首页 > 最新文献

Doklady Chemistry最新文献

英文 中文
New Method for the Preparation of 2,3-Disubstituted 2,3-Dihydrothiazolo[3,2-a]pyrimidines 制备2,3-二取代2,3-二氢噻唑[3,2-a]嘧啶的新方法
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822700070
A. S. Agarkov, A. A. Kozhikhov, A. A. Nefedova, A. S. Ovsyannikov, D. R. Islamov, S. E. Solovieva,  I. S. Antipin

A new approach to the synthesis of 2,3-disubstituted 2,3-dihydrothiazolo[3,2-a]pyrimidines under microwave activation conditions has been developed. The method consists in the nucleophilic addition of methanol to 2-arylmethylidene derivatives of thiazolo[3,2-a]pyrimidine followed by intramolecular rearrangement to form 3,5-diaryl-2,3-dihydrothiazolo[3,2-a]pyrimidine-2,6-dicarboxylates.

研究了在微波活化条件下合成2,3-二取代2,3-二氢噻唑[3,2- A]嘧啶的新方法。该方法是在噻唑[3,2-a]嘧啶的2-芳基甲基衍生物上亲核加成甲醇,然后在分子内重排形成3,5-二烷基-2,3-二氢噻唑[3,2-a]嘧啶-2,6-二羧酸盐。
{"title":"New Method for the Preparation of 2,3-Disubstituted 2,3-Dihydrothiazolo[3,2-a]pyrimidines","authors":"A. S. Agarkov,&nbsp;A. A. Kozhikhov,&nbsp;A. A. Nefedova,&nbsp;A. S. Ovsyannikov,&nbsp;D. R. Islamov,&nbsp;S. E. Solovieva,&nbsp; I. S. Antipin","doi":"10.1134/S0012500822700070","DOIUrl":"10.1134/S0012500822700070","url":null,"abstract":"<p>A new approach to the synthesis of 2,3-disubstituted 2,3-dihydrothiazolo[3,2<i>-a</i>]pyrimidines under microwave activation conditions has been developed. The method consists in the nucleophilic addition of methanol to 2-arylmethylidene derivatives of thiazolo[3,2-<i>a</i>]pyrimidine followed by intramolecular rearrangement to form 3,5-diaryl-2,3-dihydrothiazolo[3,2-<i>a</i>]pyrimidine-2,6-dicarboxylates.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 2","pages":"177 - 183"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5148448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Synthesis of Novel Derivatives of 5-Aryl/thienyl-[1,2,4]triazolo[4,3-c]quinazoline 5-芳基/噻吩基-[1,2,4]三唑啉[4,3-c]喹唑啉新衍生物的合成
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822600298
E. V. Nosova, A. E. Kopotilova, M. D. Likhacheva, T. N. Moshkina, D. S. Kopchuk

[1,2,4]Triazolo[4,3-c]quinazolines bearing p-bromophenyl or 5-bromothiophen-2-yl moiety at position 5 have been synthesized by cyclocondensation of the corresponding 4-hydrazinoquinazolines with ortho esters in boiling ethanol or glacial acidic acid. The synthesized tricyclic derivatives represent valuable intermediates for design of fluorophores and biologically active compounds. The possibility of modifying 5-(4-bromophenyl) derivatives by cross-coupling reaction has been demonstrated.

以4-肼基喹啉为原料,在沸水乙醇或冰酸中与邻苯二甲酸酯进行环缩合,合成了含有5位对溴苯基或5-溴噻吩-2-基的三唑[4,3-c]喹唑啉。合成的三环衍生物为设计荧光团和生物活性化合物提供了有价值的中间体。证明了用交叉偶联反应修饰5-(4-溴苯基)衍生物的可能性。
{"title":"Synthesis of Novel Derivatives of 5-Aryl/thienyl-[1,2,4]triazolo[4,3-c]quinazoline","authors":"E. V. Nosova,&nbsp;A. E. Kopotilova,&nbsp;M. D. Likhacheva,&nbsp;T. N. Moshkina,&nbsp;D. S. Kopchuk","doi":"10.1134/S0012500822600298","DOIUrl":"10.1134/S0012500822600298","url":null,"abstract":"<p>[1,2,4]Triazolo[4,3-<i>c</i>]quinazolines bearing <i>p</i>-bromophenyl or 5-bromothiophen-2-yl moiety at position 5 have been synthesized by cyclocondensation of the corresponding 4-hydrazinoquinazolines with ortho esters in boiling ethanol or glacial acidic acid. The synthesized tricyclic derivatives represent valuable intermediates for design of fluorophores and biologically active compounds. The possibility of modifying 5-(4-bromophenyl) derivatives by cross-coupling reaction has been demonstrated.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 2","pages":"164 - 167"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5145274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Polyfunctional Oligoetherdiols Based on Allyl Glycidyl Ether 烯丙基缩水甘油醚合成多官能团低聚醚二醇
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822700082
T. V. Grinevich, M. L. Pridatchenko, D. B. Vinogradov, P. V. Bulatov,  A. A. Berlin

