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Method to quantify the decentration of the multifocal intraocular lenses in relation to the visual axis 方法量化多焦人工晶状体相对于视轴的离体
Pub Date : 2018-12-31 DOI: 10.15234/VPA.V17I4.513
F. Polit
Since position and centration have shown to affect the effectiveness of multifocal intraocular lenses (MFIOLs), some authors have proposed using the "coaxially sighted IOL light reflex" as a landmark to allow consistent centration of MFIOLs. Postoperatively, assessing the location of the intraocular lens with respect to the visual axis is also important. Centration of the MFIOLs can be identified postoperatively by slit lamp biomicroscopy, but it is still a qualitative method. The Nidek OPD Scan III is used. The instrument obtains retro illumination images, which allows the observation of the diffractive rings of the multifocal intraocular lenses implanted following phacoemulsification. The retro illumination image describes the location of the visual axis (white cross with blue borders +), the center of the photopic (pink cross) and mesopic (turquoise cross) pupil, quantifies the distance between the center of the pupil and the visual axis, and places the visual axis in degrees. It is attempted to match the rings of the lens with that of the acetate grid. Once the best possible equidistance between the lens and grid rings has been achieved. This method can be useful to be able to have reference of a real value of decentration of the lenses and thus have a surgical plan and try to center the lenses. We are also creating a technique to properly center the lenses, in addition to performing an analysis of the results in terms of postoperative visual quality in relation to the lens's decentration and thus see how this really affects.
由于位置和集中度会影响多焦人工晶状体(MFIOLs)的有效性,一些作者建议使用“同轴视人工晶状体光反射”作为一个标志,以使MFIOLs的集中度保持一致。术后,评估人工晶状体相对于视轴的位置也很重要。术后可通过裂隙灯生物显微镜检测MFIOLs的浓度,但仍是定性方法。使用Nidek OPD Scan III。该仪器获得复古照明图像,允许观察超声乳化术后植入的多焦人工晶状体的衍射环。复古照明图像描述了视轴(白色十字带蓝色边框+)、感光瞳孔中心(粉色十字)和介观瞳孔中心(绿松石十字)的位置,量化了瞳孔中心与视轴之间的距离,并将视轴以度表示。它试图将镜头的环与醋酸网格的环相匹配。一旦镜头和栅格环之间达到了最佳的等距。这种方法可以为晶状体离心的实际值提供参考,从而制定手术计划并尝试使晶状体居中。我们也在创造一种技术来正确地将晶状体居中,除了对术后视觉质量与晶状体分散的关系进行分析,从而了解这是如何影响的。
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引用次数: 0
Lo mejor del año en uveítis 2017 2017年葡萄膜炎年度最佳
Pub Date : 2018-12-31 DOI: 10.15234/VPA.V17I4.496
C. Martínez-Rubio, P. Martínez-Lopez-Corell, Isabel Pascual-Camps, R. Gallego-Pinazo, R. Dolz-Marco, M. Díaz-Llopis
OBJETIVO: Facilitar el estudio de las aportaciones mas relevantes en el campo de la inflamacion ocular y uveitis. Se propone una revision de las principales revistas internacionales, incluyendo: Ophthalmology, American Journal of Ophthalmology, Retina, Ocular Inmunology and Inflammation y Journal of Ophthalmic Infection and Inflammation METODO: Revision bibliografica descriptiva de los articulos publicados durante el ano 2017 en las revistas anteriormente citadas. RESULTADOS De forma narrativa, se analizan las categorias de uveitis pediatricas, escleritis, uveitis infecciosas, uveitis no infecciosas, diagnostico y tratamiento CONCLUSIONES El campo de la inflamacion ocular y la uveitis evoluciona a gran velocidad, y durante el ano 2017 hemos sido testigos de un gran numero de publicaciones de alto impacto a nivel clinico, diagnostico y terapeutico.
