Timely provision of blood plays an important role in the management algorithm of patients. Interference by minor blood group (BG) antibodies has become a common entity among multi-transfused patients; other nonsignificant antibodies are too encountered rarely. We report one such interfering nonspecific antibody in a 55-year-old female patient posted for splenectomy at our institute. BG discrepancy (type one) with a pan-positive (4+) antibody screening panel was found in her testing results. Crossmatches were compatible at antihuman globulin phase and at room temperature, and autocontrol was negative. Detailed meticulous immunohematological workup helped us in concluding that the offending antibody was not directed against the ingredients of column matrix of gel cards or the enhancement media (low ionic strength solution); rather it was directed against the chemical constituents in the suspension medium of commercial cell panel. Bearing the presence of nonspecific “nuisance” antibodies in mind becomes extremely important so that they can be detected and managed quickly.
{"title":"Immunohematological discrepancy – Due to nuisance antibody!","authors":"R. Mehra, A. Bhave, Savita Pujare, N. Chavan","doi":"10.4103/gjtm.gjtm_72_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_72_22","url":null,"abstract":"Timely provision of blood plays an important role in the management algorithm of patients. Interference by minor blood group (BG) antibodies has become a common entity among multi-transfused patients; other nonsignificant antibodies are too encountered rarely. We report one such interfering nonspecific antibody in a 55-year-old female patient posted for splenectomy at our institute. BG discrepancy (type one) with a pan-positive (4+) antibody screening panel was found in her testing results. Crossmatches were compatible at antihuman globulin phase and at room temperature, and autocontrol was negative. Detailed meticulous immunohematological workup helped us in concluding that the offending antibody was not directed against the ingredients of column matrix of gel cards or the enhancement media (low ionic strength solution); rather it was directed against the chemical constituents in the suspension medium of commercial cell panel. Bearing the presence of nonspecific “nuisance” antibodies in mind becomes extremely important so that they can be detected and managed quickly.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"24 1","pages":"99 - 101"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80224732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Selective leukoreduction is all that we need in low- and middle-income countries","authors":"K. Roy","doi":"10.4103/gjtm.gjtm_93_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_93_22","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"16 1","pages":"105 - 105"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82995480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dengue is a mosquito-borne viral disease which has reached fearsome proportions in the past few years. Acute transverse myelitis (ATM) is a rare complication of dengue characterized by onset of bilateral lower limb weakness, paresthesia, and urinary retention and magnetic resonance imaging of the whole spine shows diffuse areas of abnormal hyperintensity on T2-weighted images involving the cord in the cervical and the dorsal region extending up to the level of conus. Treatment is usually steroids, intravenous immunoglobulin, and therapeutic plasma exchange (TPE). We report a case of ATM in a young male patient who was successfully treated by TPE.
{"title":"Dramatic response to therapeutic plasma exchange in acute transverse myelitis following dengue fever: A case report","authors":"Pandeep Kaur, Rakesh Kumar, Mohit Singh, P. Singh","doi":"10.4103/gjtm.gjtm_67_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_67_22","url":null,"abstract":"Dengue is a mosquito-borne viral disease which has reached fearsome proportions in the past few years. Acute transverse myelitis (ATM) is a rare complication of dengue characterized by onset of bilateral lower limb weakness, paresthesia, and urinary retention and magnetic resonance imaging of the whole spine shows diffuse areas of abnormal hyperintensity on T2-weighted images involving the cord in the cervical and the dorsal region extending up to the level of conus. Treatment is usually steroids, intravenous immunoglobulin, and therapeutic plasma exchange (TPE). We report a case of ATM in a young male patient who was successfully treated by TPE.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"8 1","pages":"102 - 104"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87614906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Pandey, Supriya Kumari, D. Setya, S. Mandal, A. Marik, M. Singh
Immunohematology reference laboratory (IRL) is defined as a fully equipped advanced laboratory that receives samples from various parts of the country for workup. This is a specialized center, where other centers experiencing difficulty in resolving immunohematological tests, refer samples for further workup and resolution. To complete the workup process, ABO RhD typing, antibody screening, identification (ID), antigen phenotyping, and direct antiglobulin tests are performed. In our retrospective observational study 528 cases, worked up from October 2019 to March 2022 were included. The prevalence of alloimmunization found in this evaluation was 68.1%. Among the different alloantibodies, anti-D was most common followed by anti-E and anti-M. In our study, most of the autoantibodies were of Immunoglobulin G (IgG) class (79.31%). Out of the 528 samples, ABO discrepancy was found in 48 samples (9%). Of these, none belonged to Group I or Group III discrepancy types. Group II discrepancies were noted in 28 cases (58.3%) and Group IV discrepancies were found in 20 cases (41.6%). Our study clearly indicates that there is an important role of IRL which is not only limited to ID of alloantibodies or resolution of ABO discrepancies but also supports all the hospitals and transfusion centers in the region by providing phenotype-matched or compatible units and advice for safe transfusion practices.