The bromination reaction of oligoetherdiol derived from allyl glycidyl ether by two procedures has been studied. It has been shown that one procedure provides monohydroxy conpounds and compounds containing no OH groups along with completely brominated oligoetherdiol. Their formation has been supposed to proceed via cyclodehydrobromination reaction due to elimination of one or two hydrogen bromide molecules from oligoetherdiol to form dioxane and dioxepane cyclic fragments. Conditions for complete bromination of oligodiol with retention of OH group functionality have been determined.

研究了由烯丙基缩水甘油酯醚经两种方法合成的低聚醚二醇的溴化反应。已经证明,一种方法可以得到单羟基化合物和不含OH基团的化合物以及完全溴化的低聚醚二醇。它们的形成被认为是通过环脱氢溴化反应进行的,因为从低聚醚二醇中消除了一个或两个溴化氢分子,形成二氧六环和二氧六环碎片。确定了保留羟基官能团的低聚二醇完全溴化反应的条件。
{"title":"Synthesis of Polyfunctional Oligoetherdiols Based on Allyl Glycidyl Ether","authors":"T. V. Grinevich,&nbsp;M. L. Pridatchenko,&nbsp;D. B. Vinogradov,&nbsp;P. V. Bulatov,&nbsp; A. A. Berlin","doi":"10.1134/S0012500822700082","DOIUrl":"10.1134/S0012500822700082","url":null,"abstract":"<p>The bromination reaction of oligoetherdiol derived from allyl glycidyl ether by two procedures has been studied. It has been shown that one procedure provides monohydroxy conpounds and compounds containing no OH groups along with completely brominated oligoetherdiol. Their formation has been supposed to proceed via cyclodehydrobromination reaction due to elimination of one or two hydrogen bromide molecules from oligoetherdiol to form dioxane and dioxepane cyclic fragments. Conditions for complete bromination of oligodiol with retention of OH group functionality have been determined.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 1","pages":"146 - 150"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5152806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Method to Prepare Ni/La2O3 Nanocomposites—Efficient Catalysts for the Partial Oxidation of Methane into Syngas 制备Ni/La2O3纳米复合材料的新方法——甲烷部分氧化制合成气的高效催化剂
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822600328
A. G. Dedov, A. S. Loktev, A. V. Gavrikov, M. A. Bykov, I. E. Mukhin, A. B. Ilyukhin

A new method was developed to prepare nanoscale Ni/La2O3 composites—efficient catalysts of the partial oxidation of methane (POM) into syngas. The catalysts are formed in situ during POM from LaNiO3 obtained by the thermal decomposition of heterometallic La–Ni nitrate complexes. The catalysts ensure an almost 100% yield of syngas and are resistant to carbon deposition.