目的:促进眼炎和葡萄膜炎领域最相关贡献的研究。我们建议对主要国际期刊进行综述,包括:《眼科》、《美国眼科杂志》、《视网膜》、《眼免疫学与炎症》和《眼感染与炎症方法杂志》:对2017年在上述期刊上发表的文章进行描述性文献综述。结果叙述的形式,分析了categorias uveitis pediatricas escleritis、uveitis非感染性传染病,uveitis diagnostico和治疗领域的结论inflamacion目镜和uveitis高速发展,在肛门2017年我们目睹了众多高水平临床影响出版物diagnostico terapeutico。
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引用次数: 0
Metformin activity in an in vitro model of posterior capsule opacification 二甲双胍在体外后囊膜混浊模型中的活性
Pub Date : 2018-12-31 DOI: 10.15234/VPA.V17I4.511
J. Lasiste, P. Zoroquiain, D. Miyamoto, M. Burnier
Purpose: To determine the activity of metformin in an in vitro model of posterior capsule opacification (PCO).Design: Experimental laboratory research. Methods: The HLE-B3 lens epithelial cell line was treated with PCO induction media (PCOM) supplemented with transforming growth factor-beta (TGF-β) and fibroblast growth factor (FGF). Different metformin concentrations (0-100 mM) were used. The following cellular parameters were assessed: (1) survival, using a viability assay; (2) morphology, via microscopy and image analysis; (3) migration, using the wound assay; (4) and expression of epithelial (Pax6, E-cadherin) and mesenchymal (α-smooth muscle actin or α-SMA, fibronectin) markers via Western blot. Expression of the uptake receptor SLC22A1 was evaluated in HLE-B3 and in human donor eyes with Western blot and immunohistochemistry, respectively. Statistical analysis of variance (ANOVA) with Tukey post-hoc test was done for analysis of cytotoxicity, morphology and migration data. Results: Metformin was lethal to half (LC50) of the cells at 30 mM, and a decrease in viability (P<0.05) was noted at 5 mM. LECs in PCOM treated with 1 mM metformin showed increased Pax6 and E-cadherin and decreased α-SMA and fibronectin expression. LECs in PCOM treated with metformin also maintained epithelial morphology. Migration was inhibited with 0.5 mM metformin (P<0.05). Both HLE-B3 and the lens epithelium in donor eyes were found to express SLC22A1.Conclusion: Metformin decreased survival and migration in LECs, maintaining epithelial phenotype and reducing mesenchymal marker expression. Metformin therefore has potential as an adjunct in PCO prevention.Financial Disclosures: This work was partially funded by Mitacs Canada.
目的:测定二甲双胍在后囊膜混浊(PCO)模型中的活性。设计:实验实验室研究。方法:用PCO诱导培养基(PCOM)加转化生长因子-β (TGF-β)和成纤维细胞生长因子(FGF)处理HLE-B3晶状体上皮细胞系。采用不同二甲双胍浓度(0 ~ 100 mM)。评估以下细胞参数:(1)存活率,采用活力测定法;(2)形态学,通过显微镜和图像分析;(3)迁移,采用伤口试验;(4) Western blot检测上皮(Pax6, E-cadherin)和间质(α-平滑肌肌动蛋白或α-SMA,纤维连接蛋白)标志物的表达。采用Western blot和免疫组织化学方法分别评价HLE-B3和人供体眼中摄取受体SLC22A1的表达。采用统计学方差分析(ANOVA)和Tukey事后检验分析细胞毒性、形态学和迁移数据。结果:二甲双胍在30 mM时致半数细胞死亡(LC50), 5 mM时细胞活力降低(P<0.05), 1 mM二甲双胍处理后PCOM细胞中Pax6和E-cadherin表达升高,α-SMA和纤维连接蛋白表达降低。二甲双胍处理的PCOM上皮细胞也保持了上皮形态。0.5 mM二甲双胍对迁移有抑制作用(P<0.05)。供体眼的HLE-B3和晶状体上皮均表达SLC22A1。结论:二甲双胍降低LECs的存活和迁移,维持上皮表型,降低间充质标志物的表达。因此,二甲双胍有可能作为预防PCO的辅助手段。财务披露:这项工作部分由Mitacs Canada资助。
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引用次数: 2
BILATERAL ABDUCENS NERVE PALSY SECUNDARY TO INTRACRANIAL SINUSES THROMBOSIS IN A CHILD WITH NEPHROTIC SYNDROM – CASE REPORT 儿童肾病综合征继发于颅内窦血栓形成的双侧外展神经麻痹1例
Pub Date : 2018-12-31 DOI: 10.15234/VPA.V17I4.507
L. Alves, L. Selegatto, C. Batalha, Gustavo Bueno De Camargo, Marcelo Sobrinho
We report a case of a child with nephrotic syndrome (NS), who presented an acute convergent strabismus, double vision and papilledema one week after a history of badly treated sinusitis. The image study revealed an extensive thrombosis of the intracranial sinuses that was treated with intravenous heparin and oral corticosteroids. Four months later, the case evolved with spontaneous resolution of the ocular deviation and no diplopia.
