于生命的第二到第四十年之间,主要影响下颌骨的前区。临床上,它可能与其他更常见的牙龈病变如化脓性肉芽肿、周围骨化纤维瘤和周围巨细胞肉芽肿表现出相似的特征。因此,准确诊断需要组织病理学检查。我们在此报告三例罕见的外周牙源性纤维瘤的临床病例,并通过完全切除病变获得良好的术后效果。
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引用次数: 1
Predictors of Obesity among Type 2 Diabetes Mellitus Patients Attending a Tertiary Care Center of Province 1, Nepal 尼泊尔第一省三级医疗中心2型糖尿病患者肥胖预测因素
Pub Date : 2022-01-02 DOI: 10.3126/jonmc.v10i2.41582
P. Roy, D. Baral, Arjun Gautam, Sarita Subedi
Background: Obesity and Diabetes Mellitus type 2 have a known association. Yet, the socio-demographic predictors of obesity in special populations like ours (Asian) who have DM remain unclear. The purpose of this study was to determine the socio-demographic predictors of obesity among newly diagnosed Diabetes Mellitus in adults. Materials and Methods: This was a descriptive cross-sectional study conducted in endocrine OPD of Nobel medical college. Total 124 subjects were enrolled who were newly diagnosed Diabetes Mellitus over a period of 1 year. Detailed history was taken for demographic and clinical variables. Height, weight, waist circumference and blood pressure were measured. Besides, Body Mass Index, the dependent variable, was calculated. Subjects were considered to have diabetes based on their fasting and postprandial blood sugar level for the first time. Results: The prevalence of obesity among the study population was 39.5%, overweight was 45.2%. Predictors for this study for obesity were found as abnormal blood pressure and hospital visit after symptoms development. Conclusion: Obesity is a important risk factor for Diabetes Mellitus and higher prevalence of obesity among type 2 diabetes was observed. Predictors for this study for obesity were found as abnormal blood pressure and hospital visit after symptoms development
背景:肥胖和2型糖尿病有一个已知的关联。然而,在像我们(亚洲人)这样患有糖尿病的特殊人群中,肥胖的社会人口学预测因素尚不清楚。本研究的目的是确定新诊断的成人糖尿病患者肥胖的社会人口学预测因素。材料与方法:这是一项在诺贝尔医学院内分泌门诊部进行的描述性横断面研究。共有124名受试者在一年内被新诊断为糖尿病。详细的病史用于人口统计学和临床变量。测量身高、体重、腰围和血压。此外,还计算了因变量体重指数。受试者首次根据空腹和餐后血糖水平被认为患有糖尿病。结果:研究人群中肥胖的患病率为39.5%,超重为45.2%。本研究的肥胖预测因素是血压异常和症状出现后的医院就诊。结论:肥胖是糖尿病的重要危险因素,2型糖尿病患者肥胖发生率较高。这项研究的肥胖预测因素是血压异常和症状出现后的医院就诊
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引用次数: 0
Lipid Profile in Patients with Lichen Planus in a Tertiary Care Hospital: A Descriptive Cross-Sectional Study 三级医院扁平苔藓患者的脂质分布:一项描述性横断面研究
Pub Date : 2021-12-31 DOI: 10.3126/jonmc.v10i2.41575
S. Karki, A. Rai, M. Pradhan
Background: Lichen planus is an immune mediated disease that affects the skin and the mucous membranes. Although the etiology and pathogenesis are not fully understood, it is believed that lichen planus represents a T-cell-mediated inflammatory disorder which produces disturbances of lipid metabolism. Materials and Methods: Patients with the clinical diagnosis of lichen planus were included in the study after taking informed written consent. In total 40 patients were included in the study. Serum lipid profile was performed in the medical laboratory of Nobel Medical College Teaching Hospital.  Results: Out of 40 patients, 13(32.5%) patients had dyslipidemia. Overall dyslipidemia was seen more in female patients (53.8%) than in male patients (46.2%). In our study, hypertrophic (32.5%) followed by eruptive (27%) and mucosal (25%) lichen planus were the most common variant. Conclusion: This study demonstrated that about one-third of lichen planus patients showed deranged lipid levels in blood so for patients presenting with lichen planus physicians should consider screening them for dyslipidemia.