提出了一种制备纳米Ni/La2O3复合材料的新方法——甲烷部分氧化制合成气的高效催化剂。这些催化剂是由La-Ni硝酸络合物热分解得到的LaNiO3在POM过程中原位生成的。这些催化剂确保了几乎100%的合成气产率,并且能够抵抗碳沉积。
{"title":"A New Method to Prepare Ni/La2O3 Nanocomposites—Efficient Catalysts for the Partial Oxidation of Methane into Syngas","authors":"A. G. Dedov,&nbsp;A. S. Loktev,&nbsp;A. V. Gavrikov,&nbsp;M. A. Bykov,&nbsp;I. E. Mukhin,&nbsp;A. B. Ilyukhin","doi":"10.1134/S0012500822600328","DOIUrl":"10.1134/S0012500822600328","url":null,"abstract":"<p>A new method was developed to prepare nanoscale Ni/La<sub>2</sub>O<sub>3</sub> composites—efficient catalysts of the partial oxidation of methane (POM) into syngas. The catalysts are formed in situ during POM from LaNiO<sub>3</sub> obtained by the thermal decomposition of heterometallic La–Ni nitrate complexes. The catalysts ensure an almost 100% yield of syngas and are resistant to carbon deposition.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 1","pages":"151 - 158"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5149652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiradical Activity of Polycyclic Compounds with Indole and Isoindole Moieties 吲哚和异吲哚多环化合物的抗自由基活性
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822600316
V. P. Osipova, M. A. Polovinkina, A. D. Kolumbet, E. N. Kutlalieva, A. V. Velikorodov, N. T. Berberova

The antiradical activity of polycyclic compounds with indole and isoindole moieties was evaluated in vitro using a number of assays. All tested compounds, except for 3,5-di(tert-butyl)-4-hydroxybenzenecarbaldehyde N-(2-oxo-1,2-dihydro-3H-indole-3-ylidene)hydrazone, demonstrated much lower activity towards DPPH, ABTS•+, and NO radicals than the well-known antioxidant ionol. All compounds showed a high radical-scavenging capacity relative to the superoxide radical anion generated in the enzymatic (NBT assay) and non-enzymatic (epinephrine autoxidation) systems. The high antiradical activity of 3,5-di(tert-butyl)-4-hydroxybenzenecarbaldehyde N-(2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazone is attributable to the presence of 2,6-di-tert-butylphenol, indoline, and azine moieties, which promote the formation of a stable intermediate.

多环化合物的抗自由基活性与吲哚和异吲哚的部分进行了评估,在体外使用一些测定。除了3,5-二(叔丁基)-4-羟基苯甲醛N-(2-氧-1,2-二氢- 3h -吲哚-3-酰基)腙外,所有被测试的化合物对DPPH、ABTS•+和NO•自由基的活性都比众所周知的抗氧化剂离子醇低得多。与酶法(NBT测定)和非酶法(肾上腺素自氧化)系统中产生的超氧自由基阴离子相比,所有化合物都显示出较高的自由基清除能力。3,5-二(叔丁基)-4-羟基苯乙醛N-(2-氧-1,2-二氢- 3h -吲哚-3-酰基)腙具有较高的抗自由基活性,这是由于2,6-二叔丁基酚、吲哚和氮的存在,促进了稳定中间体的形成。
{"title":"Antiradical Activity of Polycyclic Compounds with Indole and Isoindole Moieties","authors":"V. P. Osipova,&nbsp;M. A. Polovinkina,&nbsp;A. D. Kolumbet,&nbsp;E. N. Kutlalieva,&nbsp;A. V. Velikorodov,&nbsp;N. T. Berberova","doi":"10.1134/S0012500822600316","DOIUrl":"10.1134/S0012500822600316","url":null,"abstract":"<p>The antiradical activity of polycyclic compounds with indole and isoindole moieties was evaluated in vitro using a number of assays. All tested compounds, except for 3,5-di(<i>tert</i>-butyl)-4-hydroxybenzenecarbaldehyde <i>N</i>-(2-oxo-1,2-dihydro-3<i>H</i>-indole-3-ylidene)hydrazone, demonstrated much lower activity towards DPPH, ABTS<sup>•+</sup>, and NO<sup>•</sup> radicals than the well-known antioxidant ionol. All compounds showed a high radical-scavenging capacity relative to the superoxide radical anion generated in the enzymatic (NBT assay) and non-enzymatic (epinephrine autoxidation) systems. The high antiradical activity of 3,5-di(<i>tert</i>-butyl)-4-hydroxybenzenecarbaldehyde <i>N</i>-(2-oxo-1,2-dihydro-3<i>H</i>-indol-3-ylidene) hydrazone is attributable to the presence of 2,6-di-<i>tert</i>-butylphenol, indoline, and azine moieties, which promote the formation of a stable intermediate.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 2","pages":"159 - 163"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5153608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Versatile Method for the Synthesis of 7-Aminoazolo[1,5-a]pyrimidine-6-carbonitriles 合成7-氨基偶氮[1,5- A]嘧啶-6-碳腈的通用方法
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822600304
G. V. Urakov, K. V. Savateev,  V. L. Rusinov

