S. Jeong, J. Jung, D. Kwon, S. Seong, Ji Yun Jang, Jong Bin Park, M. Jang
{"title":"=?UTF-8?B?RGVybW9zY29waWMgZmVhdHVyZXMgb2YgYW4gdW51c3VhbCBjYXNlIG9mIHRhcmdldG9pZCBoZW1vc2lkZXJvdGljIG5ldnVz?=","authors":"S. Jeong, J. Jung, D. Kwon, S. Seong, Ji Yun Jang, Jong Bin Park, M. Jang","doi":"10.7180/kmj.22.119","DOIUrl":"https://doi.org/10.7180/kmj.22.119","url":null,"abstract":"","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41489911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Shim, T. Lee, B. Choi, J. Ryu, Jung Hee Lee, K. Yang
{"title":"=?UTF-8?B?VHJhdW1hdGljIG5ldXJvbWEgb2YgdGhlIHJpZ2h0IHBvc3RlcmlvciBoZXBhdGljIGR1Y3Qgd2l0aCBhbiBhbmF0b21pYyB2YXJpYXRpb24gbWFzcXVlcmFkaW5nIGFzIG1hbGlnbmFuY3k6IGEgY2FzZSByZXBvcnQ=?=","authors":"J. Shim, T. Lee, B. Choi, J. Ryu, Jung Hee Lee, K. Yang","doi":"10.7180/kmj.22.135","DOIUrl":"https://doi.org/10.7180/kmj.22.135","url":null,"abstract":"","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43200473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several studies have reported that melatonin may be effective in treating sleep problems in children and adolescents. However, evidence regarding the safety of melatonin use in children and adolescents in their growth and developmental stages is warranted. Therefore, we aimed to summarize the literature on the safety of melatonin use in children and adolescents with insomnia and sleep disturbances. According to existing evidence, there are no serious adverse effects of long-term melatonin use in children and adolescents. The common adverse effects reported in long-term studies are fatigue, somnolence, and mood swings. In addition, there is no evidence that long-term use of melatonin inhibits the natural secretion of melatonin. It is necessary to monitor potential drug interactions with medications such as inhibitors and enhancers of cytochrome P450 1A2 (CYP1A2). Furthermore, low CYP1A2 expression in young children requires proper dose adjustment. Although sufficient experience of melatonin use in children and adolescents has yet to be attained, accumulating evidence suggests that the use of melatonin in children and adolescents with sleep problems might be effective and tolerable. Considering the abuse or overdose risk of hypnotics or benzodiazepines, melatonin supplements may be a good therapeutic alternative. Future studies on the long-term safety of melatonin for physiological and mental function in children and adolescents are required to establish certainty about melatonin use in children and adolescents.
{"title":"Safety issues regarding melatonin use in child and adolescent patients with sleep problems","authors":"E. Moon, Jung Hyun Lee","doi":"10.7180/kmj.22.142","DOIUrl":"https://doi.org/10.7180/kmj.22.142","url":null,"abstract":"Several studies have reported that melatonin may be effective in treating sleep problems in children and adolescents. However, evidence regarding the safety of melatonin use in children and adolescents in their growth and developmental stages is warranted. Therefore, we aimed to summarize the literature on the safety of melatonin use in children and adolescents with insomnia and sleep disturbances. According to existing evidence, there are no serious adverse effects of long-term melatonin use in children and adolescents. The common adverse effects reported in long-term studies are fatigue, somnolence, and mood swings. In addition, there is no evidence that long-term use of melatonin inhibits the natural secretion of melatonin. It is necessary to monitor potential drug interactions with medications such as inhibitors and enhancers of cytochrome P450 1A2 (CYP1A2). Furthermore, low CYP1A2 expression in young children requires proper dose adjustment. Although sufficient experience of melatonin use in children and adolescents has yet to be attained, accumulating evidence suggests that the use of melatonin in children and adolescents with sleep problems might be effective and tolerable. Considering the abuse or overdose risk of hypnotics or benzodiazepines, melatonin supplements may be a good therapeutic alternative. Future studies on the long-term safety of melatonin for physiological and mental function in children and adolescents are required to establish certainty about melatonin use in children and adolescents.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46634749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Namhee Kim, Yein Kim, Jeongeun Park, Ju-Ran Choi, H. Hwang
Background: The objective of this study was to determine whether manually performed calibration and quality control (QC) processes could be replaced with an automated laboratory system when installed analyzers fail to provide automated calibration and QC functions.Methods: Alanine aminotransferase (ALT), total cholesterol (TC), creatinine (Cr), direct bilirubin (DB), and lipase (Lip) items were used as analytes. We prepared pooled serum samples at 10 levels for each test item and divided them into two groups; five for the analytical measurement range (AMR) group and five for the medical decision point (MDP) group. Calibration and QC processes were performed for five consecutive days, and ALT, TC, Cr, DB, and Lip levels were measured in the two groups using automated and manual methods. Precision and the mean difference between the calibration and QC methods were evaluated using the reported values of the test items in each group.Results: Repeatability and within-laboratory coefficients of variation (CVs) between the automated system and the conventional manual system in the AMR group were similar. However, the mean reported values for test items were significantly different between the two systems. In the MDP group, repeatability and within-laboratory CVs were better with the automation system. All calibration and QC processes were successfully implemented with the Aptio total laboratory automation system.Conclusion: The Aptio total laboratory automation system could be applied to routine practice to improve precision and efficiency.