背景:扁平苔藓是一种免疫介导的疾病,影响皮肤和粘膜。尽管病因和发病机制尚不完全清楚,但人们认为扁平苔藓是一种T细胞介导的炎症性疾病,会引起脂质代谢紊乱。材料和方法:临床诊断为扁平苔藓的患者在取得知情书面同意后纳入研究。共有40名患者被纳入研究。在诺贝尔医学院教学医院的医学实验室进行了血脂测定。结果:40例患者中有13例(32.5%)出现血脂异常。总体而言,女性患者(53.8%)的血脂异常发生率高于男性患者(46.2%)。在我们的研究中,最常见的变体是肥厚型(32.5%),其次是发疹型(27%)和粘膜型(25%)扁平苔藓。结论:这项研究表明,大约三分之一的扁平苔藓患者血液中的脂质水平紊乱,因此对于出现扁平苔藓的患者,医生应该考虑对他们进行血脂异常筛查。
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引用次数: 0
Guillain-Barre Syndrome Following Ad26.Cov2.S Covid-19 Vaccine: A Case Report Ad26.Cow2.S新冠肺炎疫苗接种后格林-巴利综合征病例报告
Pub Date : 2021-12-31 DOI: 10.3126/jonmc.v10i2.41790
Sushmita Khanal, S. Khanal
Guillain-Barre Syndrome has been reported as a rare side effect in the recipients of Johnson & Johnson®'s Janssen Ad26.COV2.S COVID-19 vaccine. We report a case of Guillain-Barre Syndrome in a 50 years old female following the administration of the aforementioned vaccine.
据报道,格林-巴利综合征是强生公司(Johnson & Johnson®)Janssen Ad26.COV2受体的一种罕见副作用。COVID-19疫苗。我们报告一例格林-巴利综合征在一个50岁的女性后,上述疫苗的管理。
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引用次数: 0
Thyroid Dysfunction and its Effect on Red Blood Cell Parameters 甲状腺功能障碍及其对红细胞参数的影响
Pub Date : 2021-12-31 DOI: 10.3126/jonmc.v10i2.41777
S. Singh
Background: Thyroid hormones are necessary for the growth and development, cellular differentiation, physiological function and metabolic regulation of almost all tissues in our body. Thyroid disorders are accompanied by alteration in hematological profile. This study aims to evaluate the effect of thyroid dysfunction on red blood cell parameters. Materials and Methods: This case-control observational study was conducted in the Department of Clinical Biochemistry, KIST Medical College and Teaching Hospital (KISTMCTH), Lalitpur, Nepal from January 2021 to June 2021.Total number of recruited subjects was 248, out of which 67 were labeled as hypothyroid, 7 were hyperthyroid and 174 were euthyroid as control. Subjects for all three groups were between 16-93 years old. Thyroid hormone profile of patients was determined by Siemens ADVIA Centaur CP immunoassay analyzer and hematological parameters by automated hematology analyzer Sysmex XN-550. Results were analyzed by SPSS 21 software and a chi-square test was applied to see significant differences among the groups. Results: The mean age of all study participants was 42.08±17.27 years and female constituted 74.6% of total subjects. Analysis of the data obtained a statistically significant difference in the mean hemoglobin (p<0.001) between hypothyroid and euthyroid groups. The difference was not significant for hemoglobin (p=0.252) among hyperthyroid and euthyroid groups. There was no statistical significant difference between thyroid cases and control for MCV, MCH and MCHC. Conclusion: The current study concluded that thyroid dysfunction have a significant effect on red blood cell parameters. Hematological parameters should be evaluated in patient with thyroid dysfunction.