Nitrile-containing azoloazines with a bridged nitrogen atom are of interest as molecules with potential antiviral and antidiabetic activity. To date, a few corresponding 7-aminoazolo[1,5-a]pyrimidine-6-carbonitriles has been described in the literature and there is no universal method for their synthesis, which limits the possibility to optimize structure for preparing derivatives with prescribed biological activity. In the present work, we have studied different conditions for cyclocondensation of aminoazoles and (ethoxymethylidene)malononotrile; we have shown that optimal method for synthesis of 7-aminoazolo[1,5-a]pyrimidine-6-carbonitriles is the heating of initial components in pyridine. This method provides a library of different nitrileazolopyrimidines containing both electron-donating and electron-withdrawing substituents in the azole fragment.

具有桥接氮原子的含腈偶氮嗪类分子具有潜在的抗病毒和抗糖尿病活性。迄今为止,文献中已经描述了一些相应的7-氨基偶氮[1,5-a]嘧啶-6-碳腈,但没有通用的合成方法,这限制了优化结构以制备具有规定生物活性的衍生物的可能性。本文研究了氨基唑和(乙氧基甲基)丙二腈在不同条件下的环缩合反应;我们已经证明了合成7-氨基偶氮[1,5-a]嘧啶-6-碳腈的最佳方法是在吡啶中加热初始组分。该方法提供了在唑片段中含有供电子和吸电子取代基的不同硝基氮唑嘧啶库。
{"title":"A Versatile Method for the Synthesis of 7-Aminoazolo[1,5-a]pyrimidine-6-carbonitriles","authors":"G. V. Urakov,&nbsp;K. V. Savateev,&nbsp; V. L. Rusinov","doi":"10.1134/S0012500822600304","DOIUrl":"10.1134/S0012500822600304","url":null,"abstract":"<p>Nitrile-containing azoloazines with a bridged nitrogen atom are of interest as molecules with potential antiviral and antidiabetic activity. To date, a few corresponding 7-aminoazolo[1,5-<i>a</i>]pyrimidine-6-carbonitriles has been described in the literature and there is no universal method for their synthesis, which limits the possibility to optimize structure for preparing derivatives with prescribed biological activity. In the present work, we have studied different conditions for cyclocondensation of aminoazoles and (ethoxymethylidene)malononotrile; we have shown that optimal method for synthesis of 7-aminoazolo[1,5-<i>a</i>]pyrimidine-6-carbonitriles is the heating of initial components in pyridine. This method provides a library of different nitrileazolopyrimidines containing both electron-donating and electron-withdrawing substituents in the azole fragment.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 2","pages":"168 - 176"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5146667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acetylene in Organic Synthesis. From the Chaos of Small Molecules to Highly Organized Structures. A Review 有机合成中的乙炔。从小分子的混沌到高度组织的结构。回顾
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2023-01-30 DOI: 10.1134/S0012500822700069
E. Yu. Schmidt,  B. A. Trofimov

The review highlights the recently discovered superbase-promoted self-organization of complex molecular structures of great synthetic significance with the participation of acetylene (a large-tonnage industrial feedstock) and simple available nucleophilic molecules. The self-organization comprises a concerted sequence of elementary chemical stages involving several molecules of acetylene, which ultimately leads to a one-pot synthesis of complex highly reactive molecular systems structurally close to essential natural compounds. This new phenomenon in organic chemistry fundamentally expands the possibilities of acetylene-driven fine organic synthesis and meets the requirements of green chemistry (one pot, atom and energy economy, theoretical waste-free production, low carbon footprint).

