Pub Date : 2023-11-25DOI: 10.1007/s42757-023-0160-3
A. Arabi, Ghassan H. Abdul-Majeed, Houari B. Boukrouche, Zakaria Larbi
{"title":"Pressure recovery model for gas–liquid two-phase flow across sudden expansions","authors":"A. Arabi, Ghassan H. Abdul-Majeed, Houari B. Boukrouche, Zakaria Larbi","doi":"10.1007/s42757-023-0160-3","DOIUrl":"https://doi.org/10.1007/s42757-023-0160-3","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"49 19","pages":"14-27"},"PeriodicalIF":6.5,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139237588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01Epub Date: 2023-03-05DOI: 10.1007/s42757-022-0150-x
Mohammad Mehedi Hasan Akash, Nilotpal Chakraborty, Jiyan Mohammad, Katie Reindl, Saikat Basu
Dense fibrous extracellular constitution of solid tumors exerts high resistance to diffusive transport into it; additionally, the scarcity of blood and lymphatic flows hinders convection. The complexity of fluidic transport mechanisms in such tumor environments still presents open questions with translational end goals. For example, clinical diagnosis and targeted drug delivery platforms for such dense tumors can ideally benefit from a quantitative framework on plasma uptake into the tumor. In this study, we present a computational model for physical parameters that may influence blood percolation and penetration into simple biomimetic solid tumor geometry. The model implements three-phase viscous-laminar transient simulation to mimic the transport physics inside a tumor-adhering blood vessel and measures the constituent volume fractions of the three considered phases, viz. plasma, RBCs (red blood cells, also known as "erythrocytes"), and WBCs (white blood cells, also known as "leukocytes") at three different flow times, while simultaneously recording the plasma pressure and velocity at the entry point to the tumor's extracellular space. Subsequently, to quantify plasma perfusion within the tumor zone, we proposed a reduced-order two-dimensional transport model for the tumor entry zone and its extracellular space for three different fenestra diameters: 0.1, 0.3, and 0.5 μm; the simulations were two-phase viscous-laminar transient. The findings support the hypothesis that plasma percolation into the tumor is proportional to the leakiness modulated by the size of fenestra openings, and the rate of percolation decays with the diffusion distance.
{"title":"Development of a multiphase perfusion model for biomimetic reduced-order dense tumors.","authors":"Mohammad Mehedi Hasan Akash, Nilotpal Chakraborty, Jiyan Mohammad, Katie Reindl, Saikat Basu","doi":"10.1007/s42757-022-0150-x","DOIUrl":"10.1007/s42757-022-0150-x","url":null,"abstract":"<p><p>Dense fibrous extracellular constitution of solid tumors exerts high resistance to diffusive transport into it; additionally, the scarcity of blood and lymphatic flows hinders convection. The complexity of fluidic transport mechanisms in such tumor environments still presents open questions with translational end goals. For example, clinical diagnosis and targeted drug delivery platforms for such dense tumors can ideally benefit from a quantitative framework on plasma uptake into the tumor. In this study, we present a computational model for physical parameters that may influence blood percolation and penetration into simple biomimetic solid tumor geometry. The model implements three-phase viscous-laminar transient simulation to mimic the transport physics inside a tumor-adhering blood vessel and measures the constituent volume fractions of the three considered phases, viz. plasma, RBCs (red blood cells, also known as \"erythrocytes\"), and WBCs (white blood cells, also known as \"leukocytes\") at three different flow times, while simultaneously recording the plasma pressure and velocity at the entry point to the tumor's extracellular space. Subsequently, to quantify plasma perfusion within the tumor zone, we proposed a reduced-order two-dimensional transport model for the tumor entry zone and its extracellular space for three different fenestra diameters: 0.1, 0.3, and 0.5 μm; the simulations were two-phase viscous-laminar transient. The findings support the hypothesis that plasma percolation into the tumor is proportional to the leakiness modulated by the size of fenestra openings, and the rate of percolation decays with the diffusion distance.</p>","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"319-329"},"PeriodicalIF":4.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43998114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-09DOI: 10.1007/s42757-022-0155-5