{"title":"Immunohematology red cell serology testing reference laboratory: An experience from a tertiary health-care center in India","authors":"P. Pandey, Supriya Kumari, D. Setya, S. Mandal, A. Marik, M. Singh","doi":"10.4103/gjtm.gjtm_85_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_85_22","url":null,"abstract":"Immunohematology reference laboratory (IRL) is defined as a fully equipped advanced laboratory that receives samples from various parts of the country for workup. This is a specialized center, where other centers experiencing difficulty in resolving immunohematological tests, refer samples for further workup and resolution. To complete the workup process, ABO RhD typing, antibody screening, identification (ID), antigen phenotyping, and direct antiglobulin tests are performed. In our retrospective observational study 528 cases, worked up from October 2019 to March 2022 were included. The prevalence of alloimmunization found in this evaluation was 68.1%. Among the different alloantibodies, anti-D was most common followed by anti-E and anti-M. In our study, most of the autoantibodies were of Immunoglobulin G (IgG) class (79.31%). Out of the 528 samples, ABO discrepancy was found in 48 samples (9%). Of these, none belonged to Group I or Group III discrepancy types. Group II discrepancies were noted in 28 cases (58.3%) and Group IV discrepancies were found in 20 cases (41.6%). Our study clearly indicates that there is an important role of IRL which is not only limited to ID of alloantibodies or resolution of ABO discrepancies but also supports all the hospitals and transfusion centers in the region by providing phenotype-matched or compatible units and advice for safe transfusion practices.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"44 1","pages":"65 - 70"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85924465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iranian Blood Transfusion Organization (IBTO) established in 1975 has been the sole responsible entity for blood adequacy and safety in Iran. It has been the same in case of providing recovered plasma. At the same time, the first commercial plasma center was authorized by IBTO to operate in the capital Tehran to contribute to the main purpose that was the investment of the private sector in fulfilling fractionation purposes and the construction of a fractionation plant. The goal that unfortunately did not materialize. To make remedies based on a well-calculated plasma document, in 2015, a plasma program developed in Iran by IBTO by which new donor centers were opened or already blood center were equipped to allow for the collection of voluntary nonremunerated source plasma. It had in it capacities of plasma collection for IBTO recovered, commercial source, and IBTO voluntary source. The latter third was a gradually growing program that lasted just 3 years and showed progress but the managerial changes and invalid arbitrary and sudden decisions brought it to the end. Whilst the paid private centers grew and ruined the voluntary nonremunerated sense that IBTO always pursued and was against the Ministry of Health requirements for what the commercial private sectors should have abided by. Safe voluntary nonremunerated source plasma collection that almost all countries pursue to grow along with existing recovered plasma share was terminated with consequences that are detailed in the present article.