我们报告一个儿童肾病综合征(NS)的情况下,谁提出了急性会聚性斜视,双重视力和乳头水肿后一周的历史治疗不良的鼻窦炎。图像研究显示颅内窦广泛血栓形成,静脉注射肝素和口服皮质类固醇治疗。4个月后,患者眼偏自行消退,无复视。
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引用次数: 0
MESSAGE FROM THE CHAIRMAN, PAOF BOARD 来自董事会主席的信息
Pub Date : 2018-12-31 DOI: 10.15234/vpa.v17i4.529
Jorge Garcia
MESSAGE FROM THE CHAIRMAN, PAOF BOARD
来自董事会主席的信息
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引用次数: 0
ALLERGAN 爱力根
Pub Date : 2018-10-03 DOI: 10.15234/vpa.v17i4.533
P. E. Dantas
ALLERGAN
爱力根
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引用次数: 6
Inferior bullous keratopathy caused by iris fibers, resolved with diode laser 532 虹膜纤维引起的下大疱性角膜病变,用二极管激光532治疗
Pub Date : 2018-10-03 DOI: 10.15234/VPA.V17I3.498
A. Polit, F. Polit, J. Pólit
Purpose: To describe a case of inferior bullous keratopathy caused by iris fibers resolved with laser diode 532.Case report: A 74-year-old woman consulted for deterioration of visual acuity in right eye, accompanied by foreign body sensation. A phacoemulsification surgery with IOL implant had been performed in both eyes three months before. Best corrected visual acuity reached 20/40 in right eye. Slit lamp examination revealed bullous keratopathy located in the central inferior quarter of the cornea of her right eye. Gonosioscopy was performed to rule out having nucleus fragments in the inferior angle. With higher magnification, a pair of fine undulating fibers were observed coming from the anterior layers of the iris and making contact with the posterior face of the cornea. Photocoagulation of the iris fibers was performed with laser diode 532 and photodisruption with Nd-YAG laser, applied at the base of the fibers. After nine days, resolution of corneal edema, and disappearance of bullae was observed.  Best corrected visual acuity improved to of 20/25.Conclusions: photocoagulation of iris fibers with laser diode 532 complemented with photodisruption with Nd-YAG laser, in patients with iridoschisis, is an alternative to avoid endothelial decompensation and corneal edema, which may require a corneal transplantation.
目的:报告1例虹膜纤维性下大疱性角膜病变,应用激光二极管532治疗。病例报告:一名74岁女性因右眼视力减退伴异物感就诊。三个月前,患者曾接受双眼超声乳化人工晶状体植入术。右眼最佳矫正视力达到20/40。裂隙灯检查显示其右眼角膜中央下四分之一处有大疱性角膜病变。进行鼻镜检查以排除下角有核碎片。在高倍镜下,可以看到一对细小的波状纤维从虹膜的前层发出,并与角膜的后表面接触。用激光二极管532对虹膜纤维进行光凝固,用Nd-YAG激光在纤维底部进行光破坏。9 d后,观察角膜水肿消退,大疱消失。最佳矫正视力提高至20/25。结论:对于虹膜裂患者,激光二极管532联合Nd-YAG激光对虹膜纤维进行光凝治疗是避免内皮失代偿和角膜水肿的一种替代方法,这可能需要角膜移植。
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引用次数: 0
JOHNSON&JOHNSON
Pub Date : 2018-10-03 DOI: 10.15234/vpa.v17i4.537
P. E. Dantas
JOHNSON&JOHNSON
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引用次数: 5
VPA DIGITAL AT YOUR FINGERTIPS Vpa数字在您的指尖
Pub Date : 2018-10-03 DOI: 10.15234/vpa.v17i4.539
P. E. Dantas
VPA DIGITAL AT YOUR FINGERTIPS
Vpa数字在您的指尖
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引用次数: 0
RESULTADOS Y COMPLICACIONES DE CIRUGÍA DE CATARATA POR FACOEMULSIFICACIÓN 超声乳化白内障手术的结果及并发症
Pub Date : 2018-10-03 DOI: 10.15234/VPA.V17I3.495
Denis Anaya Reyes, Juan F. DíazGranados, Laura Toro-Giraldo, M. Neira, Mario Osorio
RESUMEN: Objetivo : Describir resultados y complicaciones de pacientes llevados a cirugia de catarata por facoemulsificacion mas implante de lente intraocular en el Hospital de San Jose y explorar la asociacion entre posibles factores relacionados con complicaciones intraoperatorias. Materiales y metodos: Cohorte retrospectiva. Se incluyeron todos los ojos operados de catarata por facoemulsificacion entre 2010 y 2016. Se excluyeron casos con registros insuficientes, convertidos a extraccion extracapsular de catarata por causas diferentes a complicaciones y en los cuales se realizo cirugia combinada programada. Se describieron caracteristicas