Pub Date : 2022-05-04DOI: 10.1007/s13237-022-00389-0
D. Dutta, Andrea Harper, G. Gangopadhyay
{"title":"Transcriptomic analysis of high oil-yielding cultivated white sesame and low oil-yielding wild black sesame seeds reveal differentially expressed genes for oil and seed coat colour","authors":"D. Dutta, Andrea Harper, G. Gangopadhyay","doi":"10.1007/s13237-022-00389-0","DOIUrl":"https://doi.org/10.1007/s13237-022-00389-0","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"65 1","pages":"151 - 164"},"PeriodicalIF":1.8,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42459868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.1007/s13237-022-00387-2
A. C. Reis, Saulo Marçal de Sousa
{"title":"Cytogenetic characterization of Mimosa pudica L (Fabaceae): heterochromatin distribution, rDNA mapping and genome size","authors":"A. C. Reis, Saulo Marçal de Sousa","doi":"10.1007/s13237-022-00387-2","DOIUrl":"https://doi.org/10.1007/s13237-022-00387-2","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"65 1","pages":"179 - 185"},"PeriodicalIF":1.8,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43391071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-23DOI: 10.1007/s13237-022-00384-5
U. C. Lavania, Y. Vimala
{"title":"Synthetic hybrid speciation: a resource for breeding novel lineages for secondary metabolites","authors":"U. C. Lavania, Y. Vimala","doi":"10.1007/s13237-022-00384-5","DOIUrl":"https://doi.org/10.1007/s13237-022-00384-5","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"65 1","pages":"1 - 6"},"PeriodicalIF":1.8,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43514199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.1007/s13237-021-00382-z
Saloni Malik, S. Babbar, M. Chaudhary, S. Sharma, S. Raina, S. Babbar
{"title":"Authentication and deciphering interrelationships of Hippophae species using DNA barcodes","authors":"Saloni Malik, S. Babbar, M. Chaudhary, S. Sharma, S. Raina, S. Babbar","doi":"10.1007/s13237-021-00382-z","DOIUrl":"https://doi.org/10.1007/s13237-021-00382-z","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"65 1","pages":"165 - 177"},"PeriodicalIF":1.8,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52777290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature has abundant source of drugs that need to be identified/purified for use as essential biologics, either individually or in combination in the modern medical field. These drugs are divided into small bio-molecules, plant-made biologics, and a recently introduced third category known as phytopharmaceutical drugs. The development of phytopharmaceutical medicines is based on the ethnopharmacological approach, which relies on the traditional medicine system. The concept of 'one-disease one-target drug' is becoming less popular, and the use of plant extracts, fractions, and molecules is the new paradigm that holds promising scope to formulate appropriate drugs. This led to discovering a new concept known as polypharmacology, where natural products from varying sources can engage with multiple human physiology targets. This article summarizes different approaches for phytopharmaceutical drug development and discusses the progress in systems biology and computational tools for identifying drug targets. We review the existing drug delivery methods to facilitate the efficient delivery of drugs to the targets. In addition, we describe different analytical techniques for the authentication and fingerprinting of plant materials. Finally, we highlight the role of biopharming in developing plant-based biologics.
{"title":"Plant-derived natural products for drug discovery: current approaches and prospects.","authors":"Noohi Nasim, Inavolu Sriram Sandeep, Sujata Mohanty","doi":"10.1007/s13237-022-00405-3","DOIUrl":"https://doi.org/10.1007/s13237-022-00405-3","url":null,"abstract":"<p><p>Nature has abundant source of drugs that need to be identified/purified for use as essential biologics, either individually or in combination in the modern medical field. These drugs are divided into small bio-molecules, plant-made biologics, and a recently introduced third category known as phytopharmaceutical drugs. The development of phytopharmaceutical medicines is based on the ethnopharmacological approach, which relies on the traditional medicine system. The concept of 'one-disease one-target drug' is becoming less popular, and the use of plant extracts, fractions, and molecules is the new paradigm that holds promising scope to formulate appropriate drugs. This led to discovering a new concept known as polypharmacology, where natural products from varying sources can engage with multiple human physiology targets. This article summarizes different approaches for phytopharmaceutical drug development and discusses the progress in systems biology and computational tools for identifying drug targets. We review the existing drug delivery methods to facilitate the efficient delivery of drugs to the targets. In addition, we describe different analytical techniques for the authentication and fingerprinting of plant materials. Finally, we highlight the role of biopharming in developing plant-based biologics.</p>","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":" ","pages":"399-411"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40565384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The positive effect of herbal supplements on aging and age-related disorders has led to the evolution of natural curatives for remedial neurodegenerative diseases in humans. The advancement in aging is exceedingly linked to oxidative stress. Enhanced oxidative stress interrupts health of humans in various ways, necessitating to find stress alleviating herbal resources. Currently, minimal scientifically validated health and cognitive booster resources are available. Therefore, we explored the impact of plant extracts in different combinations on oxidative stress, life span and cognition using the multicellular transgenic humanized C. elegans, and further validated the same in Mus musculus, besides testing their safety and toxicity. In our investigations, the final product-the HACBF (healthy ageing cognitive booster formulation) thus developed was found to reduce major aging biomarkers like lipofuscin, protein carbonyl, lipid levels and enhanced activity of antioxidant enzymes. Further confirmation was done using transgenic worms and RT-PCR. The cognitive boosting activities analyzed in C. elegans and M. musculus model system were found to be at par with donepezil and L-dopa, the two drugs which are commonly used to treat Parkinson's and Alzheimer's diseases. In the transgenic C. elegans model system, the HACBF exhibited reduced aggregation of misfolded disease proteins α-synuclein and increased the health of nicotinic acetylcholine receptor, levels of Acetylcholine and Dopamine contents respectively, the major neurotransmitters responsible for memory, language, learning behavior and movement. Molecular studies clearly indicate that HACBF upregulated major genes responsible for healthy aging and cognitive booster activities in C. elegans and as well as in M. musculus. As such, the present herbal product thus developed may be quite useful for healthy aging and cognitive boosting activities, and more so during this covid-19 pandemic.