{"title":"Paid plasma versus voluntary nonremunerated plasma collection for plasma-derived medicine: Iran experience with a short glance at a few countries","authors":"A. Pourfathollah, K. Shamsasenjan, M. Dehshal","doi":"10.4103/gjtm.gjtm_88_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_88_22","url":null,"abstract":"Iranian Blood Transfusion Organization (IBTO) established in 1975 has been the sole responsible entity for blood adequacy and safety in Iran. It has been the same in case of providing recovered plasma. At the same time, the first commercial plasma center was authorized by IBTO to operate in the capital Tehran to contribute to the main purpose that was the investment of the private sector in fulfilling fractionation purposes and the construction of a fractionation plant. The goal that unfortunately did not materialize. To make remedies based on a well-calculated plasma document, in 2015, a plasma program developed in Iran by IBTO by which new donor centers were opened or already blood center were equipped to allow for the collection of voluntary nonremunerated source plasma. It had in it capacities of plasma collection for IBTO recovered, commercial source, and IBTO voluntary source. The latter third was a gradually growing program that lasted just 3 years and showed progress but the managerial changes and invalid arbitrary and sudden decisions brought it to the end. Whilst the paid private centers grew and ruined the voluntary nonremunerated sense that IBTO always pursued and was against the Ministry of Health requirements for what the commercial private sectors should have abided by. Safe voluntary nonremunerated source plasma collection that almost all countries pursue to grow along with existing recovered plasma share was terminated with consequences that are detailed in the present article.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"28 1","pages":"10 - 16"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84225198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Mangwana, N. Bhatnagar, L. Aravinth, Nabajyoti Choudhury
Background and Objectives: Globally, there is a wide variation in Quality management practices and availability of Quality Standards. Because of a paucity of data on QM practices in BTS in various Asian countries, this study was undertaken to understand the quality assurance (QA) programme within the blood bank settings. Methods: The study was conducted by the Quality Working Group of Asian Association of Transfusion Medicine (AATM), by an online questionnaire having 25 questions which were circulated amongst various blood centres of member Countries of Asian Association of Transfusion Medicine (AATM). Results: 60 blood centres participated. 43 were Hospital based Blood Centres and 17 were from Stand-alone Blood Centres. The majority of the responders were from a tertiary care hospital (92%). More than 83% of blood centres, either accredited or planning to move forward, were conducting internal audits, more than 86% were having Quality policy and QMS. Conclusion: It is evident from this study that blood centres, by and large, maintain good practices as they are under the purview of regulatory bodies of the respective countries and hence follow Good Manufacturing Practices (GMP). As the Asian countries come under the LMIC category; hence the financial cost could be a major hindrance in achieving quality standards, but few extra miles to achieve quality standards or accreditation will ultimately lead to better patient care.
{"title":"Assessment of quality management practices across Asian countries","authors":"S. Mangwana, N. Bhatnagar, L. Aravinth, Nabajyoti Choudhury","doi":"10.4103/gjtm.gjtm_73_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_73_22","url":null,"abstract":"Background and Objectives: Globally, there is a wide variation in Quality management practices and availability of Quality Standards. Because of a paucity of data on QM practices in BTS in various Asian countries, this study was undertaken to understand the quality assurance (QA) programme within the blood bank settings. Methods: The study was conducted by the Quality Working Group of Asian Association of Transfusion Medicine (AATM), by an online questionnaire having 25 questions which were circulated amongst various blood centres of member Countries of Asian Association of Transfusion Medicine (AATM). Results: 60 blood centres participated. 43 were Hospital based Blood Centres and 17 were from Stand-alone Blood Centres. The majority of the responders were from a tertiary care hospital (92%). More than 83% of blood centres, either accredited or planning to move forward, were conducting internal audits, more than 86% were having Quality policy and QMS. Conclusion: It is evident from this study that blood centres, by and large, maintain good practices as they are under the purview of regulatory bodies of the respective countries and hence follow Good Manufacturing Practices (GMP). As the Asian countries come under the LMIC category; hence the financial cost could be a major hindrance in achieving quality standards, but few extra miles to achieve quality standards or accreditation will ultimately lead to better patient care.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"55 1","pages":"46 - 50"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85682828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives: Concern on donors' health and safety is growing in importance in many countries. One of the key issues is related to low body iron store in regular blood donors that some countries have advocated iron supplementation in addition to education. A survey was performed to look at the dietary factors in blood donors under an iron replenishment program in Hong Kong. The objectives of this survey were to evaluate the possible causes for iron deficiency and evaluate the effectiveness of education and iron supplementation program. Methods: A pre- and post- health education survey was conducted to evaluate the effectiveness of an iron replenishment program addressing iron deficiency among regular blood donors. Eligible donors were invited to attend a health education held by a registered nurse after predonation hemoglobin test. A questionnaire was used to ask donors on their dietary habit, knowledge on iron deficiency, and iron supplement. Results: Of 428 participants, male donors preferred eating out for breakfast (P = 0.003) and lunch (P = 0.0005) than females. Those donors who preferred eating out were also likely to have higher frequency of taking tea or coffee (P = 0.0005). When compared the donors' knowledge and confident level in taking iron replacement, significance was identified between genders and pre- and posthealth education. An affirmative donor satisfaction toward the nursing support and the iron replenishment program was also observed. Conclusion: The study result provided an insight into the possible dietary factors. The positive outcome of the health education warrants further planning of educational strategies to address the gender difference but also to achieve a better effect from iron replenishment.