Hossein Amjadimanesh, M. Faramarzi, S. Sadrizadeh, O. Abouali
{"title":"Micro-particle deposition in maxillary sinus for various sizes of opening in a virtual endoscopic surgery","authors":"Hossein Amjadimanesh, M. Faramarzi, S. Sadrizadeh, O. Abouali","doi":"10.1007/s42757-022-0155-5","DOIUrl":"https://doi.org/10.1007/s42757-022-0155-5","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"262 - 271"},"PeriodicalIF":6.5,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48708905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-19DOI: 10.1007/s42757-022-0156-4
E. Frense, Xinghao Yang, F. Rüdiger, Mark-Patrick Mühlhausen, J. Fröhlich
{"title":"Experimental and numerical study on the transport of dilute bubbles in a T-junction channel flow","authors":"E. Frense, Xinghao Yang, F. Rüdiger, Mark-Patrick Mühlhausen, J. Fröhlich","doi":"10.1007/s42757-022-0156-4","DOIUrl":"https://doi.org/10.1007/s42757-022-0156-4","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"396 - 410"},"PeriodicalIF":6.5,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44169257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-11DOI: 10.1007/s42757-022-0149-3
Shiwang Li, P. Apanasevich, D. Lucas, Y. Liao
{"title":"Euler-Euler CFD simulation of high velocity gas injection at pool scrubbing conditions","authors":"Shiwang Li, P. Apanasevich, D. Lucas, Y. Liao","doi":"10.1007/s42757-022-0149-3","DOIUrl":"https://doi.org/10.1007/s42757-022-0149-3","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"365 - 380"},"PeriodicalIF":6.5,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42127362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.1007/s42757-022-0152-8
Tim Hertwig, Tim Wittmann, P. Wiśniewski, J. Friedrichs
{"title":"Modeling condensing flows of humid air in transonic nozzles","authors":"Tim Hertwig, Tim Wittmann, P. Wiśniewski, J. Friedrichs","doi":"10.1007/s42757-022-0152-8","DOIUrl":"https://doi.org/10.1007/s42757-022-0152-8","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"344 - 356"},"PeriodicalIF":6.5,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47341579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.1007/s42757-022-0148-4
N. Valle, R. Verstappen
{"title":"Conservation of energy in the direct numerical simulation of interface-resolved multiphase flows","authors":"N. Valle, R. Verstappen","doi":"10.1007/s42757-022-0148-4","DOIUrl":"https://doi.org/10.1007/s42757-022-0148-4","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"333 - 343"},"PeriodicalIF":6.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42981244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-21DOI: 10.1007/s42757-022-0144-8
D. Dodds, A. Sarhan, J. Naser
{"title":"Experimental and numerical study of free-falling streams of particles impacting an inclined surface","authors":"D. Dodds, A. Sarhan, J. Naser","doi":"10.1007/s42757-022-0144-8","DOIUrl":"https://doi.org/10.1007/s42757-022-0144-8","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"381 - 395"},"PeriodicalIF":6.5,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44242599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-10DOI: 10.1007/s42757-022-0141-y
X. Si, M. Talaat, J. Xi
{"title":"Effects of guiding vanes and orifice jet flow of a metered-dose inhaler on drug dosimetry in human respiratory tract","authors":"X. Si, M. Talaat, J. Xi","doi":"10.1007/s42757-022-0141-y","DOIUrl":"https://doi.org/10.1007/s42757-022-0141-y","url":null,"abstract":"","PeriodicalId":53125,"journal":{"name":"Experimental and Computational Multiphase Flow","volume":"5 1","pages":"247 - 261"},"PeriodicalIF":6.5,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42423240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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