背景:甲状腺激素是人体几乎所有组织生长发育、细胞分化、生理功能和代谢调节所必需的激素。甲状腺疾病伴血液学改变。本研究旨在探讨甲状腺功能障碍对红细胞参数的影响。材料与方法:本病例对照观察性研究于2021年1月至2021年6月在尼泊尔拉利特普尔KIST医学院和教学医院临床生物化学系进行。共纳入受试者248人,其中甲状腺功能减退67人,甲状腺功能亢进7人,甲状腺功能正常174人作为对照。所有三组的受试者年龄都在16-93岁之间。采用西门子ADVIA Centaur CP免疫分析仪检测患者甲状腺激素谱,采用全自动血液学分析仪Sysmex XN-550检测血液学参数。采用SPSS 21软件对结果进行分析,采用卡方检验比较各组间的差异。结果:研究对象的平均年龄为42.08±17.27岁,女性占74.6%。经数据分析,甲状腺功能低下组和甲状腺功能正常组的平均血红蛋白差异有统计学意义(p<0.001)。甲亢组和甲亢组的血红蛋白差异无统计学意义(p=0.252)。甲状腺病例与对照组MCV、MCH、MCHC的差异无统计学意义。结论:本研究认为甲状腺功能障碍对红细胞参数有显著影响。甲状腺功能障碍患者应评估血液学参数。
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引用次数: 0
Short Term Clinical Outcome of Micro Lumbar Discectomy in Tertiary Care Center 三级医疗中心微型腰椎间盘切除术的短期临床疗效
Pub Date : 2021-12-31 DOI: 10.3126/jonmc.v10i2.41774
Pramod Chaudhary, P. Kafle, Narendera Joshi, U. Gautam
Background: Minimal invasive open lumbar microdiscectomy has been associated with good success rate and low morbidity. The present study is aimed to evaluate the clinical outcome of patients who underwent open minimal invasive open lumbar microdiscectomy for herniated intervertebral disc. Materials and Methods: This is a prospective observational hospital based study of prolapsed lumbar intervertebral disc operated in the department of neurosurgery at Nobel Medical College Teaching Hospital, Biratnagar, Nepal from January 2018 to June 2021. All patients of lumbar herniated intervertebral disc subjected for surgery were included. Recurrent prolapsed intervertebral disc, Disc surgery requiring stabilization was excluded from the study. During surgery types of prolapsed intervertebral disc, level and operative time were noted. In the post-operative period Visual Analogue Scale was used to assess the change in severity of pain. Duration of hospital stay and the complications occurred were also noted. Results: The mean age of the study population was was 41.50 (±14.56) years ranging from 20 years to 79 years. The commonest lumbar prolapsed intervertebral disc was at L4-L5 level. The mean operative time was 42 minutes excluding the time for anaesthesia preparation. There was statistically significant difference (p<0.001) in pre-operative and post-operative Visual Analogue Scale. Mean duration of hospital stay was 5.58 (1.87) days. Conclusion: A through workup and surgical planning is associated with better outcome avoiding complications in minimal invasive open micro lumbar discectomy.  
背景:微创开放式腰椎微盘切除术具有良好的成功率和较低的发病率。本研究旨在评估接受开放式微创开放式腰椎微盘切除术治疗椎间盘突出症的患者的临床结果。材料和方法:这是一项基于医院的前瞻性观察研究,研究对象为2018年1月至2021年6月在尼泊尔比拉特纳加尔诺贝尔医学院教学医院神经外科手术的腰椎间盘突出症。所有接受手术治疗的腰椎间盘突出症患者均包括在内。复发性椎间盘突出,需要稳定的椎间盘手术被排除在研究之外。术中注意椎间盘突出的类型、程度和手术时间。术后使用视觉模拟量表评估疼痛严重程度的变化。还记录了住院时间和发生的并发症。结果:研究人群的平均年龄为41.50(±14.56)岁,从20岁到79岁不等。最常见的腰椎间盘突出发生在L4-L5水平。除麻醉准备时间外,平均手术时间为42分钟。术前和术后视觉模拟量表有统计学意义(p<0.001)。平均住院时间为5.58(1.87)天。结论:在微创开放式微型腰椎间盘切除术中,彻底的检查和手术计划有助于更好地避免并发症。
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引用次数: 0
Assessment of Safety of Vaginal Repair of Pelvic Organ Prolapse in Elderly at Birat Medical College Teaching Hospital, Nepal 尼泊尔比拉特医学院教学医院老年人盆腔器官脱垂阴道修复的安全性评估
Pub Date : 2021-12-31 DOI: 10.3126/jonmc.v10i2.41580
Bhanubhakta Neupane, G. Karki, H. Pokhrel, A. Adhikari
Background: Pelvic organ prolapse in elder women causes sufficient morbidity and decreased quality of life. Despite age related comorbidities and decreased physiological capabilities, elder women with pelvic organ prolapse may be benefitted by surgical repair via vaginal route.The purpose of this study is to evaluate the safety of vaginal repair of pelvic organ prolapse in women of age 60 years or older. Materials and Methods: This hospital based analytical study was carried out in Birat Medical College Teaching Hospital from September 2020 to September 2021. Fifty-four patients aged 60 years or older with third and fourth degree pelvic organ prolapse were recruited for the study. Necessary information was obtained by self-structured questionnaire and entered into Microsoft Excel. Data was analyzed by SPSS version 22. Results: Fifty-four women with third or fourth degree prolapse with cystocele and rectocele underwent vaginal hysterectomy with anterior colporrhaphy with posterior colpoperineorrhaphy. No organ injury occurred during operation. There was no mortality or severe intraoperative or postoperative complications. Conclusion: Vaginal hysterectomy with pelvic floor repair for pelvic organ prolapse in women of 60 years or older is safe.