{"title":"A survey of Chinese regular blood donors who were enrolled into an iron replenishment program – A hint for dietary factors","authors":"I. Lee, Chelly Chu, Nga Wong, L. Leung, C. Lee","doi":"10.4103/gjtm.gjtm_15_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_15_22","url":null,"abstract":"Background and Objectives: Concern on donors' health and safety is growing in importance in many countries. One of the key issues is related to low body iron store in regular blood donors that some countries have advocated iron supplementation in addition to education. A survey was performed to look at the dietary factors in blood donors under an iron replenishment program in Hong Kong. The objectives of this survey were to evaluate the possible causes for iron deficiency and evaluate the effectiveness of education and iron supplementation program. Methods: A pre- and post- health education survey was conducted to evaluate the effectiveness of an iron replenishment program addressing iron deficiency among regular blood donors. Eligible donors were invited to attend a health education held by a registered nurse after predonation hemoglobin test. A questionnaire was used to ask donors on their dietary habit, knowledge on iron deficiency, and iron supplement. Results: Of 428 participants, male donors preferred eating out for breakfast (P = 0.003) and lunch (P = 0.0005) than females. Those donors who preferred eating out were also likely to have higher frequency of taking tea or coffee (P = 0.0005). When compared the donors' knowledge and confident level in taking iron replacement, significance was identified between genders and pre- and posthealth education. An affirmative donor satisfaction toward the nursing support and the iron replenishment program was also observed. Conclusion: The study result provided an insight into the possible dietary factors. The positive outcome of the health education warrants further planning of educational strategies to address the gender difference but also to achieve a better effect from iron replenishment.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"123 1","pages":"28 - 33"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89966773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/gjtm.gjtm_100_21
P. Desai, A. Navkudkar, Nileema More, S. Rajadhyaksha
Background and Objectives: Red blood cells (RBC) transfusion is an important medical therapy in modern medicine. Blood is a scarce resource used in large numbers; therefore, it is very essential for its components to be used appropriately and judiciously. It is necessary to monitor, assess, and evaluate the existing trends and appropriateness of blood utilization. The establishment of criteria for blood transfusion and strict adherence to such criteria may be necessary to improve blood usage. The objective of this study was to understand the utilization pattern of RBC transfusions based on indications and to evaluate the appropriateness of RBC transfusion at a tertiary care oncology center. Methods: This was a prospective observational study conducted over a period of 4 months. A total of 4413 RBC transfusion events in 2012 adult oncology patients were analyzed for appropriateness as per institutional guidelines. Data were obtained from the blood requisitions, issue records of the Department of Transfusion Medicine and from the Electronic Medical Records of the patients. Results: Total of 83% of transfusion events were found to be appropriate with Anemia being the most common indication for RBC transfusion in medical and surgical oncology units. Appropriateness was significant (P < 0.05) in medical oncology as compared to surgical oncology units. Appropriateness was highest and statistically significant (P < 0.05) in operation theatres while inappropriateness was more and significant in the daycare facility (P < 0.05). Conclusion: Total 83% of RBC transfusions were found to be appropriate indicating that clinical practices of RBC transfusions in the hospital were rational with adherence to institutional guidelines.