本文重点介绍了最近发现的在乙炔(一种大吨位工业原料)和简单的亲核分子的参与下,由超碱基促进的复杂分子结构的自组织,具有重要的合成意义。自组织包括包括几个乙炔分子的基本化学阶段的协调序列,最终导致一锅合成复杂的高活性分子体系,在结构上接近基本的天然化合物。这一有机化学新现象从根本上拓展了乙炔驱动的精细有机合成的可能性,满足了绿色化学(一锅、原子和能源经济、理论上无废生产、低碳足迹)的要求。
{"title":"Acetylene in Organic Synthesis. From the Chaos of Small Molecules to Highly Organized Structures. A Review","authors":"E. Yu. Schmidt,&nbsp; B. A. Trofimov","doi":"10.1134/S0012500822700069","DOIUrl":"10.1134/S0012500822700069","url":null,"abstract":"<p>The review highlights the recently discovered superbase-promoted self-organization of complex molecular structures of great synthetic significance with the participation of acetylene (a large-tonnage industrial feedstock) and simple available nucleophilic molecules. The self-organization comprises a concerted sequence of elementary chemical stages involving several molecules of acetylene, which ultimately leads to a one-pot synthesis of complex highly reactive molecular systems structurally close to essential natural compounds. This new phenomenon in organic chemistry fundamentally expands the possibilities of acetylene-driven fine organic synthesis and meets the requirements of green chemistry (one pot, atom and energy economy, theoretical waste-free production, low carbon footprint).</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"505 1","pages":"127 - 145"},"PeriodicalIF":0.8,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5149651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antioxidant Activity of Catechol Thioethers with Heterocyclic Moieties in Reactions with Radical Promoters 杂环邻苯二酚硫醚与自由基促进剂反应的抗氧化活性
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2022-11-03 DOI: 10.1134/S0012500822600134
I. V. Smolyaninov, D. A. Burmistrova, N. P. Pomortseva, A. I. Poddel’sky, N. T. Berberova

Novel thioethers with nitrogen- and oxygen-containing heterocyclic moieties and a redox-active catechol group were synthesized. The radical scavenging and antioxidant activities of the compounds were studied in reactions with synthetic radicals and in the DNA oxidative damage. The catechols with nitrogen-containing heterocyclic substituents or a furan ring showed pronounced radical scavenging activity in reactions with diphenylpicrylhydrazyl or generated 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation. In the case of DNA oxidative damage, a dual anti/pro-oxidant effect was found. Catechol thioethers with methoxybenzoxazole or furan rings showed the highest activity in all biological assays.

合成了含氮、含氧杂环基团和具有氧化还原活性的儿茶酚基团的新型硫醚。在与合成自由基反应和DNA氧化损伤时,研究了化合物的自由基清除和抗氧化活性。含有含氮杂环取代基或呋喃环的儿茶酚在与二苯基吡啶肼反应时具有明显的自由基清除活性或生成2,2′-氮基-双(3-乙基苯并噻唑-6-磺酸)自由基阳离子。在DNA氧化损伤的情况下,发现了抗/促氧化双重作用。具有甲氧基苯并恶唑或呋喃环的邻苯二酚硫醚在所有生物试验中表现出最高的活性。
{"title":"Antioxidant Activity of Catechol Thioethers with Heterocyclic Moieties in Reactions with Radical Promoters","authors":"I. V. Smolyaninov,&nbsp;D. A. Burmistrova,&nbsp;N. P. Pomortseva,&nbsp;A. I. Poddel’sky,&nbsp;N. T. Berberova","doi":"10.1134/S0012500822600134","DOIUrl":"10.1134/S0012500822600134","url":null,"abstract":"<p>Novel thioethers with nitrogen- and oxygen-containing heterocyclic moieties and a redox-active catechol group were synthesized. The radical scavenging and antioxidant activities of the compounds were studied in reactions with synthetic radicals and in the DNA oxidative damage. The catechols with nitrogen-containing heterocyclic substituents or a furan ring showed pronounced radical scavenging activity in reactions with diphenylpicrylhydrazyl or generated 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation. In the case of DNA oxidative damage, a dual anti/pro-oxidant effect was found. Catechol thioethers with methoxybenzoxazole or furan rings showed the highest activity in all biological assays.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"504 2","pages":"100 - 105"},"PeriodicalIF":0.8,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4137702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nickel-Catalyzed N-Arylation of C-Amino-1,2,4-triazoles with Arylboronic Acids 镍催化c -氨基-1,2,4-三唑与芳香硼酸的n -芳基化反应
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2022-11-03 DOI: 10.1134/S0012500822700057
A. Yu. Chernenko, V. A. Baydikova, A. V. Astakhov, M. E. Minyaev, V. M. Chernyshev

Nickel-catalyzed N-arylation of C-amino-1,2,4-triazoles with arylboronic acids was studied for the first time. An efficient catalytic system based on nickel chloride and phenanthroline was developed and a new method for the preparation of 1-substituted 3(5)-arylamino-1,2,4-triazoles was proposed.

