Nucleus (India)最新文献

{"title":"Towards the development of phytoextract based healthy ageing cognitive booster formulation, explored through <i>Caenorhabditis elegans</i> model.","authors":"Rakesh Pandey,&nbsp;Dayanandan Mani,&nbsp;Karuna Shanker,&nbsp;Dnyaneshwar Umrao Bawankule,&nbsp;Debabrata Chanda,&nbsp;Raj Kishori Lal,&nbsp;Anirban Pal,&nbsp;Puja Khare,&nbsp;Narendra Kumar,&nbsp;Sudeep Tandon,&nbsp;Dharmendra Saikia,&nbsp;Anil Kumar Gupta,&nbsp;Ramesh Kumar Srivastava,&nbsp;Sanjay Kumar,&nbsp;Ram Suresh,&nbsp;Saudan Singh,&nbsp;Alok Kalra,&nbsp;Anil Maurya,&nbsp;Dewasya Pratap Singh,&nbsp;Taruna Pandey,&nbsp;Shalini Trivedi,&nbsp;Shachi Suchi Smita,&nbsp;Akanksha Pant,&nbsp;Laxmi Rathor,&nbsp;Jyotsna Asthana,&nbsp;Mashu Trivedi,&nbsp;Prabodh Kumar Trivedi","doi":"10.1007/s13237-022-00407-1","DOIUrl":"https://doi.org/10.1007/s13237-022-00407-1","url":null,"abstract":"<p><p>The positive effect of herbal supplements on aging and age-related disorders has led to the evolution of natural curatives for remedial neurodegenerative diseases in humans. The advancement in aging is exceedingly linked to oxidative stress. Enhanced oxidative stress interrupts health of humans in various ways, necessitating to find stress alleviating herbal resources. Currently, minimal scientifically validated health and cognitive booster resources are available. Therefore, we explored the impact of plant extracts in different combinations on oxidative stress, life span and cognition using the multicellular transgenic humanized <i>C. elegans</i>, and further validated the same in <i>Mus musculus</i>, besides testing their safety and toxicity. In our investigations, the final product-the HACBF (healthy ageing cognitive booster formulation) thus developed was found to reduce major aging biomarkers like lipofuscin, protein carbonyl, lipid levels and enhanced activity of antioxidant enzymes. Further confirmation was done using transgenic worms and RT-PCR. The cognitive boosting activities analyzed in <i>C. elegans</i> and <i>M. musculus</i> model system were found to be at par with donepezil and L-dopa, the two drugs which are commonly used to treat Parkinson's and Alzheimer's diseases. In the transgenic <i>C. elegans</i> model system, the HACBF exhibited reduced aggregation of misfolded disease proteins α-synuclein and increased the health of nicotinic acetylcholine receptor, levels of Acetylcholine and Dopamine contents respectively, the major neurotransmitters responsible for memory, language, learning behavior and movement. Molecular studies clearly indicate that HACBF upregulated major genes responsible for healthy aging and cognitive booster activities in <i>C. elegans</i> and as well as in <i>M. musculus</i>. As such, the present herbal product thus developed may be quite useful for healthy aging and cognitive boosting activities, and more so during this covid-19 pandemic.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13237-022-00407-1.</p>","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chromosomal homology between dusky langur (Trachypithecus obscurus Ried, 1837) and human (Homo sapiens) revealed by chromosome painting","authors":"Weera Thongnetr, W. Sangpakdee, A. Tanomtong, W. Nie, S. Raso, K. Pinthong","doi":"10.1007/s13237-021-00381-0","DOIUrl":"https://doi.org/10.1007/s13237-021-00381-0","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44190647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of methanolic extract of the aerial parts of Galium verum on HT29 and AGO cell lines","authors":"Sanaz Pashapour, M. Heshmati, Z. Mousavi, S. Esmaeili","doi":"10.1007/s13237-021-00380-1","DOIUrl":"https://doi.org/10.1007/s13237-021-00380-1","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42002847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of epigenetics on human health and possible tool for remediation","authors":"Somnath Paul","doi":"10.1007/s13237-021-00379-8","DOIUrl":"https://doi.org/10.1007/s13237-021-00379-8","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48167149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo genotoxicity assessment of nickel oxide nanoparticles in the model plant Allium cepa L","authors":"I. Manna, Sovan Mishra, Maumita Bandyopadhyay","doi":"10.1007/s13237-021-00377-w","DOIUrl":"https://doi.org/10.1007/s13237-021-00377-w","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43881246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic and transcriptional regulation of GnRH gene under altered metabolism and ageing","authors":"Kavya Chandra, Arnab Banerjee, Moitreyi Das","doi":"10.1007/s13237-021-00374-z","DOIUrl":"https://doi.org/10.1007/s13237-021-00374-z","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42993675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial epigenetics opens door to novel frontier in Infection biology","authors":"S. Ganguli, R. Chakraborty","doi":"10.1007/s13237-021-00375-y","DOIUrl":"https://doi.org/10.1007/s13237-021-00375-y","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45569362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic variations and epigenetic modulations in CYP genes: Implications in NSAID-treatment of arthritis patients","authors":"Shalini Roy Chowdhury, Oindrilla Dutta Gupta, A. Ghosh, P. Singha, Syed Benazir Firdaus, K. Klarskov","doi":"10.1007/s13237-021-00373-0","DOIUrl":"https://doi.org/10.1007/s13237-021-00373-0","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44315189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of epigenetic processes by non-coding RNAs","authors":"Kaitlyn Morgan Heyt, J. Thakur","doi":"10.1007/s13237-021-00372-1","DOIUrl":"https://doi.org/10.1007/s13237-021-00372-1","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49633638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight into phytic acid biosynthesis and its reduction strategies to improve mineral bioavailability","authors":"Sandhya Sharma, Lalitha Hari Dharani AnandKumar, A. Tyagi, Mehanthan Muthumilarasan, Kuldeep Kumar, K. Gaikwad","doi":"10.1007/s13237-021-00371-2","DOIUrl":"https://doi.org/10.1007/s13237-021-00371-2","url":null,"abstract":"","PeriodicalId":53176,"journal":{"name":"Nucleus (India)","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48871482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}