especiales intraoperatorias del ojo, dureza de la catarata, colaboracion intraoperatoria del paciente, resultados visuales y refractivos y complicaciones, durante el primer mes postoperatorio. Se evaluo la relacion entre caracteristicas especiales del ojo y complicaciones intraoperatorias usando la prueba de chicuadrado y considerando un p valor inferior a 0.05 como estadisticamente significativo Resultados: Se incluyeron 2175 ojos, se excluyeron 128, para 2047 estudiados. Al mes postoperatorio, el 86.8% alcanzo agudeza visual corregida de 20/40 o mejor y el 75.2% equivalente esferico de ± 1.00D. Los ojos con alguna caracteristica especial presentaron mas complicaciones intraoperatorias (p=0.01), al igual que aquellos con catarata extremadamente dura (p=0.003) y con colaboracion deficiente durante la cirugia (p<0.000). La complicacion intraoperatoria mas frecuente fue ruptura de capsula posterior y la postoperatoria, opacidad de capsula posterior.  Conclusiones: Se obtuvieron resultados visuales y refractivos satisfactorios y la incidencia de complicaciones fue similar a la reportada en la literatura. La identificacion de caracteristicas especiales intraoperatorias es importante dada su asociacion con mayor incidencia de complicaciones. ABSTRACT: Purpose: To describe outcomes and complications of patients underwent phacoemulsification cataract surgery with intraocular lens implantation in the San Jose Hospital and explore the association between possible factors with intraoperative complications. Materials and methods: Retrospective cohort. There was included all the eyes undergoing phacoemulsification cataract surgery between 2010 and 2016. There was excluded cases with insufficient records, cases converted to extracapsular cataract extraction by causes different of complications and those wich underwent scheduled combined surgery. There was described intraoperative special characteristics of the eye, cataract hardness, intraoperative colaboration of the patient, visual and refractive outcomes and complications during the first postoperative month. The association between special characteristics of the eye and intraoperative complications was evaluated using the chi square test considering a p value less than 0.05 as statistically significant. Results: There was included 2175 eyes and 128 excluded, for a tot
摘要:目的:描述在San Jose医院进行白内障超声乳化加人工晶状体手术的患者的结果和并发症,并探讨与术中并发症相关的可能因素之间的关系。方法:回顾性队列研究。我们纳入了2010年至2016年期间通过超声乳化进行白内障手术的所有眼睛。我们排除了记录不足、因非并发症原因而转为囊外摘除的病例,以及计划进行联合手术的病例。我们描述了术后第一个月眼睛的特殊术中特征、白内障的硬度、患者的术中合作、视觉和屈光结果以及并发症。结果:在2047例研究中,纳入2175只眼,排除128只眼,采用chicuadrado检验评估眼部特殊特征与术中并发症之间的关系,p值小于0.05具有统计学意义。术后一个月,86.8%的患者矫正视力达到20/40或更好,75.2%的患者达到±1.00D的球形等效视力。有特殊特征的眼睛有更多的术中并发症(p=0.01),非常严重的白内障(p=0.003)和手术中配合不良(p<0.000)。手术中最常见的并发症是后囊破裂,术后后囊混浊。结果:在一项随机对照试验中,患者的视力和屈光效果均较好,并发症发生率与文献报道的相似。确定术中特殊特征是很重要的,因为它们与较高的并发症发生率有关。摘要:目的:描述圣何塞医院眼内透镜植入白内障手术患者的结果和并发症,探讨可能因素与术中并发症之间的关系。材料与方法:回顾性队列研究。There was all the眼睛所列undergoing phacoemulsification cataract surgery 2010年与2016。There was excluded cases with记录不足、cases converted to extracapsular cataract提取制造不同of必须和那些wich underwent化combined surgery。在第一次手术后的第一个月里,描述了眼科的特殊术中特征、白内障的硬度、患者的术中合作、视觉和屈光效果及并发症。采用卡方检验评估眼部特殊特征与术中并发症之间的关联,p值小于0.05具有统计学意义。= =地理= =根据美国人口普查,这个县的总面积为,其中土地和(3.064平方公里)水。A month postoperatively, the 86.8%一最佳视觉corrected accuity of 20/40 or better and the 75.2% spherical equivalent of±1.00D。有特殊特征的眼睛出现更多的术中并发症(p=0.01),与极硬白内障(p=0.003)和手术中配合不良(p<0.000)相同。最常见的术中并发症是后囊破裂,最常见的术后并发症是后囊混浊。结论:取得了满意的视觉和屈光效果,并发症发生率与文献报道的相似。确定intraoperative特殊的特征两eye is important to its协会with higher年of必须。
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Vision PanAmerica
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