首次研究了镍催化c -氨基-1,2,4-三唑与芳基硼酸的n -芳基化反应。建立了以氯化镍和邻菲罗啉为原料的高效催化体系,提出了制备1-取代3(5)-芳基氨基-1,2,4-三唑的新方法。
{"title":"Nickel-Catalyzed N-Arylation of C-Amino-1,2,4-triazoles with Arylboronic Acids","authors":"A. Yu. Chernenko,&nbsp;V. A. Baydikova,&nbsp;A. V. Astakhov,&nbsp;M. E. Minyaev,&nbsp;V. M. Chernyshev","doi":"10.1134/S0012500822700057","DOIUrl":"10.1134/S0012500822700057","url":null,"abstract":"<p>Nickel-catalyzed N-arylation of <i>C</i>-amino-1,2,4-triazoles with arylboronic acids was studied for the first time. An efficient catalytic system based on nickel chloride and phenanthroline was developed and a new method for the preparation of 1-substituted 3(5)-arylamino-1,2,4-triazoles was proposed.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"504 2","pages":"93 - 99"},"PeriodicalIF":0.8,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4140172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Bio-Profiles of Chemical Reactions for Analysis of Solvent Impact on Overall Toxicity of C–C Cross-Coupling Process 化学反应生物谱在溶剂对C-C交联过程总毒性影响分析中的应用
IF 0.8 4区 化学 Q3 Chemistry Pub Date : 2022-11-03 DOI: 10.1134/S0012500822600080
K. S. Egorova, A. S. Galushko, L. U. Dzhemileva, V. A. D’yakonov,  V. P. Ananikov

In this work, we used a recently proposed concept of bio-Profiles and bio-Factors for studying the solvent contribution into the “overall cytotoxicity” of chemical reactions by the example of synthesis of 1,1'-biphenyl from aryl halide and phenylboronic acid. Two standard solvents (ethanol and N-methylpyrrolidone) and four ionic liquids (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, and cholinium bis(trifluoromethylsulfonyl)imide) were analyzed.

在这项工作中,我们采用了最近提出的生物概况和生物因子的概念,以芳基卤化物和苯硼酸合成1,1'-联苯为例,研究了化学反应中溶剂对“整体细胞毒性”的贡献。分析了两种标准溶剂(乙醇和n -甲基吡咯烷酮)和四种离子液体(1-乙基-3-甲基咪唑二(三氟甲基磺酰基)亚胺、1-乙基-3-甲基咪唑四氟硼酸盐、1-丁基-3-甲基咪唑二(三氟甲基磺酰基)亚胺和胆碱二(三氟甲基磺酰基)亚胺)。
{"title":"Application of Bio-Profiles of Chemical Reactions for Analysis of Solvent Impact on Overall Toxicity of C–C Cross-Coupling Process","authors":"K. S. Egorova,&nbsp;A. S. Galushko,&nbsp;L. U. Dzhemileva,&nbsp;V. A. D’yakonov,&nbsp; V. P. Ananikov","doi":"10.1134/S0012500822600080","DOIUrl":"10.1134/S0012500822600080","url":null,"abstract":"<p>In this work, we used a recently proposed concept of bio-Profiles and bio-Factors for studying the solvent contribution into the “overall cytotoxicity” of chemical reactions by the example of synthesis of 1,1'-biphenyl from aryl halide and phenylboronic acid. Two standard solvents (ethanol and <i>N</i>-methylpyrrolidone) and four ionic liquids (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, and cholinium bis(trifluoromethylsulfonyl)imide) were analyzed.</p>","PeriodicalId":530,"journal":{"name":"Doklady Chemistry","volume":"504 2","pages":"106 - 117"},"PeriodicalIF":0.8,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4137963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Doklady Chemistry
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1