背景:老年妇女的盆腔器官脱垂会导致足够的发病率和生活质量下降。尽管存在与年龄相关的合并症和生理能力下降,但患有盆腔器官脱垂的老年女性可以通过阴道途径进行手术修复。本研究的目的是评估60岁或以上女性盆腔器官脱垂阴道修复的安全性。材料和方法:这项基于医院的分析研究于2020年9月至2021年9月在比拉特医学院教学医院进行。本研究招募了54名年龄在60岁或60岁以上的三度和四度盆腔器官脱垂患者。通过自行编制的调查表获取必要的信息,并输入到Microsoft Excel中。数据采用SPSS版本22进行分析。结果:54例三度或四度脱垂伴膀胱膨出和直肠前突的妇女接受了阴道子宫切除术,前阴道修补术和后阴道修补术。术中未发生器官损伤。没有死亡或严重的术中或术后并发症。结论:60岁及以上女性经阴道子宫切除联合盆底修补术治疗盆腔器官脱垂是安全的。
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引用次数: 0
Video Assisted Thoracoscopic Surgery in Exudative Pleural Effusion and its Complication Management: An Experience in a Community Hospital 视频胸腔镜手术治疗渗出性胸腔积液及其并发症的处理:一所社区医院的经验
Pub Date : 2021-12-31 DOI: 10.3126/jonmc.v10i2.41568
R. Baral
Background: Exudative pleural effusions are common presentation of pleural disease. Long standing pleural effusion might complicate with loculations and cortex formation. Video assisted thoracoscopic surgery can be a useful tool for the diagnosis and the management of the complications. The aim of the study is to determine the cause and treat the complications related to the exudative pleural effusions. Materials and Methods: It is a retrospective analysis of prospectively collected data of all patients with exudative pleural effusions subjected to surgical management. Data were collected over a period of four years in a community hospital in Kathmandu. Results: Of 38 patients who underwent Video assisted thoracoscopic surgery only 33 were eligible for analysis. Male to female ratio was 2.3:1 with male (23) dominance. Twenty six (78.8%) had lymphocyte predominance and 23 (69.7%) had Adenosine deaminase level of more than 40 International unit in pleural fluid analysis. In histopathological examination most common finding was granulomatous inflammation 13 (39.4%), 9 (27.3%) were malignancy and 9 (27.3%) were nonspecific chronic inflammation. Of malignancies adenocarcinoma 3 (9.09%) was the most common finding, mesothelioma 2(6.06%) and 4 (12.12%) other. Conclusion: Video assisted thoracoscopic surgery has a role to play in diagnosis of exudative pleural effusions, particularly when there is dilemma in diagnosis. Video assisted thoracoscopic surgery definitely has a role in diagnosis and treatment of the complications related to pleural effusions.
背景:渗出性胸腔积液是胸膜疾病的常见表现。长期胸腔积液可能会使腔和皮层的形成复杂化。电视胸腔镜手术是诊断和处理并发症的有用工具。本研究的目的是确定渗出性胸腔积液的原因并治疗相关并发症。材料和方法:对所有接受手术治疗的渗出性胸腔积液患者前瞻性收集的数据进行回顾性分析。数据是在加德满都的一家社区医院收集的,历时四年。结果:在38例接受电视胸腔镜手术的患者中,只有33例符合分析条件。男女比例为2.3:1,男性(23)占优势。胸腔积液分析中,26例(78.8%)淋巴细胞占优势,23例(69.7%)腺苷脱氨酶水平超过40国际单位。在组织病理学检查中,最常见的发现是肉芽肿性炎症13例(39.4%),恶性9例(27.3%),非特异性慢性炎症9例(2.73%)。恶性肿瘤中腺癌3例(9.09%)最常见,间皮瘤2例(6.06%),其他4例(12.12%)。结论:电视胸腔镜手术在渗出性胸腔积液的诊断中有一定作用,尤其是在诊断困难的情况下。电视胸腔镜手术在胸腔积液并发症的诊断和治疗中具有重要作用。
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引用次数: 1
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Journal of Nobel Medical College
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