{"title":"Evaluation of automated calibration and quality control processes using the Aptio total laboratory automation system","authors":"Namhee Kim, Yein Kim, Jeongeun Park, Ju-Ran Choi, H. Hwang","doi":"10.7180/kmj.22.144","DOIUrl":"https://doi.org/10.7180/kmj.22.144","url":null,"abstract":"Background: The objective of this study was to determine whether manually performed calibration and quality control (QC) processes could be replaced with an automated laboratory system when installed analyzers fail to provide automated calibration and QC functions.Methods: Alanine aminotransferase (ALT), total cholesterol (TC), creatinine (Cr), direct bilirubin (DB), and lipase (Lip) items were used as analytes. We prepared pooled serum samples at 10 levels for each test item and divided them into two groups; five for the analytical measurement range (AMR) group and five for the medical decision point (MDP) group. Calibration and QC processes were performed for five consecutive days, and ALT, TC, Cr, DB, and Lip levels were measured in the two groups using automated and manual methods. Precision and the mean difference between the calibration and QC methods were evaluated using the reported values of the test items in each group.Results: Repeatability and within-laboratory coefficients of variation (CVs) between the automated system and the conventional manual system in the AMR group were similar. However, the mean reported values for test items were significantly different between the two systems. In the MDP group, repeatability and within-laboratory CVs were better with the automation system. All calibration and QC processes were successfully implemented with the Aptio total laboratory automation system.Conclusion: The Aptio total laboratory automation system could be applied to routine practice to improve precision and efficiency.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42782433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Moon, Sang-Il Lim, Yeonsoo Jung, Yuk Moon Heo, Seun-Ja Park, M. Park, Sung Eun Kim, Jae Hyun Kim, Kyoung-Hee Jung
{"title":"=?UTF-8?B?VGhlIGVmZmVjdHMgb2YgcmViYW1pcGlkZSwgc3VjcmFsZmF0ZSwgYW5kIHJpZmF4aW1pbiBhZ2FpbnN0IGluZmxhbW1hdGlvbiBhbmQgYXBvcHRvc2lzIGluIHJhZGlhdGlvbi1pbmR1Y2VkIG11cmluZSBpbnRlc3RpbmFsIGluanVyeQ==?=","authors":"W. Moon, Sang-Il Lim, Yeonsoo Jung, Yuk Moon Heo, Seun-Ja Park, M. Park, Sung Eun Kim, Jae Hyun Kim, Kyoung-Hee Jung","doi":"10.7180/kmj.22.140","DOIUrl":"https://doi.org/10.7180/kmj.22.140","url":null,"abstract":"","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43832663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyung-Yoon Jeon, Eun-Ji Ko, H. Chang, Seung-Hyun Lee, Byungkwon Ahn, Mee Sun Ock, Hee-Jae Cha
{"title":"=?UTF-8?B?Q29ycmVsYXRpb24gb2YgbG9uZyBpbnRlcnNwZXJzZWQgZWxlbWVudC0xIG9wZW4gcmVhZGluZyBmcmFtZSAxIGFuZCBjLU1ldCBwcm90by1vbmNvZ2VuZSBwcm90ZWluIGV4cHJlc3Npb24gaW4gcHJpbWFyeSBhbmQgcmVjdXJyZW50IGNvbG9yZWN0YWwgY2FuY2Vycw==?=","authors":"Kyung-Yoon Jeon, Eun-Ji Ko, H. Chang, Seung-Hyun Lee, Byungkwon Ahn, Mee Sun Ock, Hee-Jae Cha","doi":"10.7180/kmj.22.106","DOIUrl":"https://doi.org/10.7180/kmj.22.106","url":null,"abstract":"","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48218039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"=?UTF-8?B?QSBjYXNlIHJlcG9ydCBvZiBhIGNhcm90aWQgc3BhY2UgYWJzY2VzcyBkdWUgdG8gZXh0cmFsdW1pbmFsIG1pZ3JhdGlvbiBvZiBhIGZpc2hib25lIGludG8gdGhlIGRlZXAgY2VydmljYWwgc3BhY2U=?=","authors":"Tae H. Lee, Ki Ju Cho, S. Won, Jung Je Park","doi":"10.7180/kmj.22.141","DOIUrl":"https://doi.org/10.7180/kmj.22.141","url":null,"abstract":"","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48205973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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