Graphical abstract:
Supplementary information: The online version contains supplementary material available at 10.1007/s13237-022-00407-1.
{"title":"Towards the development of phytoextract based healthy ageing cognitive booster formulation, explored through <i>Caenorhabditis elegans</i> model.","authors":"Rakesh Pandey, Dayanandan Mani, Karuna Shanker, Dnyaneshwar Umrao Bawankule, Debabrata Chanda, Raj Kishori Lal, Anirban Pal, Puja Khare, Narendra Kumar, Sudeep Tandon, Dharmendra Saikia, Anil Kumar Gupta, Ramesh Kumar Srivastava, Sanjay Kumar, Ram Suresh, Saudan Singh, Alok Kalra, Anil Maurya, Dewasya Pratap Singh, Taruna Pandey, Shalini Trivedi, Shachi Suchi Smita, Akanksha Pant, Laxmi Rathor, Jyotsna Asthana, Mashu Trivedi, Prabodh Kumar Trivedi","doi":"10.1007/s13237-022-00407-1","DOIUrl":"https://doi.org/10.1007/s13237-022-00407-1","url":null,"abstract":"<p><p>The positive effect of herbal supplements on aging and age-related disorders has led to the evolution of natural curatives for remedial neurodegenerative diseases in humans. The advancement in aging is exceedingly linked to oxidative stress. Enhanced oxidative stress interrupts health of humans in various ways, necessitating to find stress alleviating herbal resources. Currently, minimal scientifically validated health and cognitive booster resources are available. Therefore, we explored the impact of plant extracts in different combinations on oxidative stress, life span and cognition using the multicellular transgenic humanized <i>C. elegans</i>, and further validated the same in <i>Mus musculus</i>, besides testing their safety and toxicity. In our investigations, the final product-the HACBF (healthy ageing cognitive booster formulation) thus developed was found to reduce major aging biomarkers like lipofuscin, protein carbonyl, lipid levels and enhanced activity of antioxidant enzymes. Further confirmation was done using transgenic worms and RT-PCR. The cognitive boosting activities analyzed in <i>C. elegans</i> and <i>M. musculus</i> model system were found to be at par with donepezil and L-dopa, the two drugs which are commonly used to treat Parkinson's and Alzheimer's diseases. In the transgenic <i>C. elegans</i> model system, the HACBF exhibited reduced aggregation of misfolded disease proteins α-synuclein and increased the health of nicotinic acetylcholine receptor, levels of Acetylcholine and Dopamine contents respectively, the major neurotransmitters responsible for memory, language, learning behavior and movement. Molecular studies clearly indicate that HACBF upregulated major genes responsible for healthy aging and cognitive booster activities in <i>C. elegans</i> and as well as in <i>M. musculus</i>. As such, the present herbal product thus developed may be quite useful for healthy aging and cognitive boosting activities, and more so during this covid-19 pandemic.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13237-022-00407-1.</p>","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":" ","pages":"303-320"},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-27DOI: 10.1007/s13237-021-00381-0
Weera Thongnetr, W. Sangpakdee, A. Tanomtong, W. Nie, S. Raso, K. Pinthong
{"title":"The chromosomal homology between dusky langur (Trachypithecus obscurus Ried, 1837) and human (Homo sapiens) revealed by chromosome painting","authors":"Weera Thongnetr, W. Sangpakdee, A. Tanomtong, W. Nie, S. Raso, K. Pinthong","doi":"10.1007/s13237-021-00381-0","DOIUrl":"https://doi.org/10.1007/s13237-021-00381-0","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":"65 1","pages":"233 - 237"},"PeriodicalIF":1.8,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44190647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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