{"title":"Evaluation of appropriateness of red blood cell transfusions: A prospective audit at a tertiary care oncology centre","authors":"P. Desai, A. Navkudkar, Nileema More, S. Rajadhyaksha","doi":"10.4103/gjtm.gjtm_100_21","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_100_21","url":null,"abstract":"Background and Objectives: Red blood cells (RBC) transfusion is an important medical therapy in modern medicine. Blood is a scarce resource used in large numbers; therefore, it is very essential for its components to be used appropriately and judiciously. It is necessary to monitor, assess, and evaluate the existing trends and appropriateness of blood utilization. The establishment of criteria for blood transfusion and strict adherence to such criteria may be necessary to improve blood usage. The objective of this study was to understand the utilization pattern of RBC transfusions based on indications and to evaluate the appropriateness of RBC transfusion at a tertiary care oncology center. Methods: This was a prospective observational study conducted over a period of 4 months. A total of 4413 RBC transfusion events in 2012 adult oncology patients were analyzed for appropriateness as per institutional guidelines. Data were obtained from the blood requisitions, issue records of the Department of Transfusion Medicine and from the Electronic Medical Records of the patients. Results: Total of 83% of transfusion events were found to be appropriate with Anemia being the most common indication for RBC transfusion in medical and surgical oncology units. Appropriateness was significant (P < 0.05) in medical oncology as compared to surgical oncology units. Appropriateness was highest and statistically significant (P < 0.05) in operation theatres while inappropriateness was more and significant in the daycare facility (P < 0.05). Conclusion: Total 83% of RBC transfusions were found to be appropriate indicating that clinical practices of RBC transfusions in the hospital were rational with adherence to institutional guidelines.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"18 1","pages":"34 - 39"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90967952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/gjtm.gjtm_102_21
Rekha Nirwan, Ketaki Mannur, Divya Singh
Thalassemia syndromes represent a group of inherited disorders characterized by decreased synthesis of one or more of the four globin chains in hemoglobin. The clinical spectrum ranges from asymptomatic carrier state to transfusion-dependent severe disease. The availability of better treatment options has increased the life expectancy in these patients and consequently paved the way to develop malignancies. Although many studies are published on the association of solid organ and lymphoid malignancies, only one case has been reported so far for acute myeloid leukemia (AML) coexisting with thalassemia syndromes. Herein, we report the first case of AML associated with beta-thalassemia in an adult Indian expatriate woman in Qatar. She presented with prolonged bleeding after a dental procedure. She was diagnosed as concurrent AML and beta-thalassemia trait on the laboratory evaluation. This case signifies the use of peripheral blood film evaluation for any abnormal hemograms in the modern era of automation. It also warrants caution for clinicians in suspecting malignancies in thalassemia although direct genetic linkage or associated risk is a matter of research.
{"title":"Undiagnosed dual blood disorder – Thalassemia with acute myeloid leukemia","authors":"Rekha Nirwan, Ketaki Mannur, Divya Singh","doi":"10.4103/gjtm.gjtm_102_21","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_102_21","url":null,"abstract":"Thalassemia syndromes represent a group of inherited disorders characterized by decreased synthesis of one or more of the four globin chains in hemoglobin. The clinical spectrum ranges from asymptomatic carrier state to transfusion-dependent severe disease. The availability of better treatment options has increased the life expectancy in these patients and consequently paved the way to develop malignancies. Although many studies are published on the association of solid organ and lymphoid malignancies, only one case has been reported so far for acute myeloid leukemia (AML) coexisting with thalassemia syndromes. Herein, we report the first case of AML associated with beta-thalassemia in an adult Indian expatriate woman in Qatar. She presented with prolonged bleeding after a dental procedure. She was diagnosed as concurrent AML and beta-thalassemia trait on the laboratory evaluation. This case signifies the use of peripheral blood film evaluation for any abnormal hemograms in the modern era of automation. It also warrants caution for clinicians in suspecting malignancies in thalassemia although direct genetic linkage or associated risk is a matter of research.","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"1 1","pages":"92 - 95"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82304638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Postdonation information and blood component withdrawal (recall): Need for national guidance","authors":"D. Sachan, T. Varnish, Deepthi Gundrajukuppam","doi":"10.4103/gjtm.gjtm_87_22","DOIUrl":"https://doi.org/10.4103/gjtm.gjtm_87_22","url":null,"abstract":"","PeriodicalId":52961,"journal":{"name":"Global Journal of Transfusion Medicine","volume":"11 1","pages":"108 - 108"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73699257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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